WO2006103544A8 - 4-piperazinylthieno [2, 3-d] pyrimidine compounds as platelet aggregation inhibitors - Google Patents

4-piperazinylthieno [2, 3-d] pyrimidine compounds as platelet aggregation inhibitors

Info

Publication number
WO2006103544A8
WO2006103544A8 PCT/IB2006/000736 IB2006000736W WO2006103544A8 WO 2006103544 A8 WO2006103544 A8 WO 2006103544A8 IB 2006000736 W IB2006000736 W IB 2006000736W WO 2006103544 A8 WO2006103544 A8 WO 2006103544A8
Authority
WO
WIPO (PCT)
Prior art keywords
piperazinylthieno
platelet aggregation
pyrimidine compounds
aggregation inhibitors
compounds
Prior art date
Application number
PCT/IB2006/000736
Other languages
French (fr)
Other versions
WO2006103544A3 (en
WO2006103544A2 (en
Inventor
Michael Dalton Ennis
Steven Wade Kortum
Ruth Elizabeth Tenbrink
Original Assignee
Pharmacia & Upjohn Co Llc
Michael Dalton Ennis
Steven Wade Kortum
Ruth Elizabeth Tenbrink
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc, Michael Dalton Ennis, Steven Wade Kortum, Ruth Elizabeth Tenbrink filed Critical Pharmacia & Upjohn Co Llc
Priority to EP06710605A priority Critical patent/EP1896483A2/en
Priority to JP2008503611A priority patent/JP2008534570A/en
Priority to CA002603041A priority patent/CA2603041A1/en
Publication of WO2006103544A2 publication Critical patent/WO2006103544A2/en
Publication of WO2006103544A3 publication Critical patent/WO2006103544A3/en
Publication of WO2006103544A8 publication Critical patent/WO2006103544A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) wherein A1, A2, A3, A4, A5, A6, A7, A8, X4, X6, R2k, R2l, R4, R5, and R6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
PCT/IB2006/000736 2005-03-28 2006-03-20 4-piperazinylthieno [2, 3-d] pyrimidine compounds as platelet aggregation inhibitors WO2006103544A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP06710605A EP1896483A2 (en) 2005-03-28 2006-03-20 4-piperazinylthieno [2, 3-d] pyrimidine compounds as platelet aggregation inhibitors
JP2008503611A JP2008534570A (en) 2005-03-28 2006-03-20 4-piperazinylthieno [2,3-d] pyrimidine compounds as platelet aggregation inhibitors
CA002603041A CA2603041A1 (en) 2005-03-28 2006-03-20 4-piperazinylthieno [2, 3-d] pyrimidine compounds as platelet aggregation inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66573405P 2005-03-28 2005-03-28
US60/665,734 2005-03-28

Publications (3)

Publication Number Publication Date
WO2006103544A2 WO2006103544A2 (en) 2006-10-05
WO2006103544A3 WO2006103544A3 (en) 2007-01-04
WO2006103544A8 true WO2006103544A8 (en) 2007-10-18

Family

ID=36648573

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/000736 WO2006103544A2 (en) 2005-03-28 2006-03-20 4-piperazinylthieno [2, 3-d] pyrimidine compounds as platelet aggregation inhibitors

Country Status (4)

Country Link
EP (1) EP1896483A2 (en)
JP (1) JP2008534570A (en)
CA (1) CA2603041A1 (en)
WO (1) WO2006103544A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY148901A (en) * 2007-06-18 2013-06-14 Sanofi Aventis Pyrrole derivatives as p2y12 antagonists
ES2442926T3 (en) 2007-08-22 2014-02-14 Astrazeneca Ab Cyclopropylamide derivatives `978
TWI389913B (en) * 2008-09-08 2013-03-21 Lg Life Sciences Ltd Fused heterocyclic compound
TW201039825A (en) 2009-02-20 2010-11-16 Astrazeneca Ab Cyclopropyl amide derivatives 983
MX336333B (en) 2010-02-18 2016-01-15 Astrazeneca Ab New crystalline form of a cyclopropyl benzamide derivative.
GB201114212D0 (en) * 2011-08-18 2011-10-05 Ucb Pharma Sa Therapeutic agents
AR090037A1 (en) 2011-11-15 2014-10-15 Xention Ltd DERIVATIVES OF TIENO AND / OR FURO-PYRIMIDINES AND PYRIDINES INHIBITORS OF THE POTASSIUM CHANNELS

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2200764A1 (en) * 1972-01-07 1973-07-12 Thomae Gmbh Dr K 4,6-di (substd amino) - thieno (2,3-d) pyrimidines - useful as antithrombotic agents
US5869486A (en) * 1995-02-24 1999-02-09 Ono Pharmaceutical Co., Ltd. Fused pyrimidines and pyriazines as pharmaceutical compounds
WO2003022214A2 (en) * 2001-09-06 2003-03-20 Millennium Pharmaceuticals, Inc. Piperazine and homopiperazine compounds

Also Published As

Publication number Publication date
WO2006103544A3 (en) 2007-01-04
WO2006103544A2 (en) 2006-10-05
CA2603041A1 (en) 2006-10-05
EP1896483A2 (en) 2008-03-12
JP2008534570A (en) 2008-08-28

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