WO2006111126A3 - Hyperpolarisation von li und weiteren kernen - Google Patents

Hyperpolarisation von li und weiteren kernen Download PDF

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Publication number
WO2006111126A3
WO2006111126A3 PCT/DE2006/000531 DE2006000531W WO2006111126A3 WO 2006111126 A3 WO2006111126 A3 WO 2006111126A3 DE 2006000531 W DE2006000531 W DE 2006000531W WO 2006111126 A3 WO2006111126 A3 WO 2006111126A3
Authority
WO
WIPO (PCT)
Prior art keywords
lithium
atoms
ions
hyperpolarization
nuclei
Prior art date
Application number
PCT/DE2006/000531
Other languages
English (en)
French (fr)
Other versions
WO2006111126A2 (de
Inventor
Stephan Appelt
Wolfgang Haesing
Ulrich Sieling
Holger Kuehn
Original Assignee
Forschungszentrum Juelich Gmbh
Stephan Appelt
Wolfgang Haesing
Ulrich Sieling
Holger Kuehn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forschungszentrum Juelich Gmbh, Stephan Appelt, Wolfgang Haesing, Ulrich Sieling, Holger Kuehn filed Critical Forschungszentrum Juelich Gmbh
Priority to AT06722683T priority Critical patent/ATE495459T1/de
Priority to CN2006800130441A priority patent/CN101163981B/zh
Priority to EP06722683A priority patent/EP1880227B9/de
Priority to US11/918,853 priority patent/US8248068B2/en
Priority to JP2008506911A priority patent/JP5117375B2/ja
Priority to DE502006008714T priority patent/DE502006008714D1/de
Publication of WO2006111126A2 publication Critical patent/WO2006111126A2/de
Publication of WO2006111126A3 publication Critical patent/WO2006111126A3/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent

Landscapes

  • Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Die Erfindung betrifft ein Verfahren zur Hyperpolarisation von Lithiumatomen in einem Gemisch durch optisches Pumpen in einer Probenzelle mittels optisches Pumpen von Atomen einer ersten Alkalimetallsorte und Spinaustausch vom optisch gepumpten Elektron dieses Alkalimetalls auf das Elektron des Lithium-atoms. Die Lithiumatome werden vorteilhaft zu Li+- Ionen oxidiert und akkumuliert. Die Kernspinpolarisation der Li+- Ionen kann auf den Kernspin eines Anions übertragen werden.
PCT/DE2006/000531 2005-04-18 2006-03-25 Hyperpolarisation von li und weiteren kernen WO2006111126A2 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AT06722683T ATE495459T1 (de) 2005-04-18 2006-03-25 Hyperpolarisation von li und weiteren kernen
CN2006800130441A CN101163981B (zh) 2005-04-18 2006-03-25 锂和其它原子核的超极化
EP06722683A EP1880227B9 (de) 2005-04-18 2006-03-25 Hyperpolarisation von li und weiteren kernen
US11/918,853 US8248068B2 (en) 2005-04-18 2006-03-25 Hyperpolarization of lithium and other nuclei
JP2008506911A JP5117375B2 (ja) 2005-04-18 2006-03-25 Ｌｉ及び別の核の過偏極
DE502006008714T DE502006008714D1 (de) 2005-04-18 2006-03-25 Hyperpolarisation von li und weiteren kernen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005017927.4 2005-04-18
DE102005017927A DE102005017927A1 (de) 2005-04-18 2005-04-18 Hyperpolarisation von Li und weiteren Kernen

Publications (2)

Publication Number Publication Date
WO2006111126A2 WO2006111126A2 (de) 2006-10-26
WO2006111126A3 true WO2006111126A3 (de) 2007-04-05

Family

ID=37038526

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2006/000531 WO2006111126A2 (de) 2005-04-18 2006-03-25 Hyperpolarisation von li und weiteren kernen

Country Status (8)

Country Link
US (1) US8248068B2 (de)
EP (1) EP1880227B9 (de)
JP (1) JP5117375B2 (de)
CN (1) CN101163981B (de)
AT (1) ATE495459T1 (de)
DE (2) DE102005017927A1 (de)
ES (1) ES2359078T3 (de)
WO (1) WO2006111126A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005017927A1 (de) 2005-04-18 2006-10-26 Forschungszentrum Jülich GmbH Hyperpolarisation von Li und weiteren Kernen
EP1940475A4 (de) 2005-09-28 2010-05-26 Harvard College Hyperpolarisierte feste materialien mit langen spin-erholungszeiten zur verwendung als bildgebende mittel in der magnetresonanztomographie
US20080284429A1 (en) * 2005-12-10 2008-11-20 The President And Fellows Of Harvard College Situ Hyperpolarization of Imaging Agents
EP1984757A4 (de) * 2006-01-11 2009-11-04 Harvard College Ex-vivo-hyperpolarisation von abbildungsmitteln
US8405022B2 (en) * 2006-09-20 2013-03-26 University Of New Hampshire Thermal management technology for polarizing xenon
US8698493B2 (en) * 2011-08-05 2014-04-15 Wisconsin Alumni Research Foundation Noble gas magnetic resonator
CN104698413B (zh) * 2013-12-06 2019-04-12 中国人民解放军国防科学技术大学 一种延长原子池内极化气体自旋弛豫时间的方法
JP2018514795A (ja) * 2015-05-22 2018-06-07 ウニヴェルズィテート・ウルム 核スピンを超偏極させる方法
CN110609054B (zh) * 2018-06-15 2024-07-09 中国科学院大连化学物理研究所 一种超极化稀有惰性气体发生用极化池

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999008766A2 (en) * 1997-08-18 1999-02-25 Trustees Of Princeton University Alkali metal hybrid spin-exchange optical pumping

Family Cites Families (14)

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Publication number Priority date Publication date Assignee Title
US261822A (en) * 1882-08-01 Charles atkinson
US2665412A (en) * 1952-03-31 1954-01-05 Ethyl Corp Analysis of nonferrous alloys
US3983182A (en) * 1972-09-05 1976-09-28 Massachusetts Institute Of Technology Alkali metal organic compounds and their method of preparation
US5642625A (en) * 1996-03-29 1997-07-01 The Trustees Of Princeton University High volume hyperpolarizer for spin-polarized noble gas
EP0890114A1 (de) * 1996-03-29 1999-01-13 Lawrence Berkeley National Laboratory Verbesserung von kermagnetischer resonanz und bilderzeugung durch kermagnetische resonanz im beisein von hyperpolarisierten edelgasen
US6284222B1 (en) * 1998-11-03 2001-09-04 Medi--Physics, Inc. Hyperpolarized helium-3 microbubble gas entrapment methods
DE19937566C2 (de) * 1999-08-09 2001-06-28 Forschungszentrum Juelich Gmbh Hochdruckpolarisator für Edelgase und Verfahren zum Betreiben des Polarisators
JP4169122B2 (ja) * 2002-02-26 2008-10-22 独立行政法人産業技術総合研究所 核スピン偏極希ガスの製造装置とこれを用いた偏極希ガスの製造方法
DE10238637A1 (de) * 2002-08-19 2004-03-11 Philipps-Universität Marburg Verfahren und Vorrichtung zur Herstellung hoch kernspinpolarisierter Flüssigkeiten
NO20025711D0 (no) * 2002-11-27 2002-11-27 Amersham Health As Magnetisk resonansmetode
JP4405758B2 (ja) * 2003-07-01 2010-01-27 ジーイー・メディカル・システムズ・グローバル・テクノロジー・カンパニー・エルエルシー 磁気共鳴撮像装置
DE102004023345B4 (de) * 2004-01-19 2006-11-09 Forschungszentrum Jülich GmbH Verfahren zur Hyperpolarisation von Atomkernen und Vorrichtung zur Durchführung des Verfahrens
WO2005069027A1 (de) * 2004-01-19 2005-07-28 Forschungszentrum Jülich GmbH Verfahren zur hyperpolarisation von atomkernen und vorrichtung zur durchführung des verfahrens
DE102005017927A1 (de) 2005-04-18 2006-10-26 Forschungszentrum Jülich GmbH Hyperpolarisation von Li und weiteren Kernen

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999008766A2 (en) * 1997-08-18 1999-02-25 Trustees Of Princeton University Alkali metal hybrid spin-exchange optical pumping

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANDERSON L W: "Preparation methods and depolarization processes in internal polarized targets of Li or Na", AIP CONFERENCE PROCEEDINGS USA, vol. 2, 1989, pages 1545 - 1551, XP008069828, ISSN: 0094-243X *
BALLING L C ET AL: "Optical pumping at high temperatures", PHYSICAL REVIEW LETTERS USA, vol. 22, 3 February 1969 (1969-02-03), pages 161 - 163, XP002403253, ISSN: 0031-9007 *
NEUGART R: "Spin exchange polarization and measurement of the hyperfine splitting of short-lived <8>Li", ZEITSCHRIFT FUR PHYSIK A (ATOMS AND NUCLEI) WEST GERMANY, vol. 261, 1973, pages 237 - 248, XP008069814, ISSN: 0340-2193 *

Also Published As

Publication number Publication date
US8248068B2 (en) 2012-08-21
DE102005017927A1 (de) 2006-10-26
WO2006111126A2 (de) 2006-10-26
EP1880227A2 (de) 2008-01-23
ES2359078T3 (es) 2011-05-18
DE502006008714D1 (de) 2011-02-24
EP1880227B9 (de) 2011-05-04
CN101163981B (zh) 2012-08-08
EP1880227B1 (de) 2011-01-12
CN101163981A (zh) 2008-04-16
US20090261822A1 (en) 2009-10-22
JP2008538412A (ja) 2008-10-23
ATE495459T1 (de) 2011-01-15
JP5117375B2 (ja) 2013-01-16

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