WO2007082480A1 - Cartridge-based microfluidic analyzer - Google Patents

Cartridge-based microfluidic analyzer Download PDF

Info

Publication number
WO2007082480A1
WO2007082480A1 PCT/CN2007/000198 CN2007000198W WO2007082480A1 WO 2007082480 A1 WO2007082480 A1 WO 2007082480A1 CN 2007000198 W CN2007000198 W CN 2007000198W WO 2007082480 A1 WO2007082480 A1 WO 2007082480A1
Authority
WO
WIPO (PCT)
Prior art keywords
cartridge
microchannel
fluid
microfluidic device
sample
Prior art date
Application number
PCT/CN2007/000198
Other languages
English (en)
French (fr)
Inventor
Min Guo
Xiaosheng Guan
Cheng Zhou
Dongxu Weng
Yuming Hu
Wanjie Zhang
Yonggang Guo
Guanbin Zhang
Jing Cheng
Original Assignee
Capitalbio Corporation
Tsinghua University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Capitalbio Corporation, Tsinghua University filed Critical Capitalbio Corporation
Publication of WO2007082480A1 publication Critical patent/WO2007082480A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0631—Purification arrangements, e.g. solid phase extraction [SPE]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1883—Means for temperature control using thermal insulation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/628—Detection means characterised by use of a special device being a surface plasmon resonance spectrometer
PCT/CN2007/000198 2006-01-19 2007-01-18 Cartridge-based microfluidic analyzer WO2007082480A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN200610002135.7 2006-01-19
CN2006100021357A CN101004423B (zh) 2006-01-19 2006-01-19 流体样品分析用卡盒系统

Publications (1)

Publication Number Publication Date
WO2007082480A1 true WO2007082480A1 (en) 2007-07-26

Family

ID=38287271

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2007/000198 WO2007082480A1 (en) 2006-01-19 2007-01-18 Cartridge-based microfluidic analyzer

Country Status (2)

Country Link
CN (1) CN101004423B (zh)
WO (1) WO2007082480A1 (zh)

Cited By (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2138232A1 (en) * 2008-06-23 2009-12-30 Koninklijke Philips Electronics N.V. Detection of tapped aliquots of amplified nucleic acids
ITBO20090154A1 (it) * 2009-03-17 2010-09-18 Silicon Biosystems Spa Sistema microfluidico
WO2010091410A3 (en) * 2009-02-09 2010-12-16 Forensic Science Service Limited Improvements in and relating to microfluidic devices for processing a sample
WO2011011172A1 (en) * 2009-07-21 2011-01-27 IntegenX, Inc. Microfluidic devices and uses thereof
USD645971S1 (en) 2010-05-11 2011-09-27 Claros Diagnostics, Inc. Sample cassette
USRE43122E1 (en) 1999-11-26 2012-01-24 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
US8286665B2 (en) 2006-03-22 2012-10-16 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
US8388908B2 (en) 2009-06-02 2013-03-05 Integenx Inc. Fluidic devices with diaphragm valves
US8394642B2 (en) 2009-06-05 2013-03-12 Integenx Inc. Universal sample preparation system and use in an integrated analysis system
US8420318B2 (en) 2004-06-01 2013-04-16 The Regents Of The University Of California Microfabricated integrated DNA analysis system
US8431340B2 (en) 2004-09-15 2013-04-30 Integenx Inc. Methods for processing and analyzing nucleic acid samples
US8454906B2 (en) 2007-07-24 2013-06-04 The Regents Of The University Of California Microfabricated droplet generator for single molecule/cell genetic analysis in engineered monodispersed emulsions
US8476063B2 (en) 2004-09-15 2013-07-02 Integenx Inc. Microfluidic devices
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
US8557518B2 (en) 2007-02-05 2013-10-15 Integenx Inc. Microfluidic and nanofluidic devices, systems, and applications
US8580569B2 (en) 2010-04-16 2013-11-12 Opko Diagnostics, Llc Feedback control in microfluidic systems
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
US8672532B2 (en) 2008-12-31 2014-03-18 Integenx Inc. Microfluidic methods
US8748165B2 (en) 2008-01-22 2014-06-10 Integenx Inc. Methods for generating short tandem repeat (STR) profiles
US8763642B2 (en) 2010-08-20 2014-07-01 Integenx Inc. Microfluidic devices with mechanically-sealed diaphragm valves
US8841116B2 (en) 2006-10-25 2014-09-23 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated DNA analysis system using same
WO2015013332A1 (en) * 2013-07-22 2015-01-29 President And Fellows Of Harvard College Microfluidic cartridge assembly
US9121058B2 (en) 2010-08-20 2015-09-01 Integenx Inc. Linear valve arrays
US9644623B2 (en) 2002-12-30 2017-05-09 The Regents Of The University Of California Fluid control structures in microfluidic devices
WO2017096110A1 (en) * 2015-12-04 2017-06-08 Siemens Healthcare Diagnostics Inc. Method and device for optimizing the process of identification of pathogens
USD804682S1 (en) 2015-08-10 2017-12-05 Opko Diagnostics, Llc Multi-layered sample cassette
US10191071B2 (en) 2013-11-18 2019-01-29 IntegenX, Inc. Cartridges and instruments for sample analysis
US10208332B2 (en) 2014-05-21 2019-02-19 Integenx Inc. Fluidic cartridge with valve mechanism
WO2019130290A1 (en) * 2016-12-29 2019-07-04 Ador Diagnostics S.R.L Improved cartridge for use in in-vitro diagnostics and method of use thereof
US10525467B2 (en) 2011-10-21 2020-01-07 Integenx Inc. Sample preparation, processing and analysis systems
US10690627B2 (en) 2014-10-22 2020-06-23 IntegenX, Inc. Systems and methods for sample preparation, processing and analysis
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
CN112384607A (zh) * 2018-07-10 2021-02-19 Tdk株式会社 采用恒温扩增技术检测核酸的装置与方法
CN114308162A (zh) * 2021-12-31 2022-04-12 北京百奥纳芯生物科技有限公司 辅助基因芯片探针与基片结合固定的装置
WO2022101477A1 (en) * 2020-11-13 2022-05-19 Micro Electrochemical Technologies S.L. Microfluidic flow rate control device and method
US11482052B2 (en) 2014-10-22 2022-10-25 IntegenX, Inc. Systems and methods for biometric data collections
WO2023019105A1 (en) * 2021-08-08 2023-02-16 Keydev Inc. Cartridge gel electrophoresis device for separating biomolecules

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102671729B (zh) * 2012-05-07 2014-04-16 博奥生物有限公司 一种用于多指标生化检测的微流控芯片
CN103543192B (zh) * 2012-12-06 2016-03-09 理邦（美国）诊断有限公司 一种用于诊断装置的试剂包
IL297030B2 (en) * 2013-03-11 2024-03-01 Cue Health Inc A method for activating fluid flow within a microfluidic cartridge
CN204727866U (zh) * 2014-03-31 2015-10-28 博奥生物集团有限公司 一种集核酸扩增和微阵列检测于一体的微流控装置
US10233491B2 (en) 2015-06-19 2019-03-19 IntegenX, Inc. Valved cartridge and system
CA3035143A1 (en) * 2016-10-07 2018-04-12 Boehringer Ingelheim Vetmedica Gmbh Analysis system and method for testing a sample
CN107367835B (zh) * 2017-08-08 2020-06-16 华南师范大学 一种电润湿显示器及其制备方法
US20220341848A1 (en) * 2019-09-24 2022-10-27 Mgi Tech Co., Ltd. Biochemical substance analysis system, method, and device

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1306216A (zh) * 2000-08-22 2001-08-01 中国科学院长春应用化学研究所 流动注射分析中的无泡进样阀
US20030044832A1 (en) * 1996-09-04 2003-03-06 Scandinavian Micro Biodevices A/S Microflow system for particle separation and analysis
US6615856B2 (en) * 2000-08-04 2003-09-09 Biomicro Systems, Inc. Remote valving for microfluidic flow control
US6716584B2 (en) * 1998-06-11 2004-04-06 Hitachi, Ltd. Polynucleotide separation method and apparatus therefor
US6819408B1 (en) * 2000-09-27 2004-11-16 Becton, Dickinson And Company Method for obtaining a monolayer of desired particles in a liquid sample
US20050013732A1 (en) * 2003-01-21 2005-01-20 Micronics, Inc. Method and system for microfluidic manipulation, amplification and analysis of fluids, for example, bacteria assays and antiglobulin testing
CN1635146A (zh) * 2004-09-23 2005-07-06 湖南大学 一维生物芯片及其在基因、蛋白表达分析中的应用
US20050191620A1 (en) * 2004-02-27 2005-09-01 Mcdevitt John T. Particle on membrane assay system
US20060008812A1 (en) * 2004-07-08 2006-01-12 Wolfgang Streit System having device for preventing air bubbles in a hybridization chamber and corresponding method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2380614C (en) * 1999-08-12 2007-11-13 Ut-Battelle, Llc Microfluidic devices for the controlled manipulation of small volumes
CN2515441Y (zh) * 2001-12-30 2002-10-09 中国科学院力学研究所 高压微量液体流动特性的实验装置
CN100344874C (zh) * 2003-01-28 2007-10-24 清华大学 一种流体的传输方法及实现该方法的微型蠕动泵

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030044832A1 (en) * 1996-09-04 2003-03-06 Scandinavian Micro Biodevices A/S Microflow system for particle separation and analysis
US6716584B2 (en) * 1998-06-11 2004-04-06 Hitachi, Ltd. Polynucleotide separation method and apparatus therefor
US6615856B2 (en) * 2000-08-04 2003-09-09 Biomicro Systems, Inc. Remote valving for microfluidic flow control
CN1306216A (zh) * 2000-08-22 2001-08-01 中国科学院长春应用化学研究所 流动注射分析中的无泡进样阀
US6819408B1 (en) * 2000-09-27 2004-11-16 Becton, Dickinson And Company Method for obtaining a monolayer of desired particles in a liquid sample
US20050013732A1 (en) * 2003-01-21 2005-01-20 Micronics, Inc. Method and system for microfluidic manipulation, amplification and analysis of fluids, for example, bacteria assays and antiglobulin testing
US20050191620A1 (en) * 2004-02-27 2005-09-01 Mcdevitt John T. Particle on membrane assay system
US20060008812A1 (en) * 2004-07-08 2006-01-12 Wolfgang Streit System having device for preventing air bubbles in a hybridization chamber and corresponding method
CN1635146A (zh) * 2004-09-23 2005-07-06 湖南大学 一维生物芯片及其在基因、蛋白表达分析中的应用

Cited By (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE43122E1 (en) 1999-11-26 2012-01-24 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
US9644623B2 (en) 2002-12-30 2017-05-09 The Regents Of The University Of California Fluid control structures in microfluidic devices
US9651039B2 (en) 2002-12-30 2017-05-16 The Regents Of The University Of California Fluid control structures in microfluidic devices
US8420318B2 (en) 2004-06-01 2013-04-16 The Regents Of The University Of California Microfabricated integrated DNA analysis system
US8431390B2 (en) 2004-09-15 2013-04-30 Integenx Inc. Systems of sample processing having a macro-micro interface
US8476063B2 (en) 2004-09-15 2013-07-02 Integenx Inc. Microfluidic devices
US8551714B2 (en) 2004-09-15 2013-10-08 Integenx Inc. Microfluidic devices
US9752185B2 (en) 2004-09-15 2017-09-05 Integenx Inc. Microfluidic devices
US8431340B2 (en) 2004-09-15 2013-04-30 Integenx Inc. Methods for processing and analyzing nucleic acid samples
US8286665B2 (en) 2006-03-22 2012-10-16 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
US8841116B2 (en) 2006-10-25 2014-09-23 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated DNA analysis system using same
US8557518B2 (en) 2007-02-05 2013-10-15 Integenx Inc. Microfluidic and nanofluidic devices, systems, and applications
US8454906B2 (en) 2007-07-24 2013-06-04 The Regents Of The University Of California Microfabricated droplet generator for single molecule/cell genetic analysis in engineered monodispersed emulsions
US8748165B2 (en) 2008-01-22 2014-06-10 Integenx Inc. Methods for generating short tandem repeat (STR) profiles
WO2009156915A1 (en) * 2008-06-23 2009-12-30 Koninklijke Philips Electronics N.V. Detection of tapped aliquots of amplified nucleic acids
EP2138232A1 (en) * 2008-06-23 2009-12-30 Koninklijke Philips Electronics N.V. Detection of tapped aliquots of amplified nucleic acids
US8672532B2 (en) 2008-12-31 2014-03-18 Integenx Inc. Microfluidic methods
WO2010091410A3 (en) * 2009-02-09 2010-12-16 Forensic Science Service Limited Improvements in and relating to microfluidic devices for processing a sample
US8640555B2 (en) 2009-02-09 2014-02-04 Bioaccel Performance
ITBO20090154A1 (it) * 2009-03-17 2010-09-18 Silicon Biosystems Spa Sistema microfluidico
US8388908B2 (en) 2009-06-02 2013-03-05 Integenx Inc. Fluidic devices with diaphragm valves
US8562918B2 (en) 2009-06-05 2013-10-22 Integenx Inc. Universal sample preparation system and use in an integrated analysis system
US8394642B2 (en) 2009-06-05 2013-03-12 Integenx Inc. Universal sample preparation system and use in an integrated analysis system
US9012236B2 (en) 2009-06-05 2015-04-21 Integenx Inc. Universal sample preparation system and use in an integrated analysis system
WO2011011172A1 (en) * 2009-07-21 2011-01-27 IntegenX, Inc. Microfluidic devices and uses thereof
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
US9116124B2 (en) 2010-04-16 2015-08-25 Opko Diagnostics, Llc Feedback control in microfluidic systems
US9981266B2 (en) 2010-04-16 2018-05-29 Opko Diagnostics, Llc Feedback control in microfluidic systems
US8765062B2 (en) 2010-04-16 2014-07-01 Opko Diagnostics, Llc Systems and devices for analysis of samples
US10456784B2 (en) 2010-04-16 2019-10-29 Opko Diagnostics, Llc Systems and devices for analysis of samples
US8932523B2 (en) 2010-04-16 2015-01-13 Opko Diagnostics, Llc Systems and devices for analysis of samples
US9643182B2 (en) 2010-04-16 2017-05-09 Opko Diagnostics, Llc Systems and devices for analysis of samples
US8580569B2 (en) 2010-04-16 2013-11-12 Opko Diagnostics, Llc Feedback control in microfluidic systems
US11458473B2 (en) 2010-04-16 2022-10-04 Opko Diagnostics, Llc Systems and devices for analysis of samples
US9682376B2 (en) 2010-04-16 2017-06-20 Opko Diagnostics, Llc Systems and devices for analysis of samples
USD645971S1 (en) 2010-05-11 2011-09-27 Claros Diagnostics, Inc. Sample cassette
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
US9121058B2 (en) 2010-08-20 2015-09-01 Integenx Inc. Linear valve arrays
US9731266B2 (en) 2010-08-20 2017-08-15 Integenx Inc. Linear valve arrays
US8763642B2 (en) 2010-08-20 2014-07-01 Integenx Inc. Microfluidic devices with mechanically-sealed diaphragm valves
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
US10525467B2 (en) 2011-10-21 2020-01-07 Integenx Inc. Sample preparation, processing and analysis systems
US11684918B2 (en) 2011-10-21 2023-06-27 IntegenX, Inc. Sample preparation, processing and analysis systems
US10293339B2 (en) 2013-07-22 2019-05-21 President And Fellows Of Harvard College Microfluidic cartridge assembly
US10814323B2 (en) 2013-07-22 2020-10-27 President And Fellows Of Harvard College Microfluidic cartridge assembly
WO2015013332A1 (en) * 2013-07-22 2015-01-29 President And Fellows Of Harvard College Microfluidic cartridge assembly
US9855554B2 (en) 2013-07-22 2018-01-02 President And Fellows Of Harvard College Microfluidic cartridge assembly
US10191071B2 (en) 2013-11-18 2019-01-29 IntegenX, Inc. Cartridges and instruments for sample analysis
US10989723B2 (en) 2013-11-18 2021-04-27 IntegenX, Inc. Cartridges and instruments for sample analysis
US10961561B2 (en) 2014-05-21 2021-03-30 IntegenX, Inc. Fluidic cartridge with valve mechanism
US10208332B2 (en) 2014-05-21 2019-02-19 Integenx Inc. Fluidic cartridge with valve mechanism
US11891650B2 (en) 2014-05-21 2024-02-06 IntegenX, Inc. Fluid cartridge with valve mechanism
US10690627B2 (en) 2014-10-22 2020-06-23 IntegenX, Inc. Systems and methods for sample preparation, processing and analysis
US11482052B2 (en) 2014-10-22 2022-10-25 IntegenX, Inc. Systems and methods for biometric data collections
USD804682S1 (en) 2015-08-10 2017-12-05 Opko Diagnostics, Llc Multi-layered sample cassette
USD817511S1 (en) 2015-08-10 2018-05-08 Opko Diagnostics, Llc Multi-layered sample cassette
WO2017096110A1 (en) * 2015-12-04 2017-06-08 Siemens Healthcare Diagnostics Inc. Method and device for optimizing the process of identification of pathogens
WO2019130290A1 (en) * 2016-12-29 2019-07-04 Ador Diagnostics S.R.L Improved cartridge for use in in-vitro diagnostics and method of use thereof
CN112384607A (zh) * 2018-07-10 2021-02-19 Tdk株式会社 采用恒温扩增技术检测核酸的装置与方法
EP4001646A1 (en) * 2020-11-13 2022-05-25 Micro Electrochemical Technologies S.L. Microfluidic flow rate control device and method
WO2022101477A1 (en) * 2020-11-13 2022-05-19 Micro Electrochemical Technologies S.L. Microfluidic flow rate control device and method
WO2023019105A1 (en) * 2021-08-08 2023-02-16 Keydev Inc. Cartridge gel electrophoresis device for separating biomolecules
CN114308162A (zh) * 2021-12-31 2022-04-12 北京百奥纳芯生物科技有限公司 辅助基因芯片探针与基片结合固定的装置

Also Published As

Publication number Publication date
CN101004423B (zh) 2011-12-28
CN101004423A (zh) 2007-07-25

Similar Documents

Publication Publication Date Title
WO2007082480A1 (en) Cartridge-based microfluidic analyzer
EP1304388B1 (en) Intergrated nucleic acid diagnostic device
JP3623479B2 (ja) 小型化されたインビトロ増幅アッセイを行うための装置および方法
US6168948B1 (en) Miniaturized genetic analysis systems and methods
US9086371B2 (en) Fluidics devices
US20050202504A1 (en) Miniaturized genetic analysis systems and methods
CA2559778C (en) Removable microfluidic flow cell
EP1230544B1 (en) Devices and methods for the performance of miniaturized homogeneous assays
US6706519B1 (en) Devices and methods for the performance of miniaturized in vitro amplification assays
Liu et al. DNA amplification and hybridization assays in integrated plastic monolithic devices
KR100916074B1 (ko) 어레이에 대한 마이크로유체 인터페이스 방법 및인터페이스용 시스템
JP2008082961A (ja) マイクロ流路デバイス
US20040109793A1 (en) Three-dimensional microfluidics incorporating passive fluid control structures
AU1283397A (en) Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
WO2009112030A1 (en) Controlled liquid handling
US20050100946A1 (en) Integrated nucleic acid diagnostic device and method for in-situ confocal microscopy
Kulkarni et al. A review on recent advancements in chamber-based microfluidic PCR devices
EP1577010A2 (en) Microsystem platform and its use
Liu et al. Development of integrated microfluidic system for genetic analysis
Liu et al. Self-contained, fully integrated biochips for sample preparation, PCR amplification and DNA microarray analysis
Liu et al. Microfluidic and Lab-on-Chip Technologies for Biosensors
Palmieri et al. Advanced microfluidic packaging for molecular diagnostics
Liu et al. Fully Integrated Microfluidic Biochips for DNA Analysis
Psaroudakis et al. Nikolaos Tzamtzis, Georgia-Paraskevi Nikoleli, Theodoros Varzakas, Dimitrios P. Nikolelis, Vassilios N. Psychoyios
ELISA Centrifuge-Ba

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07702130

Country of ref document: EP

Kind code of ref document: A1