WO2006117923A1 - Systeme de diagnostic et de traitement de l'interieur d'un vaisseau sanguin par onde ultrasonore - Google Patents

Systeme de diagnostic et de traitement de l'interieur d'un vaisseau sanguin par onde ultrasonore

Info

Publication number
WO2006117923A1
WO2006117923A1 PCT/JP2006/303750 JP2006303750W WO2006117923A1 WO 2006117923 A1 WO2006117923 A1 WO 2006117923A1 JP 2006303750 W JP2006303750 W JP 2006303750W WO 2006117923 A1 WO2006117923 A1 WO 2006117923A1
Authority
WO
WIPO (PCT)
Prior art keywords
probe
ultrasonic
treatment system
blood vessel
diagnosis
Prior art date
Application number
PCT/JP2006/303750
Other languages
English (en)
Japanese (ja)
Inventor
Takafumi Tsurui
Hiroshi Matsui
Toshimichi Moriwaki
Masumi Waki
Kazuya Hamaguchi
Kousyoku Sai
Original Assignee
Kobe Material Testing Laboratory Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kobe Material Testing Laboratory Co., Ltd. filed Critical Kobe Material Testing Laboratory Co., Ltd.
Priority to JP2007514481A priority Critical patent/JPWO2006117923A1/ja
Publication of WO2006117923A1 publication Critical patent/WO2006117923A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A61B17/2202—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being inside patient's body at the distal end of the catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A61B8/0833—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving detecting or locating foreign bodies or organic structures

Definitions

  • the present invention relates to an intravascular diagnosis and treatment system using an ultrasonic catheter that is inserted into a body cavity such as a blood vessel, a blood vessel, or a digestive tract and used to display a cross-sectional image of the blood vessel. Is.
  • a surgical method in which treatment is performed using a catheter.
  • This surgical method includes various methods, such as a method of expanding the stenosis with a dilatation catheter having a balloon at the tip of the catheter probe, and a method of placing a metal tube called a stent.
  • a preferred method is selected according to the situation.
  • Ultrasonic catheters are mainly used to assist in making decisions for observing the properties of stenosis and selecting treatment methods when treating such vascular stenosis. It is also used for observation. Therefore, since the tip of the catheter probe is required to be able to pass through the vascular stenosis, a smaller one is required.
  • ultrasonic echo diagnosis is used as a method for diagnosing a thrombus in a blood vessel. That is, an ultrasonic tomographic image is obtained by transmitting and receiving ultrasonic waves with an ultrasonic probe attached to the tip of a thin catheter probe inserted in a blood vessel.
  • An ultrasound probe that is inserted into a powerful blood vessel is placed inside the catheter probe. It consists of a torque wire inserted in a freely rotatable manner and a vibrator provided on the side surface of the tip of the torque wire.
  • the ultrasonic wire is rotated by rotationally driving the torque wire, and an ultrasonic tomographic image is obtained by rotational scanning. It captures data.
  • the conventional ultrasonic catheter obtains a cross-sectional image in a direction perpendicular to the axis of the body cavity by rotating and scanning the ultrasonic probe provided at the distal end with a torque wire or the like. Therefore, when observing the state of the vascular stenosis, the ultrasonic probe needs to pass through the stenosis while rotating the ultrasonic catheter.
  • the ultrasonic catheter obtains a cross-sectional image in a direction perpendicular to the axis of the body cavity at a position where the ultrasonic probe is located in the blood vessel. Therefore, when observing the state of the vascular stenosis that exists over several tens of millimeters in the axial direction, the surgeon may cause the ultrasonic probe to pass through the stenosis while rotating the ultrasonic catheter. Need to operate. At that time, in order to know the state of the vascular stenosis in detail, if the stenosis is repeatedly observed, it is necessary to repeat the passage of the vascular stenosis by the ultrasonic catheter each time. However, since it takes a lot of effort to pass the narrowed blood vessel stenosis without damaging it, repeating this work is a burden on the surgeon. It was.
  • Patent Document 1 JP-A-2004-290548
  • Patent Document 2 JP-7 - 231894
  • the present invention provides a three-dimensional observation and diagnosis of a lesion in a blood vessel in the bloodstream while simultaneously identifying a diseased part and blood vessel including a thrombus in the bloodstream in real time. To do It aims at providing the system which can do. If diagnosis and treatment can be performed at the same time, the burden of inserting a new ultrasound probe into the blood vessel and the burden on the patient can be reduced.
  • a blood vessel is obtained by oscillating in the longitudinal direction of the probe at a predetermined frequency including an ultrasonic probe for diagnosis by ultrasonic echoes and ultrasonic waves at the tip of the catheter probe.
  • An intravascular diagnosis and treatment system comprising at least a therapeutic ultrasonic transducer capable of removing an internal thrombus is provided.
  • the burden on the operator is greatly reduced, and the burden on the patient is greatly increased by performing diagnosis and treatment at the same time. Will be reduced.
  • the system according to the first aspect of the present invention further includes means for measuring a flow velocity and means for measuring the hardness of the object.
  • An intravascular diagnostic and treatment system is provided.
  • the means for measuring the flow velocity is, for example, measuring blood flow with a pressure sensor or the like. If there is a thrombus in the blood vessel, the blood is flowing in the vicinity. In addition, if it is completely occluded, blood flow stops.
  • the means for measuring the hardness of the object is, for example, a method of measuring the hardness by analyzing a waveform by an ultrasonic echo with a computer. This is to measure the hardness to distinguish the blood vessel wall from the thrombus, and to diagnose the lesion in the blood vessel with higher accuracy.
  • an intravascular diagnosis characterized in that the ultrasonic probe for diagnosis is a flat probe.
  • a treatment system is provided.
  • the flat probe is an ultrasonic beam that propagates without being bundled, and the ultrasonic beam propagates while spreading.
  • an ultrasound probe placed at the tip of the catheter probe can be used to examine the anterior blood vessel wall in the blood vessel.
  • the blood vessel is characterized in that the flat probe is inclined at a predetermined angle from the longitudinal direction of the probe.
  • An internal diagnostic and treatment system is provided.
  • the flat probe propagates the ultrasonic beam at a certain directivity angle, it is possible to diagnose thrombus without tilting the probe, but it is more accurate when tilted to a predetermined angle. Is possible. However, since the inside of the blood vessel is very narrow, it is impossible to tilt the probe greatly, and the predetermined angle is preferably around 5 °.
  • the flat probe in the system according to the third aspect described above, may be rotated at a constant speed while being inclined at a predetermined angle from the longitudinal direction of the probe.
  • An intravascular diagnosis and treatment system is provided.
  • the probe In order to diagnose the state of the entire circumference of the blood vessel wall located in front of the distal end of the catheter probe, the probe is preferably inclined at a predetermined angle and rotated at a constant speed. This makes it possible to easily scan the ultrasonic probe direction even in a narrow blood vessel.
  • the probe is rotated at a constant speed by a driving mechanism attached to the back of the catheter probe.
  • the ultrasonic probe for diagnosis is tilted or rotated to scan the ultrasonic probe direction in the blood vessel.
  • an ultrasonic probe is attached to a neck portion made of a shape memory alloy, and the ultrasonic probe direction is scanned by bending the shape memory alloy.
  • the means for applying heat to the shape memory alloy includes, for example, a method in which an electric current is passed to convert it into heat at the distal end portion of the catheter probe to conduct heat to the shape memory alloy.
  • a seventh aspect of the present invention in the system of the sixth aspect described above, at least two ultrasonic probes for diagnosis intersect with each other at the bent surfaces of the neck.
  • An intravascular diagnostic and treatment system is provided that is arranged in a direction.
  • two sets of the diagnostic ultrasonic probes described in the sixth aspect described above for improving the accuracy of ultrasonic echo diagnosis are provided, and the bent surfaces of the neck formed of a shape memory alloy are V, It is arranged in a direction that intersects at right angles.
  • two or more sets may be arranged in a direction in which the bent surfaces of the neck intersect each other.
  • an eighth aspect of the present invention in the system according to any one of the first to seventh aspects described above, there is provided a mechanism in which the therapeutic ultrasonic transducer projects forward from the probe tip force.
  • An intravascular diagnosis and treatment system is provided, characterized in that it has a front end and vibrates in an ultrasonic frequency band.
  • the therapeutic ultrasonic transducer of the present invention removes an intravascular thrombosis by vibrating in the longitudinal direction of the probe at a predetermined frequency including ultrasonic waves (herein referred to as longitudinal vibration). Even if it does not have a mechanism that projects forward from the part, it can remove the thrombus and perform treatment. However, according to the eighth aspect, since the ultrasonic transducer for treatment has a mechanism that protrudes forward from the tip of the probe, bending vibration in the longitudinal direction and perpendicular direction (here, transverse vibration) The thrombus is used for removal.
  • Crushing efficiency and performance are improved by amplifying the amplitude of the ultrasonic transducer. If the amplitude is large, sufficient crushing performance can be obtained without feeding as in the ninth aspect described above.
  • the amplification by the amplification mechanism of the therapeutic ultrasonic transducer is an amplitude expansion using a resonance vibration system.
  • An intravascular diagnosis and treatment system is provided.
  • the amplification is preferably an amplitude expansion using a resonance vibration system as modeled in a design model of a mass-panel type dynamic vibration absorber to be described later. This is to specifically amplify the longitudinal vibration of the ultrasonic vibrator.
  • a cavity is generated by the vibration of the therapeutic ultrasonic transducer.
  • cavitation means a shock wave generated by ultrasonic waves. Specifically, a large number of microscopic bubbles are generated by ultrasonic vibration, and these microscopic bubbles are rapidly collapsed to cause collision of water molecules with force, thereby generating a shock wave.
  • a cavity is also generated by the longitudinal vibration of the therapeutic ultrasonic transducer of the present invention, and the thrombus in the blood vessel is refined into particles of less than 1 ⁇ m by this cavity.
  • microthrombus can be made to flow backward in the direction away from the distal end portion of the catheter probe by the cavity.
  • the intravascular diagnosis and treatment system includes an affected part including a thrombus in the bloodstream. It is possible to observe and diagnose three-dimensional lesions in blood vessels in the bloodstream while simultaneously removing and treating blood clots. By performing diagnosis and treatment at the same time, there is an effect that the burden of inserting a new ultrasound probe into the blood vessel and the burden on the patient can be reduced.
  • FIG. 1 is a schematic structural diagram of the distal end portion of a catheter probe used in the intravascular diagnosis and treatment system according to the present invention.
  • the tip of the catheter probe 1 has a diagnostic ultrasonic probe 2 by ultrasonic echoes and vibrates in the longitudinal direction of the probe at a predetermined frequency including ultrasonic waves.
  • a therapeutic ultrasonic transducer 3 capable of removing the thrombus is provided.
  • the blood vessel to which the intravascular diagnosis and treatment system according to the present invention is mainly applied is a blood vessel of a coronary artery that may cause occlusion, and the diameter of the blood vessel is 5 to 6 mm. When this causes occlusion, the blood vessel with a length of about 10 mm to several centimeters is usually occluded.
  • the size of the distal end portion of the catheter probe 1 according to the present invention is designed so that the outer diameter is within 4 mm and the length is 5 mm.
  • the diagnostic ultrasound probe 2 housed in the distal end portion of the catheter probe has functions of ultrasonic echo diagnosis of a lesion site of a blood vessel in the bloodstream and three-dimensional imaging.
  • a therapeutic ultrasonic transducer 3 is provided adjacent to the diagnostic ultrasonic probe, and the therapeutic ultrasonic transducer is vibrated in the longitudinal direction of the probe at a predetermined frequency including ultrasonic waves. It removes intravascular thrombi.
  • the diagnostic ultrasonic probe 2 and the therapeutic ultrasonic transducer 3 will be described in detail.
  • the diagnostic ultrasound probe 2 used in the intravascular diagnosis and treatment system according to the present invention is for diagnosing a thrombus in a blood vessel or a state of a blood vessel wall, and uses an endoscope that does not transmit light. Can't! / Can be diagnosed even in opaque blood.
  • the diameter of the blood vessel is 5 to 6 mm, and in the present invention, the size of the tip of the catheter probe is within 4 mm of the outer diameter, so the diameter of the diagnostic ultrasonic probe is 2 mm and the length is 3 mm.
  • the diagnostic ultrasound probe 2 disposed at the distal end of the catheter probe 1 is preferably a flat probe so that the front blood vessel wall can be inspected in the blood vessel.
  • the flat probe propagates the ultrasonic beam without focusing as described above, and the ultrasonic beam propagates while spreading. It is easy to spread the ultrasonic beam without focusing it.
  • Figure 2 shows a schematic diagram of the propagation of an ultrasonic beam by a flat probe.
  • the flat probe 6 uses two types of the ultrasonic beam 10 to be propagated, 5 MHz and 10 MHz, to check the reflection echo from the sample surface and evaluate the detected image. It is carried out.
  • the spread angle of each ultrasonic beam directivity angle ⁇
  • 0 is a directivity angle ⁇ force of 0.4 ° at a frequency of 5 MHz, and a directivity angle ⁇ of 5.2 ° at a frequency of 10 MHz.
  • the spread of the propagation of the ultrasonic beam is important in the diagnostic ultrasonic probe 2 according to the present invention.
  • the flat probe 6 can detect a thrombus adhering to the anterior blood vessel wall 11 by the spread of the propagation of the ultrasonic beam.
  • the ultrasonic wave was oscillated from the flat probe 6 to the surface of the object 13 at a height in water, and the flat probe 6 was moved in the front, rear, left, and right, and scanned.
  • the scanning range is 8 X 6 mm and the scanning pitch is 0.05 mm.
  • the sample of the object 13 is a chicken egg shell.
  • the reason for using a chicken egg shell is that the hardness of the highly calcified thrombus that is the object of diagnosis and treatment of the system according to the present invention is very similar to this egg shell.
  • This egg shell is regarded as a thrombus and the inner lining of the egg as a blood vessel wall, aiming at breaking the shell without damaging the inner lining.
  • the ultrasonic wave generated by the probe force is reflected directly as it is, so the ultrasonic echo is high and the image is displayed dark. Also, as the force is directed outward from the center of the sample, the ultrasonic wave is reflected in various directions, so the reflected echo is lower and the image is displayed lighter.
  • FIG. 5 (a) shows an image of the result of flaw detection at a position 5 mm from the surface of the egg shell using a flat probe with a frequency of 10 MHz.
  • Fig. 5 (b) shows an image of the result of flaw detection at a position 5 mm from the surface of the egg shell using a flat probe with a frequency of 5 MHz.
  • flaw detection is performed by adjusting the sensitivity so that the maximum reflected echo height in the scanning range is the same as 5 MHz.
  • FIG. 6 is a schematic diagram showing a state in which the inside of a blood vessel is inspected using a flat probe.
  • a calcified thrombus 15 in the blood vessel wall 11 when there is a calcified thrombus 15 in the blood vessel wall 11, when the flat probe 6 approaches the thrombus, the thrombus 15 in front of the flat probe 6 is reflected by ultrasonic echo reflection. Can be measured. In addition, it is possible to estimate the distance from the contrast of the image to the thrombus.
  • the reflected echo can be detected.
  • the reflection echoes are measured by tilting the flat probe against the sample egg shell. As a result, tilting the flat probe with respect to the sample is more accurate than without tilting. It was found that it can be detected well.
  • the reflected echo was detected more accurately when the flat probe was tilted 5 ° relative to the sample than when the flat probe was tilted 0 °.
  • a thrombus can be diagnosed more accurately by tilting the flat probe about 5 ° from the longitudinal direction of the catheter probe.
  • the flat probe may be rotated at a constant speed just by tilting it from the longitudinal direction of the catheter probe.
  • a drive unit is provided behind the catheter probe, and the flat probe at the tip of the catheter probe is rotated.
  • the diagnostic ultrasonic probe of the first embodiment scans a flat type probe at a predetermined angle from the longitudinal direction of the probe, but the diagnostic ultrasonic probe shown in the second embodiment.
  • the child has an ultrasonic probe attached to a neck 3 (shown in FIG. 1) made of a shape memory alloy, and has means for applying heat to the shape memory alloy, and is made of a shape memory alloy. By scanning the neck 3, the ultrasonic probe direction is scanned.
  • the means for applying heat to the shape memory alloy is, for example, by providing a power source behind the catheter probe, arranging a lead wire up to the distal end of the catheter probe force, creating a current circuit, and using a heating wire, etc. It is converted into heat at the part and is conducted to the shape memory alloy.
  • the ultrasonic probe 2 is attached to the neck portion 3 formed of a shape memory alloy, and the ultrasonic probe 2 is scanned by bending the neck portion 3, thereby enabling a small motor or the like. This has the advantage of eliminating the need for a scanning mechanism.
  • At least two or more diagnostic ultrasonic probes 2 are arranged in a direction in which the bent surfaces of the neck portion 3 intersect each other. This is because the bending of the shape memory alloy is in the axial direction. For example, by arranging two bending surfaces at the distal end of the catheter probe so that the bending surfaces are perpendicular to each other, the scanning coverage is improved. .
  • Example 3
  • an ultrasonic transducer for treatment used in the intravascular diagnosis and treatment system according to the present invention has an amplification mechanism using structural resonance.
  • Figure 7 (a) shows the shape of the therapeutic ultrasonic transducer amplifier.
  • an amplifier 5 is mounted on the ultrasonic transducer 3.
  • the design of this amplifier 5 is based on the design of a mass-panel system dynamic vibration absorber that combines mass and panel.
  • Figure 7 (b) shows a model of the amplifier based on the design of a mass-panel dynamic vibration absorber.
  • k is the optimal panel constant of the dynamic vibration absorber
  • K is the panel constant of the vibrator
  • m to m are increased.
  • Mass of each component element of width machine M represents mass of vibrator.
  • Figures 8 (a) to 8 (c) show the manufactured amplifiers based on the design of mass-panel type dynamic vibration absorbers.
  • the amplifiers in Figs. 8 (a) and 8 (b) have the same length of the panel part of the vibrator, but different diameters and tip masses of the panel part.
  • the amplifier shown in FIG. 8 (c) is made identical by reducing the mass of the vibrator at the tip and increasing the diameter of the panel.
  • the shape is generally called a horn.
  • Fig. 9 a graph showing the frequency response of an oscillator with an amplifier.
  • the values were about 19KHz, 26KHz, and 28KHz in the order of amplifiers (a) to (c), which were relatively well in agreement with the design theoretical values calculated by the model.
  • the fact that the resonance frequency decreases as the mass of the amplifier increases is in good agreement with the design theory. Focusing on the amplitude, the maximum amplitude is about 12.3 ⁇ m, 4.9 ⁇ m, and 3.3 ⁇ m for the amplifiers (a) to (c), respectively. We succeeded in expanding the amplitude to about 4.4 times.
  • Figure 10 (a graph showing the amplitude of the frequency near the resonance point of the amplifier) shows the result of an experiment to determine the maximum amplitude at the frequency near the resonance point when the voltage is raised. When the applied voltage was 7V, a maximum amplitude of 15 m was obtained.
  • the flexural vibration in the length direction and the vertical direction was measured on the A and B planes.
  • Figure 11 shows the relationship between the A and B plane directions.
  • Figure 12 shows the results of measuring the flexural vibration in the length direction and the vertical direction on the A and B planes.
  • Figure 13 shows an enlarged view of the low frequency range, which is the resonance frequency of flexural vibration.
  • both the A and B planes resonate at 910 Hz.
  • the maximum amplitude is about 16 m on the B surface, which is larger than the amplitude in the length direction, whereas the vibration in the deflection direction is greatly reduced by simply shaking with a fingertip with weak rigidity. .
  • the present invention relates to an intravascular diagnosis and treatment system using an ultrasonic catheter that is inserted into a body cavity such as a blood vessel, a vascular vessel, or a digestive tract, and used to display a cross-sectional image of the blood vessel. Can be used.
  • FIG. 1 is a structural schematic diagram of a distal end portion of a catheter probe used in an intravascular diagnosis and treatment system according to the present invention.
  • ⁇ 2 Schematic diagram of ultrasonic beam propagation by flat probe
  • Figure 4 Shows an image of the result of flaw detection on the surface of an egg shell using a flat probe with a frequency of 5 MHz.
  • ⁇ 6 Schematic diagram showing how the inside of a blood vessel is inspected using a flat probe
  • FIG. 7 (a) Shows the shape of the therapeutic ultrasonic transducer amplifier. (B) A model of the amplifier based on the design of a mass-panel type dynamic vibration absorber is shown.
  • the amplifiers in (a) and (b) have the same mass at the tip and different panel diameters.
  • the amplifier in (c) is the same by reducing the mass of the vibrator at the tip and increasing the diameter of the panel.

Abstract

L'invention porte sur un système capable d'observer/de diagnostiquer en trois dimensions une lésion dans un vaisseau sanguin où circule du sang et simultanément de retirer/traiter un thrombus tout en faisant la différence en temps réel entre une partie affectée et un vaisseau, ainsi qu'un thrombus dans du sang en circulation. Le système comprend, à l'extrémité d'une sonde de cathéter, au moins une sonde ultrasonore de diagnostic basée sur l'écho ultrasonore, et un vibrateur ultrasonore de traitement capable de retirer un thrombus dans un vaisseau sanguin en entrant en vibration dans la direction longitudinale de la sonde à une fréquence spécifiée incluant celle d'une onde ultrasonore. La sonde ultrasonore de diagnostic est préférablement une sonde de type plat, et elle inspecte/diagnostique, dans un vaisseau sanguin, une paroi de vaisseau sanguin dans une direction frontale. Le pouvoir d'incision du vibrateur ultrasonore de traitement est amélioré et sa vibration est transmise avec un apport, tel qu'un mouvement rotatif ou alternatif. Lorsqu'un mécanisme d'amplification utilisant une résonance structurelle est ajouté, sa performance de rupture est encore augmentée.
PCT/JP2006/303750 2005-04-26 2006-02-28 Systeme de diagnostic et de traitement de l'interieur d'un vaisseau sanguin par onde ultrasonore WO2006117923A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2007514481A JPWO2006117923A1 (ja) 2005-04-26 2006-02-28 超音波による血管内の診断と治療システム

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005127937 2005-04-26
JP2005-127937 2005-04-26

Publications (1)

Publication Number Publication Date
WO2006117923A1 true WO2006117923A1 (fr) 2006-11-09

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009027846A3 (fr) * 2007-05-23 2009-08-13 Oscillon Ltd Appareil et procédé de pénétration assistée dans une occlusion totale chronique
JP2010531718A (ja) * 2007-06-28 2010-09-30 ゴア エンタープライズ ホールディングス，インコーポレイティド 改良されたカテーテル
WO2014068606A1 (fr) * 2012-10-29 2014-05-08 テルモ株式会社 Dispositif du type insertion dans des vaisseaux
WO2014081052A1 (fr) * 2012-11-22 2014-05-30 한국과학기술원 Dispositif d'élimination de déchets pour tissu vasculaire et périvasculaire en utilisant la fréquence de résonance
US8852112B2 (en) 2007-06-28 2014-10-07 W. L. Gore & Associates, Inc. Catheter with deflectable imaging device and bendable electrical conductor
US8864675B2 (en) 2007-06-28 2014-10-21 W. L. Gore & Associates, Inc. Catheter
WO2021229999A1 (fr) * 2020-05-15 2021-11-18 朝日インテック株式会社 Cathéter et système de cathéter

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05277115A (ja) * 1992-04-03 1993-10-26 Hitachi Ltd 超音波装置
JPH09135908A (ja) * 1995-11-17 1997-05-27 Aloka Co Ltd 超音波診断治療システム
JP2000081385A (ja) * 1998-09-04 2000-03-21 Olympus Optical Co Ltd 触覚センサプローブ
JP2003534032A (ja) * 2000-02-09 2003-11-18 スペンサー テクノロジーズ， インコーポレイテッド 診断用超音波と治療用超音波を合わせて血栓崩壊を増強する方法および装置

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05277115A (ja) * 1992-04-03 1993-10-26 Hitachi Ltd 超音波装置
JPH09135908A (ja) * 1995-11-17 1997-05-27 Aloka Co Ltd 超音波診断治療システム
JP2000081385A (ja) * 1998-09-04 2000-03-21 Olympus Optical Co Ltd 触覚センサプローブ
JP2003534032A (ja) * 2000-02-09 2003-11-18 スペンサー テクノロジーズ， インコーポレイテッド 診断用超音波と治療用超音波を合わせて血栓崩壊を増強する方法および装置

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009027846A3 (fr) * 2007-05-23 2009-08-13 Oscillon Ltd Appareil et procédé de pénétration assistée dans une occlusion totale chronique
JP2010527678A (ja) * 2007-05-23 2010-08-19 オスシロン リミテッド 慢性完全閉塞の誘導貫通のための装置及び方法
JP2010531718A (ja) * 2007-06-28 2010-09-30 ゴア エンタープライズ ホールディングス，インコーポレイティド 改良されたカテーテル
US8852112B2 (en) 2007-06-28 2014-10-07 W. L. Gore & Associates, Inc. Catheter with deflectable imaging device and bendable electrical conductor
US8864675B2 (en) 2007-06-28 2014-10-21 W. L. Gore & Associates, Inc. Catheter
WO2014068606A1 (fr) * 2012-10-29 2014-05-08 テルモ株式会社 Dispositif du type insertion dans des vaisseaux
WO2014081052A1 (fr) * 2012-11-22 2014-05-30 한국과학기술원 Dispositif d'élimination de déchets pour tissu vasculaire et périvasculaire en utilisant la fréquence de résonance
WO2021229999A1 (fr) * 2020-05-15 2021-11-18 朝日インテック株式会社 Cathéter et système de cathéter

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