WO2007017538A3 - Procedimiento para la obtención de beselato amlodipina - Google Patents
Procedimiento para la obtención de beselato amlodipina Download PDFInfo
- Publication number
- WO2007017538A3 WO2007017538A3 PCT/ES2006/000444 ES2006000444W WO2007017538A3 WO 2007017538 A3 WO2007017538 A3 WO 2007017538A3 ES 2006000444 W ES2006000444 W ES 2006000444W WO 2007017538 A3 WO2007017538 A3 WO 2007017538A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- amlodipine
- obtaining
- amlodipine besylate
- order
- pharmaceutical
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Se trata de un método sencillo, económico, fácilmente adaptable a escala industrial, que permite la obtención de un producto de calidad farmacéutica con un alto rendimiento, que se basa en hacer reaccionar un derivado fatlimido-amlodipina con un agente desprotector en presencia de un disolvente inerte, como puede ser una mezcla de tolueno e isopropanol, para formar amlodipina por adición de ácido bencenosulfónico, el bencenosulfonato de amlodipina crudo obtenido puede recristalizarse, para obtener así un producto sólido cristalino, de calidad farmacéutica, con un rendimiento de recristalización elevado, por encima del 95%.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200501963A ES2265781B1 (es) | 2005-08-04 | 2005-08-04 | Procedimiento para la obtencion de besilato de amlodipina. |
ESP200501963 | 2005-08-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007017538A2 WO2007017538A2 (es) | 2007-02-15 |
WO2007017538A3 true WO2007017538A3 (es) | 2007-04-12 |
Family
ID=37727672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/ES2006/000444 WO2007017538A2 (es) | 2005-08-04 | 2006-07-28 | Procedimiento para la obtención de beselato amlodipina |
Country Status (2)
Country | Link |
---|---|
ES (1) | ES2265781B1 (es) |
WO (1) | WO2007017538A2 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113041244B (zh) | 2019-11-08 | 2022-06-21 | 施慧达药业集团(吉林)有限公司 | 含苯磺酸左氨氯地平水合物的组合物及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4572909A (en) * | 1982-03-11 | 1986-02-25 | Pfizer Inc. | 2-(Secondary aminoalkoxymethyl) dihydropyridine derivatives as anti-ischaemic and antihypertensive agents |
WO2004058711A1 (en) * | 2002-12-30 | 2004-07-15 | Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. | Isolation of dihydropyridine derivative and preparation salts thereof |
WO2005023769A1 (en) * | 2003-09-04 | 2005-03-17 | Cipla Limited | Process for the preparation of amlodipine salts |
-
2005
- 2005-08-04 ES ES200501963A patent/ES2265781B1/es not_active Expired - Fee Related
-
2006
- 2006-07-28 WO PCT/ES2006/000444 patent/WO2007017538A2/es active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4572909A (en) * | 1982-03-11 | 1986-02-25 | Pfizer Inc. | 2-(Secondary aminoalkoxymethyl) dihydropyridine derivatives as anti-ischaemic and antihypertensive agents |
WO2004058711A1 (en) * | 2002-12-30 | 2004-07-15 | Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. | Isolation of dihydropyridine derivative and preparation salts thereof |
WO2005023769A1 (en) * | 2003-09-04 | 2005-03-17 | Cipla Limited | Process for the preparation of amlodipine salts |
Also Published As
Publication number | Publication date |
---|---|
ES2265781A1 (es) | 2007-02-16 |
WO2007017538A2 (es) | 2007-02-15 |
ES2265781B1 (es) | 2007-12-01 |
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