WO2007039699A3 - Substrat proteique pour la detection de l'activite calpaine 3 - Google Patents
Substrat proteique pour la detection de l'activite calpaine 3 Download PDFInfo
- Publication number
- WO2007039699A3 WO2007039699A3 PCT/FR2006/050964 FR2006050964W WO2007039699A3 WO 2007039699 A3 WO2007039699 A3 WO 2007039699A3 FR 2006050964 W FR2006050964 W FR 2006050964W WO 2007039699 A3 WO2007039699 A3 WO 2007039699A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- calpain
- activity
- detection
- proteinaceous substrate
- proteinaceous
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/22—Cysteine endopeptidases (3.4.22)
- C12Y304/22054—Calpain-3 (3.4.22.54), i.e. calpain p94
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96466—Cysteine endopeptidases (3.4.22)
Abstract
L'invention a trait à un substrat protéique comprenant une protéine calpaine 3 dépourvue d'activité autolytique et une étiquette de détection, ainsi qu'à une méthode de détection in vitro de l'activité calpaine 3 dans un échantillon biologique.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0552980A FR2891544A1 (fr) | 2005-09-30 | 2005-09-30 | Substrat proteique pour la detection de l'activite calpaine 3 |
FR0552980 | 2005-09-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007039699A2 WO2007039699A2 (fr) | 2007-04-12 |
WO2007039699A3 true WO2007039699A3 (fr) | 2007-05-24 |
Family
ID=36581666
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2006/050964 WO2007039699A2 (fr) | 2005-09-30 | 2006-09-29 | Substrat proteique pour la detection de l'activite calpaine 3 |
Country Status (2)
Country | Link |
---|---|
FR (1) | FR2891544A1 (fr) |
WO (1) | WO2007039699A2 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11975078B2 (en) | 2014-01-21 | 2024-05-07 | Universiteit Gent | Muscle-specific nucleic acid regulatory elements and methods and use thereof |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2962041B1 (fr) | 2010-07-01 | 2012-07-27 | Genethon | Inhibiteurs de la calpaine 3 pour le traitement de dystrophies musculaires et de cardiomyopathies |
WO2018035451A1 (fr) | 2016-08-19 | 2018-02-22 | Calimmune, Inc. | Méthodes et compositions pour le traitement d'affections à l'aide d'un virus adéno-associé recombinant auto-complémentaire |
WO2018106956A2 (fr) | 2016-12-07 | 2018-06-14 | University Of Florida Research Foundation, Incorporated | Adnc d'il-1ra |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003002730A2 (fr) * | 2001-06-29 | 2003-01-09 | Genethon | Methode de detection de l'activite de la calpaine 3 dans un echantillon biologique et peptides pour la mise en oeuvre de ladite methode |
-
2005
- 2005-09-30 FR FR0552980A patent/FR2891544A1/fr not_active Withdrawn
-
2006
- 2006-09-29 WO PCT/FR2006/050964 patent/WO2007039699A2/fr active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003002730A2 (fr) * | 2001-06-29 | 2003-01-09 | Genethon | Methode de detection de l'activite de la calpaine 3 dans un echantillon biologique et peptides pour la mise en oeuvre de ladite methode |
Non-Patent Citations (4)
Title |
---|
FANIN MARINA ET AL: "Loss of calpain-3 autocatalytic activity in LGMD2A patients with normal protein expression.", AMERICAN JOURNAL OF PATHOLOGY, vol. 163, no. 5, November 2003 (2003-11-01), pages 1929 - 1936, XP002386341, ISSN: 0002-9440 * |
GUBITZ AMELIE K ET AL: "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 7, 15 February 2002 (2002-02-15), pages 5631 - 5636, XP002386342, ISSN: 0021-9258 * |
ONO Y ET AL: "Functional defects of a muscle-specific calpain, p94, caused by mutations associated with limb-girdle muscular dystrophy type 2A", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 273, no. 27, 3 July 1998 (1998-07-03), pages 17073 - 17078, XP002238594, ISSN: 0021-9258 * |
YANG YI ET AL: "RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 277, no. 28, 12 July 2002 (2002-07-12), pages 25756 - 25774, XP002216975, ISSN: 0021-9258 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11975078B2 (en) | 2014-01-21 | 2024-05-07 | Universiteit Gent | Muscle-specific nucleic acid regulatory elements and methods and use thereof |
Also Published As
Publication number | Publication date |
---|---|
FR2891544A1 (fr) | 2007-04-06 |
WO2007039699A2 (fr) | 2007-04-12 |
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