WO2007068330A1 - 2-ADAMANTYLUREA DERIVATIVES AS SELECTIVE 11β-HSD1 INHIBITORS - Google Patents
2-ADAMANTYLUREA DERIVATIVES AS SELECTIVE 11β-HSD1 INHIBITORS Download PDFInfo
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- WO2007068330A1 WO2007068330A1 PCT/EP2006/011156 EP2006011156W WO2007068330A1 WO 2007068330 A1 WO2007068330 A1 WO 2007068330A1 EP 2006011156 W EP2006011156 W EP 2006011156W WO 2007068330 A1 WO2007068330 A1 WO 2007068330A1
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- adamantan
- urea
- phenyl
- methyl
- acid
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- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
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Abstract
Description
Claims
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/097,643 US8188288B2 (en) | 2005-12-16 | 2006-11-22 | 2-adamantylurea derivatives as selective 11beta-HSD1 inhibitors |
DK06818709.5T DK1960352T3 (en) | 2005-12-16 | 2006-11-22 | 2-ADAMANTYLURINE INGREDIENTS AS SELECTIVE 11BETA-HSD1 INHIBITORS |
JP2008544787A JP5356825B2 (en) | 2005-12-16 | 2006-11-22 | 2-Adamantyl urea derivatives as selective 11β-HSD1 inhibitors |
KR1020087017137A KR101394586B1 (en) | 2005-12-16 | 2006-11-22 | 2-ADAMANTYLUREA DERIVATIVES AS SELECTIVE 11β-HSD1 INHIBITORS |
PL06818709T PL1960352T3 (en) | 2005-12-16 | 2006-11-22 | 2-adamantylurea derivatives as selective 11beta-hsd1 inhibitors |
CA2633186A CA2633186C (en) | 2005-12-16 | 2006-11-22 | 2-adamantylurea derivatives as selective 11.beta.-hsd1 inhibitors |
CN2006800471499A CN101331114B (en) | 2005-12-16 | 2006-11-22 | 2-adamantylurea derivatives as selective 11beta-HSD1 inhibitors |
AU2006326703A AU2006326703B2 (en) | 2005-12-16 | 2006-11-22 | 2-adamantylurea derivatives as selective 11-beta-HSD1 inhibitors |
SI200631675T SI1960352T1 (en) | 2005-12-16 | 2006-11-22 | 2-adamantylurea derivatives as selective 11beta-hsd1 inhibitors |
EP06818709.5A EP1960352B1 (en) | 2005-12-16 | 2006-11-22 | 2-adamantylurea derivatives as selective 11beta-hsd1 inhibitors |
ES06818709T ES2434077T3 (en) | 2005-12-16 | 2006-11-22 | Derivatives of 2-adamantylurea as selective inhibitors of 11 beta-HSD1 |
BRPI0619839A BRPI0619839B8 (en) | 2005-12-16 | 2006-11-22 | 2-adamantilurea derivatives, their method of preparation and their uses, pharmaceutical composition, and kit |
EA200801426A EA017923B1 (en) | 2005-12-16 | 2006-11-22 | 2-ADAMANTYLUREA DERIVATIVES AS SELECTIVE 11β-HSD1 INHIBITORS |
IL192053A IL192053A (en) | 2005-12-16 | 2008-06-11 | 2-adamantylurea derivatives as selective 11beta-hsd1 inhibitors and the use thereof in the preparation of medicaments |
US13/367,947 US8466200B2 (en) | 2005-12-16 | 2012-02-07 | 2-adamantylurea derivatives as selective 11β-HSD1 inhibitors |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05292724.1 | 2005-12-16 | ||
EP05292724A EP1801098A1 (en) | 2005-12-16 | 2005-12-16 | 2-Adamantylurea derivatives as selective 11B-HSD1 inhibitors |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/097,643 A-371-Of-International US8188288B2 (en) | 2005-12-16 | 2006-11-22 | 2-adamantylurea derivatives as selective 11beta-HSD1 inhibitors |
US13/367,947 Division US8466200B2 (en) | 2005-12-16 | 2012-02-07 | 2-adamantylurea derivatives as selective 11β-HSD1 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2007068330A1 true WO2007068330A1 (en) | 2007-06-21 |
Family
ID=36123301
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/EP2006/011156 WO2007068330A1 (en) | 2005-12-16 | 2006-11-22 | 2-ADAMANTYLUREA DERIVATIVES AS SELECTIVE 11β-HSD1 INHIBITORS |
Country Status (19)
Country | Link |
---|---|
US (2) | US8188288B2 (en) |
EP (2) | EP1801098A1 (en) |
JP (1) | JP5356825B2 (en) |
KR (1) | KR101394586B1 (en) |
CN (1) | CN101331114B (en) |
AR (1) | AR058546A1 (en) |
AU (1) | AU2006326703B2 (en) |
BR (1) | BRPI0619839B8 (en) |
CA (1) | CA2633186C (en) |
CY (1) | CY1114660T1 (en) |
DK (1) | DK1960352T3 (en) |
EA (1) | EA017923B1 (en) |
ES (1) | ES2434077T3 (en) |
IL (1) | IL192053A (en) |
PL (1) | PL1960352T3 (en) |
PT (1) | PT1960352E (en) |
SI (1) | SI1960352T1 (en) |
WO (1) | WO2007068330A1 (en) |
ZA (1) | ZA200806148B (en) |
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US8569292B2 (en) | 2008-05-01 | 2013-10-29 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
US8592410B2 (en) | 2008-05-01 | 2013-11-26 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11BETA-hydroxysteroid dehydrogenase 1 |
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US8835426B2 (en) | 2007-02-26 | 2014-09-16 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
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US8933072B2 (en) | 2010-06-16 | 2015-01-13 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
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Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4036979A (en) * | 1974-01-25 | 1977-07-19 | American Cyanamid Company | Compositions containing 4,5,6,7-tetrahydrobenz[b]thien-4-yl-ureas or derivatives and methods of enhancing growth rate |
GB1499582A (en) * | 1974-01-25 | 1978-02-01 | American Cyanamid Co | Substituted tetrahydrobenzothiophenes |
US4349552A (en) | 1978-10-30 | 1982-09-14 | Fujisawa Pharmaceutical Company, Ltd. | 5-Fluorouracil derivatives, and their pharmaceutical compositions |
WO2003065983A2 (en) | 2002-02-01 | 2003-08-14 | Merck & Co., Inc. | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia |
WO2003078400A1 (en) | 2002-03-18 | 2003-09-25 | Solvay Pharmaceuticals B.V. | Neurotensin active 2,3-diaryl-pyrazolidine derivatives |
EP1402887A1 (en) * | 2002-09-18 | 2004-03-31 | Jerini AG | New compounds for the inhibition of undesired cell proliferation and use thereof |
WO2004033427A1 (en) | 2002-10-11 | 2004-04-22 | Astrazeneca Ab | 1,4-disubstituted piperidine derivatives and their use as 11-betahsd1 inhibitors |
WO2004041264A1 (en) | 2002-11-07 | 2004-05-21 | Astrazeneca Ab | 2-oxo-ethanesulfonamide derivates |
WO2004056744A1 (en) | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
WO2004065351A1 (en) | 2003-01-24 | 2004-08-05 | Novartis Ag | Amide derivatives and their use as inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1 |
WO2004089896A1 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS |
WO2004089380A2 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | Pharmaceutical use of fused 1,2,4-triazoles |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3621100A (en) * | 1965-11-18 | 1971-11-16 | Geigy Chem Corp | Composition and method for producing a tuberculostatic effect |
US4154740A (en) | 1976-03-23 | 1979-05-15 | American Cyanamid Company | Substituted tetrahydrobenzothiophenes and method of preparation thereof |
FR2692575B1 (en) | 1992-06-23 | 1995-06-30 | Sanofi Elf | NOVEL PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
US5292736A (en) | 1993-02-26 | 1994-03-08 | Sterling Winthrop Inc. | Morpholinoalkylindenes as antiglaucoma agents |
US5532237A (en) | 1995-02-15 | 1996-07-02 | Merck Frosst Canada, Inc. | Indole derivatives with affinity for the cannabinoid receptor |
FR2741621B1 (en) | 1995-11-23 | 1998-02-13 | Sanofi Sa | NOVEL PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
AU1856997A (en) | 1996-02-02 | 1997-08-22 | Merck & Co., Inc. | Method for raising hdl cholesterol levels |
AR008789A1 (en) | 1996-07-31 | 2000-02-23 | Bayer Corp | PIRIDINES AND SUBSTITUTED BIPHENYLS |
WO1998041519A1 (en) | 1997-03-18 | 1998-09-24 | Smithkline Beecham Corporation | Novel cannabinoid receptor agonists |
WO1999001423A1 (en) | 1997-07-01 | 1999-01-14 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
US6613942B1 (en) | 1997-07-01 | 2003-09-02 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
KR20010021696A (en) | 1997-07-11 | 2001-03-15 | 미즈노 마사루 | Quinoline compounds and medicinal uses thereof |
EP1017375A2 (en) * | 1997-09-24 | 2000-07-12 | Nova Molecular, Inc. | Methods for increasing apoe levels for the treatment of neurodegenerative disease |
CA2334551A1 (en) | 1998-06-11 | 1999-12-16 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
DE19837627A1 (en) | 1998-08-19 | 2000-02-24 | Bayer Ag | New aminoacid esters of arylsulfonamides are useful for e.g. treating neurodegenerative diseases, pain, convulsions or bacterial or viral infections |
JP2002544254A (en) | 1999-05-17 | 2002-12-24 | ノボ ノルディスク アクティーゼルスカブ | Glucagon antagonist / inverse agonist |
EP1187614A4 (en) | 1999-06-04 | 2005-06-22 | Merck & Co Inc | Substituted piperidines as melanocortin-4 receptor agonists |
TWI279402B (en) | 1999-08-20 | 2007-04-21 | Banyu Pharma Co Ltd | Spiro compounds having NPY antagonistic activities and agents containing the same |
ES2307534T3 (en) | 1999-09-28 | 2008-12-01 | Bayer Corporation | RECEIVER AGONISTS 3 (R3) OF THE ACTIVATOR PEPTIDE OF THE HYPOPHYSIARY CYCLASS ADENYLATE (PACAP) AND ITS PHARMACOLOGICAL USE METHODS. |
EP1268449A4 (en) | 2000-03-23 | 2004-09-15 | Merck & Co Inc | Substituted piperidines as melanocortin receptor agonists |
JP2003527444A (en) | 2000-03-23 | 2003-09-16 | メルク エンド カムパニー インコーポレーテッド | Spiropiperidine derivatives acting as melanocortin receptor agonists |
PL364221A1 (en) | 2001-02-02 | 2004-12-13 | Takeda Chemical Industries, Ltd. | Fused heterocyclic compounds |
DE60219295T2 (en) | 2001-02-28 | 2008-01-03 | Merck & Co., Inc. | ACYLATED PIPERIDINE DERIVATIVES THAN MELANOCORTIN-4 RECEPTOR AGONISTS |
RU2281941C2 (en) | 2001-03-22 | 2006-08-20 | Солвей Фармасьютикалс Б.В. | Derivatives of 4,5-dihydro-1h-pyrazole possessing cb1-antagonistic activity |
US6573287B2 (en) | 2001-04-12 | 2003-06-03 | Bristo-Myers Squibb Company | 2,1-oxazoline and 1,2-pyrazoline-based inhibitors of dipeptidyl peptidase IV and method |
FR2824825B1 (en) | 2001-05-15 | 2005-05-06 | Servier Lab | NOVEL ALPHA-AMINOACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
JP2005500308A (en) | 2001-06-20 | 2005-01-06 | メルク エンド カムパニー インコーポレーテッド | Dipeptidyl peptidase inhibitors for the treatment of diabetes |
CA2450579A1 (en) | 2001-06-20 | 2003-01-03 | Merck & Co., Inc. | Dipeptidyl peptidase inhibitors for the treatment of diabetes |
US6674272B2 (en) | 2001-06-21 | 2004-01-06 | Champion Microelectronic Corp. | Current limiting technique for a switching power converter |
CA2419888A1 (en) | 2001-06-27 | 2003-01-09 | Probiodrug Ag | Peptide structures useful for competitive modulation of dipeptidyl peptidase iv catalysis |
ATE370943T1 (en) | 2001-06-27 | 2007-09-15 | Smithkline Beecham Corp | FLUOROPYRROLIDINE AS DIPEPTIDYL-PEPTIDASE INHIBITORS |
IL158923A0 (en) | 2001-06-27 | 2004-05-12 | Smithkline Beecham Corp | Fluoropyrrolidines as dipeptidyl peptidase inhibitors |
JP4300108B2 (en) | 2001-06-27 | 2009-07-22 | スミスクライン ビーチャム コーポレーション | Pyrrolidines as dipeptidyl peptidase inhibitors |
EP1404675B1 (en) | 2001-07-03 | 2008-03-12 | Novo Nordisk A/S | Dpp-iv-inhibiting purine derivatives for the treatment of diabetes |
UA74912C2 (en) | 2001-07-06 | 2006-02-15 | Merck & Co Inc | Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes |
AU2002319627A1 (en) | 2001-07-20 | 2003-03-03 | Merck And Co., Inc. | Substituted imidazoles as cannabinoid receptor modulators |
US6977264B2 (en) | 2001-07-25 | 2005-12-20 | Amgen Inc. | Substituted piperidines and methods of use |
US20040014422A1 (en) | 2002-07-19 | 2004-01-22 | Nokia Corporation | Method and system for handovers using service description data |
-
2005
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Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4036979A (en) * | 1974-01-25 | 1977-07-19 | American Cyanamid Company | Compositions containing 4,5,6,7-tetrahydrobenz[b]thien-4-yl-ureas or derivatives and methods of enhancing growth rate |
GB1499582A (en) * | 1974-01-25 | 1978-02-01 | American Cyanamid Co | Substituted tetrahydrobenzothiophenes |
US4349552A (en) | 1978-10-30 | 1982-09-14 | Fujisawa Pharmaceutical Company, Ltd. | 5-Fluorouracil derivatives, and their pharmaceutical compositions |
WO2003065983A2 (en) | 2002-02-01 | 2003-08-14 | Merck & Co., Inc. | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia |
WO2003078400A1 (en) | 2002-03-18 | 2003-09-25 | Solvay Pharmaceuticals B.V. | Neurotensin active 2,3-diaryl-pyrazolidine derivatives |
EP1402887A1 (en) * | 2002-09-18 | 2004-03-31 | Jerini AG | New compounds for the inhibition of undesired cell proliferation and use thereof |
WO2004033427A1 (en) | 2002-10-11 | 2004-04-22 | Astrazeneca Ab | 1,4-disubstituted piperidine derivatives and their use as 11-betahsd1 inhibitors |
WO2004041264A1 (en) | 2002-11-07 | 2004-05-21 | Astrazeneca Ab | 2-oxo-ethanesulfonamide derivates |
WO2004056744A1 (en) | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
WO2004065351A1 (en) | 2003-01-24 | 2004-08-05 | Novartis Ag | Amide derivatives and their use as inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1 |
WO2004089896A1 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS |
WO2004089380A2 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | Pharmaceutical use of fused 1,2,4-triazoles |
Non-Patent Citations (11)
Title |
---|
C. G. BELLOWS ET AL., BONE, vol. 23, 1998, pages 119 - 125 |
CHEMIKER-ZEITUNG , 107(6), 206-7 CODEN: CMKZAT; ISSN: 0009-2894, 1983 * |
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KREUTZBERGER, ALFRED ET AL: "Antiviral agents. XXIII. Addition reactions with 2-aminoadamantane", XP002376963, retrieved from STN accession no. RN:87170-68-1 Database accession no. 1983:521956 * |
EVANS B E ET AL: "ORALLY ACTIVE, NONPEPTIDE OXYTOCIN ANTAGONISTS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 35, no. 21, 16 October 1992 (1992-10-16), pages 3919 - 3927, XP000568851, ISSN: 0022-2623 * |
HONG C I ET AL: "SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SOME N4-SUBSTITUTED 4-AMINOPYRAZOLO3,4DPYRIMIDINES", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 19, no. 4, 1976, pages 555 - 558, XP000916640, ISSN: 0022-2623 * |
KREUTZBERGER A ET AL: "ANTIVIRALE WIRKSTOFFE 22. MIT.:N-ALIPHATISCH, N-ALIZYKLISCH UND N-POLYZYKLISCH SUBSTUTUIERTE N'-(2-ADAMANTYL) HARNSTOFFE UND THIOHARNSTOFFE)", ARZNEIMITTEL FORSCHUNG. DRUG RESEARCH, ECV EDITIO CANTOR VERLAG, AULENDORF, DE, vol. 33, no. 4, 1983, pages 512 - 514, XP001002749, ISSN: 0004-4172 * |
KREUTZBERGER, ALFRED ET AL: "Antivirale Wirkstoffe. XIX. N-(2-Adamantyl)-N'-(fluoroaryl)harnstoffe und -Thioharnstoffe", JOURNAL OF FLUORINE CHEMISTRY , 18(2), 177-83 CODEN: JFLCAR; ISSN: 0022-1139, 1981, XP009065199 * |
KREUTZBERGER, ALFRED ET AL: "Synthese und virustatische Wirksamkeit von N'-substituierten N-(adamantyl-(2))-thioharnstoffen", TETRAHEDRON LETTERS , NO. 9, 687-8 CODEN: TELEAY; ISSN: 0040-4039, 1973, XP002376870 * |
M. S. COOPER ET AL., BONE, vol. 27, 2000, pages 375 - 381 |
SINGH S ET AL: "Synthesis and antiamoebic activity of 3,7-dimethyl-pyrazolo[3,4-e][1 ,2,4] triazin-4-yl thiosemicarbazide derivatives", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, ELSEVIER, AMSTERDAM, NL, vol. 25, no. 2-3, June 2005 (2005-06-01), pages 255 - 262, XP004903823, ISSN: 0928-0987 * |
U. URLEB ET AL: "A new approach for the synthesis of pteridines:the synthesis of 3-substituted-2-thioxo-1,2-dihydro-4(3H)-pteridinones", J.HETEROCYCLIC CHEM., vol. 27, 1990, pages 433 - 437, XP002376869 * |
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KR20080079317A (en) | 2008-08-29 |
DK1960352T3 (en) | 2013-10-28 |
AR058546A1 (en) | 2008-02-13 |
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AU2006326703B2 (en) | 2012-02-23 |
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CA2633186A1 (en) | 2007-06-21 |
EA017923B1 (en) | 2013-04-30 |
US8466200B2 (en) | 2013-06-18 |
IL192053A (en) | 2014-01-30 |
BRPI0619839B8 (en) | 2021-05-25 |
CY1114660T1 (en) | 2016-10-05 |
SI1960352T1 (en) | 2013-12-31 |
BRPI0619839B1 (en) | 2021-01-12 |
CN101331114A (en) | 2008-12-24 |
US8188288B2 (en) | 2012-05-29 |
ES2434077T3 (en) | 2013-12-13 |
KR101394586B1 (en) | 2014-05-12 |
PL1960352T3 (en) | 2013-12-31 |
AU2006326703A1 (en) | 2007-06-21 |
CN101331114B (en) | 2013-08-07 |
EP1801098A1 (en) | 2007-06-27 |
CA2633186C (en) | 2014-08-12 |
JP5356825B2 (en) | 2013-12-04 |
EP1960352A1 (en) | 2008-08-27 |
BRPI0619839A2 (en) | 2011-10-18 |
EP1960352B1 (en) | 2013-08-07 |
IL192053A0 (en) | 2008-12-29 |
US20120172396A1 (en) | 2012-07-05 |
ZA200806148B (en) | 2009-06-24 |
EA200801426A1 (en) | 2008-10-30 |
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