WO2010078376A3 - Fc-specific polymer-conjugated antibodies and their diagnostic use - Google Patents
Fc-specific polymer-conjugated antibodies and their diagnostic use Download PDFInfo
- Publication number
- WO2010078376A3 WO2010078376A3 PCT/US2009/069748 US2009069748W WO2010078376A3 WO 2010078376 A3 WO2010078376 A3 WO 2010078376A3 US 2009069748 W US2009069748 W US 2009069748W WO 2010078376 A3 WO2010078376 A3 WO 2010078376A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- specific polymer
- conjugated antibodies
- diagnostic use
- conjugates
- present
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention provides molecular conjugates of antibodies and hydrophilic, non-immunogenic polymers. More particularly, the present invention provides Fc-specific polymer-conjugated antibody signal- generating moiety conjugates and methods for making and using the conjugates.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14160208P | 2008-12-30 | 2008-12-30 | |
US61/141,602 | 2008-12-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2010078376A2 WO2010078376A2 (en) | 2010-07-08 |
WO2010078376A3 true WO2010078376A3 (en) | 2010-09-16 |
Family
ID=42021649
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2009/069748 WO2010078376A2 (en) | 2008-12-30 | 2009-12-29 | Fc-specific polymer-conjugated antibodies and their diagnostic use |
Country Status (1)
Country | Link |
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WO (1) | WO2010078376A2 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013003555A1 (en) | 2011-06-28 | 2013-01-03 | Whitehead Institute For Biomedical Research | Using sortases to install click chemistry handles for protein ligation |
BR112015021764B1 (en) * | 2013-03-05 | 2022-07-19 | Hanmi Pharm. Co., Ltd. | IMPROVED PREPARATION METHOD FOR HIGH YIELD PRODUCTION OF PHYSIOLOGICALLY ACTIVE POLYPEPTIDE CONJUGATE |
EP3546485A1 (en) | 2013-05-10 | 2019-10-02 | Whitehead Institute for Biomedical Research | In vitro production of red blood cells with sortaggable proteins |
EP2994530A4 (en) | 2013-05-10 | 2016-11-16 | Whitehead Biomedical Inst | Protein modification of living cells using sortase |
WO2015073746A2 (en) | 2013-11-13 | 2015-05-21 | Whitehead Institute For Biomedical Research | 18f labeling of proteins using sortases |
EP3140653B1 (en) * | 2014-05-08 | 2022-05-11 | Novodiax, Inc. | Direct immunohistochemistry assay |
JP6979941B2 (en) | 2015-08-20 | 2021-12-15 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Particle-based immunoassay with PEGylated analyte-specific binder |
US12048753B2 (en) | 2015-10-01 | 2024-07-30 | Whitehead Institute For Biomedical Research | Labeling of antibodies |
CN114152604A (en) * | 2020-09-07 | 2022-03-08 | 南京大学 | Reagent-free electrochemiluminescence detection method for cell imaging |
CN112326953A (en) * | 2020-11-03 | 2021-02-05 | 广东海洋大学深圳研究院 | Method for directionally labeling polybiotin by using antibody |
CN116836235A (en) * | 2022-03-25 | 2023-10-03 | 中国科学院上海药物研究所 | Affinity fragment-directed cleavable fragments, their design, synthesis and use in the preparation of site-directed drug conjugates |
CN118373870A (en) * | 2024-05-10 | 2024-07-23 | 中汉生物医学技术研究(昆山)有限公司 | Protein coupling method based on aldehyde sulfhydryl reaction |
Citations (3)
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US4732863A (en) * | 1984-12-31 | 1988-03-22 | University Of New Mexico | PEG-modified antibody with reduced affinity for cell surface Fc receptors |
US20070117153A1 (en) * | 2005-11-23 | 2007-05-24 | Christopher Bieniarz | Molecular conjugate |
US20070122408A1 (en) * | 2005-10-20 | 2007-05-31 | The Scripps Research Institute | Fc Labeling for Immunostaining and Immunotargeting |
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US4671958A (en) | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
DD266710A3 (en) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Process for the biotechnical production of alkaline phosphatase |
US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
DE3920358A1 (en) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE |
US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
US7018809B1 (en) | 1991-09-19 | 2006-03-28 | Genentech, Inc. | Expression of functional antibody fragments |
US5789199A (en) | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
US6040498A (en) | 1998-08-11 | 2000-03-21 | North Caroline State University | Genetically engineered duckweed |
US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
DE60022369T2 (en) | 1999-10-04 | 2006-05-18 | Medicago Inc., Sainte Foy | PROCESS FOR REGULATING THE TRANSCRIPTION OF FOREIGN GENES IN THE PRESENCE OF NITROGEN |
DK1877101T3 (en) | 2005-04-28 | 2017-01-09 | Ventana Med Syst Inc | ENZYMES CONJUGATED TO ANTIBODIES THROUGH A PEG hetero LINKER |
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2009
- 2009-12-29 WO PCT/US2009/069748 patent/WO2010078376A2/en active Application Filing
Patent Citations (3)
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US4732863A (en) * | 1984-12-31 | 1988-03-22 | University Of New Mexico | PEG-modified antibody with reduced affinity for cell surface Fc receptors |
US20070122408A1 (en) * | 2005-10-20 | 2007-05-31 | The Scripps Research Institute | Fc Labeling for Immunostaining and Immunotargeting |
US20070117153A1 (en) * | 2005-11-23 | 2007-05-24 | Christopher Bieniarz | Molecular conjugate |
Non-Patent Citations (6)
Title |
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CUNNINGHAM-RUNDLES C ET AL: "Biological activities of polyethylene-glycol immunoglobulin conjugates resistance to enzymatic degradation", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 152, no. 2, 10 August 1992 (1992-08-10), pages 177 - 190, XP023945030, ISSN: 0022-1759, [retrieved on 19920810] * |
EKINS R ET AL: "IMMUNOASSAY AND OTHER LIGAND ASSAYS: PRESENT STATUS AND FUTURE TRENDS", INTERNATIONAL FEDERATION OF CLINICAL CHEMISTRY. JOURNAL, XX, XX, vol. 9, no. 3, 1 September 1997 (1997-09-01), pages 100,102 - 109, XP001153007 * |
FISCHER-DURAND NATHALIE ET AL: "Synthesis of metal-carbonyl-dendrimer-antibody immunoconjugates: towards a new format for carbonyl metallo immunoassay", CHEMBIOCHEM - A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY, WILEY VCH, WEINHEIM, DE, vol. 5, no. 4, 2 April 2004 (2004-04-02), pages 519 - 525, XP002495438, ISSN: 1439-4227 * |
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Also Published As
Publication number | Publication date |
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WO2010078376A2 (en) | 2010-07-08 |
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