WO2007059330A3 - Analogue du nucleoside de cubane - Google Patents

Analogue du nucleoside de cubane Download PDF

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Publication number
WO2007059330A3
WO2007059330A3 PCT/US2006/044835 US2006044835W WO2007059330A3 WO 2007059330 A3 WO2007059330 A3 WO 2007059330A3 US 2006044835 W US2006044835 W US 2006044835W WO 2007059330 A3 WO2007059330 A3 WO 2007059330A3
Authority
WO
WIPO (PCT)
Prior art keywords
cubane
nucleoside analogs
nucleoside
methods
viral
Prior art date
Application number
PCT/US2006/044835
Other languages
English (en)
Other versions
WO2007059330A2 (fr
Inventor
Miroslav Trampota
Randall B Murphy
Original Assignee
Medkura Inc
Miroslav Trampota
Randall B Murphy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medkura Inc, Miroslav Trampota, Randall B Murphy filed Critical Medkura Inc
Publication of WO2007059330A2 publication Critical patent/WO2007059330A2/fr
Publication of WO2007059330A3 publication Critical patent/WO2007059330A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des analogues du nucléoside de cubane utiles en tant qu’agents anti-viral et anti-cancéreux. Elle concerne également des procédés de préparation desdits analogues. L’invention concerne, en outre, des compositions pharmaceutiques contenant un ou plusieurs analogues nucléosides de cubane et un ou plusieurs véhicules, excipients ou diluants pharmaceutiquement acceptables. L’invention concerne également des procédés destinés à traiter des infections cancéreuses et virales chez des mammifères. Les nucléosides de cubane décrits ici sont des composés répondant à la formule générale (I) dans laquelle B représente une base nucléoside de purine éventuellement substituée ou de pyrimidines et R1, R2, R3, R4, R5, R6, et R7 sont définis ici.
PCT/US2006/044835 2005-11-17 2006-11-17 Analogue du nucleoside de cubane WO2007059330A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73747505P 2005-11-17 2005-11-17
US60/737,475 2005-11-17

Publications (2)

Publication Number Publication Date
WO2007059330A2 WO2007059330A2 (fr) 2007-05-24
WO2007059330A3 true WO2007059330A3 (fr) 2007-12-21

Family

ID=38049324

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/044835 WO2007059330A2 (fr) 2005-11-17 2006-11-17 Analogue du nucleoside de cubane

Country Status (1)

Country Link
WO (1) WO2007059330A2 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5959100A (en) * 1996-03-27 1999-09-28 Nexstar Pharmaceuticals, Inc. Pyrimidine nucleosides as therapeutic and diagnostic agents
US6649600B1 (en) * 1999-11-12 2003-11-18 Biogen, Inc. Adenosine receptor antagonists and methods of making and using the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5959100A (en) * 1996-03-27 1999-09-28 Nexstar Pharmaceuticals, Inc. Pyrimidine nucleosides as therapeutic and diagnostic agents
US6649600B1 (en) * 1999-11-12 2003-11-18 Biogen, Inc. Adenosine receptor antagonists and methods of making and using the same

Also Published As

Publication number Publication date
WO2007059330A2 (fr) 2007-05-24

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