WO2007076302A3 - Dosage a haut rendement pour des modulateurs de l'activite de peptidylarginine deiminase - Google Patents

Dosage a haut rendement pour des modulateurs de l'activite de peptidylarginine deiminase Download PDF

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Publication number
WO2007076302A3
WO2007076302A3 PCT/US2006/062141 US2006062141W WO2007076302A3 WO 2007076302 A3 WO2007076302 A3 WO 2007076302A3 US 2006062141 W US2006062141 W US 2006062141W WO 2007076302 A3 WO2007076302 A3 WO 2007076302A3
Authority
WO
WIPO (PCT)
Prior art keywords
modulators
high throughput
throughput assay
peptidylarginine deiminase
deiminase activity
Prior art date
Application number
PCT/US2006/062141
Other languages
English (en)
Other versions
WO2007076302A2 (fr
Inventor
Brian Glenn Werneburg
Martha Priscilla Brown
Dorothy Mae Freeman
Jeffrey David Yingling
Original Assignee
Boehringer Ingelheim Int
Boehringer Ingelheim Pharma
Brian Glenn Werneburg
Martha Priscilla Brown
Dorothy Mae Freeman
Jeffrey David Yingling
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int, Boehringer Ingelheim Pharma, Brian Glenn Werneburg, Martha Priscilla Brown, Dorothy Mae Freeman, Jeffrey David Yingling filed Critical Boehringer Ingelheim Int
Publication of WO2007076302A2 publication Critical patent/WO2007076302A2/fr
Publication of WO2007076302A3 publication Critical patent/WO2007076302A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching

Abstract

La présente invention concerne un dosage à haut rendement de l'activité de peptidylarginine déiminase. Le dosage est destiné à l'identification de modulateurs de catalyse de peptidylarginine déiminase pour le traitement de la sclérose en plaques et de la polyarthrite rhumatoïde.
PCT/US2006/062141 2005-12-20 2006-12-15 Dosage a haut rendement pour des modulateurs de l'activite de peptidylarginine deiminase WO2007076302A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74305405P 2005-12-20 2005-12-20
US60/743,054 2005-12-20

Publications (2)

Publication Number Publication Date
WO2007076302A2 WO2007076302A2 (fr) 2007-07-05
WO2007076302A3 true WO2007076302A3 (fr) 2008-04-03

Family

ID=38191069

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/062141 WO2007076302A2 (fr) 2005-12-20 2006-12-15 Dosage a haut rendement pour des modulateurs de l'activite de peptidylarginine deiminase

Country Status (1)

Country Link
WO (1) WO2007076302A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011524170A (ja) * 2008-06-16 2011-09-01 チラリックス ビー．ブイ． ペプチジルアルギニンデイミナーゼ（ｐａｄ）阻害剤
JP2014508537A (ja) 2011-03-25 2014-04-10 アルマック・サイエンシーズ・（スコットランド）・リミテッド 酵素アッセイ
CN110426514B (zh) * 2019-08-28 2023-05-12 苏州新格诺康生物技术有限公司 肽酰基精氨酸脱亚胺酶(pad)的测活法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1275733A2 (fr) * 2001-07-13 2003-01-15 Pfizer Limited Méthodes d'essai pour modulateurs des peptidases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1275733A2 (fr) * 2001-07-13 2003-01-15 Pfizer Limited Méthodes d'essai pour modulateurs des peptidases

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ROTHNAGEL J A ET AL: "Citrulline in proteins from the enzymatic deimination of arginine residues.", METHODS IN ENZYMOLOGY 1984, vol. 107, 1984, pages 624 - 631, XP009086183, ISSN: 0076-6879 *
TAKAHARA H ET AL: "SPECIFIC MODIFICATION OF THE FUNCTIONAL ARGININE RESIDUE IN SOYBEAN TRYPSIN INHIBITOR KUNITZ BY PEPTIDYLARGININE DEIMINASE", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 260, no. 14, 1985, pages 8378 - 8383, XP002440995, ISSN: 0021-9258 *
VOSSENAAR E R ET AL: "PAD, A GROWING FAMILY OF CITRULLINATING ENZYMES: GENES, FEATURES AND INVOLVEMENT IN DISEASE", BIOESSAYS, CAMBRIDGE, GB, vol. 25, no. 11, 17 October 2003 (2003-10-17), pages 1106 - 1118, XP008057229, ISSN: 0265-9247 *

Also Published As

Publication number Publication date
WO2007076302A2 (fr) 2007-07-05

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