WO2006113422A3 - Variantes humaines du recepteur du sucre et de l'umami - Google Patents

Variantes humaines du recepteur du sucre et de l'umami Download PDF

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Publication number
WO2006113422A3
WO2006113422A3 PCT/US2006/014045 US2006014045W WO2006113422A3 WO 2006113422 A3 WO2006113422 A3 WO 2006113422A3 US 2006014045 W US2006014045 W US 2006014045W WO 2006113422 A3 WO2006113422 A3 WO 2006113422A3
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WO
WIPO (PCT)
Prior art keywords
snps
taste
different
sweet
perceive
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PCT/US2006/014045
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English (en)
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WO2006113422A2 (fr
Inventor
Dennis T Drayna
Un-Kyung Kim
Original Assignee
Ud Gov Health & Human Serv
Dennis T Drayna
Un-Kyung Kim
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Publication date
Application filed by Ud Gov Health & Human Serv, Dennis T Drayna, Un-Kyung Kim filed Critical Ud Gov Health & Human Serv
Priority to US11/911,517 priority Critical patent/US8796441B2/en
Publication of WO2006113422A2 publication Critical patent/WO2006113422A2/fr
Publication of WO2006113422A3 publication Critical patent/WO2006113422A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne différentes séquences codant le récepteur du sucré et de l'umami chez plusieurs populations humaines. L'invention concerne plus particulièrement plusieurs polymorphismes d'un nucléotide simple (PNS) se présentant dans des exons ou la séquence codante (c'est-à-dire codant des PNS et PNSc) de l'un des trois gènes T1R. Certains PNS provoquent des substitutions d'acides aminés, alors que d'autres introduisent un codon de terminaison de chaîne, ce qui rend un produit tronqué. On pense que les différences dans ces gènes affectent le sens du goût d'individus de façon que l'on suppose que des individus à PNS différents (ou dont les haplotypes diffèrent) perçoivent le sucré ou l'umami (par exemple le Glutamate) d'une façon différente de celle du reste de la population. La possibilité de d'essayer cette information allélique est utile pour la mise au point d'agents de sapidité et d'exhausteurs de goût dans la mesure où l'on peut s'en servir pour définir des groupes et des populations percevant de façon différente les saveurs. Cela permet par conséquent de solliciter les préférences de goûts de ces groupes au niveau moléculaire.
PCT/US2006/014045 2005-04-13 2006-04-13 Variantes humaines du recepteur du sucre et de l'umami WO2006113422A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/911,517 US8796441B2 (en) 2005-04-13 2006-04-13 Human sweet and umami taste receptor variants

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67117305P 2005-04-13 2005-04-13
US60/671,173 2005-04-13

Publications (2)

Publication Number Publication Date
WO2006113422A2 WO2006113422A2 (fr) 2006-10-26
WO2006113422A3 true WO2006113422A3 (fr) 2007-02-08

Family

ID=36928285

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/014045 WO2006113422A2 (fr) 2005-04-13 2006-04-13 Variantes humaines du recepteur du sucre et de l'umami

Country Status (2)

Country Link
US (1) US8796441B2 (fr)
WO (1) WO2006113422A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9371317B2 (en) 2013-02-19 2016-06-21 Senomyx, Inc. Sweet flavor modifier
US9382196B2 (en) 2008-07-31 2016-07-05 Senomyx, Inc. Processes and intermediates for making sweet taste enhancers
US9420814B2 (en) 2012-08-06 2016-08-23 Senomyx, Inc. Sweet flavor modifier

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KR101356914B1 (ko) 2006-04-20 2014-01-28 지보당 에스아 단맛 강화 방법
US9603848B2 (en) 2007-06-08 2017-03-28 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
US7928111B2 (en) * 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
HUE051845T2 (hu) 2012-03-20 2021-03-29 Univ Washington Through Its Center For Commercialization Módszerek a tömegesen párhuzamos DNS-szekvenálás hibaarányának csökkentésére duplex konszenzus szekvenálással
EP3387152B1 (fr) 2015-12-08 2022-01-26 Twinstrand Biosciences, Inc. Adaptateurs améliorés, procédés, et compositions pour le séquençage en double hélice
WO2018011566A1 (fr) * 2016-07-11 2018-01-18 Ranvier Health Limited Procédé de pertinence de diagnostic basé sur la reconnaissance du goût
CN106978426B (zh) * 2017-05-23 2020-09-01 中国科学院南海海洋研究所 凡纳滨对虾Na,K-ATPaseα亚基基因及SNP标记筛查的扩增引物和方法
AU2018366213A1 (en) 2017-11-08 2020-05-14 Twinstrand Biosciences, Inc. Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters
KR20210059694A (ko) 2018-07-12 2021-05-25 트윈스트랜드 바이오사이언시스, 인코포레이티드 게놈 편집, 클론 팽창 및 연관된 분야를 규명하기 위한 방법 및 시약
SG11202100846YA (en) 2018-08-07 2021-02-25 Firmenich Incorporated 5-substituted 4-amino-1h-benzo[c][1,2,6]thiadiazine 2,2-dioxides and formulations and uses thereof

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US20040219632A1 (en) * 2001-04-20 2004-11-04 Robert Margolskee T1r3 a novel taste receptor
US20050032158A1 (en) * 2001-01-03 2005-02-10 Senomyx, Inc. Binding assays that use human T1R2 to identify potential taste modulators
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9382196B2 (en) 2008-07-31 2016-07-05 Senomyx, Inc. Processes and intermediates for making sweet taste enhancers
US9420814B2 (en) 2012-08-06 2016-08-23 Senomyx, Inc. Sweet flavor modifier
US9371317B2 (en) 2013-02-19 2016-06-21 Senomyx, Inc. Sweet flavor modifier
US9475803B2 (en) 2013-02-19 2016-10-25 Senomyx, Inc. Sweet flavor modifier

Also Published As

Publication number Publication date
US20080287310A1 (en) 2008-11-20
WO2006113422A2 (fr) 2006-10-26
US8796441B2 (en) 2014-08-05

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