WO2007021990A3 - Melanocortin receptor-specific piperazine compounds with diamine groups - Google Patents

Melanocortin receptor-specific piperazine compounds with diamine groups Download PDF

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Publication number
WO2007021990A3
WO2007021990A3 PCT/US2006/031472 US2006031472W WO2007021990A3 WO 2007021990 A3 WO2007021990 A3 WO 2007021990A3 US 2006031472 W US2006031472 W US 2006031472W WO 2007021990 A3 WO2007021990 A3 WO 2007021990A3
Authority
WO
WIPO (PCT)
Prior art keywords
melanocortin receptor
agonist
melanocortin
diamine
diamine groups
Prior art date
Application number
PCT/US2006/031472
Other languages
French (fr)
Other versions
WO2007021990A2 (en
Inventor
Shubh D Sharma
Yi-Qun Shi
Kevin Burris
Zhijun Wu
Papireddy Purma
Yadi Reddy Bonuga
Original Assignee
Palatin Technologies Inc
Shubh D Sharma
Yi-Qun Shi
Kevin Burris
Zhijun Wu
Papireddy Purma
Yadi Reddy Bonuga
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Palatin Technologies Inc, Shubh D Sharma, Yi-Qun Shi, Kevin Burris, Zhijun Wu, Papireddy Purma, Yadi Reddy Bonuga filed Critical Palatin Technologies Inc
Priority to EP06813393A priority Critical patent/EP1922072A4/en
Priority to JP2008526249A priority patent/JP2009504671A/en
Publication of WO2007021990A2 publication Critical patent/WO2007021990A2/en
Priority to TW096126956A priority patent/TW200817341A/en
Priority to ARP070103459A priority patent/AR062219A1/en
Publication of WO2007021990A3 publication Critical patent/WO2007021990A3/en
Priority to US11/836,897 priority patent/US7834017B2/en
Priority to PCT/GB2007/003039 priority patent/WO2008017852A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nutrition Science (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Melanocortin receptor-specific compounds with diamine groups of the general formula (I) and pharmaceutically acceptable salts thereof, where W is a diamine heteroatom unit with at least one cationic center, hydrogen bond donor or hydrogen bond acceptor, J, Q, L1, L2, L3, R1a, R1b, R2a, R2b and X are as defined in the specification, and the carbon atom marked with an asterisk can have any stereochemical configuration. Compounds disclosed herein bind to one or more melanocortin receptors and may be an agonist, a partial agonist, an antagonist, an inverse agonist or an antagonist of an inverse agonist as to one or more melanocortin receptors, and may be employed for treatment of one or more melanocortin receptor-associated conditions or disorders, including specifically treatment of obesity and related conditions.
PCT/US2006/031472 2005-08-11 2006-08-11 Melanocortin receptor-specific piperazine compounds with diamine groups WO2007021990A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP06813393A EP1922072A4 (en) 2005-08-11 2006-08-11 Melanocortin receptor-specific piperazine compounds with diamine groups
JP2008526249A JP2009504671A (en) 2005-08-11 2006-08-11 Melanocortin receptor-specific piperazine compounds with diamine groups
TW096126956A TW200817341A (en) 2006-08-11 2007-07-24 Diamine-containing, tetra-substituted piperazine compounds having identical 1-and 4-substituents
ARP070103459A AR062219A1 (en) 2006-08-11 2007-08-06 TETRA- REPLACED PIPERAZINE COMPOUNDS CONTAINING DIAMINE AND HAVING 1 AND 4 IDENTICAL SUBSTITUTES
US11/836,897 US7834017B2 (en) 2006-08-11 2007-08-10 Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents
PCT/GB2007/003039 WO2008017852A1 (en) 2006-08-11 2007-08-10 Diamine-containing, tetra- substituted piperazine compounds as melanocortin receptor modulators

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70748805P 2005-08-11 2005-08-11
US60/707,488 2005-08-11

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/031474 Continuation-In-Part WO2007021991A2 (en) 2005-08-11 2006-08-11 Melanocortin receptor-specific piperazine and keto-piperazine compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/464,069 Continuation-In-Part US7727990B2 (en) 2003-05-01 2006-08-11 Melanocortin receptor-specific piperazine and keto-piperazine compounds

Publications (2)

Publication Number Publication Date
WO2007021990A2 WO2007021990A2 (en) 2007-02-22
WO2007021990A3 true WO2007021990A3 (en) 2007-08-09

Family

ID=37758229

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2006/031472 WO2007021990A2 (en) 2005-08-11 2006-08-11 Melanocortin receptor-specific piperazine compounds with diamine groups
PCT/US2006/031474 WO2007021991A2 (en) 2005-08-11 2006-08-11 Melanocortin receptor-specific piperazine and keto-piperazine compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2006/031474 WO2007021991A2 (en) 2005-08-11 2006-08-11 Melanocortin receptor-specific piperazine and keto-piperazine compounds

Country Status (4)

Country Link
EP (2) EP1919479A4 (en)
JP (2) JP2009504671A (en)
CN (2) CN101272789A (en)
WO (2) WO2007021990A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7727991B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Substituted melanocortin receptor-specific single acyl piperazine compounds
EP1919479A4 (en) * 2005-08-11 2010-11-17 Palatin Technologies Inc Melanocortin receptor-specific piperazine and keto-piperazine compounds
WO2008090357A2 (en) * 2007-01-24 2008-07-31 Palatin Technologies, Inc. N, n; -substituted piperazines binding to melanocortin receptor
WO2009144432A1 (en) * 2008-05-30 2009-12-03 Palatin Technologies, Inc. Mc4-r agonists for the treatment of obesity
WO2017090743A1 (en) * 2015-11-27 2017-06-01 田辺三菱製薬株式会社 Novel imidazole compound and use thereof as melanocortin receptor agonist

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040204398A1 (en) * 2003-03-03 2004-10-14 Bakshi Raman K. Acylated piperazine derivatives as melanocortin-4 receptor agonists
US20040224957A1 (en) * 2003-05-01 2004-11-11 Palatin Technologies, Inc. Melanocortin receptor-specific compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7732451B2 (en) * 2001-08-10 2010-06-08 Palatin Technologies, Inc. Naphthalene-containing melanocortin receptor-specific small molecule
US7354923B2 (en) * 2001-08-10 2008-04-08 Palatin Technologies, Inc. Piperazine melanocortin-specific compounds
EP1919479A4 (en) * 2005-08-11 2010-11-17 Palatin Technologies Inc Melanocortin receptor-specific piperazine and keto-piperazine compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040204398A1 (en) * 2003-03-03 2004-10-14 Bakshi Raman K. Acylated piperazine derivatives as melanocortin-4 receptor agonists
US20040224957A1 (en) * 2003-05-01 2004-11-11 Palatin Technologies, Inc. Melanocortin receptor-specific compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1922072A4 *

Also Published As

Publication number Publication date
WO2007021991A2 (en) 2007-02-22
CN101272789A (en) 2008-09-24
WO2007021991A3 (en) 2007-07-12
JP2009504672A (en) 2009-02-05
EP1922072A4 (en) 2010-12-29
CN101272788A (en) 2008-09-24
JP2009504671A (en) 2009-02-05
EP1922072A2 (en) 2008-05-21
WO2007021990A2 (en) 2007-02-22
EP1919479A2 (en) 2008-05-14
EP1919479A4 (en) 2010-11-17

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