WO2007054978A3 - Process for preparing paroxetine hydrochloride hemihydrate - Google Patents

Process for preparing paroxetine hydrochloride hemihydrate Download PDF

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Publication number
WO2007054978A3
WO2007054978A3 PCT/IN2006/000446 IN2006000446W WO2007054978A3 WO 2007054978 A3 WO2007054978 A3 WO 2007054978A3 IN 2006000446 W IN2006000446 W IN 2006000446W WO 2007054978 A3 WO2007054978 A3 WO 2007054978A3
Authority
WO
WIPO (PCT)
Prior art keywords
paroxetine hydrochloride
hydrochloride hemihydrate
preparing paroxetine
preparing
hemihydrate
Prior art date
Application number
PCT/IN2006/000446
Other languages
French (fr)
Other versions
WO2007054978A2 (en
Inventor
Shailendra Kumar Dubey
Pramod Kumar
Sushil Kumar Dubey
Original Assignee
Jubilant Organosys Ltd
Shailendra Kumar Dubey
Pramod Kumar
Sushil Kumar Dubey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jubilant Organosys Ltd, Shailendra Kumar Dubey, Pramod Kumar, Sushil Kumar Dubey filed Critical Jubilant Organosys Ltd
Publication of WO2007054978A2 publication Critical patent/WO2007054978A2/en
Publication of WO2007054978A3 publication Critical patent/WO2007054978A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Disclosed herein a process for the preparation of crystalline paroxetine hydrochloride in hemihydrate form employing a selective solvent system to achieve stable and non- hygroscopic form which is easy to prepare and convenient to operate on commercial scale.
PCT/IN2006/000446 2005-11-10 2006-11-10 Process for preparing paroxetine hydrochloride hemihydrate WO2007054978A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3007/DEL/2005 2005-11-10
IN3007DE2005 2005-11-10

Publications (2)

Publication Number Publication Date
WO2007054978A2 WO2007054978A2 (en) 2007-05-18
WO2007054978A3 true WO2007054978A3 (en) 2008-01-03

Family

ID=38023690

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2006/000446 WO2007054978A2 (en) 2005-11-10 2006-11-10 Process for preparing paroxetine hydrochloride hemihydrate

Country Status (1)

Country Link
WO (1) WO2007054978A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE407933T1 (en) * 2005-05-26 2008-09-15 Apotecnia S A METHOD FOR PRODUCING PAROXETINE HYDROCHLORIDE HEMIHYDRATE
UY30730A1 (en) 2006-12-04 2008-07-03 Mitsubishi Tanabe Pharma Corp CRYSTAL FORM OF HEMIHYDRATE 1- (B (BETA) -D-GLUCOPYRANOSIL) -4-METHYL-3- [5- (4-FLUOROPHENYL) -2-TIENYLMETHYL] BENZENE
CL2008003653A1 (en) 2008-01-17 2010-03-05 Mitsubishi Tanabe Pharma Corp Use of a glucopyranosyl-derived sglt inhibitor and a selected dppiv inhibitor to treat diabetes; and pharmaceutical composition.
JP2010260826A (en) * 2009-05-08 2010-11-18 Sumitomo Chemical Co Ltd Method of manufacturing paroxetine hydrochloride semihydrate

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4721723A (en) * 1985-10-25 1988-01-26 Beecham Group P.L.C. Anti-depressant crystalline paroxetine hydrochloride hemihydrate
US5856493A (en) * 1995-02-06 1999-01-05 Smithkline Beecham Corporation Process for making novel form of paroxeting hydrochloride anhydrate
WO2000032594A1 (en) * 1998-11-30 2000-06-08 Smithkline Beecham Plc Mixed paroxetine propan-2-ol solvates

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4721723A (en) * 1985-10-25 1988-01-26 Beecham Group P.L.C. Anti-depressant crystalline paroxetine hydrochloride hemihydrate
US5856493A (en) * 1995-02-06 1999-01-05 Smithkline Beecham Corporation Process for making novel form of paroxeting hydrochloride anhydrate
WO2000032594A1 (en) * 1998-11-30 2000-06-08 Smithkline Beecham Plc Mixed paroxetine propan-2-ol solvates

Also Published As

Publication number Publication date
WO2007054978A2 (en) 2007-05-18

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