WO2007104834A1 - Terminating substrates for dna polymerases - Google Patents

Terminating substrates for dna polymerases Download PDF

Info

Publication number
WO2007104834A1
WO2007104834A1 PCT/FI2007/050127 FI2007050127W WO2007104834A1 WO 2007104834 A1 WO2007104834 A1 WO 2007104834A1 FI 2007050127 W FI2007050127 W FI 2007050127W WO 2007104834 A1 WO2007104834 A1 WO 2007104834A1
Authority
WO
WIPO (PCT)
Prior art keywords
lanthanide
substrate according
dna
terminating
lll
Prior art date
Application number
PCT/FI2007/050127
Other languages
English (en)
French (fr)
Inventor
Jari Hovinen
Original Assignee
Wallac Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wallac Oy filed Critical Wallac Oy
Priority to GB0818768A priority Critical patent/GB2450454B/en
Publication of WO2007104834A1 publication Critical patent/WO2007104834A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
PCT/FI2007/050127 2006-03-13 2007-03-08 Terminating substrates for dna polymerases WO2007104834A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB0818768A GB2450454B (en) 2006-03-13 2007-03-08 Terminating substrates for DNA polymerases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20065162A FI20065162A0 (fi) 2006-03-13 2006-03-13 Terminoivia DNA polymeraasisubstraatteja
FI20065162 2006-03-13

Publications (1)

Publication Number Publication Date
WO2007104834A1 true WO2007104834A1 (en) 2007-09-20

Family

ID=36192007

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FI2007/050127 WO2007104834A1 (en) 2006-03-13 2007-03-08 Terminating substrates for dna polymerases

Country Status (3)

Country Link
FI (1) FI20065162A0 (fi)
GB (1) GB2450454B (fi)
WO (1) WO2007104834A1 (fi)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8119800B2 (en) 2007-12-21 2012-02-21 Korea Research Institute Of Chemical Technology Processes for preparing HIV reverse transcriptase inhibitors
US8334295B2 (en) 2007-06-29 2012-12-18 Korea Research Institute Of Chemical Technology Pyrimidine derivatives as HIV reverse transcriptase inhibitors
US8354421B2 (en) 2007-06-29 2013-01-15 Korea Research Insitute Of Chemical Technology HIV reverse transcriptase inhibitors
US9745253B2 (en) 2015-03-13 2017-08-29 Forma Therapeutics, Inc. Alpha-cinnamide compounds and compositions as HDAC8 inhibitors

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0251786A2 (en) * 1986-07-02 1988-01-07 E.I. Du Pont De Nemours And Company Alkynylamino-nucleotides
EP0340675A2 (en) * 1988-05-02 1989-11-08 The Perkin-Elmer Corporation Time-resolved fluorimetric detection of lanthanide labeled nucleotides
WO1990000623A1 (en) * 1988-07-08 1990-01-25 Wallac Oy Multi-label time-resolved fluorescence analysis of nucleic acid sequences using lanthanide chelates
US5798210A (en) * 1993-03-26 1998-08-25 Institut Pasteur Derivatives utilizable in nucleic acid sequencing
US6255475B1 (en) * 1995-01-31 2001-07-03 Marek Kwiatkowski Chain terminators, the use thereof for nucleic acid sequencing and synthesis and a method of their preparation
US20050084451A1 (en) * 2003-08-29 2005-04-21 Wallac Oy Novel chelating agents and chelates and their use
US20050181393A1 (en) * 2003-12-18 2005-08-18 Wallac Oy Novel chelating agents and highly luminescent and stable chelates and their use

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0251786A2 (en) * 1986-07-02 1988-01-07 E.I. Du Pont De Nemours And Company Alkynylamino-nucleotides
EP0340675A2 (en) * 1988-05-02 1989-11-08 The Perkin-Elmer Corporation Time-resolved fluorimetric detection of lanthanide labeled nucleotides
WO1990000623A1 (en) * 1988-07-08 1990-01-25 Wallac Oy Multi-label time-resolved fluorescence analysis of nucleic acid sequences using lanthanide chelates
US5798210A (en) * 1993-03-26 1998-08-25 Institut Pasteur Derivatives utilizable in nucleic acid sequencing
US6255475B1 (en) * 1995-01-31 2001-07-03 Marek Kwiatkowski Chain terminators, the use thereof for nucleic acid sequencing and synthesis and a method of their preparation
US20050084451A1 (en) * 2003-08-29 2005-04-21 Wallac Oy Novel chelating agents and chelates and their use
US20050181393A1 (en) * 2003-12-18 2005-08-18 Wallac Oy Novel chelating agents and highly luminescent and stable chelates and their use

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8334295B2 (en) 2007-06-29 2012-12-18 Korea Research Institute Of Chemical Technology Pyrimidine derivatives as HIV reverse transcriptase inhibitors
US8354421B2 (en) 2007-06-29 2013-01-15 Korea Research Insitute Of Chemical Technology HIV reverse transcriptase inhibitors
US8119800B2 (en) 2007-12-21 2012-02-21 Korea Research Institute Of Chemical Technology Processes for preparing HIV reverse transcriptase inhibitors
US9745253B2 (en) 2015-03-13 2017-08-29 Forma Therapeutics, Inc. Alpha-cinnamide compounds and compositions as HDAC8 inhibitors
US10266487B2 (en) 2015-03-13 2019-04-23 Forma Therapeutics, Inc. Alpha-cinnamide compounds and compositions as HDAC8 inhibitors
US10508077B2 (en) 2015-03-13 2019-12-17 Forma Therapeutics, Inc. Alpha-cinnamide compounds and compositions as HDAC8 inhibitors
US10988441B2 (en) 2015-03-13 2021-04-27 Valo Early Discovery, Inc. Alpha-cinnamide compounds and compositions as HDAC8 inhibitors
US11919839B2 (en) 2015-03-13 2024-03-05 Valo Health, Inc. Alpha-cinnamide compounds and compositions as HDAC8 inhibitors

Also Published As

Publication number Publication date
FI20065162A0 (fi) 2006-03-13
GB2450454B (en) 2011-04-13
GB0818768D0 (en) 2008-11-19
GB2450454A (en) 2008-12-24

Similar Documents

Publication Publication Date Title
US9938573B2 (en) Methods and kits for nucleic acid sequencing
US5185439A (en) Acridinium ester labelling and purification of nucleotide probes
AU763671B2 (en) Detection using degradation of a tagged sequence
EP3898643B1 (en) 3' reversibly protected nucleotides for sequencing by synthesis using nanopores
KR101107315B1 (ko) ３′―하이드록실기에 형광을 띄는 장애그룹이 부착된 뉴클레오시드 삼인산을 가역적 종결자로서 이용한 ｄｎａ 염기서열 분석 방법
JP2003532092A (ja) Ｔａｇライブラリー化合物、組成物、キットおよび使用の方法
JPH075170A (ja) 放射エネルギー検出方法及びシステム
EP0312248B1 (en) Acridinium ester labelling and purification of nucleotide probes
WO2007104834A1 (en) Terminating substrates for dna polymerases
CA2873370A1 (en) Nucleic acid probe, method for designing nucleic acid probe, and method for detecting target sequence
US6074824A (en) Method for determining DNA nucleotide sequence
US7482444B2 (en) Terminating substrates for DNA polymerases
EP1296997B1 (en) Base analogues
JPH01500353A (ja) ２′‐デオキシアデノシン誘導体を含む核酸検出用プローブ
AU619223B2 (en) Acridinium ester labelling and purification of nucleotide probes
McGall Nucleoside triphosphate analogs for nonradioactive labeling of nucleic acids
EP1161681A2 (en) Use of lna in mass spectrometry
WO2007105623A1 (ja) オリゴヌクレオチド固定化固相担体

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07712617

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 0818768

Country of ref document: GB

Kind code of ref document: A

Free format text: PCT FILING DATE = 20070308

WWE Wipo information: entry into national phase

Ref document number: 0818768.4

Country of ref document: GB

122 Ep: pct application non-entry in european phase

Ref document number: 07712617

Country of ref document: EP

Kind code of ref document: A1