WO2007060583A3 - Method and apparatus for determining concentrations of analytes in a turbid medium - Google Patents

Method and apparatus for determining concentrations of analytes in a turbid medium Download PDF

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Publication number
WO2007060583A3
WO2007060583A3 PCT/IB2006/054311 IB2006054311W WO2007060583A3 WO 2007060583 A3 WO2007060583 A3 WO 2007060583A3 IB 2006054311 W IB2006054311 W IB 2006054311W WO 2007060583 A3 WO2007060583 A3 WO 2007060583A3
Authority
WO
WIPO (PCT)
Prior art keywords
turbid medium
spectrum
effective
μeff
determining
Prior art date
Application number
PCT/IB2006/054311
Other languages
French (fr)
Other versions
WO2007060583A2 (en
Inventor
Hooft Gert T
Wouter H J Rensen
Gerhardus W Lucassen
Original Assignee
Koninkl Philips Electronics Nv
Hooft Gert T
Wouter H J Rensen
Gerhardus W Lucassen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninkl Philips Electronics Nv, Hooft Gert T, Wouter H J Rensen, Gerhardus W Lucassen filed Critical Koninkl Philips Electronics Nv
Publication of WO2007060583A2 publication Critical patent/WO2007060583A2/en
Publication of WO2007060583A3 publication Critical patent/WO2007060583A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Medical Informatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Emergency Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

A method of non-invasively measuring the concentration of at least one analyte in a turbid medium with an effective attenuation coefficient μeff(λ). The proposed method comprises the steps of: irradiating the turbid medium with a spectrum of electromagnetic radiation by means of a number of radiation sources (8a, 8b), detecting a reflection spectrum of said electromagnetic radiation reflected from the turbid medium by means of a number of detectors (10), such that the reflection spectrum is detected at at least two different source-detector distances pu, said distances being chosen such that pi,2»l/μeff, determining a first quantity representative of a relative change in reflection with respect to the source-detector distance (p) and deriving from said first quantity a second quantity representative of the effective attenuation coefficient μeff, and determining said concentration from said second quantity. Thus the proposed method effectively makes the measured spectrum linear in the various analytes present in the turbid medium, allowing for a simple linear regression analysis. This is accomplished by a judicious choice of effective medium thickness and alternative definition of the effective absorption coefficient.
PCT/IB2006/054311 2005-11-28 2006-11-17 Method and apparatus for determining concentrations of analytes in a turbid medium WO2007060583A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05111359.5 2005-11-28
EP05111359 2005-11-28

Publications (2)

Publication Number Publication Date
WO2007060583A2 WO2007060583A2 (en) 2007-05-31
WO2007060583A3 true WO2007060583A3 (en) 2007-08-30

Family

ID=37912429

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/054311 WO2007060583A2 (en) 2005-11-28 2006-11-17 Method and apparatus for determining concentrations of analytes in a turbid medium

Country Status (1)

Country Link
WO (1) WO2007060583A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8703492B2 (en) 2007-04-06 2014-04-22 Qiagen Gaithersburg, Inc. Open platform hybrid manual-automated sample processing system
US8355132B2 (en) 2007-04-06 2013-01-15 Qiagen Gaithersburg, Inc. Sample adequacy measurement system having a plurality of sample tubes and using turbidity light scattering techniques
US8877507B2 (en) 2007-04-06 2014-11-04 Qiagen Gaithersburg, Inc. Ensuring sample adequacy using turbidity light scattering techniques
WO2009037644A2 (en) 2007-09-20 2009-03-26 Koninklijke Philips Electronics N.V. Method and apparatus for estimating the content of an analyte in a multi-layer medium
CN102288548A (en) * 2011-07-21 2011-12-21 天津大学 Measuring method for improving ingredient detection accuracy of turbid medium
JP5944511B2 (en) * 2012-08-31 2016-07-05 株式会社日立メディコ Biological light measurement device and biological light measurement method using the same

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5513642A (en) * 1994-10-12 1996-05-07 Rensselaer Polytechnic Institute Reflectance sensor system
US5517987A (en) * 1993-06-02 1996-05-21 Hamamatsu Photonics K.K. Method for measuring internal information in scattering medium and apparatus for the same
US5632273A (en) * 1994-02-04 1997-05-27 Hamamatsu Photonics K.K. Method and means for measurement of biochemical components
US5772587A (en) * 1993-12-16 1998-06-30 The Board Of Trustees Of The University Of Illinois Photosensor with multiple light sources
US6031603A (en) * 1995-06-09 2000-02-29 Cybro Medical, Ltd. Sensor, method and device for optical blood oximetry
WO2001009589A1 (en) * 1999-08-03 2001-02-08 Abbott Laboratories Optical sensor having a selectable sampling distance for determination of analytes
US6278889B1 (en) * 1993-08-24 2001-08-21 Mark R. Robinson Robust accurate non-invasive analyte monitor
US6850656B1 (en) * 1998-10-07 2005-02-01 Ecole Polytechnique Federale De Lausanne Method and apparatus for measuring locally and superficially the scattering and absorption properties of turbid media

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5517987A (en) * 1993-06-02 1996-05-21 Hamamatsu Photonics K.K. Method for measuring internal information in scattering medium and apparatus for the same
US6278889B1 (en) * 1993-08-24 2001-08-21 Mark R. Robinson Robust accurate non-invasive analyte monitor
US5772587A (en) * 1993-12-16 1998-06-30 The Board Of Trustees Of The University Of Illinois Photosensor with multiple light sources
US5632273A (en) * 1994-02-04 1997-05-27 Hamamatsu Photonics K.K. Method and means for measurement of biochemical components
US5513642A (en) * 1994-10-12 1996-05-07 Rensselaer Polytechnic Institute Reflectance sensor system
US6031603A (en) * 1995-06-09 2000-02-29 Cybro Medical, Ltd. Sensor, method and device for optical blood oximetry
US6850656B1 (en) * 1998-10-07 2005-02-01 Ecole Polytechnique Federale De Lausanne Method and apparatus for measuring locally and superficially the scattering and absorption properties of turbid media
WO2001009589A1 (en) * 1999-08-03 2001-02-08 Abbott Laboratories Optical sensor having a selectable sampling distance for determination of analytes

Also Published As

Publication number Publication date
WO2007060583A2 (en) 2007-05-31

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