WO2006114286A3 - Herstellung von albumin-fluorescein-konjugaten für die intraoperative diagnostik - Google Patents

Herstellung von albumin-fluorescein-konjugaten für die intraoperative diagnostik Download PDF

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Publication number
WO2006114286A3
WO2006114286A3 PCT/EP2006/003832 EP2006003832W WO2006114286A3 WO 2006114286 A3 WO2006114286 A3 WO 2006114286A3 EP 2006003832 W EP2006003832 W EP 2006003832W WO 2006114286 A3 WO2006114286 A3 WO 2006114286A3
Authority
WO
WIPO (PCT)
Prior art keywords
production
albumin
conjugates
intraoperative diagnosis
fluorescein conjugates
Prior art date
Application number
PCT/EP2006/003832
Other languages
English (en)
French (fr)
Other versions
WO2006114286A9 (de
WO2006114286A2 (de
Inventor
Hannsjoerg Sinn
Marcel Muelbaier
Original Assignee
Hannsjoerg Sinn
Marcel Muelbaier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hannsjoerg Sinn, Marcel Muelbaier filed Critical Hannsjoerg Sinn
Publication of WO2006114286A2 publication Critical patent/WO2006114286A2/de
Publication of WO2006114286A3 publication Critical patent/WO2006114286A3/de
Publication of WO2006114286A9 publication Critical patent/WO2006114286A9/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13—Labelling of peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043—Fluorescein, used in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

Die vorliegende Erfindung betrifft Konjugate umfassend einen Fluoreszenzfarbstoff und ein Protein, Arnzeimittel umfassend solche Konjugate, insbesondere zur Darstellung von soliden Tumoren, entzündlichen Prozessen und/oder sentinellen Lymphknoten, deren Verwendung sowie Verfahren zu deren Herstellung.
PCT/EP2006/003832 2005-04-25 2006-04-25 Herstellung von albumin-fluorescein-konjugaten für die intraoperative diagnostik WO2006114286A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005019104.5 2005-04-25
DE102005019104A DE102005019104A1 (de) 2005-04-25 2005-04-25 Herstellung von Albumin-Fluorescein-Konjugaten für die intra-operative Diagnostik

Publications (3)

Publication Number Publication Date
WO2006114286A2 WO2006114286A2 (de) 2006-11-02
WO2006114286A3 true WO2006114286A3 (de) 2007-02-01
WO2006114286A9 WO2006114286A9 (de) 2007-03-15

Family

ID=36609359

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/003832 WO2006114286A2 (de) 2005-04-25 2006-04-25 Herstellung von albumin-fluorescein-konjugaten für die intraoperative diagnostik

Country Status (2)

Country Link
DE (1) DE102005019104A1 (de)
WO (1) WO2006114286A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112546221B (zh) * 2020-12-11 2023-12-19 深圳先进技术研究院 一种肿瘤诊疗药物及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356820A (en) * 1991-07-29 1994-10-18 Abbott Laboratories Haptens, tracers, immunogens and antibodies for immunoassays for propoxyphene
US20050036946A1 (en) * 2003-08-11 2005-02-17 Pathak Chandrashekhar P. Radio-opaque compounds, compositions containing same and methods of their synthesis and use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10108857A1 (de) * 2001-02-14 2002-09-19 Hans-Dieter Hunger Bioaktive und biokompatible Konjugate mit magnetischen Eigenschaften und Verfahren zu deren Herstellung
EP1419787A1 (de) * 2002-11-18 2004-05-19 Uwe Prof. Dr. Till Lymphknoten-Kontrastmittel

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356820A (en) * 1991-07-29 1994-10-18 Abbott Laboratories Haptens, tracers, immunogens and antibodies for immunoassays for propoxyphene
US20050036946A1 (en) * 2003-08-11 2005-02-17 Pathak Chandrashekhar P. Radio-opaque compounds, compositions containing same and methods of their synthesis and use

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HOSHINO A ET AL: "Applications of T-lymphoma labeled with fluorescent quantum dots to cell tracing markers in mouse body", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 314, no. 1, 30 January 2004 (2004-01-30), pages 46 - 53, XP004483559, ISSN: 0006-291X *
ICHIOKA T; MIYATAKE SI; ASAI N; KAJIMOTO Y; NAKAGAWA T; HAYASHI H; KUROIWA T: "Enhanced detection of malignant glioma xenograft by fluorescein-human serum albumin conjugate", JOURNAL OF NEURO-ONCOLOGY, vol. 67, no. 1-2, March 2004 (2004-03-01), pages 47 - 52, XP002394392 *
KREMER P; WUNDER A; SINN H; HAASE T; RHEINWALD M; ZILLMANN U; ALBERT F K; KUNZE S: "Laser-induced fluorescence detection of malignant gliomas using fluorescein-labeled serum albumin: experimental and preliminary clinical results", NEUROLOGICAL RESEARCH, XX, XX, vol. 22, no. 5, July 2000 (2000-07-01), pages 481 - 489, XP008067466 *

Also Published As

Publication number Publication date
DE102005019104A1 (de) 2006-10-26
WO2006114286A9 (de) 2007-03-15
WO2006114286A2 (de) 2006-11-02

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