WO2007097318A1 - Marqueur diagnostique - Google Patents

Marqueur diagnostique Download PDF

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Publication number
WO2007097318A1
WO2007097318A1 PCT/JP2007/053068 JP2007053068W WO2007097318A1 WO 2007097318 A1 WO2007097318 A1 WO 2007097318A1 JP 2007053068 W JP2007053068 W JP 2007053068W WO 2007097318 A1 WO2007097318 A1 WO 2007097318A1
Authority
WO
WIPO (PCT)
Prior art keywords
diagnostic marker
formula
following formula
lectin
particle
Prior art date
Application number
PCT/JP2007/053068
Other languages
English (en)
Japanese (ja)
Inventor
Shinji Sakuma
Shinji Yamashita
Ken-Ichiro Hiwatari
Yoshikazu Shoji
Original Assignee
Adeka Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adeka Corporation filed Critical Adeka Corporation
Priority to EP07714571.2A priority Critical patent/EP1987846B1/fr
Priority to JP2007515723A priority patent/JP5116468B2/ja
Priority to US11/918,465 priority patent/US8735177B2/en
Publication of WO2007097318A1 publication Critical patent/WO2007097318A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0039—Coumarin dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043—Fluorescein, used in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0089—Particulate, powder, adsorbate, bead, sphere
    • A61K49/0091—Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
    • A61K49/0093—Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle

Abstract

La présente invention concerne un marqueur diagnostique comprenant une particule d'un diamètre compris entre 1 nm et 100 μm, sur la surface de laquelle se trouve un site doté d'une haute capacité de liaison spécifique à un antigène spécifique situé sur une membrane muqueuse d'un cancer gastro-intestinal et un site doté d'une faible capacité de liaison à une membrane muqueuse du système digestif, ladite particule incluant une substance différentiable.
PCT/JP2007/053068 2006-02-23 2007-02-20 Marqueur diagnostique WO2007097318A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP07714571.2A EP1987846B1 (fr) 2006-02-23 2007-02-20 Marqueur diagnostique
JP2007515723A JP5116468B2 (ja) 2006-02-23 2007-02-20 診断用マーカー
US11/918,465 US8735177B2 (en) 2006-02-23 2007-02-20 Diagnostic marker

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006046412 2006-02-23
JP2006-046412 2006-02-23

Publications (1)

Publication Number Publication Date
WO2007097318A1 true WO2007097318A1 (fr) 2007-08-30

Family

ID=38437358

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/053068 WO2007097318A1 (fr) 2006-02-23 2007-02-20 Marqueur diagnostique

Country Status (4)

Country Link
US (1) US8735177B2 (fr)
EP (1) EP1987846B1 (fr)
JP (1) JP5116468B2 (fr)
WO (1) WO2007097318A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009053071A (ja) * 2007-08-28 2009-03-12 Adeka Corp 凝集検査用微粒子
JP2015101543A (ja) * 2013-11-21 2015-06-04 株式会社Adeka 重合性基を有するクマリン化合物
JP2015228840A (ja) * 2014-06-06 2015-12-21 学校法人常翔学園 癌の検出液
US11396567B2 (en) 2016-09-26 2022-07-26 National University Corporation Saitama University Fine fluorescent particle containing AIE-active compound

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10510250A (ja) * 1994-12-07 1998-10-06 インスティトゥート・フュア・ディアゴノスティクフォルシュング・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング・アン・デル・フライエン・ウニヴェルジテート・ベルリン Ｎｉｒ光を利用したイン・ビボ診断のための方法
JPH10307138A (ja) * 1997-05-08 1998-11-17 Nihon Medi Physics Co Ltd 腫瘍診断剤および治療剤
JP2002348564A (ja) * 2001-05-28 2002-12-04 Asahi Denka Kogyo Kk 帯電防止剤
JP2005505580A (ja) * 2001-09-21 2005-02-24 ジ アドミニストレイターズ オブ ザ チューレン エデュケイショナル ファンド 診断用もしくは治療用ソマトスタチンまたはボンベシン類似体の結合体およびその使用法
JP3669752B2 (ja) * 1995-01-30 2005-07-13 第一化学薬品株式会社 診断用マーカー

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5110911A (en) 1989-11-02 1992-05-05 Biomira, Inc. Human tumor-associated thomsen-friedenreich antigen
US6084072A (en) * 1990-04-11 2000-07-04 The Regents Of The University Of Michigan Purified lectin and methods of use
AU4497096A (en) 1995-01-30 1996-08-21 Daiichi Pure Chemicals Co., Ltd. Diagnostic marker
US6331289B1 (en) * 1996-10-28 2001-12-18 Nycomed Imaging As Targeted diagnostic/therapeutic agents having more than one different vectors
US20020106327A1 (en) 2000-11-15 2002-08-08 Brian Storrie B/b-like fragment targeting for the purposes of photodynamic therapy and medical imaging
DE10311248A1 (de) 2003-03-14 2004-09-30 Müller-Hermelink, Hans Konrad, Prof. Dr. Humaner monoklonaler Antikörper
US20060281076A1 (en) * 2005-05-18 2006-12-14 Nanosphere, Inc. Substrate functionalization method for high sensitivity applications

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10510250A (ja) * 1994-12-07 1998-10-06 インスティトゥート・フュア・ディアゴノスティクフォルシュング・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング・アン・デル・フライエン・ウニヴェルジテート・ベルリン Ｎｉｒ光を利用したイン・ビボ診断のための方法
JP3669752B2 (ja) * 1995-01-30 2005-07-13 第一化学薬品株式会社 診断用マーカー
JPH10307138A (ja) * 1997-05-08 1998-11-17 Nihon Medi Physics Co Ltd 腫瘍診断剤および治療剤
JP2002348564A (ja) * 2001-05-28 2002-12-04 Asahi Denka Kogyo Kk 帯電防止剤
JP2005505580A (ja) * 2001-09-21 2005-02-24 ジ アドミニストレイターズ オブ ザ チューレン エデュケイショナル ファンド 診断用もしくは治療用ソマトスタチンまたはボンベシン類似体の結合体およびその使用法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1987846A4 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009053071A (ja) * 2007-08-28 2009-03-12 Adeka Corp 凝集検査用微粒子
JP2015101543A (ja) * 2013-11-21 2015-06-04 株式会社Adeka 重合性基を有するクマリン化合物
JP2015228840A (ja) * 2014-06-06 2015-12-21 学校法人常翔学園 癌の検出液
US11396567B2 (en) 2016-09-26 2022-07-26 National University Corporation Saitama University Fine fluorescent particle containing AIE-active compound

Also Published As

Publication number Publication date
US20090075301A1 (en) 2009-03-19
US8735177B2 (en) 2014-05-27
JPWO2007097318A1 (ja) 2009-07-16
EP1987846A4 (fr) 2012-11-21
EP1987846A1 (fr) 2008-11-05
JP5116468B2 (ja) 2013-01-09
EP1987846B1 (fr) 2016-07-13

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