WO2006106129A3 - Polypeptidmarker zur diagnose von prostatakrebs - Google Patents

Polypeptidmarker zur diagnose von prostatakrebs Download PDF

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Publication number
WO2006106129A3
WO2006106129A3 PCT/EP2006/061374 EP2006061374W WO2006106129A3 WO 2006106129 A3 WO2006106129 A3 WO 2006106129A3 EP 2006061374 W EP2006061374 W EP 2006061374W WO 2006106129 A3 WO2006106129 A3 WO 2006106129A3
Authority
WO
WIPO (PCT)
Prior art keywords
mass
migration time
markers
diagnosis
prostate cancer
Prior art date
Application number
PCT/EP2006/061374
Other languages
English (en)
French (fr)
Other versions
WO2006106129A2 (de
Inventor
Harald Mischak
Original Assignee
Mosaiques Diagnostics & Therap
Harald Mischak
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mosaiques Diagnostics & Therap, Harald Mischak filed Critical Mosaiques Diagnostics & Therap
Priority to CA002604037A priority Critical patent/CA2604037A1/en
Priority to AU2006231611A priority patent/AU2006231611B2/en
Priority to BRPI0607016-7A priority patent/BRPI0607016A2/pt
Priority to US11/887,562 priority patent/US20090298184A1/en
Priority to JP2008504769A priority patent/JP2008537112A/ja
Priority to EP06725599A priority patent/EP1866648A2/de
Publication of WO2006106129A2 publication Critical patent/WO2006106129A2/de
Publication of WO2006106129A3 publication Critical patent/WO2006106129A3/de
Priority to US14/584,146 priority patent/US20150133343A1/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57434—Specifically defined cancers of prostate

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Verfahren zur Diagnose von Prostatakrebs umfassend den Schritt der Bestimmung einer An- oder Abwesenheit mindestens dreier Polypeptidmarkers in einer Probe, wobei der Polypeptidmarker ausgewählt ist aus den Markern 1 bis 44 und 52 bis 78 (Frequenzmarker), oder der Bestimmung der Amplitude mindestens eines Polypeptidmarkers, ausgewählt aus den Markern 45 bis 51 und 79-115 (Amplitudenmarker), die durch folgende Werte für die Molekularmassen und die Migrationszeit charakterisiert sind: Nummer Masse [Da] CE-Zeit Nummer Masse [Da] CE-Zeit 1 1579,7 26,4 27 1180,5 33,9 2 1991,9 17,1 28 2421,1 32,5 3 1955,9 24,8 29 4345,9 30,6 4 1140,5 21,4 30 2077,1 16,9 5 1677,3 7,4 31 1134,6 19,4 6 10753,1 13,6 32 1444,8 13,5 7 1412,6 22,1 33 1046,5 21,9 8 1636,8 27,2 34 1992,2 16,8 9 1946,9 28,4 35 4069,6 21,3 10 5887,6 25,1 36 1191,5 34,5 11 12407,9 22,2 37 1239,5 32,5 12 1186,6 17,4 38 2191,9 17,2 13 1240,6 23,3 39 1865,8 30,0 14 1326,6 24,8 40 1265,6 23,4 15 3802,1 30,1 41 1936,1 10,5 16 1749,9 19,4 42 911,3 31,9 17 2216,1 31,0 43 1494,7 26,4 18 1069,5 22,7 44 1209,6 22,5 19 1341,6 26,6 45 1193,3 34,2 20 1353,7 21,8 46 1235,4 34,3 21 1716,8 24,6 47 1390,5 35,0 22 2939,1 31,1 48 2292,1 23,7 23 3002,0 19,2 49 2736,3 17,1 24 1110,4 31,5 50 3385,5 21,0 25 1496,7 26,5 51 3945,2 21,4 26 1825,8 28,4 - 34 - Num me r Ma sse n (Da) CE-Ze it [min] Num m e r Masse n (Da) CE-Ze it [min] 52 1636,8 27,2 66 1878, 9 15, 3 53 1412,6 22,1 67 3593, 4 14, 5 54 1579,7 26,4 68 1236, 7 13, 3 55 1390,5 35,0 69 2736, 3 17, 1 56 1196,6 15,8 70 2973, 4 20, 0 57 11041,4 16,6 71 1134, 6 19, 4 58 2971,4 17,9 72 2191, 9 17, 2 59 3136,6 20,0 73 2205, 1 25, 1 60 4409,9 14,2 74 3959, 7 14, 0 61 1494,7 26,4 75 1749, 9 19, 4 62 1833,9 24,2 76 4069, 6 21, 3 63 2752,4 14,0 77 2816, 3 24, 7 64 3515,8 15,3 78 3435, 8 15, 0 65 1082,5 17,7 - 35 - Numme r Ma sse [Da ] CE-Ze i t [min] 79 973,26 35,44 80 1128,54 25,66 81 1173,58 37,47 82 1184,6 26,43 83 1290,39 30,85 84 1338,66 23,96 85 1428,45 36,73 86 1450,6 37,47 87 1460,71 19,83 88 1498,46 35,31 89 1526,76 23,54 90 1588,77 30,24 91 1675,77 29,23 92 1703,91 33,67 93 1808,87 23,72 94 1863,96 44,01 95 1867,79 33,29 96 1925,9 23,2 97 2036,97 31,53 98 2114,05 31,59 99 2196,11 33,16 100 2212,06 33,36 101 2257,95 36,02 102 2544,06 26,14 103 2599,21 28,05 104 2761,38 21,47 105 3334,17 31,01 106 3361,41 24,32 107 3426,43 27,73 108 3765,51 20,18 109 3864,56 33,82 110 3870,8 33,47 111 4252,03 28,77 112 6211,93 20,27 113 6650,86 25,55 114 6820,37 21,03 115 16918,24 19,8 , wobei es sich bei der Probe um eine Urinprobe oder Samenflüssigkeitspro- be handelt.
PCT/EP2006/061374 2005-04-07 2006-04-06 Polypeptidmarker zur diagnose von prostatakrebs WO2006106129A2 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA002604037A CA2604037A1 (en) 2005-04-07 2006-04-06 Polypeptide markers for the diagnosis of prostate cancer
AU2006231611A AU2006231611B2 (en) 2005-04-07 2006-04-06 Polypeptide markers for the diagnosis of prostate cancer
BRPI0607016-7A BRPI0607016A2 (pt) 2005-04-07 2006-04-06 marcadores polipeptìdicos para o diagnóstico de cáncer de próstata
US11/887,562 US20090298184A1 (en) 2005-04-07 2006-04-06 Polypeptide Markers for the Diagnosis of Prostate Cancer
JP2008504769A JP2008537112A (ja) 2005-04-07 2006-04-06 前立腺がんの診断のためのポリペプチドマーカー
EP06725599A EP1866648A2 (de) 2005-04-07 2006-04-06 Polypeptidmarker zur diagnose von prostatakrebs
US14/584,146 US20150133343A1 (en) 2005-04-07 2014-12-29 Polypeptide markers for the diagnosis of prostate cancer

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05102741 2005-04-07
EP05102741.5 2005-04-07
EP05105434.4 2005-06-21
EP05105434 2005-06-21

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/887,562 A-371-Of-International US20090298184A1 (en) 2005-04-07 2006-04-06 Polypeptide Markers for the Diagnosis of Prostate Cancer
US14/584,146 Continuation US20150133343A1 (en) 2005-04-07 2014-12-29 Polypeptide markers for the diagnosis of prostate cancer

Publications (2)

Publication Number Publication Date
WO2006106129A2 WO2006106129A2 (de) 2006-10-12
WO2006106129A3 true WO2006106129A3 (de) 2007-09-20

Family

ID=36609504

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/061374 WO2006106129A2 (de) 2005-04-07 2006-04-06 Polypeptidmarker zur diagnose von prostatakrebs

Country Status (7)

Country Link
US (2) US20090298184A1 (de)
EP (2) EP1866648A2 (de)
JP (1) JP2008537112A (de)
AU (1) AU2006231611B2 (de)
BR (1) BRPI0607016A2 (de)
CA (1) CA2604037A1 (de)
WO (1) WO2006106129A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060286602A1 (en) * 2004-05-10 2006-12-21 Harald Mischak Method and markers for the diagnosis of renal diseases
EP2118666B1 (de) * 2007-03-07 2011-08-03 Mosaiques Diagnostics And Therapeutics AG Verfahren zur normierung der konzentration von analyten in einer urinprobe
EP1972940A1 (de) * 2007-03-14 2008-09-24 mosaiques diagnostics and therapeutics AG Verfahren und Marker zur Diagnose von Nierenerkrankungen
WO2009047280A2 (de) * 2007-10-09 2009-04-16 Mosaiques Diagnostics And Therapeutics Ag Polypeptidmarker zur diagnose von prostatakrebs
EP2051078A1 (de) * 2007-10-19 2009-04-22 mosaiques diagnostics and therapeutics AG Verfahren und Marker zur Diagnose von Diabetes Mellitus
WO2009115570A2 (de) * 2008-03-19 2009-09-24 Mosaiques Diagnostics And Therapeutics Ag Verfahren und marker zur diagnose von tubulären nierenschäden und -erkrankungen
WO2010031822A1 (de) * 2008-09-17 2010-03-25 Mosaiques Diagnostics And Therapeutics Ag Nierenzellkarzinom
EP2487251A1 (de) * 2011-02-13 2012-08-15 Protagen AG Markersequenzen für die Diagnose von Prostatakarzinom und deren Verwendung

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001025791A2 (en) * 1999-10-07 2001-04-12 Ciphergen Biosystems, Inc. Prostate cancer marker proteins
WO2003072710A2 (en) * 2002-02-21 2003-09-04 Eastern Virginia Medical School Protein biomarkers that distinguish prostate cancer from non-malignant cells

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001249275B2 (en) * 2000-03-20 2005-12-08 Eastern Virginia Medical School Prostate cancer markers
GB2385276B (en) 2000-03-30 2004-09-08 Orde Levinson Urine funnelling trumpet
DE10021737C2 (de) 2000-05-04 2002-10-17 Hermann Haller Verfahren und Vorrichtung zur qualitativen und/oder quantitativen Bestimmung eines Protein- und/oder Peptidmusters einer Flüssigkeitsprobe, die dem menschlichen oder tierischen Körper entnommen wird
BR0211697A (pt) * 2001-08-03 2004-07-13 Biotron Ltd Marcador de câncer e usos deste na diagnose de câncer
DE10142785C2 (de) 2001-08-31 2003-07-03 Henning Trappe Verfahren zur Bestimmung lokaler Ähnlichkeit aus seismischen 3D-Meßdaten
EP1549938A4 (de) * 2002-04-26 2010-05-12 Univ Johns Hopkins Identifizierung von biomarkern zum nachweis von prostatakrebs
JP2005080524A (ja) * 2003-09-05 2005-03-31 Japan Science & Technology Agency 前立腺癌マーカポリペプチド、該ポリペプチドに対する抗体、及び該ポリペプチドを利用した前立腺癌の診断方法
DE10341193A1 (de) * 2003-09-06 2005-03-31 Mosaiques Diagnostics And Therapeutics Ag Vorrichtung und Verfahren zur quantitativen Auswertung der in einer Körperflüssigkeitsprobe enthaltenden Polypeptide sowie Marker zur Erkennung von pathologischen Zuständen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001025791A2 (en) * 1999-10-07 2001-04-12 Ciphergen Biosystems, Inc. Prostate cancer marker proteins
WO2003072710A2 (en) * 2002-02-21 2003-09-04 Eastern Virginia Medical School Protein biomarkers that distinguish prostate cancer from non-malignant cells

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CAZARES, L. H. ET AL.: "Normal, benign, preneoplastic, and malignant prostate cells have distinct protein exression profiles resolved by Surface Enhanced Laser Desorption/Ionization Mass Spectrometry", CLINICAL CANCER RESEARCH, vol. 8, 2002, pages 2541 - 2552, XP002344816 *
FERNANDEZ C ET AL: "A preliminary study of urinary transferrin as a marker for prostatic cancer", CLINICA CHIMICA ACTA 1986 NETHERLANDS, vol. 161, no. 3, 1986, pages 335 - 339, XP002413221 *
REHMAN I ET AL: "Proteomic analysis of voided urine after prostatic massage from patients with prostate cancer: a pilot study.", UROLOGY. DEC 2004, vol. 64, no. 6, December 2004 (2004-12-01), pages 1238 - 1243, XP002413220, ISSN: 1527-9995 *
THEODORESCU D ET AL: "PILOT STUDY OF CAPILLARY ELECTROPHORESIS COUPLED TO MASS SPECTROMETRY AS A TOOL TO DEFINE POTENTIAL PROSTATE CANCER BIOMARKERS IN URINE", ELECTROPHORESIS, WILEY-VCH VERLAG, WEINHEIM, DE, vol. 26, 2005, pages 2797 - 2808, XP000962767, ISSN: 0173-0835 *

Also Published As

Publication number Publication date
AU2006231611B2 (en) 2012-12-06
EP2317320A3 (de) 2011-07-13
US20150133343A1 (en) 2015-05-14
BRPI0607016A2 (pt) 2009-08-04
WO2006106129A2 (de) 2006-10-12
AU2006231611A1 (en) 2006-10-12
CA2604037A1 (en) 2006-10-12
EP1866648A2 (de) 2007-12-19
EP2317320A2 (de) 2011-05-04
US20090298184A1 (en) 2009-12-03
JP2008537112A (ja) 2008-09-11

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