WO2007012854A1 - Ensemble indicateur de comptage a bague rotative monte sur recipient pour inhalateur doseur - Google Patents

Ensemble indicateur de comptage a bague rotative monte sur recipient pour inhalateur doseur Download PDF

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Publication number
WO2007012854A1
WO2007012854A1 PCT/GB2006/002798 GB2006002798W WO2007012854A1 WO 2007012854 A1 WO2007012854 A1 WO 2007012854A1 GB 2006002798 W GB2006002798 W GB 2006002798W WO 2007012854 A1 WO2007012854 A1 WO 2007012854A1
Authority
WO
WIPO (PCT)
Prior art keywords
ring
canister
housing
engaging
lever
Prior art date
Application number
PCT/GB2006/002798
Other languages
English (en)
Inventor
Robert Owen Kivlin
Francis Dominic Lloyd-Lucas
Original Assignee
Cambridge Consultants Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Consultants Limited filed Critical Cambridge Consultants Limited
Publication of WO2007012854A1 publication Critical patent/WO2007012854A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A61M15/0073—Mechanical counters having a display or indicator on a ring
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/04—Design features of general application for driving the stage of lowest order
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/08—Design features of general application for actuating the drive
    • G06M1/083—Design features of general application for actuating the drive by mechanical means

Definitions

  • This invention relates to a dose counter assembly, and in particular, to a dose counter assembly having an improved dosage indicator for indicating the number of metered dosages that have been dispensed from, or remain in, a canister.
  • Patients having certain conditions can be treated with medicaments dispersed in an aerosol form and administered to that patient by inhalation.
  • the aerosol and medicaments are contained in a canister, or container, and dispensed in metered or measured dosages from an inhalation device.
  • the inhalation device it is important for the inhalation device to provide an accurate indication of either the number of doses remaining in the canister, or the number of doses already dispensed therefrom.
  • a conventional aerosol canister typically includes a body and a valve stem extending from one end of the body to emit a metered dose of aerosol and medicament.
  • the canister is usually supplied with a predetermined number of metered doses, generally between 100 and 200 doses of medicament although products outside of this range exist.
  • the aerosol canister is removable from the inhaler housing to permit effective cleaning of the structure defining the airflow path.
  • the housing is designed to accept a succession of user-introduced aerosol medicament canisters, as well as to provide for canister removal for cleaning.
  • U.S. Pat. No. 6,142,339 describes an inhalation device having a dose counter including a worm screw and a ratchet drive in a housing and an indicator having a circular gear thereon for engaging the worm screw.
  • a canister is received within the housing and is reciprocally movable along a longitudinal axis of the housing. The reciprocal movement of the canister drives the ratchet and the worm to rotate, which in turn drives the indicator to advance and to count a dosage.
  • the dose counter disclosed in the U.S. Pat. No. 6,142,339 is not linked to a specific canister or removable from the housing . If a user swap a new canister with the canister associated with the housing, the dosage on the dose indicator which is attached to the housing does not show the correct remaining dosage of the new canister.
  • U.S. Pat. No. 6,435,372 describes a dose counter also attached to the housing, but not to the canister. Again, the device presents a danger that the dose indicator may show incorrect remaining dosage of the canister if the canister has been swapped with another canister by the user.
  • the present invention provides a dose counter assembly for use with a medicament dispensing device, preferably, a metered dose inhaler.
  • the dose counter assembly is canister-supported and has a rotating ring count readout.
  • the inhaler includes a housing disposed about a longitudinal axis with a mouthpiece section at one end, a canister extending along a central axis, and a dose counter assembly mounted on the canister.
  • the canister can be a known type of aerosol dispensing canister in the art, which generally has a cylindrical shape.
  • a patient's inhalation at the mouthpiece or pressing downward at the cap causes the canister to move downward to an activated position, resulting in the release of a measured dose of medicament through a dispensing nozzle of the canister and into the mouthpiece at the same time as the patient breathes in.
  • the patient inhales air with a metered dose of medicament.
  • the canister then returns to a rest position.
  • the canister is received within the housing, where the central axis of the canister is substantially coaxial with the longitudinal axis of the housing.
  • the canister is reciprocally moveable along the longitudinal axis of the housing.
  • the dose counter assembly for use with the inhaler includes a carrier, which has an annular shape and is mounted on an outer surface of the canister, a first ring rotatably mounted on the carrier about the central axis, a second ring rotatably mounted on the carrier about the central axis, engaging means pivotally mounted on the carrier, and activating means mounted on the outer surface of the first ring and an inner surface of the housing.
  • the first ring has ratchet teeth on an outer circumference of the first ring.
  • the second ring has ratchet teeth on an outer circumference of the second ring.
  • the activating means is for operatively engaging the ratchet teeth of the first ring so as to rotate the first ring in response to the reciprocal movement of the canister along the longitudinal axis of the housing.
  • the engaging means is for operatively engaging the first ring with the ratchet teeth of the second ring so as to rotate the second ring in response to a predetermined amount of rotation of the first ring.
  • the canister can be formed to incorporate the carrier.
  • the first ring includes digits on its outer surface
  • the second ring includes digits on its outer surface.
  • the first ring shows digits "0-9" and repeating thereon
  • the second ring shows digits "0-20" thereon, wherein digit "0" on the second ring can be blank.
  • the rings are oriented to permit a composite view of a multi-digit number formed by the digits of first ring and second ring.
  • the present invention can employ other indication mechanism for indicating the dosage, such as a fuel gauge type indicator.
  • the ratchet teeth on the first ring are beveled with respect to the central axis of the canister and the activating means includes a set of multipoint teeth on an inner surface of the housing for engaging the beveled ratchet teeth of the first ring to rotate the first ring by one step when the canister is pressed downward along the longitudinal axis of the housing.
  • the engaging means is a lever pivotally mounted on the carrier.
  • the lever preferably includes a first pawl for engaging an engaging element on the outer surface of the first ring and a second pawl for engaging the ratchet teeth of the second ring, whereby the engaging element forces the lever to rotate, which in turn, forces the second ring to rotate by one step (one tooth).
  • the first ring includes an array of engaging elements separated by a predetermined amount of distance on the outer surface of the first ring. For example, the engaging elements may occur at every tenth tooth of the first ring, which means that the second ring rotates one step (count one time) while the first ring rotates ten steps (count ten times).
  • the activating means includes a lever pivotally mounted on the outer surface of the carrier and a cam surface on the inner surface of the housing.
  • a "cam surface” may be a proud feature extending from an element or a recessed track extending into an element.
  • a boss feature on the lever is guided by the cam feature when the canister is pressed downward, thereby causing the lever to move.
  • the lever includes a pawl for engaging the ratchet teeth of the first ring, and the cam surface is adapted to force the lever to rotate about a pivot when the canister is pressed downward, whereby the pawl engages and rotates the first ring by one step.
  • the engaging means may include a connector, which preferably includes an elongated element slideably mounted on an inner surface of the lever facing the canister.
  • the elongated element includes a first pawl at one end for engaging at least one engaging elements on the outer surface of the first ring and a second pawl at the other end for engaging an array of engaging elements on the outer surface of the second ring.
  • the connector is activated in response to a predetermined movement of the first ring, the predetermined movement being defined by the separation distance of the at least one engaging elements on the first ring.
  • the connector contacts the second ring, such that the second ring rotates upon return of the activating lever to the neutral position.
  • the connector of the engaging means is rotatably mounted on the inner surface of the lever.
  • the connector includes a first pawl for engaging an array of engaging elements (e.g., protrusions) extending from the outer surface of the first ring and a second pawl for engaging the ratchet teeth of the second ring or an array of engaging elements (e.g., protrusions) extending from the outer surface of the second ring.
  • the dose counter assembly preferably includes reverse rotation prevention means mounted on the carrier to cause the first ring and the second ring to rotate in predetermined directions and prevent the first ring and the second ring from rotating in directions opposite the predetermined directions.
  • the canister includes alignment means and the housing includes receiving means for receiving the alignment means, thereby maintaining the canister in a predetermined alignment within the housing and preventing the canister from rotary movement relative to the housing when the canister is received within the housing.
  • FIGS. IA and IB show two perspective views from different angles of the inhaler together with a dose counter assembly according to one preferred embodiment of the present invention
  • FIG.2 shows a schematic view of a dose counter assembly according to one preferred embodiment of the present invention
  • FIGS.3 A and 3B show schematic views of a dose counter assembly according to another preferred embodiment of the present invention.
  • FIG. 4 shows an exploded perspective view of the inhaler in FIGS. IA and IB;
  • FIGS. 5 A - 5D illustrate schematic views of an exemplary dose counter assembly together with a canister from different angles according to one preferred embodiment of the present invention;
  • FIG. 6 illustrates a scale used in the dose counter assembly according to one preferred embodiment of the present invention
  • FIG. 7 illustrates an indication mechanism for indicating the dosage according to yet another preferred embodiment of the present invention.
  • FIGS. IA and IB An exemplary inhaler embodying the present invention is shown in FIGS. IA and IB.
  • the inhaler 10 includes a housing 12 disposed about a longitudinal axis A with a mouthpiece section 14 at one end and an end cap 16 at the other end, a canister 20 extending along a central axis B, and a dose counter assembly 30 mounted on the canister 20.
  • the canister 20 is received within the housing 12, where the central axis B of the canister 20 is substantially coaxial with the longitudinal axis A of the housing 12.
  • the canister 20 is reciprocally moveable along the longitudinal axis A of the housing 12.
  • the canister 20 can be a known type of aerosol dispensing canister in the art, which generally has a cylindrical shape.
  • the aerosol dispensing canister has a stem 21 which contains an aerosol dispensing valve (not shown).
  • the inhaler 10 used with the present invention can be a pressure actuation inhaler (pressing the canister to deliver the medicament), or a breath actuation inhaler.
  • a patient's inhalation at the mouthpiece 14 or pressing downward the cap 16 causes the canister 20 to move downward to an activated position, and allows the release of a measured dose of medicament through the dispensing nozzle and into the mouthpiece 14 at the same time as the patient breathes in.
  • the canister 20 then returns to a rest position.
  • Both actuation mechanisms can be used in the inhaler 10 embodying the present invention and both are known in the art, and are not described in detail in the present disclosure.
  • the dose counter assembly 30 for use with the inhaler 10 is shown in FIG.2.
  • the dose counter assembly 30 includes a carrier 24, which has an annular shape and is mounted on an outer surface of the canister 20 (or the canister 20 is formed to incorporate the carrier 24), a first ring 32 rotatably mounted on the carrier 24 about the central axis B, a second ring 36 rotatably mounted on the carrier 24 about the central axis B, engaging means 40 pivotally mounted on the carrier 24, and activating means 50 mounted on the outer surface of the first ring 32 and an inner surface of the housing 12.
  • the first ring 32 has ratchet teeth 34 on an outer circumference of the first ring 32.
  • the second ring 36 has ratchet teeth 38 on an outer circumference of the second ring 36.
  • the activating means 50 is for operatively engaging the ratchet teeth 34 of the first ring 32 so as to rotate the first ring 32 in response to the reciprocal movement of the canister 20 along the longitudinal axis A of the housing 12 by a predetermined distance associated with delivery of a dose of medicament from the canister.
  • the engaging mans 40 is for operatively engaging the first ring 32 with the ratchet teeth 38 of the second ring 36 so as to rotate the second ring 36 in response to a predetermined amount of rotation of the first ring 32.
  • the first ring 32 includes digits on the outer surface of the first ring 32
  • the second ring 36 includes digits on an outer surface of the second ring 36.
  • the carrier 24 includes a scale 22 thereon
  • the scale 22 has dosage indicia as shown in FIG. 6.
  • the second ring 36 includes a pointer 35 on the outer surface of the second ring 36 for registering against the scale 22 as shown in FIG.7.
  • the scale 22 is on the housing 12.
  • the present invention can employ other indication mechanisms for indicating the dosage.
  • the second ring 36 may include indicia thereon and the carrier, the canister or the housing includes a pointer for registering against the indicia on the second ring 36.
  • FIG.2 shows an opened view of the inhaler with a section of the canister 20 in the middle and a section of the housing 12 on the left.
  • the ratchet teeth 34 on the first ring 32 are beveled with respect to the central axis B of the canister 20 and the activating means 50 includes a set of multipoint teeth 51 on the inner surface of the housing 12 for engaging the beveled ratchet teeth 34 of the first ring 32 to rotate the first ring 32 by one step when the canister 20 is pressed downward along the longitudinal axis A of the housing 12.
  • the engaging means 40 is a lever (as indicated by reference number 40 in FIG.2) pivotally mounted on the carrier 24.
  • the lever 40 preferably includes a first pawl 58 for engaging an engaging element 62 on the outer surface of the first ring 32 and a second pawl 60 for engaging the ratchet teeth 38 of the second ring 36, whereby the engaging element 62 forces the lever 40 to rotate, which in turn, forces the second ring 36 to rotate by one step (one tooth).
  • the first ring 32 includes an array of engaging elements separated by a predetermined amount of distance on the outer surface of the first ring 32.
  • the engaging elements 62 may be placed at every tenth tooth of the first ring 32, which means that the second ring 36 rotates one step (count one time) while the first ring 32 rotates ten steps (count ten times).
  • the activating means 50 includes a lever 64 pivotally mounted on the outer surface of the carrier 24, a boss 65 extending from a point at or near the bottom of the lever, and a cam surface 66 on the inner surface of the housing 12.
  • the lever 64 includes a pawl 68 for engaging the ratchet teeth 34 of the first ring 32, and the cam surface 66 is adapted to force the boss 65 to move along the cam surface 66, thereby causing the lever 64 to rotate from an initial position about a pivot when the canister 20 is pressed downward, whereby the pawl 68 engages and rotates the first ring 32 by one step.
  • the engaging means 40 may include a connector 82, which preferably includes an elongated element slideably mounted on an inner surface of the lever 64 facing the carrier 24.
  • the elongated element includes a first pawl 84 at one end and a second pawl 88 at the other end.
  • the first ring 32 includes a step-like structure 92 defining at least one recess 94 for engaging the first pawl 84 of the connector 82.
  • the second ring 36 includes a step-like structure 96 defining an array of recesses 98 for engaging the second pawl 88 of the connector 82.
  • one recess 94 on the first ring 32 arrives at the location of the connector 82, and the first pawl 84 and the second pawl 88 respectively are driven into the recess 94 and recess 98, such that the second ring 36 is advanced by the activating lever 64 during return of the lever 64 to the initial position after movement of the canister 20 by the predetermined distance in one dispensing activity.
  • the first pawl 84 is driven out of the recess 94 and the second ring 36 is disconnected from the activating lever 64.
  • the connector 82 is activated in response to a predetermined amount of movement of the first ring 32, the predetermined movement being defined by the separation distance of the at least one recesses 94 on the first ring 32.
  • the connector 82 of the engaging means 40 is rotatably mounted on the inner surface of the lever 64.
  • the connector 82 includes a first pawl 84 for engaging an array of engaging elements (e.g., protrusions) extending from the outer surface of the first ring 32 and a second pawl 88 for engaging the ratchet teeth of the second ring 36.
  • the dose counter assembly preferably includes reverse rotation prevention means mounted on the carrier 24 to allow the first ring 32 and the second ring 36 to rotate in predetermined directions and prevent the first ring 32 and the second ring 36 from rotating in directions opposite the predetermined directions.
  • the reverse rotation prevention means includes an elongated element 70 having a clip 72 near one end for engaging the ratchet teeth 34 of the first ring 32, allowing the first ring 32 to rotate in the direction A, and another clip 74 near the other end for engaging the ratchet teeth 38 of the second ring 36, allowing the second ring 36 to rotate in the direction B, which is opposite to direction A.
  • the canister 20 includes alignment means and the housing 12 includes receiving means for receiving the alignment means, thereby maintaining the canister 20 in a predetermined alignment within the housing 12 and preventing the canister 20 from rotary movement relative to the housing 12 when the canister 20 is received within the housing 12.
  • the alignment means is the elongated element 70 and the receiving means of the housing 12 is a slot defined on the inner surface of the housing 12 for receiving the elongated element 70.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Biophysics (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

L'invention concerne un ensemble de comptage de doses utilisé avec un inhalateur qui comporte un logement placé autour d'un axe longitudinal et un récipient qui s'étend le long de l'axe central. Le récipient est conçu pour s'adapter dans le logement, l'axe central étant sensiblement coaxial avec l'axe longitudinal et le récipient réciproquement mobile le long de l'axe longitudinal du logement. L'ensemble de comptage de doses comprend une première bague montée rotative sur le récipient qui comporte des dents d'encliquetage; une seconde bague montée rotative sur le récipient qui comporte des dents d'encliquetage; des moyens d'activation montés sur une surface extérieure de la première bague; une surface intérieure du logement; un levier permettant de coupler fonctionnelle la première bague de manière à l'entraîner en rotation en réponse au déplacement du récipient le long de l'axe longitudinal du logement; et enfin, des moyens de prise permettant de coupler fonctionnelle la première bague avec les dents d'encliquetage de la seconde bague, de manière à entraîner en rotation la seconde bague en réponse à un degré de rotation prédéterminé de la première bague.
PCT/GB2006/002798 2005-07-27 2006-07-27 Ensemble indicateur de comptage a bague rotative monte sur recipient pour inhalateur doseur WO2007012854A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0515475A GB2429166A (en) 2005-07-27 2005-07-27 Inhaler counter
GB0515475.2 2005-07-27

Publications (1)

Publication Number Publication Date
WO2007012854A1 true WO2007012854A1 (fr) 2007-02-01

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PCT/GB2006/002798 WO2007012854A1 (fr) 2005-07-27 2006-07-27 Ensemble indicateur de comptage a bague rotative monte sur recipient pour inhalateur doseur

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WO (1) WO2007012854A1 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010103315A2 (fr) 2009-03-10 2010-09-16 Euro-Celtique S. A. Compteur
US8332020B2 (en) 2010-02-01 2012-12-11 Proteus Digital Health, Inc. Two-wrist data gathering system
US8419638B2 (en) 2007-11-19 2013-04-16 Proteus Digital Health, Inc. Body-associated fluid transport structure evaluation devices
WO2013064821A1 (fr) 2011-11-01 2013-05-10 Euro-Celtique S.A. Dispositif de distribution
US9014779B2 (en) 2010-02-01 2015-04-21 Proteus Digital Health, Inc. Data gathering system
US9084566B2 (en) 2006-07-07 2015-07-21 Proteus Digital Health, Inc. Smart parenteral administration system
US9125979B2 (en) 2007-10-25 2015-09-08 Proteus Digital Health, Inc. Fluid transfer port information system
US9415178B2 (en) 2009-03-10 2016-08-16 Euro-Celtique S.A. Counter
US9592355B2 (en) 2005-09-09 2017-03-14 Raymond John Bacon Dispenser
US9707360B2 (en) 2004-11-19 2017-07-18 Clinical Designs Limited Substance source

Families Citing this family (2)

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Publication number Priority date Publication date Assignee Title
GB0428204D0 (en) 2004-12-23 2005-01-26 Clinical Designs Ltd Medicament container
GB201223008D0 (en) 2012-12-20 2013-01-30 Euro Celtique Sa Counter

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GB2372543A (en) * 2001-02-23 2002-08-28 Bespak Plc Dosage counting device
EP1369139A1 (fr) * 2002-06-03 2003-12-10 3M Innovative Properties Company Indicateurs de dose et systèmes de dispension comprenants des nourrisses et des indicateurs

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GB2372542B (en) * 2001-02-23 2003-08-20 Bespak Plc Dosage counting devices
GB0222023D0 (en) * 2002-09-21 2002-10-30 Aventis Pharma Ltd Inhaler
EP1730676B1 (fr) * 2004-02-16 2013-08-28 Glaxo Group Limited Compteur a utiliser avec un distributeur de medicament
GB2414187B (en) * 2004-05-21 2007-03-07 Bespak Plc Dispensing apparatus
US7543582B2 (en) * 2004-09-20 2009-06-09 Trudell Medical International Dose indicating device with display elements attached to container

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DE10061723A1 (de) * 2000-12-12 2002-07-11 Eckert Rosemarie Zählwerk zum Zählen dosierter Abgaben flüssiger, pastöser oder fester Produkte sowie Einrichtung zum dosierten Abgeben solcher Produkte
GB2372543A (en) * 2001-02-23 2002-08-28 Bespak Plc Dosage counting device
EP1369139A1 (fr) * 2002-06-03 2003-12-10 3M Innovative Properties Company Indicateurs de dose et systèmes de dispension comprenants des nourrisses et des indicateurs

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9707360B2 (en) 2004-11-19 2017-07-18 Clinical Designs Limited Substance source
US10369307B2 (en) 2005-09-09 2019-08-06 Clinical Designs Limited Dispenser
US9592355B2 (en) 2005-09-09 2017-03-14 Raymond John Bacon Dispenser
US9084566B2 (en) 2006-07-07 2015-07-21 Proteus Digital Health, Inc. Smart parenteral administration system
US9125979B2 (en) 2007-10-25 2015-09-08 Proteus Digital Health, Inc. Fluid transfer port information system
US8419638B2 (en) 2007-11-19 2013-04-16 Proteus Digital Health, Inc. Body-associated fluid transport structure evaluation devices
US9114221B2 (en) 2009-03-10 2015-08-25 Euro-Celtique S.A. Counter
TWI494869B (zh) * 2009-03-10 2015-08-01 Euro Celtique Sa 計數器及具有此計數器的分配器
WO2010103315A2 (fr) 2009-03-10 2010-09-16 Euro-Celtique S. A. Compteur
US9415178B2 (en) 2009-03-10 2016-08-16 Euro-Celtique S.A. Counter
US9987441B2 (en) 2009-03-10 2018-06-05 Euro-Celtique S.A. Counter
US9014779B2 (en) 2010-02-01 2015-04-21 Proteus Digital Health, Inc. Data gathering system
US9008761B2 (en) 2010-02-01 2015-04-14 Proteus Digital Health, Inc. Two-wrist data gathering system
US8332020B2 (en) 2010-02-01 2012-12-11 Proteus Digital Health, Inc. Two-wrist data gathering system
US10376218B2 (en) 2010-02-01 2019-08-13 Proteus Digital Health, Inc. Data gathering system
WO2013064821A1 (fr) 2011-11-01 2013-05-10 Euro-Celtique S.A. Dispositif de distribution
EP3335753A1 (fr) 2011-11-01 2018-06-20 Euro-Celtique S.A. Distributeur avec compteur de doses

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Publication number Publication date
GB2429166A (en) 2007-02-21
GB0515475D0 (en) 2005-08-31

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