WO2006108558A1 - Device for dosing and dry nebulization - Google Patents
Device for dosing and dry nebulization Download PDFInfo
- Publication number
- WO2006108558A1 WO2006108558A1 PCT/EP2006/003155 EP2006003155W WO2006108558A1 WO 2006108558 A1 WO2006108558 A1 WO 2006108558A1 EP 2006003155 W EP2006003155 W EP 2006003155W WO 2006108558 A1 WO2006108558 A1 WO 2006108558A1
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- WO
- WIPO (PCT)
- Prior art keywords
- nebulization channel
- reservoir
- attachment piece
- nebulization
- valve
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/14—Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
- A61M16/201—Controlled valves
- A61M16/202—Controlled valves electrically actuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/14—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas designed for spraying particulate materials
- B05B7/1404—Arrangements for supplying particulate material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
- A61M11/065—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type using steam as driving gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0027—Accessories therefor, e.g. sensors, vibrators, negative pressure pressure meter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Definitions
- the invention relates to a device and a method for dosing and dry nebulization of nebulizable material, in particular powdered pharmaceutical preparations.
- the invention further relates to the use of such a device for dry nebulization of a powdered pharmaceutical preparation, in particular a lung surfactant preparation.
- nebulizable material for example a powdered pharmaceutical preparation
- a compressed gas or carrier gas in a specially provided chamber and, within this chamber, is converted to a state which is referred to as dry mist.
- the grains of the material are in this case present in a preferably uniform and finely dispersed form across the entire volume of compressed gas or carrier gas and are then discharged from the chamber in this state via suitable devices.
- Such devices are used in particular to form pharmaceutical preparations for inhaled administration to spontaneously ventilating or ventilated patients.
- the devices are generally connected to a suitable mouthpiece or a breathing mask.
- these devices are built into the respirator.
- the known devices were suitable for the nebulization of pharmaceutical quantities in the range from approximately 1 ⁇ g to approximately 20 mg.
- Pharmaceutical preparations of which large amounts, for example in the gram range, have to be administered to the lungs within a long time period are what are called lung surfactant preparations. Administration of a large amount of such lung surfactants is necessary in acute situations.
- nebulizable material which is present as a loose charge in a storage container, for example a commercially available pharmaceutical vial, tends to agglomerate, by reason of its surface
- CONFIRSUIATiON COPY quality and/or its moisture content resulting in blockage of a comparatively narrow aperture cross section of the vial.
- Such agglomeration also occurs in lung surfactant preparations.
- Such blockages can normally be obviated only by suitable mechanical means, in order to ensure a continuous dosing of the nebulizable material over quite a long period of time.
- agglomerated particles of nebulizable material for example lung surfactant preparations, are not generally able to access the lungs.
- dry nebulization of nebulizable material is understood as its aerosolization, i.e. its conversion into a state carried by carrier gas.
- a device is made available in which, in accordance with the principle of a jet pump, a nebulizable material stored in a reservoir is sucked by an underpressure in the reservoir into a nebulization channel and is nebulized in this channel with the compressed gas.
- the underpressure in the reservoir is in this case generated by the compressed gas flowing past the connection between reservoir and nebulization channel.
- the dry nebulizer according to the invention can be used for acute treatment in spontaneously ventilating patients.
- the second attachment piece of the nebulization channel can be connected via an attachment piece to a device for administration to spontaneously ventilating patients. Examples of such devices are a mouthpiece and breathing mask.
- the dry nebulizer When used on a ventilated patient, i.e. in invasive use, the dry nebulizer is built into the respirator.
- the second attachment piece of the nebulization channel is in this case preferably joined to the respiratory air intake line of the respirator, in particular to the side port of the respirator.
- the duration and/or the time of the pressure pulse from the source of compressed carrier gas is preferably regulated so as to be synchronized, in the case of invasive use, with the respiration rate of the respirator and, in the case of use on spontaneously ventilating patients, with the breathing rate of the patient.
- a synchronous control is at all times ensured when the mixture of compressed gas and material, that is to say the combination of nebulizable material and compressed carrier gas, reaches the patient before or during an inhalation cycle so that direct uptake of the dry mist by the patient is possible.
- the control can also be such that direct uptake of the dry mist by the patient is possible at every x-th breath.
- the control is such that a control signal is set depending on the length of the nebulization channel and/or of any respirator attachment or attachment piece to a device for administration to spontaneously ventilation patients, and also depending on the desired time of entry of the dry mist into the breathing tube.
- a device is made available in which, during the pressure pulse from the source of compressed carrier gas, i.e. when the valve is opened, an underpressure is present in the reservoir, which underpressure is compensated between the pressure pulses, i.e. when the valve is closed, by gas flowing back.
- the back-flowing gas can be a respiratory gas used in the respirator. In the use on spontaneously ventilating patients, it can also be ambient air.
- the reservoir is arranged above the nebulization chamber and has a connection to the nebulization channel.
- This connection is configured so as to be gas-tight with respect to the environment.
- This connection can consist of one or more openings.
- nebulizable material on the one hand, but also gas stored in the reservoir, on the other, is sucked into the nebulization channel.
- agglomeration of the charge located above the aperture of the reservoir may take place.
- such an agglomeration is broken up by the pressure compensation in the device between the pressure pulses, since ambient air and/or respiratory air flowing back into the nebulization channel also passes through the charge in the reservoir in order to bring about a pressure compensation in the reservoir.
- the device according to the invention is designed in such a way that, when the valve is closed, a pressure compensation takes place in the nebulization channel and in the reservoir.
- a pressure compensation takes place in the nebulization channel and in the reservoir.
- the source of compressed carrier gas is connected to the first attachment of the nebulization channel via a valve in such a way that such pressure compensation is able to take place.
- the pressure compensation is made possible by the fact that the nebulization channel is closed off in a sufficiently gas-tight manner at its first attachment piece. This ensures that the pressure compensation takes place at least for the most part in the nebulization channel and in the reservoir, and not, for instance, via the first attachment piece.
- the device according to the invention thus easily allows nebulizable material to be dosed in large amounts in a highly reproducible manner and preferably without mechanical parts.
- a loosening of the charge and, if appropriate, a deagglomeration of the nebulizable material is achieved. It is thus possible that the mixture of compressed gas and material predominantly contains particles, preferably exclusively particles, which correspond to the size of the primary particles of the nebulizable material.
- the nebulizable material is in the form of powdered pharmaceutical preparations, in particular lung surfactants, it is possible that the primary particles of the pharmaceutical preparation located in the reservoir are present in the mixture of compressed gas and material.
- the device according to the invention permits, preferably completely free of mechanical parts, optimal dispersing of the nebulizable material even down to the size of the primary particles.
- the size of the primary particles of the nebulizable material preferably corresponds to a mass median aerodynamic diameter (MMAD) which is such that the particles are able to access the lungs, i.e. the site of action in the alveoli of the lungs.
- MMAD mass median aerodynamic diameter
- the MMAD of particles that can access the lungs is in the range of 1 to 5 ⁇ m.
- the desired MMAD range, according to the invention, of the particles in the mixture of compressed gas and material is consequently 1 to 5 ⁇ m, preferably 1 to 3 ⁇ m.
- the invention thus provides a device, the use thereof, and a method, by means of which a constant dosing of a nebulizable material is ensured over a considerable time period, and with which large amounts of pharmaceutical preparations of several grams can also be administered to the patient by inhalation over a comparatively short time period, for example of less than 15 minutes.
- the device according to the invention thus doses the amount of material to be nebulized preferably solely on the basis of the amount of compressed gas output per pressure pulse and the duration of this pressure pulse. Further mechanical dosing devices are not required in the device according to the invention.
- a dosing chamber is arranged between the reservoir and the nebulization channel.
- the dosing of an amount of nebulizable material to be output per pressure pulse can advantageously take place without any restrictions concerning the aperture of the reservoir itself toward the dosing chamber.
- the diameters of the apertures and of the reservoir and also of the dosing chamber lying below this aperture are matched to one another in such a way that exactly the amount of nebulizable material present within the dosing chamber is nebulized during a pressure pulse.
- the source of compressed gas in the device according to the invention can be connected to the nebulization channel via a controllable valve.
- a controllable valve here is particularly preferably a solenoid valve which, in the manner known to the skilled person, controls the time and duration of a pressure pulse into the nebulization channel.
- the valve is controlled in a manner adapted to the respiration or ventilation rate of the patient, and, in a preferred embodiment of the device according to the invention, a control signal for the valve is emitted by a pressure sensor which, in invasive use, is located inside the respirator.
- a pressure compensation takes place between the pressure pulses in the nebulization channel and the reservoir and, if appropriate, the dosing chamber.
- This pressure compensation can take place by suitable means in the device through the introduction of ambient air.
- this pressure compensation takes place through the introduction of respiratory air or ventilation air counter to the direction of the pressure pulse into the nebulization channel and into the reservoir.
- a closed and preferably sterile system can be provided in which contamination by microorganisms or pollutants in the ambient air can be safely avoided.
- the compressed gas can advantageously be introduced into the nebulization channel via a capillary which particularly preferably has an internal diameter of 0.8 to 1 mm, very preferably of approximately 1 mm.
- the outlet of the capillary is arranged in the nebulization channel in the area under the connection between reservoir or dosing chamber and the nebulization channel.
- a swirling of the compressed gas emerging from the capillary supports the swirling of nebulizable material in the nebulization channel and, consequently, the production of a dry mist.
- This swirling can additionally contribute to breaking up possible agglomerates of the nebulizable material, so that almost exclusively primary particles of the nebulizable material are present in the obtained mixture of compressed gas and material.
- the second attachment piece of the nebulization channel of the device according to the invention is advantageously connected to the respirator attachment piece (in the case of invasive use) or to an attachment piece to a device for administration to spontaneously ventilating patients (in the case of non-invasive use) in such a way that the dry mist, i.e. the mixture of compressed gas and material, is transferred to the patient without said mixture striking against baffle surfaces or other obstacles.
- the dry mist can pass unimpeded into the ventilation gas of the respirator and can combine with the ventilation gas there. In this way it is possible to prevent a situation where nebulizable material carried by carrier gas strikes obstacles, settles on these and thus is unable to reach the site of action in the lungs.
- nebulization channel and preferably the dispersing nozzle to the respirator attachment or the attachment piece to the device for administration to spontaneously ventilating patients
- adherence of nebulized material for example to the inner walls of the respirator attachment (for example the respirator side port or the breathing tube) or of the mouthpiece, is safely suppressed.
- 30 to 180 ml of compressed gas can preferably be introduced into the nebulization channel per pressure pulse.
- an amount of compressed gas that is particularly advantageous for the nebulization of the desired amount of nebulizable material, and which amount is sufficient to nebulize an amount of nebulizable material which can be taken up by the lungs of the patient in question.
- the amount to be nebulized with such a volume of compressed carrier gas is sufficiently small to exclude the possibility of the patient's breathing or ventilation being adversely affected.
- a predefined amount of the powdered material preferably 10 to 50 mg, particularly preferably 10 to 30 mg, can be nebulized per pressure pulse.
- a device is made available which in a particularly simple manner permits a uniformly dosed nebulization of powdered material in an amount which is advantageously adapted to the uptake capacity of the lungs of the patient.
- the reservoir for the nebulizable material is connected to the device and is preferably a conventional vial for injectable preparations. Its external diameter is typically in the range of 2 cm. Before the vial is fitted on the device according to the invention, its closure piece, usually a rubber stopper, is removed. In a further preferred embodiment of the device according to the invention, the reservoir contains 0.5 to 3 g, particularly preferably 1 to 2 g, of nebulizable material. This means that, in a particularly advantageous manner, the amount of material to be nebulized by the device can be adapted to the dose and duration of administration required particularly in intensive care medicine in inhaled administration of powdered pharmaceutical preparations.
- nebulizable material is understood as a material from which at least some converts into a state carried by carrier gas during operation of the device according to the invention.
- the nebulizable material is preferably a pharmaceutical preparation which can be administered in particular by inhalation.
- This pharmaceutical preparation is advantageously powdered, for example a micronized powder.
- the pharmaceutical preparation comprises a surfactant, in particular a lung surfactant.
- a lung surfactant is a substance mixture which is contained in the lungs of all vertebrates. It has surface-active properties and reduces the surface tension in the alveolar region of the lungs to such an extent that collapse of the final airway regions is avoided during exhalation.
- Essential components in the lung surfactant are proteins, designated by SP-A, SP-B and SP-C.
- the lung surfactant contained in the nebulizable material is particularly advantageously a recombinant lung surfactant, such as is described in WO 95/32992.
- This is a mutant of human SP-C (also designated as rSP-C).
- the most preferred lung surfactant is Venticute® (INN: lusupultide, also designated as rSP-C (FF/I)).
- rSP-C (FF/I) is described in WO 95/32992.
- the pharmaceutical preparation can contain a further lung surfactant from the group of SP-A and SP-B. Moreover, it may also contain phospholipids and other additives familiar to the skilled person.
- the pharmaceutical preparation is or comprises a powdered lung surfactant preparation which is produced as described in EP-B-877 602.
- a powdered lung surfactant preparation which is produced as described in EP-B-877 602.
- an organic solution or suspension containing lung surfactant and possibly other constituents is subjected to spray drying.
- Venticute® is the most preferred lung surfactant in this context.
- Lung surfactants are suitable for the prevention and early treatment of acute lung diseases. This use is described in WO 01/76619.
- Diseases to be treated by lung surfactant are, for example, asthma, pulmonary fibrosis, pneumonias, bronchitis, chronic obstructive pulmonary disease (COPD) and various respiratory distress syndromes (RDS), adult respiratory distress syndrome (ARDS), and infant respiratory distress syndrome (IRDS).
- COPD chronic obstructive pulmonary disease
- RDS various respiratory distress syndromes
- ARDS adult respiratory distress syndrome
- IRDS infant respiratory distress syndrome
- the use of the device for nebulization of Venticute® for treatment of ARDS is a particularly preferred area of use.
- a method is made available for dosing and dry nebulization of nebulizable material by means of an above-described device.
- This method includes the steps of introducing a pressure pulse into the nebulization channel, in order to generate an underpressure in the reservoir for the nebulizable material, the resulting sucking of a subsidiary amount of the nebulizable material into the nebulization channel, and the aerosolization of this subsidiary amount inside the nebulization channel.
- pressure compensation takes place after completion of each pressure pulse in which introduced air from the outside and/or respiratory air flows back from the breathing tube or the like into the nebulization channel and the reservoir.
- the gas flows through the charge of material which is located above the aperture of the reservoir and if appropriate above the aperture of the dosing chamber, and which is possibly compacted and agglomerated there, and the latter is thus loosened and deagglomerated.
- the content of the reservoir is completely nebulized and delivered to the patient within a defined time period of preferably less than 15 minutes, particularly preferably of less than 10 minutes.
- a method is made available which particularly advantageously satisfies the requirements in intensive care of patients or in emergency treatment of patients, where rapid administration of high doses of pharmaceutical preparations is necessary.
- Fig. 1 shows a schematic representation of a first embodiment of the device according to the invention
- Fig. 2 shows a partially sectioned side view of a first embodiment of the device according to the invention
- Fig. 3 shows the state of a device according to the invention during output of a pressure pulse into the nebulization chamber
- Fig. 4 shows a state of the device according to the invention during a time period between two pressure pulses
- Fig. 5 shows a partially sectioned schematic side view of a second embodiment of the device according to the invention.
- a partially sectioned, perspective view of the device 1 is shown in which a nebulization channel 3 is arranged inside a nozzle block 2.
- the nozzle block 2 At its first end (on the left in Fig. 1), the nozzle block 2 comprises a capillary seat 4 into which a capillary tube holder 14 supporting a capillary tube 13 is fitted.
- This capillary tube holder 14 is in turn connected to a connecting line 15 which opens into a solenoid valve 16, the latter being regulated by a control system labelled schematically with reference number 17.
- the flow of the compressed gas from the compressed air attachment line 18 into the capillary tube 13 is regulated by the control system 17.
- the control system 17 At its second end (on the right in Fig.
- the nebulization channel 3 opens into a dispersing nozzle 5 whose cross section increases continuously in a direction extending away from the capillary tube 13.
- the dispersing nozzle 5 in turn opens into an attachment piece 2a which is an integral component part of the nozzle block 2 onto which is fitted a respirator attachment piece 6 or an attachment piece 7 to a device for administration to spontaneously ventilating patients.
- the device 1 also comprises, above the nebulization channel, a receiving seat 9 for the medicament reservoir 10.
- the edge 11 of the reservoir 10 is fitted into the receiving seat 9 provided in the nozzle block 2, the aperture 19 of the reservoir 10 being located above a dosing chamber 8 with a conically tapering shape.
- Located above this aperture 19 is a charge of the pharmaceutical preparation 12 which is agglomerated to such an extent that almost no grain of the nebulizable material 12 enters the dosing chamber 8.
- Fig. 2 shows a partially sectioned side view of the device 1 shown in Fig. 1 , but, in contrast to the view shown in Fig. 1 , with the dosing chamber 8 already filled.
- the dosing chamber 8 has been filled by material falling through the aperture 19 until the material 12 in the reservoir 10 has compacted to the extent that no further material 12 can slip into the dosing chamber 8.
- the control system 17 has not emitted any signal to the solenoid valve 16, so that no compressed air passes through the valve 16 and the capillary tube 13 into the nebulization chamber 3.
- Fig. 3 shows a partially sectioned side view of the device 1 at a time after the control system 17 has sent an opening signal to the solenoid valve 16. From this time onwards, compressed air passes through the solenoid valve 16 and the capillary tube 13 into the nebulization channel 3. In the nebulization channel 3, an underpressure is created by the flow of the compressed air in the reservoir 10 and in the dosing chamber 8, by means of which underpressure at least the charge of material 12 present in the dosing chamber 8 is entrained in the stream of compressed air, which is indicated by the empty arrows.
- the nebulizable material 12 is aerosolized with the compressed air, such that the dry mist, indicated by the presence of filled arrows and also empty arrows, is guided into the respirator attachment 6 and the attachment piece 7.
- the dry mist generated in this way can be transported with the respiratory air or ventilation gas into the lungs of the patient.
- Fig. 4 shows a partially sectioned side view of the first embodiment of the device 1 according to the invention at a time when the control system 17 sends no opening signal to the solenoid valve 16, as a result of which the steam of compressed gas from the compressed-gas source (not shown) into the nebulization channel 3 is also interrupted.
- ventilation air or respiratory air flows into the nebulization channel 3 and through the dosing chamber 8 into the reservoir 10.
- Fig. 5 shows an embodiment of the device 1 according to the invention in which the device 1 is arranged concentrically with respect to a cylindrical breathing tube 21.
- compressed gas flows through the compressed air attachment line 18 and the capillary tube 13 into the nebulization channel 3 after the solenoid valve 16 is opened, which solenoid valve 16 is regulated by a control system 17.
- directly above the open end of the capillary tube 13 is the aperture of the dosing chamber 8, above which the reservoir 10 is positioned in a receiving seat 9 provided for it.
- the longitudinal axis of the nebulization channel 3 lies on the longitudinal axis of the breathing tube 21 and parallel to a multiplicity of respiratory air intake openings 23 through which respiratory air is conveyed from a source (not shown) through the breathing tube 21.
- the breathing tube 21 ends in a schematically depicted mouthpiece 24 around which the patient can place his or her lips, so as to inhale the respiratory air to which the dry mist has been added.
Abstract
Description
Claims
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2006800113427A CN101155609B (en) | 2005-04-08 | 2006-04-07 | Device for dosing and dry nebulization |
ES06724100T ES2727000T3 (en) | 2005-04-08 | 2006-04-07 | Dosing and dry fogging device |
AU2006233606A AU2006233606B2 (en) | 2005-04-08 | 2006-04-07 | Device for dosing and dry nebulization |
KR1020077025401A KR101379999B1 (en) | 2005-04-08 | 2006-04-07 | Device for dosing and dry nebulization |
US11/887,392 US9636470B2 (en) | 2005-04-08 | 2006-04-07 | Device for dosing and dry nebulization |
JP2008504690A JP5021616B2 (en) | 2005-04-08 | 2006-04-07 | Equipment for metering and dry spraying |
MX2007012228A MX2007012228A (en) | 2005-04-08 | 2006-04-07 | Device for dosing and dry nebulization. |
BRPI0608674A BRPI0608674B8 (en) | 2005-04-08 | 2006-04-07 | device and method for dosing and dry misting |
CA2603397A CA2603397C (en) | 2005-04-08 | 2006-04-07 | Device for dosing and dry nebulization |
NZ561878A NZ561878A (en) | 2005-04-08 | 2006-04-07 | Device for dosing and dry nebulization |
EP06724100.0A EP1868670B1 (en) | 2005-04-08 | 2006-04-07 | Device for dosing and dry nebulization |
EA200702144A EA012055B1 (en) | 2005-04-08 | 2006-04-07 | Device for dosing and dry nebulization |
IL186196A IL186196A0 (en) | 2005-04-08 | 2007-09-24 | Device for dosing and dry nebulization |
NO20075451A NO20075451L (en) | 2005-04-08 | 2007-10-29 | Device for dosing and dry spraying |
HK08106603.8A HK1116437A1 (en) | 2005-04-08 | 2008-06-16 | Device for dosing and dry nebulization |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005016102A DE102005016102B3 (en) | 2005-04-08 | 2005-04-08 | Device for metering and dry fogging |
DE102005016100A DE102005016100B3 (en) | 2005-04-08 | 2005-04-08 | Device for metering and dry fogging |
DE102005016100.6 | 2005-04-08 |
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Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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US9839772B2 (en) * | 2008-05-06 | 2017-12-12 | Cook Medical Technologies Llc | Apparatus and methods for delivering therapeutic agents |
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB191324848A (en) * | 1913-10-31 | 1914-03-26 | Henrik Wiking | Improvements in and relating to Insufflators or Apparatus for Spraying Powders. |
US3442454A (en) * | 1965-04-17 | 1969-05-06 | Siemens Ag | Power suction device |
FR2257351A1 (en) * | 1974-01-11 | 1975-08-08 | Obert Jean Claude | Aerosol device for solid vaccines - feed and breaker screws deliver material sideways into blower chamber |
FR2598918A1 (en) * | 1986-05-23 | 1987-11-27 | Lille Ii Universite Droit Sant | Device allowing insufflation into the respiratory passages of a radio-opaque powder in the finely divided state |
GB2310816A (en) * | 1996-03-05 | 1997-09-10 | Ceradent Ltd | A feed mechanism for use in powder spraying utilising a porous member |
US6681767B1 (en) * | 1991-07-02 | 2004-01-27 | Nektar Therapeutics | Method and device for delivering aerosolized medicaments |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1934793A (en) * | 1932-03-02 | 1933-11-14 | Crain | Insufflator |
US1988017A (en) * | 1933-01-24 | 1935-01-15 | Anthony T Norwick | Spraying apparatus |
BE471028A (en) * | 1946-02-08 | |||
US2570774A (en) * | 1947-10-21 | 1951-10-09 | Frank P C Davis | Insufflator |
US3888252A (en) * | 1974-01-23 | 1975-06-10 | Anthony J Side | Powder inhaler |
US4071170A (en) * | 1975-12-29 | 1978-01-31 | Meiko, Inc. | Portable motor driven dusting apparatus |
US4502640A (en) * | 1982-09-08 | 1985-03-05 | Italo Nonis | Multi-purpose spray gun |
DK479189D0 (en) * | 1989-01-06 | 1989-09-28 | Hans Gernot Schenk | INHALER |
US5039017A (en) * | 1989-06-02 | 1991-08-13 | David Howe | Portable texturing machine |
GB9027234D0 (en) * | 1990-12-15 | 1991-02-06 | Harris Pharma Ltd | An inhalation device |
ATE189124T1 (en) * | 1991-07-02 | 2000-02-15 | Inhale Inc | METHOD AND DEVICE FOR DELIVERING MEDICATIONS IN AEROSOL FORM |
US5337740A (en) * | 1991-08-01 | 1994-08-16 | New England Pharmaceuticals, Inc. | Inhalation devices |
RU2120826C1 (en) * | 1995-10-31 | 1998-10-27 | Институт гидродинамики им.М.А.Лаврентьева СО РАН | Method and device for spraying powder materials |
US5875776A (en) * | 1996-04-09 | 1999-03-02 | Vivorx Pharmaceuticals, Inc. | Dry powder inhaler |
US6014972A (en) * | 1997-12-11 | 2000-01-18 | Thayer Medical Corporation | Dry drug particle delivery system and method for ventilator circuits |
US6234169B1 (en) * | 1998-08-14 | 2001-05-22 | Arthur Slutsky | Inhaler |
GB2343122B (en) * | 1998-10-26 | 2003-01-08 | Medic Aid Ltd | Improvements in and relating to nebulisers |
GB2353222B (en) * | 1999-06-23 | 2001-09-19 | Cambridge Consultants | Inhalers |
US20040254112A1 (en) * | 2000-04-12 | 2004-12-16 | Dietrich Hafner | Use of pulmonary surfactant for the early treatment of acute pulmonary diseases |
US6691892B2 (en) * | 2001-03-21 | 2004-02-17 | Chapin Manufacturing, Inc. | Granular pump |
US7025056B2 (en) * | 2001-05-10 | 2006-04-11 | Vectura Delivery Devices Limited | Assymetric inhaler |
US6978779B2 (en) * | 2002-04-19 | 2005-12-27 | Instrumentarium Corp. | Vibrating element liquid discharging apparatus having gas pressure sensing |
US20050121025A1 (en) * | 2003-12-04 | 2005-06-09 | Gamard Stephan C.F. | Portable gas operating inhaler |
CA2559403C (en) * | 2004-01-22 | 2013-01-15 | Amir Belson | Respiratory system for inducing therapeutic hypothermia |
RU2379062C2 (en) * | 2004-02-24 | 2010-01-20 | Майкродоуз Терапьютикс, Инк. | Method and synthesising-jet device for drug delivery |
-
2005
- 2005-04-08 DE DE102005016100A patent/DE102005016100B3/en active Active
- 2005-04-08 DE DE102005016102A patent/DE102005016102B3/en active Active
-
2006
- 2006-04-07 JP JP2008504695A patent/JP5021617B2/en active Active
- 2006-04-07 EA EA200702147A patent/EA013024B1/en not_active IP Right Cessation
- 2006-04-07 KR KR1020077025401A patent/KR101379999B1/en active IP Right Grant
- 2006-04-07 CA CA2603397A patent/CA2603397C/en active Active
- 2006-04-07 KR KR1020077025398A patent/KR101357508B1/en active IP Right Grant
- 2006-04-07 AU AU2006233606A patent/AU2006233606B2/en active Active
- 2006-04-07 MX MX2007012228A patent/MX2007012228A/en active IP Right Grant
- 2006-04-07 WO PCT/EP2006/003172 patent/WO2006105980A1/en active Application Filing
- 2006-04-07 CN CN2006800113323A patent/CN101155608B/en active Active
- 2006-04-07 MX MX2007012227A patent/MX2007012227A/en active IP Right Grant
- 2006-04-07 US US11/887,392 patent/US9636470B2/en active Active
- 2006-04-07 BR BRPI0608674A patent/BRPI0608674B8/en active IP Right Grant
- 2006-04-07 WO PCT/EP2006/003155 patent/WO2006108558A1/en active Application Filing
- 2006-04-07 JP JP2008504690A patent/JP5021616B2/en active Active
- 2006-04-07 CA CA2603406A patent/CA2603406C/en active Active
- 2006-04-07 US US11/887,513 patent/US9713682B2/en active Active
- 2006-04-07 EP EP06724100.0A patent/EP1868670B1/en active Active
- 2006-04-07 EA EA200702144A patent/EA012055B1/en not_active IP Right Cessation
- 2006-04-07 AU AU2006232774A patent/AU2006232774B2/en active Active
- 2006-04-07 EP EP06724114.1A patent/EP1868671B1/en active Active
- 2006-04-07 BR BRPI0609536-4A patent/BRPI0609536A2/en not_active IP Right Cessation
- 2006-04-07 CN CN2006800113427A patent/CN101155609B/en active Active
-
2007
- 2007-09-14 ZA ZA200707863A patent/ZA200707863B/en unknown
- 2007-09-17 ZA ZA200707931A patent/ZA200707931B/en unknown
- 2007-09-24 IL IL186197A patent/IL186197A0/en not_active IP Right Cessation
- 2007-09-24 IL IL186196A patent/IL186196A0/en not_active IP Right Cessation
- 2007-10-29 NO NO20075451A patent/NO20075451L/en not_active Application Discontinuation
- 2007-10-31 NO NO20075500A patent/NO20075500L/en not_active Application Discontinuation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB191324848A (en) * | 1913-10-31 | 1914-03-26 | Henrik Wiking | Improvements in and relating to Insufflators or Apparatus for Spraying Powders. |
US3442454A (en) * | 1965-04-17 | 1969-05-06 | Siemens Ag | Power suction device |
FR2257351A1 (en) * | 1974-01-11 | 1975-08-08 | Obert Jean Claude | Aerosol device for solid vaccines - feed and breaker screws deliver material sideways into blower chamber |
FR2598918A1 (en) * | 1986-05-23 | 1987-11-27 | Lille Ii Universite Droit Sant | Device allowing insufflation into the respiratory passages of a radio-opaque powder in the finely divided state |
US6681767B1 (en) * | 1991-07-02 | 2004-01-27 | Nektar Therapeutics | Method and device for delivering aerosolized medicaments |
GB2310816A (en) * | 1996-03-05 | 1997-09-10 | Ceradent Ltd | A feed mechanism for use in powder spraying utilising a porous member |
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CN101918062A (en) * | 2007-12-19 | 2010-12-15 | 文廷文特股份公司 | Be used in the atomising device in the CPAP system |
US8910627B2 (en) | 2009-04-23 | 2014-12-16 | Takeda Gmbh | Apparatus for the aerosolization of large volumes of dry powder |
CN102421473A (en) * | 2009-04-23 | 2012-04-18 | 奈科明有限责任公司 | Improved apparatus for the aerosolization of large volumes of dry powder |
AU2010240909B2 (en) * | 2009-04-23 | 2014-07-31 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. | Improved apparatus for the aerosolization of large volumes of dry powder |
WO2010122103A1 (en) | 2009-04-23 | 2010-10-28 | Nycomed Gmbh | Improved apparatus for the aerosolization of large volumes of dry powder |
EA021036B1 (en) * | 2009-04-23 | 2015-03-31 | Такеда Гмбх | Improved apparatus for the aerosolization of large volumes of dry powder |
US9545490B2 (en) | 2009-04-23 | 2017-01-17 | Takeda Gmbh | Apparatus for the aerosolization of large volumes of dry powder |
WO2012020004A1 (en) | 2010-08-09 | 2012-02-16 | Nycomed Gmbh | Device and system for delivery of an aerosol to a patient on ventilatory support |
US10252014B2 (en) | 2010-08-09 | 2019-04-09 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Device and system for delivery of an aerosol to a patient on ventilatory support |
US9693955B2 (en) | 2010-08-23 | 2017-07-04 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Humidified particles comprising a therapeutically active substance |
WO2012025496A1 (en) | 2010-08-23 | 2012-03-01 | Nycomed Gmbh | Humidified particles comprising a therapeutically active substance |
US10335558B2 (en) | 2011-06-07 | 2019-07-02 | Parion Sciences, Inc. | Methods of treatment |
US10549052B2 (en) | 2012-02-28 | 2020-02-04 | Sipnose Ltd. | Nasal delivery device |
US11123513B2 (en) | 2014-03-05 | 2021-09-21 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Humidifier for humidifying an aerosol |
US10737088B2 (en) | 2014-03-05 | 2020-08-11 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Device for providing a constant amount of aerosol |
US11571524B2 (en) | 2016-07-13 | 2023-02-07 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Respiration-controlled application of aerosol in powder form during the artificial respiration or supported respiration of a patient |
WO2018010954A1 (en) * | 2016-07-13 | 2018-01-18 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Respiration-controlled application of aerosol in powder form during the artificial respiration or supported respiration of a patient |
US11207475B2 (en) | 2016-07-28 | 2021-12-28 | Chiesi Farmaceutici S.P.A | Method and system for delivery of an aerosolized medicament |
WO2018019719A1 (en) * | 2016-07-28 | 2018-02-01 | Chiesi Farmaceutici S.P.A | Method and system for delivery of an aerosolized medicament |
US20210275760A1 (en) * | 2017-05-19 | 2021-09-09 | Pneuma Respiratory, Inc. | Dry powder delivery device and methods of use |
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US11738158B2 (en) | 2017-10-04 | 2023-08-29 | Pneuma Respiratory, Inc. | Electronic breath actuated in-line droplet delivery device and methods of use |
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US11793945B2 (en) | 2021-06-22 | 2023-10-24 | Pneuma Respiratory, Inc. | Droplet delivery device with push ejection |
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