WO2007113505A2 - Culture medium containing kinase inhibitors. and uses thereof - Google Patents
Culture medium containing kinase inhibitors. and uses thereof Download PDFInfo
- Publication number
- WO2007113505A2 WO2007113505A2 PCT/GB2007/001163 GB2007001163W WO2007113505A2 WO 2007113505 A2 WO2007113505 A2 WO 2007113505A2 GB 2007001163 W GB2007001163 W GB 2007001163W WO 2007113505 A2 WO2007113505 A2 WO 2007113505A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cells
- inhibitor
- antagonist
- culture medium
- mek inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0031—Serum-free culture media
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases (EC 2.)
- C12N2501/727—Kinases (EC 2.7.)
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009502219A JP5680850B2 (en) | 2006-03-30 | 2007-03-30 | Culture medium containing kinase inhibitor and use thereof |
EP07732217A EP1999249B8 (en) | 2006-03-30 | 2007-03-30 | Culture medium containing kinase inhibitors. and uses thereof |
AT07732217T ATE530637T1 (en) | 2006-03-30 | 2007-03-30 | CULTURE MEDIA CONTAINING KINASE INHIBITORS AND USE |
CA002645170A CA2645170A1 (en) | 2006-03-30 | 2007-03-30 | Culture medium containing kinase inhibitors, and uses thereof |
AU2007232393A AU2007232393A1 (en) | 2006-03-30 | 2007-03-30 | Culture medium containing kinase inhibitors. and uses thereof |
IL193495A IL193495A0 (en) | 2006-03-30 | 2008-08-17 | Culture medium containing kinase inhibitors and uses thereof |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0606392.9A GB0606392D0 (en) | 2006-03-30 | 2006-03-30 | Culture medium containing kinase inhibitors, and uses thereof |
GB0606392.9 | 2006-03-30 | ||
GBGB0615327.4A GB0615327D0 (en) | 2006-03-30 | 2006-08-01 | Culture medium containing kinase inhibitors and uses thereof |
GB0615327.4 | 2006-08-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007113505A2 true WO2007113505A2 (en) | 2007-10-11 |
WO2007113505A3 WO2007113505A3 (en) | 2007-11-29 |
Family
ID=38050545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2007/001163 WO2007113505A2 (en) | 2006-03-30 | 2007-03-30 | Culture medium containing kinase inhibitors. and uses thereof |
Country Status (10)
Country | Link |
---|---|
US (2) | US9074180B2 (en) |
EP (2) | EP1999249B8 (en) |
JP (2) | JP5680850B2 (en) |
AT (1) | ATE530637T1 (en) |
AU (1) | AU2007232393A1 (en) |
CA (1) | CA2645170A1 (en) |
GB (1) | GB2436737B (en) |
IL (1) | IL193495A0 (en) |
TW (1) | TW200815597A (en) |
WO (1) | WO2007113505A2 (en) |
Cited By (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100330677A1 (en) * | 2008-02-11 | 2010-12-30 | Cambridge Enterprise Limited | Improved Reprogramming of Mammalian Cells, and Cells Obtained |
WO2011068103A1 (en) * | 2009-12-01 | 2011-06-09 | 独立行政法人国立がん研究センター | Method for constructing chimeric rat using rat embryonic stem cells |
WO2011081222A1 (en) * | 2009-12-29 | 2011-07-07 | 武田薬品工業株式会社 | Method for manufacturing pancreatic-hormone-producing cells |
WO2011125948A1 (en) * | 2010-04-02 | 2011-10-13 | 独立行政法人理化学研究所 | Method for preparing es cells |
WO2011159684A2 (en) | 2010-06-15 | 2011-12-22 | Cellular Dynamics International, Inc. | Generation of induced pluripotent stem cells from small volumes of peripheral blood |
JP2012511935A (en) * | 2008-12-17 | 2012-05-31 | ザ スクリプス リサーチ インスティチュート | Production and maintenance of stem cells |
US8278105B2 (en) * | 2008-09-09 | 2012-10-02 | University Of Southern California | Induction, propagation and isolation of liver progenitor cells |
WO2013009825A1 (en) | 2011-07-11 | 2013-01-17 | Cellular Dynamics International, Inc. | Methods for cell reprogramming and genome engineering |
WO2013109142A1 (en) | 2012-01-16 | 2013-07-25 | Stichting Het Nederlands Kanker Instituut | Combined pdk and mapk/erk pathway inhibition in neoplasia |
JP2013532961A (en) * | 2010-05-25 | 2013-08-22 | メモリアル スローン−ケタリング キャンサー センター | Methods and uses thereof for nociceptor differentiation of human embryonic stem cells |
WO2015041534A1 (en) | 2013-09-20 | 2015-03-26 | Stichting Het Nederlands Kanker Instituut | P90rsk in combination with raf/erk/mek |
WO2015041533A1 (en) | 2013-09-20 | 2015-03-26 | Stichting Het Nederlands Kanker Instituut | Rock in combination with mapk-pathway |
US9005968B2 (en) | 2009-10-16 | 2015-04-14 | The Scripps Research Institute | Induction of pluripotent cells |
US9068170B2 (en) | 2008-03-17 | 2015-06-30 | The Scripps Research Institute | Generation of pluripotent stem cells using recombinant proteins |
WO2015147047A1 (en) * | 2014-03-26 | 2015-10-01 | 国立大学法人京都大学 | Culture medium for pluripotent stem cells |
WO2015156674A2 (en) | 2014-04-10 | 2015-10-15 | Stichting Het Nederlands Kanker Instituut | Method for treating cancer |
CN105002134A (en) * | 2015-07-24 | 2015-10-28 | 北京大学 | Composite, method and reagent box for preparing pluripotent stem cells and application thereof |
WO2015178770A1 (en) | 2014-05-19 | 2015-11-26 | Stichting Het Nederlands Kanker Instituut | Compositions for cancer treatment |
US9315779B2 (en) | 2010-03-31 | 2016-04-19 | The Scripps Research Institute | Reprogramming cells |
US9376664B2 (en) | 2010-06-14 | 2016-06-28 | The Scripps Research Institute | Reprogramming of cells to a new fate |
US9546384B2 (en) | 2013-12-11 | 2017-01-17 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for the targeted modification of a mouse genome |
EP3060650A4 (en) * | 2013-10-25 | 2017-04-19 | Agency For Science, Technology And Research | Culturing pluripotent stem cells |
WO2017075389A1 (en) | 2015-10-30 | 2017-05-04 | The Regents Of The Universtiy Of California | Methods of generating t-cells from stem cells and immunotherapeutic methods using the t-cells |
US9732319B2 (en) | 2010-12-22 | 2017-08-15 | Fate Therapeutics, Inc. | Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs |
US10260041B2 (en) | 2009-02-17 | 2019-04-16 | Memorial Sloan Kettering Cancer Center | Methods for neural conversion of human embryonic stem cells |
US10280398B2 (en) | 2011-11-04 | 2019-05-07 | Memorial Sloan-Kettering Cancer Center | Midbrain dopamine (DA) neurons for engraftment |
US10329582B2 (en) | 2013-02-20 | 2019-06-25 | Regeneron Pharmaceuticals, Inc. | Genetic modification of rats |
US10385359B2 (en) | 2013-04-16 | 2019-08-20 | Regeneron Pharmaceuticals, Inc. | Targeted modification of rat genome |
US10590386B2 (en) | 2010-06-13 | 2020-03-17 | Insitute Of Biophysics, Chinese Academy Of Sciences | Methods and compositions for preparing cardiomyocytes from stem cells and uses thereof |
US11268069B2 (en) | 2014-03-04 | 2022-03-08 | Fate Therapeutics, Inc. | Reprogramming methods and cell culture platforms |
US11441126B2 (en) | 2015-10-16 | 2022-09-13 | Fate Therapeutics, Inc. | Platform for the induction and maintenance of ground state pluripotency |
US11649431B2 (en) | 2013-04-26 | 2023-05-16 | Memorial Sloan-Kettering Cancer Center | Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0615327D0 (en) * | 2006-03-30 | 2006-09-13 | Univ Edinburgh | Culture medium containing kinase inhibitors and uses thereof |
ES2589122T3 (en) | 2007-08-31 | 2016-11-10 | Whitehead Institute For Biomedical Research | Stimulation of the Wnt pathway in reprogramming somatic cells |
WO2009147400A1 (en) * | 2008-06-05 | 2009-12-10 | Iti Scotland Limited | Stem cell culture media and methods |
US20110088107A1 (en) * | 2009-04-24 | 2011-04-14 | Yaqub Hanna | Compositions and methods for deriving or culturing pluripotent cells |
ES2539487T3 (en) * | 2009-11-04 | 2015-07-01 | Cellular Dynamics International, Inc. | Episomic reprogramming with chemical compounds |
CN104378975A (en) * | 2012-03-27 | 2015-02-25 | 转基因股份有限公司 | Humanized mouse |
CN104508121B (en) | 2012-07-23 | 2018-01-19 | 中国科学院生物物理研究所 | External evoked pluripotent stem cell differentiation is the method for ventricular muscle cell |
CN105531365A (en) | 2013-04-23 | 2016-04-27 | 耶达研究及发展有限公司 | Isolated naive pluripotent stem cells and methods of generating same |
WO2014197934A1 (en) | 2013-06-14 | 2014-12-18 | The University Of Queensland | Renal progenitor cells |
EP3194572B1 (en) | 2014-07-30 | 2023-10-25 | Yeda Research and Development Co. Ltd. | Media for culturing pluripotent stem cells |
US10894948B2 (en) | 2014-08-22 | 2021-01-19 | Cambridge Enterprise Limited | Resetting pluripotent stem cells |
US20170313978A1 (en) * | 2014-10-07 | 2017-11-02 | Max-Delbrück-Centrum Für Molekulare Medizin In Der Helmholtz-Gemeinschaft | Endogenous retrovirus transcription as a marker for primate naive pluripotent stem cells |
ES2741387T3 (en) * | 2014-10-15 | 2020-02-10 | Regeneron Pharma | Methods and compositions for generating or maintaining pluripotent cells |
WO2018064323A1 (en) | 2016-09-28 | 2018-04-05 | Organovo, Inc. | Use of engineered renal tissues in assays |
AU2018376391A1 (en) | 2017-11-30 | 2020-06-04 | Kyoto University | Method for culture of cells |
JPWO2020262531A1 (en) * | 2019-06-26 | 2020-12-30 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9308271D0 (en) | 1993-04-21 | 1993-06-02 | Univ Edinburgh | Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method |
EP0716690A1 (en) | 1993-08-30 | 1996-06-19 | Northwestern University | Rat pluripotent embryonic stem cells and method of obtaining and using same |
JP2002511732A (en) | 1996-10-11 | 2002-04-16 | ザ・テキサス・エイ・アンド・エム・ユニヴァーシティ・システム | Compositions and methods for generating transgenic animals |
US6214795B1 (en) * | 1996-11-12 | 2001-04-10 | Praecis Pharmaceuticals, Inc. | Peptide compounds useful for modulating FGF receptor activity |
WO1999027076A1 (en) | 1997-11-25 | 1999-06-03 | Arc Genomic Research | Pluripotent embryonic stem cells and methods of obtaining them |
GB9819912D0 (en) * | 1998-09-11 | 1998-11-04 | Univ Edinburgh | Propagation and/or derivation of embryonic stem cells |
US7455983B2 (en) * | 2000-01-11 | 2008-11-25 | Geron Corporation | Medium for growing human embryonic stem cells |
US20020045260A1 (en) * | 2000-10-17 | 2002-04-18 | Shih-Chieh Hung | Method of isolating mesenchymal stem cells |
US20030204862A1 (en) * | 2002-03-05 | 2003-10-30 | Ralf Kuehn | Inbred embryonic stem-cell derived mice |
GB0210539D0 (en) * | 2002-05-08 | 2002-06-19 | Univ Edinburgh | Control of es cell self renewal and lineage specification, and medium therefor |
US7338957B2 (en) * | 2003-08-28 | 2008-03-04 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
WO2005085427A1 (en) | 2004-03-04 | 2005-09-15 | Dainippon Sumitomo Pharma Co., Ltd. | Rat embryonic stem cell |
JP2007530654A (en) * | 2004-03-30 | 2007-11-01 | ファイザー・プロダクツ・インク | Signal transduction inhibitor combinations |
WO2005110438A2 (en) | 2004-04-15 | 2005-11-24 | Massachusetts Institute Of Technology | Methods and products related to the intracellular delivery of polysaccharides |
US20080268533A1 (en) * | 2004-08-25 | 2008-10-30 | University Of Georgia Research Foundation, Inc. | Methods and Compositions Utilizing Myc and Gsk3Beta to Manipulate the Pluripotency of Embryonic Stem Cells |
AU2006257859B2 (en) | 2005-06-10 | 2009-12-10 | Irm Llc | Compounds that maintain pluripotency of embryonic stem cells |
ES2332822T3 (en) * | 2005-11-28 | 2010-02-12 | Choongwae Pharma Corporation | EXPASION WITHOUT SERUM OF CELLS IN CULTURE. |
GB0615327D0 (en) | 2006-03-30 | 2006-09-13 | Univ Edinburgh | Culture medium containing kinase inhibitors and uses thereof |
AU2007254491A1 (en) * | 2006-05-15 | 2007-11-29 | Irm Llc | Compositions and methods for FGF receptor kinases inhibitors |
-
2007
- 2007-03-30 EP EP07732217A patent/EP1999249B8/en not_active Not-in-force
- 2007-03-30 AU AU2007232393A patent/AU2007232393A1/en not_active Abandoned
- 2007-03-30 WO PCT/GB2007/001163 patent/WO2007113505A2/en active Application Filing
- 2007-03-30 JP JP2009502219A patent/JP5680850B2/en not_active Expired - Fee Related
- 2007-03-30 EP EP11182239A patent/EP2457995A1/en not_active Withdrawn
- 2007-03-30 GB GB0706239A patent/GB2436737B/en not_active Expired - Fee Related
- 2007-03-30 US US11/694,351 patent/US9074180B2/en not_active Expired - Fee Related
- 2007-03-30 CA CA002645170A patent/CA2645170A1/en not_active Abandoned
- 2007-03-30 AT AT07732217T patent/ATE530637T1/en not_active IP Right Cessation
- 2007-03-30 TW TW096111227A patent/TW200815597A/en unknown
-
2008
- 2008-08-17 IL IL193495A patent/IL193495A0/en unknown
-
2009
- 2009-10-20 US US12/581,981 patent/US20100041137A1/en not_active Abandoned
-
2013
- 2013-01-24 JP JP2013011454A patent/JP5728036B2/en not_active Expired - Fee Related
Non-Patent Citations (1)
Title |
---|
None |
Cited By (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100330677A1 (en) * | 2008-02-11 | 2010-12-30 | Cambridge Enterprise Limited | Improved Reprogramming of Mammalian Cells, and Cells Obtained |
US9926533B2 (en) | 2008-03-17 | 2018-03-27 | The Scripps Research Institute | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
US9540615B2 (en) | 2008-03-17 | 2017-01-10 | The Scripps Research Institute | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
US9534205B2 (en) | 2008-03-17 | 2017-01-03 | The Scripps Research Institute | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
US9394524B2 (en) | 2008-03-17 | 2016-07-19 | The Scripps Research Institute | Chemical approaches for generation of induced pluripotent stem cells |
JP2018104473A (en) * | 2008-03-17 | 2018-07-05 | ザ スクリプス リサーチ インスティテュート | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
US9771563B2 (en) | 2008-03-17 | 2017-09-26 | The Scripps Research Institute | Chemical approaches for generation of induced pluripotent stem cells |
US9068170B2 (en) | 2008-03-17 | 2015-06-30 | The Scripps Research Institute | Generation of pluripotent stem cells using recombinant proteins |
JP2021143194A (en) * | 2008-03-17 | 2021-09-24 | ザ スクリプス リサーチ インスティテュート | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
US8278105B2 (en) * | 2008-09-09 | 2012-10-02 | University Of Southern California | Induction, propagation and isolation of liver progenitor cells |
JP2022105220A (en) * | 2008-12-17 | 2022-07-12 | ザ スクリプス リサーチ インスティテュート | Production and maintenance of stem cells |
JP2016052305A (en) * | 2008-12-17 | 2016-04-14 | ザ スクリプス リサーチ インスティテュート | Production and maintenance of stem cells |
US8906677B2 (en) | 2008-12-17 | 2014-12-09 | The Scripps Research Institute | Generation and maintenance of stem cells |
JP2012511935A (en) * | 2008-12-17 | 2012-05-31 | ザ スクリプス リサーチ インスティチュート | Production and maintenance of stem cells |
JP2020054403A (en) * | 2008-12-17 | 2020-04-09 | ザ スクリプス リサーチ インスティテュート | Production and maintenance of stem cells |
US9695395B2 (en) | 2008-12-17 | 2017-07-04 | The Scripps Research Institute | Generation and maintenance of stem cells |
JP2017079802A (en) * | 2008-12-17 | 2017-05-18 | ザ スクリプス リサーチ インスティテュート | Production and maintenance of stem cells |
US10287546B2 (en) | 2009-02-17 | 2019-05-14 | Memorial Sloan Kettering Cancer Center | Kits for neural conversion of human embryonic stem cells |
US10260041B2 (en) | 2009-02-17 | 2019-04-16 | Memorial Sloan Kettering Cancer Center | Methods for neural conversion of human embryonic stem cells |
US11560546B2 (en) | 2009-02-17 | 2023-01-24 | Memorial Sloan Kettering Cancer Center | Methods for neural conversion of human embryonic stem cells |
US9909105B2 (en) | 2009-10-16 | 2018-03-06 | The Scripps Research Institute | Induction of pluripotent cells |
US9005968B2 (en) | 2009-10-16 | 2015-04-14 | The Scripps Research Institute | Induction of pluripotent cells |
US11046933B2 (en) | 2009-10-16 | 2021-06-29 | The Scripps Research Institute | Induction of pluripotent cells |
CN102762717A (en) * | 2009-12-01 | 2012-10-31 | 日本国立癌症研究中心 | Method for constructing chimeric rat using rat embryonic stem cells |
US9309537B2 (en) | 2009-12-01 | 2016-04-12 | National Cancer Center | Chimeric rat produced using rat embryonic stem cells in the presence of an ES cell differentiation suppressant |
WO2011068103A1 (en) * | 2009-12-01 | 2011-06-09 | 独立行政法人国立がん研究センター | Method for constructing chimeric rat using rat embryonic stem cells |
US8932853B2 (en) | 2009-12-29 | 2015-01-13 | Takeda Pharmaceutical Company Limited | Method for manufacturing pancreatic-hormone-producing cells |
WO2011081222A1 (en) * | 2009-12-29 | 2011-07-07 | 武田薬品工業株式会社 | Method for manufacturing pancreatic-hormone-producing cells |
US10738281B2 (en) | 2010-03-31 | 2020-08-11 | The Scripps Research Institute | Reprogramming cells |
US9315779B2 (en) | 2010-03-31 | 2016-04-19 | The Scripps Research Institute | Reprogramming cells |
US10214729B2 (en) | 2010-03-31 | 2019-02-26 | The Scripps Research Institute | Reprogramming cells |
US9657274B2 (en) | 2010-03-31 | 2017-05-23 | The Scripps Research Institute | Reprogramming cells |
WO2011125948A1 (en) * | 2010-04-02 | 2011-10-13 | 独立行政法人理化学研究所 | Method for preparing es cells |
JP2019205468A (en) * | 2010-05-25 | 2019-12-05 | メモリアル スローン ケタリング キャンサー センター | Method of nociceptor differentiation of human embryonic stem cells and uses thereof |
JP2016032478A (en) * | 2010-05-25 | 2016-03-10 | メモリアル スローン−ケタリング キャンサー センター | Method of nociceptor differentiation of human embryonic stem cells and uses thereof |
JP2017055767A (en) * | 2010-05-25 | 2017-03-23 | メモリアル スローン−ケタリング キャンサー センター | Method of nociceptor differentiation of human embryonic stem cells and uses thereof |
JP7003095B2 (en) | 2010-05-25 | 2022-02-04 | メモリアル スローン ケタリング キャンサー センター | Methods and Uses for Nociceptor Differentiation of Human Embryonic Stem Cells |
JP2013532961A (en) * | 2010-05-25 | 2013-08-22 | メモリアル スローン−ケタリング キャンサー センター | Methods and uses thereof for nociceptor differentiation of human embryonic stem cells |
JP2015038150A (en) * | 2010-05-25 | 2015-02-26 | メモリアル スローン−ケタリング キャンサー センター | Method of nociceptor differentiation of human embryonic stem cells and uses thereof |
US9453198B2 (en) | 2010-05-25 | 2016-09-27 | Memorial Sloan Kettering Cancer Center | Method of nociceptor differentiation of human embryonic stem cells and uses thereof |
JP2018139592A (en) * | 2010-05-25 | 2018-09-13 | メモリアル スローン ケタリング キャンサー センター | Method for nociceptor differentiation in human embryonic stem cells and use thereof |
US10590386B2 (en) | 2010-06-13 | 2020-03-17 | Insitute Of Biophysics, Chinese Academy Of Sciences | Methods and compositions for preparing cardiomyocytes from stem cells and uses thereof |
US10934528B2 (en) | 2010-06-14 | 2021-03-02 | The Scripps Research Institute | Reprogramming of cells to a new fate |
US9376664B2 (en) | 2010-06-14 | 2016-06-28 | The Scripps Research Institute | Reprogramming of cells to a new fate |
US9556417B2 (en) | 2010-06-14 | 2017-01-31 | The Scripps Research Institute | Reprogramming of cells to a new fate |
US10308912B2 (en) | 2010-06-14 | 2019-06-04 | The Scripps Research Institute | Reprogramming of cells to a new fate |
WO2011159684A2 (en) | 2010-06-15 | 2011-12-22 | Cellular Dynamics International, Inc. | Generation of induced pluripotent stem cells from small volumes of peripheral blood |
US8691574B2 (en) | 2010-06-15 | 2014-04-08 | Cellular Dynamics International, Inc. | Generation of induced pluripotent stem cells from small volumes of peripheral blood |
US9447382B2 (en) | 2010-06-15 | 2016-09-20 | Cellular Dynamics International, Inc. | Generation of induced pluripotent stem cells from small volumes of peripheral blood |
EP3382008A1 (en) | 2010-06-15 | 2018-10-03 | FUJIFILM Cellular Dynamics, Inc. | Generation of induced pluripotent stem cells from small volumes of peripheral blood |
US10260048B2 (en) | 2010-06-15 | 2019-04-16 | FUJIFILM Cellular Dynamics, Inc. | Generation of induced pluripotent stem cells from small volumes of peripheral blood |
US10844356B2 (en) | 2010-12-22 | 2020-11-24 | Fate Therapeutics, Inc. | Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs |
US9732319B2 (en) | 2010-12-22 | 2017-08-15 | Fate Therapeutics, Inc. | Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs |
WO2013009825A1 (en) | 2011-07-11 | 2013-01-17 | Cellular Dynamics International, Inc. | Methods for cell reprogramming and genome engineering |
US10280398B2 (en) | 2011-11-04 | 2019-05-07 | Memorial Sloan-Kettering Cancer Center | Midbrain dopamine (DA) neurons for engraftment |
US11970712B2 (en) | 2011-11-04 | 2024-04-30 | Memorial Sloan-Kettering Cancer Center | Midbrain dopamine (DA) neurons for engraftment |
US10711243B2 (en) | 2011-11-04 | 2020-07-14 | Memorial Sloan-Kettering Cancer Center | Midbrain dopamine (DA) neurons for engraftment |
WO2013109142A1 (en) | 2012-01-16 | 2013-07-25 | Stichting Het Nederlands Kanker Instituut | Combined pdk and mapk/erk pathway inhibition in neoplasia |
US10329582B2 (en) | 2013-02-20 | 2019-06-25 | Regeneron Pharmaceuticals, Inc. | Genetic modification of rats |
US10894965B2 (en) | 2013-02-20 | 2021-01-19 | Regeneron Pharmaceuticals, Inc. | Genetic modification of rats |
US10385359B2 (en) | 2013-04-16 | 2019-08-20 | Regeneron Pharmaceuticals, Inc. | Targeted modification of rat genome |
US10975390B2 (en) | 2013-04-16 | 2021-04-13 | Regeneron Pharmaceuticals, Inc. | Targeted modification of rat genome |
US11649431B2 (en) | 2013-04-26 | 2023-05-16 | Memorial Sloan-Kettering Cancer Center | Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells |
WO2015041533A1 (en) | 2013-09-20 | 2015-03-26 | Stichting Het Nederlands Kanker Instituut | Rock in combination with mapk-pathway |
WO2015041534A1 (en) | 2013-09-20 | 2015-03-26 | Stichting Het Nederlands Kanker Instituut | P90rsk in combination with raf/erk/mek |
EP3060650A4 (en) * | 2013-10-25 | 2017-04-19 | Agency For Science, Technology And Research | Culturing pluripotent stem cells |
US10087416B2 (en) | 2013-10-25 | 2018-10-02 | Agency For Science, Technology And Research | Culturing pluripotent stem cells |
US10711280B2 (en) | 2013-12-11 | 2020-07-14 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for the targeted modification of a mouse ES cell genome |
US11820997B2 (en) | 2013-12-11 | 2023-11-21 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for the targeted modification of a genome |
US9546384B2 (en) | 2013-12-11 | 2017-01-17 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for the targeted modification of a mouse genome |
US10208317B2 (en) | 2013-12-11 | 2019-02-19 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for the targeted modification of a mouse embryonic stem cell genome |
US11268069B2 (en) | 2014-03-04 | 2022-03-08 | Fate Therapeutics, Inc. | Reprogramming methods and cell culture platforms |
JPWO2015147047A1 (en) * | 2014-03-26 | 2017-04-13 | 国立大学法人京都大学 | Medium for pluripotent stem cell culture |
WO2015147047A1 (en) * | 2014-03-26 | 2015-10-01 | 国立大学法人京都大学 | Culture medium for pluripotent stem cells |
US11015169B2 (en) | 2014-03-26 | 2021-05-25 | Kyoto University | Culture medium for pluripotent stem cells |
WO2015156674A2 (en) | 2014-04-10 | 2015-10-15 | Stichting Het Nederlands Kanker Instituut | Method for treating cancer |
WO2015178770A1 (en) | 2014-05-19 | 2015-11-26 | Stichting Het Nederlands Kanker Instituut | Compositions for cancer treatment |
CN105002134A (en) * | 2015-07-24 | 2015-10-28 | 北京大学 | Composite, method and reagent box for preparing pluripotent stem cells and application thereof |
US11441126B2 (en) | 2015-10-16 | 2022-09-13 | Fate Therapeutics, Inc. | Platform for the induction and maintenance of ground state pluripotency |
WO2017075389A1 (en) | 2015-10-30 | 2017-05-04 | The Regents Of The Universtiy Of California | Methods of generating t-cells from stem cells and immunotherapeutic methods using the t-cells |
Also Published As
Publication number | Publication date |
---|---|
EP1999249A2 (en) | 2008-12-10 |
US9074180B2 (en) | 2015-07-07 |
US20100041137A1 (en) | 2010-02-18 |
JP2013066495A (en) | 2013-04-18 |
EP1999249B1 (en) | 2011-10-26 |
WO2007113505A3 (en) | 2007-11-29 |
ATE530637T1 (en) | 2011-11-15 |
EP2457995A1 (en) | 2012-05-30 |
JP2009531054A (en) | 2009-09-03 |
AU2007232393A1 (en) | 2007-10-11 |
JP5728036B2 (en) | 2015-06-03 |
CA2645170A1 (en) | 2007-10-11 |
JP5680850B2 (en) | 2015-03-04 |
EP1999249B8 (en) | 2012-02-15 |
US20080014638A1 (en) | 2008-01-17 |
IL193495A0 (en) | 2011-08-01 |
TW200815597A (en) | 2008-04-01 |
GB2436737B (en) | 2008-07-09 |
GB2436737A (en) | 2007-10-03 |
GB0706239D0 (en) | 2007-05-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1999249B8 (en) | Culture medium containing kinase inhibitors. and uses thereof | |
US20090130759A1 (en) | Culture Medium Containing Kinase Inhibitor, and Use Thereof | |
AU2014248167B2 (en) | Methods and compositions for culturing endoderm progenitor cells in suspension | |
Vallier et al. | Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells | |
US9458426B2 (en) | Small molecules supporting pluripotent cell growth and methods thereof | |
JP5128946B2 (en) | Feeder-independent long-term culture of embryonic stem cells | |
JP2016005462A (en) | Compositions and methods useful for culturing differentiable cells | |
EP2737057B1 (en) | Novel markers for dopaminergic neuron progenitor cells | |
US20110044954A1 (en) | Methods of producing germ-like cells and related therapies | |
KR20140059729A (en) | Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof | |
US8815590B2 (en) | Composition and method for differentiation of human embryonic stem cells | |
US20070178439A1 (en) | Control of es cell self renewal and lineage specification, and medium therefor | |
JP2022533745A (en) | Method for culturing human pluripotent cells | |
JP7065517B2 (en) | Method for producing PTF1A-positive cells | |
Shephard | Targeted Differentiation of Pluripotent Stem Cells to Hepatocytes | |
WO2009055868A1 (en) | Process and compositions for culturing cells | |
Tuomisto | Component screening for novel xeno-free medium for human embryonic stem cells |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 07732217 Country of ref document: EP Kind code of ref document: A2 |
|
DPE1 | Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 193495 Country of ref document: IL |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007232393 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007732217 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 3577/KOLNP/2008 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2645170 Country of ref document: CA |
|
ENP | Entry into the national phase |
Ref document number: 2007232393 Country of ref document: AU Date of ref document: 20070330 Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 200780011232.5 Country of ref document: CN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2009502219 Country of ref document: JP |
|
NENP | Non-entry into the national phase |
Ref country code: DE |