WO2006125978A3 - Particules de dosage - Google Patents

Particules de dosage Download PDF

Info

Publication number
WO2006125978A3
WO2006125978A3 PCT/GB2006/001896 GB2006001896W WO2006125978A3 WO 2006125978 A3 WO2006125978 A3 WO 2006125978A3 GB 2006001896 W GB2006001896 W GB 2006001896W WO 2006125978 A3 WO2006125978 A3 WO 2006125978A3
Authority
WO
WIPO (PCT)
Prior art keywords
microspheres
agent
magnetizable
assay particles
core
Prior art date
Application number
PCT/GB2006/001896
Other languages
English (en)
Other versions
WO2006125978A2 (fr
Inventor
Christopher Oldfield
Tom Johnston
David Nichols
Original Assignee
Nanosphere Ltd
Christopher Oldfield
Tom Johnston
David Nichols
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanosphere Ltd, Christopher Oldfield, Tom Johnston, David Nichols filed Critical Nanosphere Ltd
Publication of WO2006125978A2 publication Critical patent/WO2006125978A2/fr
Publication of WO2006125978A3 publication Critical patent/WO2006125978A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/01—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials
    • H01F1/03—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity
    • H01F1/032—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials
    • H01F1/04—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials metals or alloys
    • H01F1/06—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials metals or alloys in the form of particles, e.g. powder
    • H01F1/063—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials metals or alloys in the form of particles, e.g. powder with a non magnetic core

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Power Engineering (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne des microsphères, plus particulièrement des microsphères magnétisables pouvant être utilisées dans des procédures de séparation, ou pouvant être utilisées comme base pour la construction de microsphères pouvant être utilisées dans des procédures de séparation. L'invention concerne également des procédés de fabrication desdites microsphères. Ces microsphères comprennent un noyau, un agent d'ancrage et un agent magnétisable ancré au noyau par liaison à l'agent d'ancrage.
PCT/GB2006/001896 2005-05-23 2006-05-23 Particules de dosage WO2006125978A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0510461A GB0510461D0 (en) 2005-05-23 2005-05-23 Assay particles
GB0510461.7 2005-05-23

Publications (2)

Publication Number Publication Date
WO2006125978A2 WO2006125978A2 (fr) 2006-11-30
WO2006125978A3 true WO2006125978A3 (fr) 2007-03-29

Family

ID=34834474

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/001896 WO2006125978A2 (fr) 2005-05-23 2006-05-23 Particules de dosage

Country Status (2)

Country Link
GB (2) GB0510461D0 (fr)
WO (1) WO2006125978A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009102258A1 (fr) * 2008-02-15 2009-08-20 Ge Healthcare Bio-Sciences Ab Séparation des biomolécules
WO2013022730A1 (fr) * 2011-08-05 2013-02-14 Veridex, Llc Nouveau procédés de couplage de molécules à des surfaces en métal/oxyde métallique
ES2439167B1 (es) * 2012-06-21 2014-11-17 Consejo Superior De Investigaciones Científicas (Csic) Compuestos con funcionalidad magnética, implantes o geles derivados de ellos, y el uso de ambos para determinar la actividad enzimática de una enzima
CN108267570B (zh) * 2016-12-27 2023-09-12 北京达微生物科技有限公司 一种预储存试剂微珠的多孔板及其制备和使用方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4177253A (en) * 1976-07-30 1979-12-04 Imperial Chemical Industries Limited Magnetic particles for immunoassay
DE4308668A1 (de) * 1992-03-19 1993-10-21 Nippon Paint Co Ltd Kontrastmittel zur Ultraschalldiagnose
WO2001078087A2 (fr) * 2000-04-06 2001-10-18 Luminex Corporation Microbilles a reaction magnetique
US20020162798A1 (en) * 2001-05-02 2002-11-07 Johnson James R. Composite particles
WO2003062787A2 (fr) * 2001-11-27 2003-07-31 The Regents Of The University Of California Dosage biologique et identification biomoleculaire, procedes de tri et de collecte utilisant des microspheres magnetiques

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6007845A (en) * 1994-07-22 1999-12-28 Massachusetts Institute Of Technology Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
US6656587B2 (en) * 2001-05-02 2003-12-02 Phillips Plastics Corporation Composite particles

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4177253A (en) * 1976-07-30 1979-12-04 Imperial Chemical Industries Limited Magnetic particles for immunoassay
DE4308668A1 (de) * 1992-03-19 1993-10-21 Nippon Paint Co Ltd Kontrastmittel zur Ultraschalldiagnose
WO2001078087A2 (fr) * 2000-04-06 2001-10-18 Luminex Corporation Microbilles a reaction magnetique
US20020162798A1 (en) * 2001-05-02 2002-11-07 Johnson James R. Composite particles
WO2003062787A2 (fr) * 2001-11-27 2003-07-31 The Regents Of The University Of California Dosage biologique et identification biomoleculaire, procedes de tri et de collecte utilisant des microspheres magnetiques

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GUPTA P K ET AL: "ULTRASTRUCTURAL DISPOSITION OF ADRIAMYCIN-ASSOCIATED MAGNETIC ALBUMIN MICROPHERES IN RATS", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 78, no. 4, 1 April 1989 (1989-04-01), pages 290 - 294, XP000104192, ISSN: 0022-3549 *
LALLA J K ET AL: "DRUG TARGETING USING NON-MAGNETIC AND MAGNETIC ALBUMIN-GLOBULIN MIX MICROSPHERES OF MEFENAMIC ACID", JOURNAL OF MICROENCAPSULATION, TAYLOR AND FRANCIS, BASINGSTOKE, GB, vol. 8, no. 1, January 1991 (1991-01-01), pages 37 - 52, XP000204967, ISSN: 0265-2048 *
ZHANG Q ET AL: "Electroless nickel plating on hollow glass microspheres", SURFACE AND COATINGS TECHNOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 192, no. 2-3, 21 March 2005 (2005-03-21), pages 213 - 219, XP004697557, ISSN: 0257-8972 *

Also Published As

Publication number Publication date
WO2006125978A2 (fr) 2006-11-30
GB2426583A (en) 2006-11-29
GB0610209D0 (en) 2006-07-05
GB0510461D0 (en) 2005-06-29

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