WO2007088558A3 - Procédé de purification du valsartan - Google Patents

Procédé de purification du valsartan Download PDF

Info

Publication number
WO2007088558A3
WO2007088558A3 PCT/IN2007/000021 IN2007000021W WO2007088558A3 WO 2007088558 A3 WO2007088558 A3 WO 2007088558A3 IN 2007000021 W IN2007000021 W IN 2007000021W WO 2007088558 A3 WO2007088558 A3 WO 2007088558A3
Authority
WO
WIPO (PCT)
Prior art keywords
valsartan
purification
solvent
crystallizing
washing
Prior art date
Application number
PCT/IN2007/000021
Other languages
English (en)
Other versions
WO2007088558A2 (fr
Inventor
Pandurang Balwant Deshpande
Parven Kumar Luthra
Anand Kumar Pandey
Hetal Rameshchandra Shah
Original Assignee
Alembic Ltd
Pandurang Balwant Deshpande
Parven Kumar Luthra
Anand Kumar Pandey
Hetal Rameshchandra Shah
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alembic Ltd, Pandurang Balwant Deshpande, Parven Kumar Luthra, Anand Kumar Pandey, Hetal Rameshchandra Shah filed Critical Alembic Ltd
Publication of WO2007088558A2 publication Critical patent/WO2007088558A2/fr
Publication of WO2007088558A3 publication Critical patent/WO2007088558A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention porte sur un procédé de purification du Valsartan consistant: (i) à le cristalliser à partir d'un solvant organique; et (ii) à laver le produit cristallisé obtenu en (i) au moyen d'un solvant choisi parmi des hydrocarbures aliphatiques.
PCT/IN2007/000021 2006-02-02 2007-01-19 Procédé de purification du valsartan WO2007088558A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN164MU2006 2006-02-02
IN164/MUM/2006 2006-02-02

Publications (2)

Publication Number Publication Date
WO2007088558A2 WO2007088558A2 (fr) 2007-08-09
WO2007088558A3 true WO2007088558A3 (fr) 2007-10-25

Family

ID=38229031

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000021 WO2007088558A2 (fr) 2006-02-02 2007-01-19 Procédé de purification du valsartan

Country Status (1)

Country Link
WO (1) WO2007088558A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007017897A2 (fr) * 2005-05-25 2007-02-15 Ipca Laboratories Ltd. Nouvelles formes cristallines de (s)-n-(1-carboxy-2-methyl-prop-1-yl)-n-pentanoyl-n-[2'-(1h-tetrazol-5-yl)bi-phenyl-4-ylmethyl]-amine
CN102329276B (zh) * 2011-09-30 2013-09-25 浙江新赛科药业有限公司 一种缬沙坦母液的回收方法
CN103739564A (zh) * 2012-02-20 2014-04-23 中国科学院上海药物研究所 缬沙坦的多晶型及其制备方法
CN103435567B (zh) * 2013-09-09 2015-08-26 山东新华制药股份有限公司 缬沙坦的精制方法
CN104030996B (zh) * 2014-05-21 2016-06-01 丽珠医药集团股份有限公司 一种缬沙坦的合成方法
CN108047152A (zh) * 2017-12-12 2018-05-18 湖南千金协力药业有限公司 一种缬沙坦的精制方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399578A (en) * 1990-02-19 1995-03-21 Ciba-Geigy Corp Acyl compounds
WO2003089417A1 (fr) * 2002-04-15 2003-10-30 Dr. Reddy's Laboratories Limited Nouvelles formes cristallines de (s)-n-(1-carboxy-2-methyl-prop-1-yl) -n-pentanoyl-n- [2'-(1h-tetrazol-5-yl-)- biphenyl-4-yl methyl] amine (valsartan)
WO2005049587A1 (fr) * 2003-11-21 2005-06-02 Ranbaxy Laboratories Limited Procede de preparation de tetrazole de biphenyle
US20060149079A1 (en) * 2005-01-03 2006-07-06 Padi Pratap R Process for preparing valsartan
EP1714963A1 (fr) * 2005-04-19 2006-10-25 IPCA Laboratories Limited Procédé pour la préparation du Valsartan et de ses intermédiaires

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399578A (en) * 1990-02-19 1995-03-21 Ciba-Geigy Corp Acyl compounds
WO2003089417A1 (fr) * 2002-04-15 2003-10-30 Dr. Reddy's Laboratories Limited Nouvelles formes cristallines de (s)-n-(1-carboxy-2-methyl-prop-1-yl) -n-pentanoyl-n- [2'-(1h-tetrazol-5-yl-)- biphenyl-4-yl methyl] amine (valsartan)
WO2005049587A1 (fr) * 2003-11-21 2005-06-02 Ranbaxy Laboratories Limited Procede de preparation de tetrazole de biphenyle
US20060149079A1 (en) * 2005-01-03 2006-07-06 Padi Pratap R Process for preparing valsartan
EP1714963A1 (fr) * 2005-04-19 2006-10-25 IPCA Laboratories Limited Procédé pour la préparation du Valsartan et de ses intermédiaires

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MOENIUS TH ET AL: "Carbon-14 labelling of DIOVAN(TM) in its valine-moiety", 2000, JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS 2000 UNITED KINGDOM, VOL. 43, NR. 13, PAGE(S) 1245-1252, ISSN: 0362-4803, XP002442573 *

Also Published As

Publication number Publication date
WO2007088558A2 (fr) 2007-08-09

Similar Documents

Publication Publication Date Title
WO2007134846A3 (fr) Procédé de purification de l'anastrozole
GB0803651D0 (en) A process for purification of trichologalactactosucrose based on direct extraction in organic solvent from reaction mixture followed by evaporative removal
WO2007109654A3 (fr) Polymorphes de docétaxel et procédés
WO2011077099A3 (fr) Procédés de purification de cucurbiturile
WO2006074331A3 (fr) Procede de distillation
BRPI0923849A2 (pt) Processo integrado para a produção de acetato de vinila a partir de ácido acético via acetato de etila.
WO2007088558A3 (fr) Procédé de purification du valsartan
BRPI0922092A2 (pt) processo integrado para a produção de acetato de vinila partir do ácido acético via etileno
WO2007011951A3 (fr) Preparation de paricalcitol
WO2009084023A3 (fr) Rameltéon amorphe et son procédé de préparation
WO2009146052A3 (fr) Cristallisation de sucralose à partir de flux d’alimentation contenant du sucralose
WO2009076948A3 (fr) Réductones utilisées pour la production de biogaz
WO2009137192A3 (fr) Purification de flux d'alimentation contenant du sucralose pour cristallisation de sucralose
EP2047917A4 (fr) Procédé de fabrication d'une couche mince organique par l'utilisation d'un procédé d'amélioration des propriétés physiques du film
WO2007031865A3 (fr) Forme polymorphique d'hydrochlorure de lercanidipine et son procede de preparation
WO2006122020A3 (fr) Procede de production de 4-biphenylyazetidin-2-ones
ATE442371T1 (de) Víllig lísungsmittelfreie cefotetan säure und verfahren zu ihrer herstellung.
WO2010089267A3 (fr) Procédé de production de dérivés d'acide 2-halogénométhylphénylacétique
WO2009024478A3 (fr) Procédé de purification de silicium polycristallin
EP1995037A4 (fr) Procede de production de pieces moulees par soufflage
WO2009022600A1 (fr) Procédé de fabrication d'un composé hydrazine, intermédiaire pour la production d'un composé hydrazine, et procédé de fabrication de l'intermédiaire
WO2008089005A3 (fr) Inhibiteurs de rénine
WO2007121466A3 (fr) Procédé de préparation du rimonabant
WO2007054784A8 (fr) Procede ameliore de preparation de chlorhydrate de granisetron
WO2009057137A3 (fr) Procédé de purification du lévétiracétam

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07736499

Country of ref document: EP

Kind code of ref document: A2