AR062219A1 - TETRA- REPLACED PIPERAZINE COMPOUNDS CONTAINING DIAMINE AND HAVING 1 AND 4 IDENTICAL SUBSTITUTES - Google Patents
TETRA- REPLACED PIPERAZINE COMPOUNDS CONTAINING DIAMINE AND HAVING 1 AND 4 IDENTICAL SUBSTITUTESInfo
- Publication number
- AR062219A1 AR062219A1 ARP070103459A ARP070103459A AR062219A1 AR 062219 A1 AR062219 A1 AR 062219A1 AR P070103459 A ARP070103459 A AR P070103459A AR P070103459 A ARP070103459 A AR P070103459A AR 062219 A1 AR062219 A1 AR 062219A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrogen
- cyclohethyl
- rest
- index value
- vch
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
El uso de tales compuestos en el tratamiento de una afeccion que responde a los cambios en la funcion del receptor de melanocortina en un ser humano o mamífero no humano (por ej., disfuncion sexual masculina, disfuncion sexual femenina, un trastorno alimenticio, peso corporal por encima del optimo, obesidad, peso corporal por debajo el optimo o caquexia. Reivindicacion 1: Un compuesto que tiene la formula de estructura 1 o su enantiomero, estereoisomero o diastereoisomero, o su sal farmacéuticamente aceptable, donde uno o dos de R1a, R1b, R2a, y R2b son independientemente una cadena lineal o ramificada alifática C1 a C6 y el resto de R1a, R1b, R2a, y R2b son hidrogeno, siempre y cuando al menos uno de R1a y R1b y al menos uno de R2a y R2b son hidrogeno; o uno de R1a, R1b, R2a, y R2b son como en formulas (2) y el resto de R1a, R1b, R2a, y R2b son hidrogeno; o R1a y R1b juntos forman =O y uno de R2a y R2b es una cadena lineal o ramificada alifática de C1 a C6, como en formulas (2), y el resto de R2a y R2b es hidrogeno; y es en cada aparicion un valor de índice independiente del 0 al 5; W es una unidad de heteroátomos de diamina con al menos un centro cationico, donante de enlace a hidrogeno o aceptor de enlace a hidrogeno; L2 es un enlace o (CH2)z; z es un valor de índice del 1 al 6; X es CH2, C=O o C=S; los grupos -C(R8)(CH2)vCH(R9)(CH2)y-Q y -C(R8)(CH2)vCH(R9)(CH2)y-J son iguales y, en aquellos grupos, R8 es H o =O; R9 es hidrogeno o N(R10a)R10b; R10a y R10b son independientemente hidrogeno, acetilo, metilo, etilo, propilo, isopropilo, butilo, pentilo, hexilo, isobutilo, bencilo, benzoílo, hexanoílo, propionilo, butanoílo, pentanoílo, heptanollo, ciclopropilo, ciclopropilmetilo, ciclobutilo, ciclobutilmetilo, ciclohexilo, ciclohexilmetilo, o polietilenglicol; v es un valor de índice del 0 al 2; y Q y J son iguales y representan un anillo carbocíclico aromático seleccionado del grupo formado por fenilo, fenilo sustituido, naftilo y naftilo sustituido; donde los átomos de carbono marcados con un asterisco pueden tener cualquier configuracion estereoquímica.The use of such compounds in the treatment of a condition that responds to changes in the function of the melanocortin receptor in a human or non-human mammal (eg, male sexual dysfunction, female sexual dysfunction, an eating disorder, body weight above the optimum, obesity, body weight below the optimal or cachexia Claim 1: A compound having the formula of structure 1 or its enantiomer, stereoisomer or diastereoisomer, or its pharmaceutically acceptable salt, where one or two of R1a, R1b , R2a, and R2b are independently an aliphatic linear or branched chain C1 to C6 and the rest of R1a, R1b, R2a, and R2b are hydrogen, as long as at least one of R1a and R1b and at least one of R2a and R2b are hydrogen; or one of R1a, R1b, R2a, and R2b are as in formulas (2) and the rest of R1a, R1b, R2a, and R2b are hydrogen; or R1a and R1b together form = O and one of R2a and R2b is an aliphatic linear or branched chain from C1 to C6, as in formulas (2), and the rest of R2a and R2b is hydrogen; and is in each occurrence an independent index value from 0 to 5; W is a unit of diamine heteroatoms with at least one cationic center, hydrogen bonding donor or hydrogen bonding acceptor; L2 is a bond or (CH2) z; z is an index value from 1 to 6; X is CH2, C = O or C = S; the groups -C (R8) (CH2) vCH (R9) (CH2) and-Q and -C (R8) (CH2) vCH (R9) (CH2) and-J are the same and, in those groups, R8 is H or = O; R9 is hydrogen or N (R10a) R10b; R10a and R10b are independently hydrogen, acetyl, methyl, ethyl, propyl, isopropyl, butyl, pentyl, hexyl, isobutyl, benzyl, benzoyl, hexanoyl, propionyl, butanoyl, pentanoyl, heptanol, cyclopropyl, cyclopropylmethyl, cyclobutyl, cyclohethyl, cyclohethyl, cyclohethyl, cyclohethyl, cyclohexyl , or polyethylene glycol; v is an index value from 0 to 2; and Q and J are the same and represent an aromatic carbocyclic ring selected from the group consisting of phenyl, substituted phenyl, naphthyl and substituted naphthyl; where carbon atoms marked with an asterisk can have any stereochemical configuration.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82213506P | 2006-08-11 | 2006-08-11 | |
| PCT/US2006/031472 WO2007021990A2 (en) | 2005-08-11 | 2006-08-11 | Melanocortin receptor-specific piperazine compounds with diamine groups |
| US11/464,069 US7727990B2 (en) | 2003-05-01 | 2006-08-11 | Melanocortin receptor-specific piperazine and keto-piperazine compounds |
| PCT/US2006/031474 WO2007021991A2 (en) | 2005-08-11 | 2006-08-11 | Melanocortin receptor-specific piperazine and keto-piperazine compounds |
| US11/464,053 US7968548B2 (en) | 2003-05-01 | 2006-08-11 | Melanocortin receptor-specific piperazine compounds with diamine groups |
| US88643407P | 2007-01-24 | 2007-01-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR062219A1 true AR062219A1 (en) | 2008-10-22 |
Family
ID=39929411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070103459A AR062219A1 (en) | 2006-08-11 | 2007-08-06 | TETRA- REPLACED PIPERAZINE COMPOUNDS CONTAINING DIAMINE AND HAVING 1 AND 4 IDENTICAL SUBSTITUTES |
Country Status (2)
| Country | Link |
|---|---|
| AR (1) | AR062219A1 (en) |
| TW (1) | TW200817341A (en) |
-
2007
- 2007-07-24 TW TW096126956A patent/TW200817341A/en unknown
- 2007-08-06 AR ARP070103459A patent/AR062219A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TW200817341A (en) | 2008-04-16 |
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