WO2006136782A1 - Récupérateur de condensat de respiration - Google Patents

Récupérateur de condensat de respiration Download PDF

Info

Publication number
WO2006136782A1
WO2006136782A1 PCT/GB2006/002122 GB2006002122W WO2006136782A1 WO 2006136782 A1 WO2006136782 A1 WO 2006136782A1 GB 2006002122 W GB2006002122 W GB 2006002122W WO 2006136782 A1 WO2006136782 A1 WO 2006136782A1
Authority
WO
WIPO (PCT)
Prior art keywords
breath
chamber
air
collection vessel
condensate
Prior art date
Application number
PCT/GB2006/002122
Other languages
English (en)
Inventor
Helle Funch Nielsen
Lee Bulbrook
Original Assignee
Equine Healthcare Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Equine Healthcare Limited filed Critical Equine Healthcare Limited
Publication of WO2006136782A1 publication Critical patent/WO2006136782A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/097—Devices for facilitating collection of breath or for directing breath into or through measuring devices

Definitions

  • the invention concerns apparatus for collection of breath condensate, and also apparatus specifically for collection of breath condensate from animals, especially horses.
  • the device consists essentially of a tube 1 with a side-arm 2. Within the tube are two one-way valves, 3 and 4, located either side of the side arm.
  • the side arm acts as a mouthpiece, and may be specifically shaped to assist sealing by a user's lips. During use, a patient inserts the mouthpiece into their mouth, and is instructed to breathe through their mouth (rather than nose).
  • valve arrangement allows air to pass through the lower one-way valve, 4, with the upper valve, 3, remaining closed, as indicated in Figure l(a).
  • the lower valve 4 closes, and the upper valve opens, causing the air to pass through the upper portion of the tube 1.
  • Breath condensate then collects on the inner surface of the tube 1, from where it may be harvested. Cooling may be applied to the outside of the tube, 1, to promote condensation.
  • the upper valve 3 is of a so-called "duckbill" configuration - a generally dome-shaped configuration, made of a rubber-like material, and having a slit at the domed end, forming a pair of lip-like structures.
  • the duckbill valve In its relaxed state, the duckbill valve is in a closed configuration. A decreased pressure within the dome of the valve, as would be experienced during inhalation tends to maintain this closed configuration. An increased pressure within the dome, as would be experienced during exhalation against the now closed second valve, 4, causes the valve to open.
  • one-way valves and especially those of the "duckbill” configuration
  • the device may prevent a user from exhaling. Unless rectified by an informed user before use, this phenomenon may cause alarm. Whilst an informed adult user might recognise the problem, and take actions to remedy it, a child may tend to become distressed, or annoyed.
  • devices of this nature require the user to consciously breathe through their mouths, rather than through their nose. Again, when used with informed and cooperative users this is usually not problematic, but can become problematic where communication with the patient, or subject, is difficult.
  • devices of this nature are relatively complex, and require multiple one-way valves, located within the body of a narrow tube, in order to function. This tends to increase manufacture costs.
  • the invention provides a breath condensate collector comprising: a chamber having a breath inlet port, an air inlet port and an outlet port; a one-way valve, located in said air inlet port, to allow flow of air into the chamber, whilst resisting flow of air or breath out of the chamber; a condensate collection vessel, adapted to receive air from the chamber outlet, and having air exhaust means; cooling means, to promote, in use, condensation of vapour from breath entering the condensate collection vessel; and characterised by the feature that the flow path from the breath inlet port to the condensate collection vessel is unimpeded by a valve.
  • the chamber outlet port is provided with a restriction, to cause air to impinge on a surface of the condensate collection vessel. This improves the efficiency of collection of condensate.
  • the condensate collection vessel comprises a syringe body. This allows easier subsequent pooling and handling of the collected condensate.
  • the cooling means comprises a coolable sleeve, adapted to abut a surface of the condensate collection vessel. This encourages condensation of vapour from the exhaled breath.
  • the exterior surface of the chamber outlet port is provided with a number of resiliently defomiable fins, to releaseably secure the condensate collection vessel to the chamber and to define a passage between the collection vessel and chamber outlet that can function as the air exhaust means.
  • the invention also provides a veterinary breath condensate collector comprising a breath condensate collector as described above and a mask, said mask being connectable to the chamber inlet, and adapted to fit over an animal's nostril.
  • the mask is deformable, to fit the contours surrounding the animal's nostril and provide an air-tight seal. More preferably, the mask is resiliently deformable, so that is more than one attempt is required to fit the mask over the nostril, the mask will spring back to shape between attempts. The mask may also, therefore, be used again with a different animal.
  • Figure 1 shows, schematically, a typical configuration of a known device
  • Figure 2 shows a cross-section of a device according to the present invention
  • Figure 3 shows a cross-section of an embodiment of the air outlet port
  • Figure 4 shows a cross-section of an embodiment of the connection between the air outlet port and the condensate collection vessel
  • Figure 5 shows a cross-section of an embodiment of the connection between the air outlet port and the condensate collection vessel, and illustrating the cooling means
  • Figure 6 shows a cross-section of an embodiment of the connection between the air outlet port and the condensate collection vessel, and illustrating the cooling means and insulating jacket. Description of Preferred Embodiments
  • FIG. 5 shows a cross-section of an embodiment of a breath collection device, generally indicated by 5, according to the present invention.
  • the device is of generally cylindrical form, and may conveniently be made of a plastics material.
  • On one side of the chamber 6 is an air inlet port 9.
  • the air inlet port 9 is provided with a one-way valve, 10.
  • the one-way valve 10 takes the form of a diaphragm valve.
  • the valve 10 comprises a readily-deformable but resilient disc 11, loosely mounted on a spigot 12.
  • Positive pressure inside the chamber 6 causes the disc 11 to seal against the housing of the valve 9, thereby resisting flow of air out of the chamber.
  • Negative pressure within the chamber 6, e.g. during an inhalation cycle by a user causes the disc to deform, and to thereby allow air into the chamber through the inlet port 9.
  • the use of a diaphragm valve is particularly effective in requiring only a low pressure differential to activate, and therefore not significantly impeding the inhalation cycle of a user.
  • the outlet port 8 is provided with a tapered section, 9, - effectively a partial Venturi constriction - to cause the exhaled air to impinge on the opposite wall of the condensate collection vessel 13.
  • This embodiment also illustrates the particularly preferred use of a syringe body as the condensate collection vessel. Disposable, pre-sterilised syringes are widely available, and their use in this context facilitates further processing of the collected breath condensate.
  • the syringe body has an outlet port 14, which in other circumstances would be fitted with a needle. Fur use in this context, the port may be capped.
  • the condensate collection vessel 13 is connected to the outlet ports by a number of resiliently deformable fins 15. These are more clearly illustrated in the cross-sectional views shown in Figures 3-6. All these show a cross-section of the device indicated by line A-A in Figure 2.
  • Figure 3 illustrates how the resiliently deformable fins 15 are positioned on the outside surface of the outlet port 8.
  • Figure 4 shows the condensate collection vessel 13 in place on the fins 15. The fins deform to hold the collection vessel 13 in place, and also define a gap, or passage 16 through which, in use, exhaled air may flow.
  • FIG. 5 illustrates the same cross-section as figure 4, but shows the placement of a cooling jacket 17 around the condensate collection vessel.
  • This jacket may be readily made of a material with a large specific heat capacity — such as metal — that can be cooled prior to use in a freezer.
  • the jacket 17 could be a freezable gel or liquid contained in a bag or pouch.
  • Figure 6 illustrates the further addition of an insulating jacket 18 around the assembly illustrated in figure 5. This serves to keep the cooling jacket cool, in use. This is particularly important when using the device in a veterinary context, where it might take considerable time to take a breath sample.
  • a disposable tube made e.g. of cardboard may be connected to the inlet port 7 to facilitate a user blowing into the device without having to place the device itself into the mouth, with evident hygienic benefits.
  • the outlet port 7 may be connected to a mask, adapted to fit over one or more nostrils of an animal.
  • the mask, 19, illustrated in figure 2 is specifically adapted to fit over a horse's nostril.
  • the mask 19 is shown in cross-section, and has generally cylindrical symmetry.
  • Known devices for breath collection rely on a user putting the device in their mouth and breathing out, into the device, through the mouth rather than the nose.
  • the provision of a mask adapted to receive exhaled breath from the nostrils overcomes this problem.
  • a suitable mask might fit over both the nose and the mouth.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

La présente invention propose un récupérateur de condensat de respiration comprenant une chambre (6) avec un orifice d'entrée de respiration (7), un orifice d'entrée d'air (9) et un orifice de sortie (8); un clapet antiretour (10) est situé dans l'orifice d'admission d'air, pour permettre un écoulement vers la chambre, tout en s'opposant à la sortie d'air ou à l'expiration vers l'extérieur de la chambre. Le récupérateur comporte un récipient de récupération du condensat (13), destiné à recevoir l'air à partir de la sortie de la chambre, ainsi qu'une évacuation d'air (15). Des moyens de refroidissement (17) sont également prévus, pour favoriser la condensation de la vapeur provenant de la respiration; le trajet d'écoulement depuis l'orifice d'entrée de la respiration vers le récipient de récupération du condensat n'est restreint par aucune valve. Avec utilisation d'un masque de forme appropriée, le récupérateur convient particulièrement à une utilisation vétérinaire.
PCT/GB2006/002122 2005-06-24 2006-06-09 Récupérateur de condensat de respiration WO2006136782A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0512867A GB2427686A (en) 2005-06-24 2005-06-24 Breath condensate collector
GB0512867.3 2005-06-24

Publications (1)

Publication Number Publication Date
WO2006136782A1 true WO2006136782A1 (fr) 2006-12-28

Family

ID=34856062

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/002122 WO2006136782A1 (fr) 2005-06-24 2006-06-09 Récupérateur de condensat de respiration

Country Status (2)

Country Link
GB (1) GB2427686A (fr)
WO (1) WO2006136782A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103168233A (zh) * 2010-12-01 2013-06-19 浙江大学 同时检测人体呼出气体中EBCs和VOCs的一体化分析装置
WO2022060917A1 (fr) * 2020-09-16 2022-03-24 Northwestern University Détermination de la présence de sars-cov-2 ou d'un autre pathogène respiratoire chez une personne

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2451249A (en) * 2007-07-24 2009-01-28 Equine Healthcare Ltd A breath condensate collector
EP3946047A4 (fr) * 2019-03-31 2023-02-15 Agscent Pty Ltd Dispositif de capture d'échantillon biologique

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1536746A (en) * 1918-03-25 1925-05-05 Charles H Jockmus Doing Busine Device for making water
WO1995031721A1 (fr) * 1994-05-13 1995-11-23 Filt Forschungsgesellschaft Für Lungen- Und Thoraxerkrankungen Mbh Procede et dispositif permettant de recueillir un condensat de souffle expire
US20040127808A1 (en) * 2001-04-17 2004-07-01 Vaughan John W. Device and method for assessing asthma and other diseases
US20040138577A1 (en) * 2002-12-20 2004-07-15 Kline Jeffrey A. Disposable hand-held device for collection of exhaled breath condensate
US20040162500A1 (en) * 2003-02-14 2004-08-19 The Charlotte-Mecklenburg Hospital Authority Device and method for collection of exhaled alveolar breath condensate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE29712836U1 (de) * 1997-07-10 1997-09-18 Filt Forschungsgesellschaft für Lungen- und Thoraxerkrankungen mbH, 13125 Berlin Kondensatabscheider zum Sammeln von ausgeatmetem Atemkondensat
NL1006857C1 (nl) * 1997-08-27 1999-03-02 Advuco Ijsblokjes Koeltechniek Werkwijze voor het bepalen van bestanddelen in adem.
EP1409985A4 (fr) * 2000-05-01 2009-01-07 Respiratory Res Inc Procede et dispositif pour recueillir et analyser de l'air exhale
GB0015309D0 (en) * 2000-06-21 2000-08-16 Djupesland Per G Apparatus

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1536746A (en) * 1918-03-25 1925-05-05 Charles H Jockmus Doing Busine Device for making water
WO1995031721A1 (fr) * 1994-05-13 1995-11-23 Filt Forschungsgesellschaft Für Lungen- Und Thoraxerkrankungen Mbh Procede et dispositif permettant de recueillir un condensat de souffle expire
US20040127808A1 (en) * 2001-04-17 2004-07-01 Vaughan John W. Device and method for assessing asthma and other diseases
US20040138577A1 (en) * 2002-12-20 2004-07-15 Kline Jeffrey A. Disposable hand-held device for collection of exhaled breath condensate
US20040162500A1 (en) * 2003-02-14 2004-08-19 The Charlotte-Mecklenburg Hospital Authority Device and method for collection of exhaled alveolar breath condensate

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RESPIRATORY RESEARCH, INC: "Why is There a Hole in the Blue Valve?", 2005, XP002398857, Retrieved from the Internet <URL:http://www.rtube.com/library/how-to/Why-is-there-a-hole-in-the-blue-valve.pdf> [retrieved on 20060913] *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103168233A (zh) * 2010-12-01 2013-06-19 浙江大学 同时检测人体呼出气体中EBCs和VOCs的一体化分析装置
WO2022060917A1 (fr) * 2020-09-16 2022-03-24 Northwestern University Détermination de la présence de sars-cov-2 ou d'un autre pathogène respiratoire chez une personne

Also Published As

Publication number Publication date
GB2427686A (en) 2007-01-03
GB0512867D0 (en) 2005-08-03

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