ATE407933T1 - METHOD FOR PRODUCING PAROXETINE HYDROCHLORIDE HEMIHYDRATE - Google Patents

METHOD FOR PRODUCING PAROXETINE HYDROCHLORIDE HEMIHYDRATE

Info

Publication number
ATE407933T1
ATE407933T1 AT06010476T AT06010476T ATE407933T1 AT E407933 T1 ATE407933 T1 AT E407933T1 AT 06010476 T AT06010476 T AT 06010476T AT 06010476 T AT06010476 T AT 06010476T AT E407933 T1 ATE407933 T1 AT E407933T1
Authority
AT
Austria
Prior art keywords
paroxetine hydrochloride
hydrochloride hemihydrate
hemihydrate
crystalline
producing paroxetine
Prior art date
Application number
AT06010476T
Other languages
German (de)
Inventor
Franca Segnalini
Stefano Magnanti
Original Assignee
Apotecnia S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apotecnia S A filed Critical Apotecnia S A
Application granted granted Critical
Publication of ATE407933T1 publication Critical patent/ATE407933T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A process for manufacturing crystalline paroxetine hydrochloride hemihydrate which comprises converting - in the solid state - a crystalline anhydrous solvate of paroxetine hydrochloride into the corresponding crystalline hemihydrate is described, process which is advantageous both in term of yields and purity with respect to the classical crystallization method described in the prior art.
AT06010476T 2005-05-26 2006-05-22 METHOD FOR PRODUCING PAROXETINE HYDROCHLORIDE HEMIHYDRATE ATE407933T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68523705P 2005-05-26 2005-05-26

Publications (1)

Publication Number Publication Date
ATE407933T1 true ATE407933T1 (en) 2008-09-15

Family

ID=36969441

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06010476T ATE407933T1 (en) 2005-05-26 2006-05-22 METHOD FOR PRODUCING PAROXETINE HYDROCHLORIDE HEMIHYDRATE

Country Status (4)

Country Link
EP (1) EP1726591B1 (en)
JP (1) JP2007008918A (en)
AT (1) ATE407933T1 (en)
DE (1) DE602006002650D1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100797983B1 (en) * 2006-11-01 2008-01-24 정태석 Toll collection apparatus and toll collection system
KR20100058660A (en) † 2007-10-23 2010-06-03 테바 파마슈티컬 인더스트리즈 리미티드 Polymorphs of dasatinib and process for preparation thereof
JP2010260826A (en) * 2009-05-08 2010-11-18 Sumitomo Chemical Co Ltd Method of manufacturing paroxetine hydrochloride semihydrate
CN112641750A (en) * 2021-01-12 2021-04-13 江苏睿实生物科技有限公司 Paroxetine hydrochloride tablet and preparation method thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3688827T2 (en) * 1985-10-25 1994-03-31 Beecham Group Plc Piperidine derivative, its manufacture and its use as a medicine.
US5856493A (en) * 1995-02-06 1999-01-05 Smithkline Beecham Corporation Process for making novel form of paroxeting hydrochloride anhydrate
GB9826180D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel process
GB9920147D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
CA2470496A1 (en) * 2001-12-28 2003-07-17 Teva Pharmaceutical Industries Ltd. A stable pharmaceutical formulation of paroxetine hydrochloride and a process for preparation thereof
AU2003271055B2 (en) * 2002-09-19 2009-03-12 Sumitomo Chemical Company, Limited Methods of crystal precipitation
WO2007054978A2 (en) * 2005-11-10 2007-05-18 Jubilant Organosys Limited Process for preparing paroxetine hydrochloride hemihydrate

Also Published As

Publication number Publication date
JP2007008918A (en) 2007-01-18
EP1726591A2 (en) 2006-11-29
DE602006002650D1 (en) 2008-10-23
EP1726591A3 (en) 2007-07-25
EP1726591B1 (en) 2008-09-10

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Legal Events

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