WO2007054151A3 - Verwendung von choriongonadotropin als immunsuppressivum - Google Patents

Verwendung von choriongonadotropin als immunsuppressivum Download PDF

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Publication number
WO2007054151A3
WO2007054151A3 PCT/EP2006/009079 EP2006009079W WO2007054151A3 WO 2007054151 A3 WO2007054151 A3 WO 2007054151A3 EP 2006009079 W EP2006009079 W EP 2006009079W WO 2007054151 A3 WO2007054151 A3 WO 2007054151A3
Authority
WO
WIPO (PCT)
Prior art keywords
immunosuppressor
chorionic gonadotropin
versus
treatment
graft
Prior art date
Application number
PCT/EP2006/009079
Other languages
English (en)
French (fr)
Other versions
WO2007054151A2 (de
Inventor
Ahmet H Elmaagacli
Original Assignee
Univ Duisburg Essen
Ahmet H Elmaagacli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duisburg Essen, Ahmet H Elmaagacli filed Critical Univ Duisburg Essen
Publication of WO2007054151A2 publication Critical patent/WO2007054151A2/de
Publication of WO2007054151A3 publication Critical patent/WO2007054151A3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Gegenstand der Erfindung ist die Verwendung mindestens eines Proteohormons, insbesondere Glykoprotein-Hormons, bevorzugt eines gonadotropen Hormons (Gonadotropins), besonders bevorzugt von insbesondere humanem Choriongonadotropin (HCG), als Immunsuppressivum bzw. zur Herstellung eines Arzneimittels zur Immunsuppression, wobei als Anwendungsgebiete insbesondere die Behandlung von Autoimmunerkrankungen und die Behandlung von Transplantatabstoßungsreaktionen, insbesondere Wirt-gegen-Transplantat-Reaktionen ('host-versus-graft reaction') oder Transplantat-gegen-Wirt-Reaktionen ('graft- versus-host disease [=GVHD]'), nach Transplantationen in Betracht kommen.
PCT/EP2006/009079 2005-11-09 2006-09-19 Verwendung von choriongonadotropin als immunsuppressivum WO2007054151A2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102005053843.6 2005-11-09
DE102005053843 2005-11-09
DE102005054454A DE102005054454A1 (de) 2005-11-09 2005-11-13 Verwendung von Choriongonadotropin als Immunsuppressivum
DE102005054454.1 2005-11-13

Publications (2)

Publication Number Publication Date
WO2007054151A2 WO2007054151A2 (de) 2007-05-18
WO2007054151A3 true WO2007054151A3 (de) 2007-08-02

Family

ID=37946200

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/009079 WO2007054151A2 (de) 2005-11-09 2006-09-19 Verwendung von choriongonadotropin als immunsuppressivum

Country Status (2)

Country Link
DE (1) DE102005054454A1 (de)
WO (1) WO2007054151A2 (de)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999059617A2 (en) * 1998-05-20 1999-11-25 Erasmus Universiteit Rotterdam Immunoregulator
WO2002038168A2 (de) * 2000-11-07 2002-05-16 Nemod Immuntherapie Ag Verwendung von selektin-bindenden wirkstoffen zur behandlung von entzündlichen- und tumor-erkrankungen
EP1466612A1 (de) * 2003-04-08 2004-10-13 Biotempt B.V. Behandlung von Entzündung und Sepsis mit hCG-Peptidderivate
WO2006029088A2 (en) * 2004-09-02 2006-03-16 Biotech Institute For International Innovation, Inc. Methods for restoring immune balance for the treatment of t-cell mediated diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1138692A1 (de) * 2000-03-29 2001-10-04 Erasmus Universiteit Rotterdam Fragmente des menschlichen Choriongonadotropins als Immunoregulatoren
US7501391B2 (en) * 2001-12-21 2009-03-10 Biotempt B.V. Treatment of transplant survival
EP1466613A1 (de) * 2003-04-08 2004-10-13 Biotempt B.V. HCG-Fragmente enthaltene Zusammensetzungen zur mukosalen und oralen Anwendung

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999059617A2 (en) * 1998-05-20 1999-11-25 Erasmus Universiteit Rotterdam Immunoregulator
WO2002038168A2 (de) * 2000-11-07 2002-05-16 Nemod Immuntherapie Ag Verwendung von selektin-bindenden wirkstoffen zur behandlung von entzündlichen- und tumor-erkrankungen
EP1466612A1 (de) * 2003-04-08 2004-10-13 Biotempt B.V. Behandlung von Entzündung und Sepsis mit hCG-Peptidderivate
WO2006029088A2 (en) * 2004-09-02 2006-03-16 Biotech Institute For International Innovation, Inc. Methods for restoring immune balance for the treatment of t-cell mediated diseases

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, vol. 59, no. 4, 1980, pages 355 - 359, ISSN: 0001-6349 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1980, FUCHS T ET AL: "IN-VITRO INDUCTION OF MURINE SUPPRESSOR T CELLS BY HUMAN CHORIONIC GONADOTROPIN", XP002434850, Database accession no. PREV198171052809 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1982, MAJUMDAR S ET AL: "PREGNANCY SPECIFIC PROTEINS SUPPRESSION OF IN-VITRO BLASTOGENIC RESPONSE TO MITOGEN BY THESE PROTEINS", XP002434851, Database accession no. PREV198375070879 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; January 1976 (1976-01-01), GUISANTES A ET AL: "Effects of human chorionic somatomammotropin and human chorionic gonadotropin on skin homografts in rats.", XP002434849, Database accession no. NLM800386 *
INTERNATIONAL JOURNAL OF FERTILITY, vol. 27, no. 2, 1982, pages 66 - 69, ISSN: 0020-725X *
REPRODUCCIÓN 1976 JAN-JUN, vol. 3, no. 1-2, January 1976 (1976-01-01), pages 135 - 139, ISSN: 0303-5220 *
STECKEL N K ET AL: "Indoleamine 2,3-dioxygenase expression in monocytes of healthy nonpregnant women after induction with human choriongonadotropine.", SCANDINAVIAN JOURNAL OF IMMUNOLOGY FEB 2005, vol. 61, no. 2, February 2005 (2005-02-01), pages 213 - 214, XP002431654, ISSN: 0300-9475 *
STECKEL N K ET AL: "Indoleamine 2,3-dioxygenase expression in patients with acute graft-versus-host disease after allogeneic stem cell transplantation and in pregnant women: association with the induction of allogeneic immune tolerance?", SCANDINAVIAN JOURNAL OF IMMUNOLOGY FEB 2003, vol. 57, no. 2, February 2003 (2003-02-01), pages 185 - 191, XP002434571, ISSN: 0300-9475 *

Also Published As

Publication number Publication date
WO2007054151A2 (de) 2007-05-18
DE102005054454A1 (de) 2007-06-28

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