WO2006088342A1 - Textile article for therapeutic use - Google Patents

Abstract

This invention deals with the field of textile manufacturing and medical industry and concerns the manufacture of textiles such as: tights, stockings, socks, shinguards, wristlets, cuffs, elbow pads, gloves, T-shirts, shirts, drawers, tube-like articles for partly amputated extremities, non-elastic bandage, elastic bandage, interfacing, bandage etc. These items prevent fungal and bacterian infections and facilitate the treatment and prevention of venous insufficiency as well as improving the condition of feet in diabetes mellitus. The goal of this invention is the manufacture of textiles causing pressure on the enveloped surface of the body and possessing a prolonged antiseptic and bio-stimulating effect. The goal is attained via a basic interlacing of metallic threads with a double even coating, the internal layer contains a natural antiseptic, and the external layer contains metallic coating. In addition to that, the products contain threads with human composites. The textile products are used in surgery, dermatology and hygiene.

Description

TEXTILE ARTICLE FOR THERAPEUTIC USE

Origins of the invention

[0001] 1. Area of the invention

[0002] This invention deals with the area of textile manufacturing and medical industry and concerns the manufacture of textiles including compressive products of closed geometric shape as well as antiseptic bandaging materials. These textile products are intended for the prevention of fungal infections and treatments of complications in the case of diseases caused by bacterial and fungal infections, and are used in surgery, dermatology, and hygiene. The elaborated products will facilitate the treatment and prevention of chronic venous insufficiency and its pathologies as well as will improve the condition of patient feet in the case of diabetes mellitus.

[0003] 2. Description of the process

[0004] In the case of chronic diseases of skin and hyperhidrosis (excessive sweating), which are expressed especially clearly in feet and shins, axillaries creases and the groin, iii many cases hyperproliferative states of epidermis may be observed, which are recorded in more than 3% of the world's population (1). At that, there are developed inflammatory responses in epidermis and in derma, complicated by the symbiosis of fungal and bacterial infections, as a result of which there arise pathological changes in various organs and systems. Peculiarity and complexity of chronic pathologic states of skin lies in the fact that the means and products applied should simultaneously produce anti-fungal and anti-inflammatory effects as well as keratolytic effects. They should also possess the capability to inhibit skin cells that are at the stage of proliferation, and in addition to that should simultaneously contribute to the restoration of normal skin layers (2;3).

[0005] In order to prevent the development of fungal infections and to treat complexities in the case of diseases caused by fungal and bacterial infections in the symbiosis, as claimed in [0004], various types of preparations: capsules, tablets, special ointments, which can include silver or other metals or alloys hereof (4), have been scientifically studies. However, in the case of protracted course of treatment (taking of tablets), there can be observed side-effects causing complications of functions of the liver, kidneys, deterioration of blood-formation, which provokes the development of anemia, hemoglobin is reduced lower than the standard to as little as 50 %. In the case of protracted application of hormonal ointments, skin atrophy is provoked, and the surface of derma, in the section where ointment is applied, remains humid and viscous, which contributes to the permeation of fungal and bacterial infections, and which causes dermatitis.

[0006] In additional to the preparations as claimed in [0005], it is known of the application of biogenic compositions, in order to remove a hyperproliferative layer of epidermis, as claimed in [0004]. There have been scientifically developed preparations having a keratolytic effect, on the basis of natural silt and peat curative muds, in particular TOPLA preparations (manufacturer - Torf Preparation, Wroclaw, Poland) (5). Bioactive liquid phases represent a biogenic solution and are characterized by a high concentration of humin acids that efficiently affect the hyperproliferative layer of epidermis.

[0007] In the patent of Japan (6) under number JP2001248066, as claimed in [0004], the problem of manufacturing products having a sterilizing and antimicrobial effect is solved. This effect lies in the application of sterilizing and antimicrobial metals and alloys whereof. Non-woven material or woven material is describes as the substate, in which at least one side of the substate is coated with Ag, Cu, Zn or AgTi, AgNi, NiCu or other alloys, the thickness of coating being 50 ~ 2000 A. The substate with a metallized coating has sterilizing and antimicrobial properties. In order to develop the substate, it is possible to chiefly use the following threads: Polyester, Acryl, Nylon, Polyethylene, and Polypropylene. Thickness of the article 0.01 - 1 Den, and up to 10% of natural yarns may be used. When non-woven material as bandage or non- elastic bandage is applied to the injured part of a human body, metal ions penetrate the surface of the body, thus preventing reproduction of virus and microbes. In the case of interaction between the dry surface (i.e. the most comfortable one for a human body) of the material comprising a metallized coating and the damaged region, antimicrobial conditions are created, hygienic state hereof is supported, the possibility of faster health improvement of the damaged region is increased. However, the manufactured products containing natural and synthetic threads, with further metallization of at least one side of the surface of the substate, do not allow manufacturing bandaging material preserving antimicrobial properties of the product due to the fact that natural threads are characterized by low adhesion ability (7). In addition to that, the use of up to 90 % of synthetic threads when manufacturing the article (bandages or non-elastic bandage) without subsequent processing of the sides of the article, as it is known, results in instability of bandaging material when it is used, due to its poor adhesiveness and low coefficient of friction between those.

[0008] Compression pressure is an important component of any medical or preventive product, as it facilitates the article's tight fitting to the human body, thus conditions are created for an active interaction of metallic threads with a definite surface of the human body. Besides, as a result of compression caused by the article to the enveloped surface of the human body, venous hemodynamics is improved, the risk of thrombosis of deep veins is reduced, the effect of venous hypertension is eliminated, lymph outflow and intracellular metabolism processes are activated, conjunctive tissues are strengthened, the possibility of development of ulcer skin affection, especially on feet and shins, is excluded (8). There are used compression articles of various types manufactured by applying a knitted or woven method, such as tights, stockings, knee-length socks, socks, wristlets, cuffs, shinguards, knee pads, etc.

[0009] Elaboration of the following compressive knitted article is known: it secures distribution of pressure to the enveloped part of the human body and has bactericide, sterilizing and fast healing effects on the whole surface of the article enveloping the human body or in a specific region thereof (9). The said compressive knitted article for treatment and prevention of chronic venous insufficiency and its pathologies, complicated by the presence of bacterial and fungal infections, has a leg section, a foot section and the section of the cervix of the upper part of the leg. This article is manufactured with the application of knitted structure, the length of the basic thread in the loop I (mm), an additional thread with metallic coating of Ag, Au, Pt or AgTi, AgNi and other alloys, the thread being introduced into the material's structure by knitted structure/interlacing, with the model of the loop σ of basic interlacing and the length of elastic thread in the loop Z_L (mm). Besides, the article is developed with differential elasticity from section to section, and the pressure in sections of the compressive knitted article is discovered on the working model; the connection of the mode of deformation at the analysis of interaction of the model of the leg with the article's membrane is expressed by the following equation:

Ψ ( E; Jn₁(O); f_L (c) ) = F( [ Z i]; { q } ),

where Ψ ( E ; m^σ); fL (c)) - Functional of the article membrane's pressure;

E - modulus of longitudinal elasticity, characterizing the toughness of the article membrane material at deformation hereof;

Hi₁ (σ) - function of the thread length in the loop of basic interlacing depending on the linear modulus of the loop; f_L (c) - function of the elastic thread length in the loop depending on its tension;

[ K ] - matrix of rigidity of the model's material of the leg;

{ q } - transference of the central points on the corresponding sections in the global coordinate system.

This elaboration has been chosen as the prototype of the invention. Sections of the compressive knitted article are formed by basic threads of natural or synthetic fibers, by additional threads comprising a metallized coating of Ag, Au, Pt or AgTi, AgNi and other alloys and with the elastomeric threads. The difference of elasticity in different sections of the article is achieved by the changing the percentage of content of polyurethane threads and density of the knitting of basic interlacing. The known article allows to manufacture in the process of knitting the given distributions of pressure in the sections of the compressive knitted article as well as to produce bactericide, sterilizing and fast healing effects on the whole surface of the article enveloping the human body or in a specific region thereof, pursuant to the appropriate medical requirements. In addition to that, in the article, according to the prototype, there has been considered the mechanism of interaction of the article's membrane and the leg model at joint operation thereof, which allows increasing the efficiency of therapeutic effect of 'the compressive knitted article. However, if the fungal and bacterial infections are in a symbiosis when trophism of skin fibers and subcutaneous cellular tissues is damaged, it is advisable to have an opportunity of prolonged effect on the part of the article having a bactericide and simultaneously a reparative effect on the pathological part of the body. The known article does not allow to reach a prolonged bactericide effect and reparative bio-stimulating effect on the surface of the article enveloping the human body or locally, in order to renew normal function of epidermis.

[0010] Until now, there has not been elaborated a compressive article of closed geometric shape, manufactured with differential pressure from section to section of the article, or antiseptic bandaging material manufactured using elastic or non-elastic plaiting, using multicomponent threads having prolonged bactericide and reparative bio-stimulating effects applied for the prevention of development of fungal infections and treatment of complications caused by symbiotic bacterial and fungal infections as well as for the treatment and prevention of chronic venous insufficiency of lower extremities.

Summary of the invention

[0011] The objective of this invention is the manufacture of textile articles including a compressive product of closed geometric shape or an antiseptic bandaging material causing certain pressure on the enveloped surface of the human body and having a prolonged mechanism of effect of antiseptic and bio-stimulating agents.

[0012] The set goal is attained thanks to the fact that the compressive article has a closed geometric shape with knitted sections for therapeutic application, having at least a leg section, a foot section and the section of cervix the leg part between the leg section and the foot section. Moreover, the said sections of the compressive article have a differential pressure from section to section, and are developed with an elastic knitted structure, preferably combined, having the elastomer reinforced threads and basic threads in its composition. Basic interlacing, preferably the composite of multicomponent threads row after row, consists of at least two types of threads: the first type - threads with double even coating, the internal layer of threads is coated with a natural antiseptic, preferred is a 0.1 % solution of Viride nitens, the external layer metallized with Ag, Au, Pt, Zn, Cu etc or AgTi, AgNi and other alloys, the thickness of metallized coating being 50 ~ 2000 A; the second type - threads treated with humin substances, preferably with a 0.005 ~ 0.1 % solution of potassium humate.

[0013] In another preferred embodiment, antiseptic bandaging material for therapeutic application as bandage has a stripe of material of limited length, the width, being 5 to 15 cm. The antiseptic bandaging material is manufactured by weaving, preferably a composite of multicomponent threads row after row, by elastic or non-elastic plaiting. The plaiting includes at least two types of multicomponent weft threads: the first type of the threads includes double even coating, the internal layer of threads is coated with a natural antiseptic, preferred is a 0.1 % solution of Viride nitens, the external layer metallized with Ag, Au, Pt, Zn, Cu etc or AgTi, AgNi and other alloys, the thickness of metallized coating being 50 ~ 2000 A; the second type - threads treated with humin substances, preferably with a 0.005 — 0.1 % solution of potassium humate. The elasticity of the material is attained by alternation of introduced elastomer reinforced threads and basic threads, and it is permissible to use up to 80 % of natural threads, both basic threads and weft threads.

[0014] In another preferred embodiment, the material worked out by knitted structure or weaving or non-woven material, elastic or non-elastic plaiting, has the elastomer reinforced threads and basic threads in its composition. Basic interlacing, preferably the composite of multicomponent threads row after row, consists of at least two types of threads: the first type - threads with double even coating, the internal layer of the threads is coated with a natural antiseptic, preferred is a 0.1 % solution of Viride nitens, the external layer metallized with Ag, Au, Pt, Zn, Cu etc or AgTi, AgNi and other alloys, the thickness of metallized coating being 50 ~ 2000 A; the second type - threads treated with humin substances, preferably with a 0.005 ~ 0.1 % solution of potassium humate. The article takes the shape as a result of subsequent cutting out of parts according to the set form. [0015] In the context of this invention, the term "closed geometric shape" means that a compressive article manufactured by knitted structure or weaving elastic or non- elastic plaiting is a one-piece article or takes the shape as a result of subsequent cutting out of the parts in accordance with the set form and sewing the parts together. As claimed in [0012] and [0014], such products are: tights, stockings, knee-length socks, shinguards, wristlets, cuffs, elbow pads, gloves, T-shirts, shirts, drawers, tube- like article for partly amputated extremities etc.

[0016] In the context of this invention, the term "bandaging material" means that textile ..article worked .out byjcnitted structure -βr weaving JOX nβn-.w-Qyen .material, elastic or non-elastic plaiting, using a differential pressure or without pressure, acquire functional properties when it is given the shape of_a ring ox-spiral or is cut out according to the set form. As claimed in [0013] and [0014], such articles include: non- elastic bandage, elastic bandage, interfacing, bandage, etc.

Detailed description of preferred embodiments

[0017] As mentioned before, the patent JNb LV 13043 describes the production of antimicrobial and sterilizing effects by applying certain metals and their alloys, including Ag. The properties of metallized materials with Ag coating, used for medical purposes, have not been studied enough, and more frequently, silver is used to coat textile materials as decoration or for industrial purposes (10;l 1). Treatment of threads using humin substances and application hereof for medical purposes has not been known up to now.

[0018] However, in the process of developing the invention, there became available a compressive article of closed geometrical shape, manufactured with a differential pressure from one part to another part of the article, or antiseptic bandaging material that are worked out by elastic or non-elastic plaiting, using multicomponent threads, having a prolonged mechanism of effect of antiseptic and bio-stimulating agents that are used for the prevention of fungal infections and treatment of complications in the case of diseases caused by symbiotic bacterial and fungal infections as well as treatment and prevention of chronic venous insufficiency of lower extremities. The essence of the invention is explained by the figures, where in Fig. 1, there is the shape of a textile article of closed geometric shape, including the following sections: upper part of the article 1 - proximal part of the shin as far as the middle line of the muscle of a shin (m. gastrocnemius); narrowing of the upper part 2 - distal third of the shin; cervix of the upper part of the article 3 - ankle part; part of the foot 4 - foot; 5 - finite element, the articles membrane being divided into these. In Fig. 2, there is an interlacing, reflecting the composite of multicomponent threads in a knitted article, where 6 - a thread with a double antiseptic coating; 7 - Elastan thread; 8 - thread treated by humin substances; 9 - Elastan thread. In Fig. 3, there is depicted an interlacing in a woven non-elastic material, where 10 - basic thread, cotton thread; 11 - weft thread, cotton thread; 12 - weft thread with a double antiseptic coating; 13 - weft thread, cotton thread; 14 - weft thread, treated by humin substances. In Fig. 4, there is an interlacing in woven elastic material, where 15 - basic thread, cotton thread; 16 - basic thread, Elastan thread; 17 - weft thread, cotton thread; 18 - weft thread with double antiseptic coating; 19 - weft thread, cotton thread; 20 - weft thread treated by humin substances. [0019] In the process of developing the invention, the known Polyester, Acryl, Nylon, Polyethylene, and Polypropylene threads have been selected for the development of a compressive article. Preferably those should be Polyamide and Elastan, recommended for use in medicine for the manufacture of compressive articles. Elastan belongs to the general class of artificial elastan fibers (it is known in the USA and Canada as spandex, in Europe - LYCRA®) and is technically defined as segmented polyurethane.

[0020] In a preferred embodiment of the composites, the applied Polyamide threads are evenly coated with two types of composites, the first type of coating has a double layer - the internal one and the external one; the second type of coating has one layer. Based upon this, the term "multicomponent" threads comprise both one-layer and two-layer coatings of threads.

[0021] In a preferred embodiment of the composites, the applied Polyamide threads of the first type, as claimed in [0020], on all sides are evenly coated with a natural antiseptic, which is its internal layer. The following stages are at least included:

[0022] a) formation of reels and preliminary cleaning of threads; [0023] b) impregnation of threads with an antiseptic; [0024] c) drying and winding threads from reels to spools.

[0025] Concentration of antiseptic has been verified by a known method of spectrophotometric analysis (13).

[0026] In accordance with the invention as claimed in [0021], winding Polyamide threads from bobbins to reeling, i.e. formation of reels at the stage a) before preliminary cleaning of threads as claimed in [0022].

[0027] For preliminary cleaning of threads, at the performance of [0022] of stage a), it is preferred to use the known industrial cleaning machines securing the supply of water at t° = + 40° C with the addition of liquid antibacterial soap, with the following washing of threads by water and centrifugation of wringing of threads.

[0028] As claimed in the invention, in order to treat threads with a natural antiseptic, when performing [0023] of stage b), the use of the known industrial washing machines is preferred, and at the same time, impregnation of threads with a natural antiseptic, preferred with a 0.1% solution of Viride nitens, in distilled water at t⁰ = + 35⁰C, after which threads are wrung by centrifugation.

[0029] Threads treated with a natural antiseptic as claimed in [0028], are placed in drying chambers to perform [0024] of stage c), humidity of threads is set at the level of 3 - 5 %, and is controlled while drying by a known device, quartz moisture meter BK-I (12). [0030] In accordance with the invention, Polyamide threads of the first type as claimed in [0021], are evenly coated on all sides with a natural antiseptic, preferably a 0.1 % solution of Viride nitens, which is an internal layer.

[0031] The composite of a natural antiseptic on the treated threads, acquired in the process of developing of the invention, was studied by spectrophotometric analysis (13), which proved that the concentration of the natural antiseptic complied with the set standard.

[0032] As claimed in [0024] of stage c), threads from reels are wound to spools, in order to apply the external layer.

[0033] Treated Polyamide threads of the first type, as claimed in [0020], are evenly coated on all sides with metal or alloys being the external layer. The following stages are at least included:

[0034] a) feeding of spools and preliminary cleaning of the surface of threads, i.e. of the substate;

[0035] b) application of metallic layer to the substate' s surface; [0036] c) winding of threads from spools to bobbins.

[0037] The composites worked out in the process of developing the invention reveal adhesion between the metallic layer and substate, when passing the tape Tesa test.

[0038] As claimed in the invention, Polyamide threads are evenly coated with Ag, Au, Ag, Au, Pt, Zn, Cu and other or AgTi, AgNi and other alloys being the external level. The alloys display higher resistance corrosion, compared with the layers of pure metal. Based on that, the term "metallized" coating includes alloys. It is preferred to apply Ag, which is characterized by a high bactericide and sterilizing effect and is an antiseptic.

[0039] The thickness of metallized coating 50 ~ 2000 A, preferably 100 ~ 1200 A, as at these stages the composite reflects infrared radiation, ultraviolet radiation, protection from heat loss (14).

[0040] As claimed in the invention, the spools fed in a vacuum machine go through preliminary cleaning as claimed in [0034] of stage a), before applying a metallic layer as claimed in [0035] of stage b).

[0041] For primary purification, as claimed in [0034] when performing a), it is preferred to use glow discharge treatment in plasma-forming gas has been applied, as this method appears a promising one and it is a relatively efficient method of modification of the surface of practically any polymers before the application of coating. The most probable mechanism of the activation effect of a glow discharge is the formation of the electrets structure in the polymer's surface layer. A significant influence on the characteristics of the surface is exerted by the chemical processes proceeding on such surface as well as the formation of radicals under the influence of the components of a gas discharge. Owing to that, good adhesion between the metal and the substate is made possible. This accounts for the fact that it is preferred to use glow discharge treatment in plasma-forming gas in the invention, where glow discharge treatment in plasma-forming gas is carried out at a reduced pressure 5-10^"2 - HO^"1 mmHg.

[0042] Besides, for primary purification of the substate, glow discharge treatment in plasma-forming gas such as Ar is preferred, as the use of Ar provides good primary purification of the substate even after a short treatment.

[0043] Application of a metallic layer as claimed in [0035] at stage b), is preferred by using a magnetron sputtering machine. Magnetron sputtering has the following advantages: almost any alloy including refractory metals may be sputtered in this manner; more rapid condensation of materials; reduced contamination of condensate owing to entrapped gases; reduced temperature of the substate. In addition to the above, the use of vacuum metallization prevents pollution of the environment. Operation of a magnetron-sputtering machine is based upon the sputtering of a target cathode in an irregular glow discharge in heterogeneous crossed electric and magnetic fields. Target sputtering is carried out by argon ions at a high density of ion current owing to plasma localization close to the target, which was being sputtered, by means of powerful transverse magnetic and electric fields. This known technique of the application of coating is described in (15).

[0044] Metallic layer (thickness 50 ~ 2000 A, 100 ~ 1200 A is preferred) is applied.

[0045] According to the invention, Polyamide threads of the first type as claimed in [0033] on all sides are evenly coated with metal, the thickness of metallized coating to be 50 ~ 2000 A, 100 ~ 1200 A is preferred. It shall be the external layer.

[0046] As claimed in [0036] of stage c), in order to make threads of required length, winding of threads from spools to bobbins is carried out, so threads are be ready for processing on a seamless hosiery machine.

[0047] In the context of this research, passing the tape test means that, when attempting to remove a strip of a Tesa tape applied to the metallized, layer of the substate, the substate is either broken apart, or the Tesa tape may be removed without damaging the substate or without transferring the metal.

[0048] In a preferred embodiment of the composites, applied Polyamide threads of the second type as claimed in [0020], are evenly coated by humin substances on all sides. The following stages are at least included;

[0049] a) formation of reels and preliminary purification of threads;

[0050] b) treatment of treads with humin substances;

[0051] c) drying and winding of threads from reels to bobbins.

[0052] Concentration of humin substances has been verified by a known method of spectrophotometric analysis. [0053] According to the invention as claimed in [0048], winding of Polyamide threads from bobbins to reeling is performed, i.e. reels are formed at stage a), before a preliminary purification of threads as claimed in [0049].

[0054] For the preliminary purification of threads, when carrying out [0049] of stage a), it is preferred to use known industrial washing machines supplying water at t⁰ = + 40° C, with the addition of liquid antibacterial soap, with further washing of threads and wringing threads through centrifugation.

[0055] According to the invention, in order to treat threads with humin substances, a solution of potassium humate being preferred, when implementing [0050] of stage b), the known industrial washing machine is used, and at the same time even treatment of threads with 0.005 ~ 0,1 % solution of potassium humate, preferred 0.005 ~ 0.01%, in distilled water at t⁰ = + 30⁰C, following which threads are wrung by centrifugation. This concentration of potassium humate does not cause the destruction of Polyamide threads.

[0056] Potassium humate is manufactured by applying the known cavitations technology of extraction of humin substances (16), the essence of which the accelerated process of disperhion and extraction of humin substances from organic matter (peat or sapropel); chemical formula of humin substances, as one of the variants C₇₀H₇₅O₃₅N4. Cavitations technology is more promising, as the acquired humin substances are characterized by increased physiological activity owing to the fact that when this technology is applied, there increases the content of phenol structures that activate humin substances, by 2 - 3 times.

[0057] Threads that are treated with a potassium humate solution as claimed in [0055], are placed in drying chambers to perform [0051] of stage c), humidity of threads is set at the level of 5 - 9 %, and is controlled while drying by a known device, quartz moisture meter,

[0058] According to the invention, Polyamide threads of the second type as claimed in [0048], on all sides are evenly coated with a 0.005 ~ 0.01 % solution of potassium humate, which is one layer.

[0059] The composite of potassium humate on the treated threads, obtained during the developing of the invention, was studied by spectrophotometric analysis, which revealed that the concentration of potassium humate complied with the standard.

[0060] According to [0051] of stage c) threads are wound from reels to bobbins, which are ready for operation on a seamless hosiery machine.

[0061] In a preferred embodiment of the invention, multicomponent threads, along with Elastan threads are used for knitting on the whole shape (perimeter) of the compressive article of closed geometric shape. Either multicomponent threads are introduced to basic interlacing and along with Elastan threads are knitted on the given local section of an article.

[0062] Compressive article of closed geometric shape may be manufactured on a high-class one-cylinder or two-cylinder seamless hosiery machine according to a calculated process chart and a set knitting programme, allowing to manufacture a compressive article of closed geometrical shape that comprises sections of the upper part, narrowing of the upper part, foot and cervix of the upper part of the article, with the set distribution of pressure on the sections of the article.

[0063] Taking into account mechanical properties of the knitted article as well as biomechanical and geometrical parameters of a human body, as a variant of a human leg, there is carried out a calculation of a stressedly-deformed state of the article's membrane and that of the leg model, which allows, to determine the distribution of pressure in the article's membrane on the surface of the contact with a specific leg model, using a known method of finite elements, which is the most efficient in the case of mathematical modeling of stressedly-deformed state of the article's membrane and leg model (17). The relation of the deformation mode at the analysis of interaction of the leg model with the article's membrane is expressed with the following dependence:

Ψ ( E; m₁(σ); f_L (c) ) = F( [ Z ]; { ^ } ),

where Ψ ( E ; mj(σ); fL (c) ) - Functional article's membrane pressure;

E - modulus of longitudinal elasticity characterizing the toughness of the article's membrane material at deformation;

In₁(O) - function of the thread length in the basic interlacing loop, depending on the linear modulus of the loop; f_L (c) - function of the elastomeiic thread length in the loop depending on its tension;

[ K ] - rigidity matrix of the leg model's material;

{ q } - transference of the central points on the corresponding sections in the global co-ordinate system.

[0064] In another preferred embodiment of the invention, as claimed in [0013] antiseptic bandage material for therapeutic application is elaborated as a non-elastic bandage, worked out by weaving, preferably reps 2 x 2, on a rapier loom by a known method of manufacturing an article (18). A distinctive feature of this method is accounted for by the simultaneous passing of two weft threads: multicomponent threads, where multicomponent threads are alternated row after row, and natural ones, preferably cotton threads, the structure of interlacing including up to 80 % of natural threads, preferably cotton ones, that allow to manufacture antiseptic bandaging material - non-elastic bandage (Fig. 3). In Fig. 3, there is depicted the interlacing in the woven non-elastic material, where 10 is the basic thread, cotton thread; 11 - weft thread, cotton thread; 12 - weft thread with a double antiseptic coating; 13 - weft thread, cotton thread; 14 - weft thread, treated with humin substances.

[0065] According to this invention, Polyamide threads that are recommended for application to manufacture an antiseptic bandaging material, are coated with two types of composites, as claimed in [0021], [0033], [0048] that are multicomponent 12, 14 (Fig. 3) and are used as two types of weft threads, to manufacture a non-elastic bandage. [0066] According to this invention, natural threads that recommended to be used in medicine for the manufacture of antiseptic bandaging material are preferably cotton threads, which are basic threads 10 and weft threads 11, 13 (Fig. 3).

[0067] In a preferred embodiment of the composites, the applied cotton threads, as weft threads 11, 13 (Fig. 3), for those to acquire bactericide protection, are evenly coated on all sides by a natural antiseptic, preferred is a 0.1% solution of Viride nitens, as claimed in [0021], it being one layer of coating.

[0068] In a preferred embodiment of the composites, the applied cotton threads, as basic threads 10 (Fig. 3), to provide bactericide protection, are coated on all sides by a natural antiseptic, preferred being a 0.1% solution of Viride nitens, preferably by a 0,1% solution of Viride nitens, which is one layer of coating. The following stages are included, at least:

[0069] a) preliminary purification of threads and sterilization hereof; [0070] b) impregnation of threads with an antiseptic; [0071] c) drying of the surface of threads.

[0072] Concentration of antiseptic has been verified by a known method of spectrophotometric analysis.

[0073] According to the invention, as claimed in [0068], to perform preliminary purification of threads and sterilization hereof, as claimed in [0069] at stage a), there is performed warping of cotton threads to the warp-beam of the warping mill of SP type using a known method (19).

[0074] To perform [0069] of stage a), it is preferred to use the known chamber sizing machines ITIKB (RU) (12), that are installed one after another, besides, there is secured even supply of threads v - 25 m/min. from the warped beam to the first machine, which has a special bath, that comprises boiled distilled water with the addition of liquid antibacterial soap. In the next machine, at t⁰ = + 35 ° C, threads are washed by distilled water and are transferred to a drying chamber, wherefrom they are transferred to the final chamber, where γ-sterilization is taking place by a known method (20).

[0075] In order to impregnate threads with an antiseptic, when performing [0070] of stage b), it is preferred to use the known chamber sizing machines SKB, besides, there is secured even supply of threads v = 25 m/min. from the warped beam to the machine having a special bath, that will consist of the solution of a natural antiseptic, 0.1% solution of Viride nitens is preferred, in distilled water.

[0076] Threads treated with a natural antiseptic as claimed in [0075], are transferred to a drying chamber of the sizing machine IHKB to pass stage [0071] c), and the humidity of threads is set within the limits of 4 - 5%, and is controlled in the process of drying by a known device, the quartz moisture meter. [0077] In a preferred embodiment of the composites, cotton threads, as basic threads, as claimed in [0068], are evenly coated on all sides with a natural antiseptic, preferred is a 0.1% solution of Viride nitens, it being one layer of coating.

[0078] The natural antiseptic composite on the treated cotton threads that is obtained in the invention, was studied by spectrophotometric analysis, which revealed the concentration of a natural antiseptic being within the established standard norm.

[0079] According to the invention, when manufacturing an antiseptic bandaging material, non-elastic bandage, the structure of basic interlacing includes up to 80 % of natural threads, preferred being cotton threads. Besides, at the final stage of the manufacture of the said article, it is not required to treat the article's edges due to the fact that in the process of weaving, if two weft threads, a multicoraponent one and cotton one, are fed simultaneously, as a result of the twisting moment, transferred by rapier loom, threads are twisted. The angle of contact α of threads rises, and the coefficient of friction μ between threads increases, which results in the increase of force of adhesiveness of threads by e^μα times; this force preventing multicόmpόήeήt threads from slipping out of the material structure when using the article.

[0080] In another preferred embodiment, as claimed in [0013], antiseptic bandaging material is used for therapeutic reason as elastic bandage, and it is worked out by weaving, reps 2 x 2 preferred, on a rapier narrow loom, by a known method of manufacturing an article (18). A distinctive feature of this method is accounted for by the simultaneous passing of two weft threads: raulticomponent threads obtained as claimed in [0021], [0033], [0048], where multicomponent threads are alternated row after row in the process of weaving, and natural ones, preferably cotton threads, that allow to obtain antiseptic bandaging material - elastic bandage (Fig. 4). Material elasticity is achieved by alternation of introduced reinforced elastomer threads with basic threads. Fig. 4 shows interlacing in woven elastic material, where 15 - basic thread, cotton thread; 16 - basic thread, Elastan thread; 17 - weft thread, cotton thread; 18 - weft thread with double antiseptic coating; 19 - weft thread, cotton thread; 20 - weft thread, treated with hurniή substances.

[0081] In another preferred embodiment, the material that was worked out by knitted structure or weaving or non-woven material, elastic or non-elastic interlacings, comprises a reinforced elastomeric threads and basic threads. Basic interlancing, preferred being the combination of raulticomponent threads row after row, consists of at least two types of threads: the first one with a double even coating, the internal layer being coated with a natural antiseptic, preferred is a 0.1 % solution of Viride nitens, the external one is metallized with Ag, Au, Pt, Zn, Cu and other alloys of AgTi₅ AgNi and others^ the thickness of metallized coating being 50 ~ 2000 A; the second type - threads are treated with humin substances, preferred being treatment with a 0.005 ~ 0.1% solution of potassium humate. The article takes its shape as a result of subsequent cutting out of parts in accordance with the elaborated profiles and with treatment or without treatment of edges of the specified article or by sewing the article according to the set form.

[0082] The underlying object of the invention is satisfied by the following: a compressive article of closed geometric shape has been manufactured with knitted sections to be used for therapeutic purposes, which has at least a section of the article's upper part, the foot section and the cervix of the article's upper part between the parts of foot and the upper part. Besides, the specified sections of the compressive article are characterized by differential pressure from part to part and are worked out by elastic knitted interlacing, preferred combined interlacing, comprising reinforced elastomeric threads and basic threads. Basic interlacing, preferred being the combination of multicomponent threads row after row, consists of at least two types of threads: the first type - threads with double even coating, where the internal layer of threads is coated with a natural antiseptic, preferred being a 0.1% solution of Viride nitens, and the external one is metallized with Ag, Au, Pt, Zn, Cu and other or alloys of AgTi, AgNi and others, the thickness of metallized coating 50 ~ 2000 A; the second type - threads are treated with humin substances, preferred is a 0.005 ~ 0.1 % solution of potassium humate. Besides, the article is characterized by a prolonged mechanism of effect of antiseptic and bio-stimulating agents.

[0083] The underlying object of the invention is satisfied by the following: an antiseptic bandaging material for therapeutic application is used as bandage having a strip of limited length, the width of 5 to 15 cm. Antiseptic bandaging material is developed by woven interlacing, preferred being the combination of multicomponent threads row after row, elastic or non-elastic interlacing. The interlacing comprises at least two types of multicomponent weft threads: the first type of threads that comprises double even coating, the internal layer of threads coated with a natural antiseptic, preferred a 0.1% solution of Viride nitens, the external one metallized with Ag, Au, Pt, Zn, Cu and others or AgTi, AgNi and other alloys, the thickness of metallized coating being 50 ~ 2000 A; the second type - threads treated with humin substances, preferably with a 0.005 ~ 0.1 % solution of potassium humate. The elasticity of the material is attained by alternation of introduced elastomer reinforced threads and basic threads, and it is permissible to use up to 80 % of natural threads, both basic threads and weft threads, preferred cotton threads — both basic threads and weft threads. Besides, the article is characterized by a prolonged mechanism of effect of antiseptic and bio-stimulating agents.

[0084] The underlying object of the invention is satisfied by the following: there is attained a material that is worked out by knitted structure or weaving or non-woven material, elastic or non-elastic weaving that comprises a reinforced elastomeric threads and basic threads. Basic interlacing, preferred composite of multicomponent threads row after row, consists of at least two types of threads: the first type - threads with double even coating, the internal layer of threads is coated with a natural antiseptic, preferred is a 0.1% solution of Viride nitens, the external layer is metallized with Ag₅ Au, Pt, Zn, Cu and others or AgTi, AgM or other alloys, the thickness of metallized coating being 50 ~ 2000 A; the second type - threads treated with humin substances, preferably with a 0.005 ~ 0.1 % solution of potassium humate. The article takes the shape as a result of subsequent cutting out of parts according to the set form. Besides, the article is characterized by a prolonged mechanism of effect of antiseptic and bio-stimulating agents.

[0085] The invention is expounded more in detail in this example, but is not limited to this example. Example

[0086] The most popular group of medical products is hosiery and tights, that is, products of closed geometric shape (21). That is why the specific example of the manufacture of a compressive article with multicomponent threads in its structure is left for this case. This specific example is worked out for a compressive product - a knee-length sock that was elaborated with compressive pressure, in accordance with the invention as claimed in [0012]. This example is elaborated for a compressive article of size 5 (height 170-176 cm; foot size 26-27 cm) and recommended distribution of pressures on the sections of the article, namely: 1 - upper part - 19 mmHg; 2 - narrowing of the upper part - 20 mmHg; 3 - cervix of the upper part - 22 mmHg; 4 - foot - 22 mmHg (Fig.1).

[0087] The compressive article was manufactured on a circular knitting machine EBA 4R, 34 cl., with the diameter of the needle cylinder 3 ³A", 400 needles. Tex threads, correspondingly: Polyamide - 5,0 tex (Technical Standard 6-13-31-90), Elastan - 15,6 tex, twisted by Polyamide thread 3,3 x 2 tex (Technical Standard 6-06-0196-85).

[0088] During calculations, the compressive article was considered as final. The design size of each section was determined in accordance with the standard of figure management to design mass hosiery (ISO 8559 1989-C7).

[0089] The compressive article was elaborated by combined interlacing (Fig.2), where 6 - thread with double antiseptic coating; 7 - Elastan thread; 8 - thread treated with humin substances; 9 - Elastan thread. Elastomeric thread was knitted through in every second row by jacquard structure, with the index of jacquard loop 1 + 1. The basic interlacing is plated, preferred composite being multicomponent threads row after row, including each of multicomponent thread being knitted simultaneously with a Polyamide thread (basic thread) without coating. Such row after row composite of multicomponent threads prevents inhibiting effect of threads with humin coating with respect to threads with double antiseptic coating.

[0090] Basic interlacing of multicomponent threads, according to the invention, consists of at least two types of threads: the first type - threads 6 (Fig. 2) with double even coating, the internal layer of threads being covered with a natural antiseptic, preferred a 0.1 % solution of Viride nitens, the external one is metallized with Ag, Au, Pt, Zn, Cu and others or AgTi, AgNi and other alloys, the the thickness of metallized coating being 50 ~ 2000 A; the second type - threads 8 (Fig.2), treated with humin substances, preferably with a 0.005 ~ 0.1 % solution of potassium humate.

[0091] In a preferred embodiment of composites, the applied Polyamide threads 5.0 tex, type one, were evenly coated on all sides by a natural antiseptic, which was an internal layer.

[0092] According to the invention, before the preliminary purification of the surface of Polyamide threads, there were formed reels, i.e. threads were wound from bobbins to reeling.

[0093] For preliminary purification of threads, an industrial washing machine was used, which secured the supply of water at t⁰ = + 40 ° C with the addition of liquid antibacterial soap, with subsequent washing of threads by water and by wringing of threads by centrifegation.

[0094] According to the invention, for the treatment of threads with a natural antiseptic, there was used an industrial washing machine, and during the said treatment, impregnation of threads by a natural antiseptic was performed, preferably by a 0.1% solution of Viride nitens, in distilled water at t⁰ = + 35⁰C, following which threads were wrung by eentrifugation. _;

[0095] Polyamide threads, treated with a natural antiseptic were placed in drying chambers. Humidity of threads was set at the level of 3 - 5 %, and was controlled while drying by a quartz moisture meter.

[0096] In accordance with the invention, Polyamide threads of the first type are evenly coated on all sides with a natural antiseptic, preferably a 0.1% solution of Viride nitens, which is an internal layer.

[0097] The composite of a natural antiseptic on the treated threads, acquired in the process of developing of the invention, was studied by spectrophotometric analysis, which proved that the concentration of the natural antiseptic complied with the set standard.

[0098] In order to apply the external layer of coating on the Polyamide threads that _x had been treated with a natural antiseptic, threads were wound from reels to spools.

[0099] The treated Polyamide threads 5.0 tex, type one, were evenly coated by metal on all sides, the metal being the external layer.

[0100] According to the invention, Polyamide threads were evenly coated by Ag.

[0101] Thread spools that had been treated by a natural antiseptic were installed in the holder was attached to the holder of the vacuum chamber (UV-I VL) at the height of 20 cm from the magnetron device. In order to secure even coating with metal, there was performed forced pumping movement of threads over the evaporator, which was transferred owing to the movement of the holders to the spools. Further, the working chamber was vacuumized to 10^'3 mmHg. Preliminary activation and glow discharge treatment were performed at the reduced pressure of 10^"1 mmHg with argon as a working gas. The discharge voltage was about 1300 V, the current strength 0.1 A; frequency 50 Hz. The processing was performed in a dynamic gas mode. Further, glow discharge was switched off and plasma-forming gas was supplied. Working volume was pumped out until 10^"4 mmHg. Next, argon was filled again to the working pressure of 10^'3 mmHg and a magnetron sputterer was switched on. Target sputtering was carried out by argon ions at a high density of ion current owing to plasma localization close to the target, which was being sputtered, by means of powerful transverse magnetic and electric fields. Ag layer was being formed on the surface of the substate, at the speed of condensation of 0.4 microns/min. The thickness of Ag layer depends on the duration of influence as well as on the capacity of the evaporator.

[0102] The thickness of metallized coating - 50 ~ 2000 A, preferred - 100 - 1200 A. [0103] The thickness of the metal layer was determined by the known interference method on a glass plate.

[0104] Pursuant to the invention, Polyamide threads of the first type are metallized, Ag is preferred, the thickness of silver coating being 50 ~ 2000 A, preferred 100 ~ 1200 A, which is the external layer.

[0105] In order to determine adhesion between the, metallic layer and the substate in these composites, a tape test was conducted. A strip of Tesa tape was applied to the metallized layer. An attempt to remove Tesa from the tape ended in that no metal was removed from the tape.

[0106] Polyamide threads with double even coating of type one was wound from spools to bobbins, which were ready for operation on a seamless hosiery machine.

[0107] In a preferred embodiment of composites, the applied Polyamide threads 5.0 tex of type two were evenly coated on all sides by a solution of humin substances, preferred being a solution of potassium humate, which was one layer.

[0108] According to the invention, before the preliminary purification of the surface of Polyamide threads, reels were formed, i.e. threads were wound from bobbins to reeling.

[0109] For the preliminary purification of threads, there was used a known industrial washing machine supplying water at t⁰ = + 40° C, with the addition of liquid antibacterial soap, with further washing of threads and wringing threads through centrifugation.

[0110] According to the invention, in order to treat threads with humin substances, a solution of potassium humate was preferred, an industrial washing machine was used, and at the same there was secured even treatment of threads with 0.005 ~ 0,1 % solution of potassium humate. preferred 0.005 ~ 0.01%, in distilled water at t⁰ = +30⁰C, following which threads were wrung by centrifugation.

[0111] Polyamide threads treated with a solution of potassium humate, were placed in drying chambers. Humidity of threads was set at 5 - 9 %, and was controlled while drying by a quartz moisture meter.

[0112] According to the invention, Polyamide threads of type two on all sides are evenly coated with a 0.005 ~ 0.01 % solution of potassium humate, which is one layer.

[0113] The composite of potassium humate on the treated threads, obtained during the developing of the invention, was studied by spectrophotometric analysis, which revealed that the concentration of potassium humate complied with the standard.

[0114] Polyamide threads that were treated with a solution of potassium humate, were wound from reels to bobbins, which were ready for operation on a seamless hosiery machine. [0115] The length of threads in loops was determined for basic sections taking into account its stretch ability to comply with the leg's size, as well as practical limits of the length of threads in a loop, which could be obtained on this seamless hosiery machine.

[0116] In the case of known meanings of modulus of loop σ_ls the length of threads in the loop of basic interlacing was determined in accordance with the formula (22):

£ = O_HC/I + K(T)^1/2; where I is the length of threads in the loop of basic interlacing, mm;

O_H - leg for the appropriate section of a compressive article, mm;

T - linear density of threads, tex;

I - the number of needles on a seamless hosiery machine;

C - coefficient of stretch ability, C = 1.85 (22);

K - the constant, which characterizes the type of raw materials, K = 0.23 (22).

[0117] The loop structure of jacquard elastomeric threads approximated as a sinusoid, whereas the length of elastomeric threads in the loop depending on its tension was at

where £L is the length of elastomeric threads in the loop, mm; c — the height of the sinusoid arc or amplitude, which depends on the tension of elastomeric threads, that is served in the loop-forming system, mm; ω - Frequency of sinusoid, <a = 2π/A, mm^'1;

A - loop step of elastomeric threads in the repeat of interlacing, which equals the period of sinusoid, mm; x - the current meaning of the argument, in the chosen interval of division of sinusoid.

This formula has a core difference from the existing formulae to calculate the length of elastomeric threads in the loop. It allows calculating the length of elastomeric threads in the loop 'with any form and composite of elements of loop structure depending on the tension of elastomeric threads. In addition to that, the calculation in accordance with this formula enables to plan the consumption of elastomeric threads at the stage of designing of the compressive article as well as to design the article with a previously set dimensions for a ready-made article and a differentiated pressure on the sections of the compressive article.

[0118] The number of courses for each section of the compressive article was determined in accordance with the height of the course that was determined according to the empirical formula:

B = α ₁ £ - α ₂ A- α₃ T^1/2, where B is the height of the course in the examined section of the compressive article, mm;

I - length of threads in the loop of basic interlacing, mm; on, Ot₂, (X₃ - multipliers of the first, second and third members of the formula, characterizing the properties of knitted fabric of this interlacing and threads;

A - course of basic interlacing on the examined section of the compressive article, mm;

T - linear density of threads, tex.

[0119] The programme of knitting of the compressive article on a seamless hosiery machine was set according to a calculated process chart and the article was manufactured. Following that the compressive article went through a finishing treatment.

[0120] The compressive article or the article's membrane consists of basic loops of Polyamide threads of various length for each calculated part of the article, and Elastan threads account for the elastic deformation of the article. These Elastan threads are knitted with a constant tension, according to an estimated process chart. Elastan threads do not only contribute to the compact adjoining of the article's membrane to the human body, but also create the set distribution of pressures on the corresponding sections of the compressive article.

[0121] Verification of stretch ability of the ready-made compressive article was conducted on the section 3 of cervix of the upper part of the article (Fig.l) according to State Standard 3813-72, which enabled to reason about adequate operating practices of manufacture of a compressive article.

[0122] In order to determine the distributed pressure on the surface of contact of the article's membrane and the human leg's mode, there were previously studied the mechanical characteristics of the material of patterns along and across loop rows on the sections of the compressive article, which are characterized by the modulus of elasticity Ey, (where i, j - axes of orthogonal coordinate system, i, j - 1, 2 ); shear modulus - Gy and Poisson's coefficient - μy. Following the processing of the experiment's results and the study of structural characteristics of the compressive article (Ph, Pg, £) that are controlled in the process of knitting, the following figures were acquired for the indicated sections of the article (see Table I).

Table I. Mechanical and structural characteristics of the material of patterns on the sections of the compressive article

where P₁, is the density of loopy structure of the basic interlacing vertically; P_g - density of loopy structure of the basic interlacing horizontally.

[0123] There were established geometrical and biomechanical characteristics of the material of the leg model taking into account biological peculiarities of the leg materials (leg model on the part of the shin is represented as the sector of tibia (24) and the shin's muscular tissue). Geometrical characteristics of muscular tissue, i.e. perimeters of the part of the shin, were measured at the level of the ankle, the centerline of the muscle m.gastrocnemius and the popliteal section, and the length of the shin was measured from the popliteal section to the ankle. As a biomechanical evaluation of the condition of the shin muscle, there was applied the rigidity of muscular tissue, which is characterized by the modulus of elasticity Ey, (where i, j - axes of orthogonal coordinate system, i, j = 1, 2 ); shear modulus - Gy and Poisson's coefficient - μij. Based upon dissipative losses of mechanical energy in the oscillation process of the muscle, which was assessed according to the decrement of oscillations, there was determined the rigidity of the muscular tissue of the leg (25), (see table II).

Table II. Biomechanical characteristics of the material of the model legs

[0124] Taking into account the mechanical characteristics [0122], and based upon the finite element representation 5 (Fig. 1) of the article's membrane, as well as biomechanical and geometrical parameters of the human leg [0123], there was determined the distribution of pressure in the article's membrane on the surface of the contact with a specific leg model. Thus, the pressure in each point of the article's membrane was determined taking into account structural and mechanical characteristics of material of each section of the compressive article, estimated for actual geometric and biomechanical parameters of the material of the leg model, based on the stressedly-deformed state when analyzing the interaction of the leg model with the article's membrane.

[0125] A compressive article of closed geometric shape was manufactured - a knee- length stocking, securing the distribution of pressure on the enveloped surface of the body in accordance with the established medical recommendations, namely: cervix of the upper part - 22 rnmHg; narrowing of the upper part of the article (as far as the middle line of the muscle of a shin m. gastrocnemius) - 20 mrnHg; upper part of the article - 19 rnmHg. This estimation of distributed pressure has a core advantage compared with the known medical products, as the pressure in each point of the article's membrane is determined taking into account structural and mechanical characteristics of the material of each section of the compressive article, estimated for actual geometric and biomechanical parameters of the material of the leg model, based on the stressedly-deformed state when analyzing the interaction of the leg model with the article's membrane.

[0126] A compressive article of closed geometric shape was manufactured - a knee- length stocking, with multicomponent threads in its structure. Basic interlacing of threads, preferred combination of multicomponent threads row after row, consists of at least two types of threads: the first type - threads with double even coating, the internal layer of threads being covered with a natural antiseptic - a 0.1 % solution of Viride nitens, the external one is metallized with Ag. The thickness of metallized layer is 100 ~ 1200 A. The second type - threads are treated with a 0.005 ~ 0.01 % solution of potassium humate. This type of article with multicomponent threads in its structure has core advantages compared with the known medical products, as ions of metal, in particular, of silver, being the external layer on multicomponent threads, are preserved in active form, which was proved by an X-ray diffract-meter analysis. In addition to that, multicomponent threads treated with humin substances stimulate the activity of epidermis and contribute to the regeneration of healthy sections of skin.

[0127] Another core advantage of the compressive article is the mechanism of operation of multicomponent threads, which consists in the following: when a person is wearing a compressive article, ions of metal from the external layer of metallized threads (of type one) are transferred to the human body, thus preventing from the development of bacteria, fungi and viruses. In the case of weeping skin process the ions of metal actively transfer to the area of affection of skin, and, when in contact with the surface of the skin, multicomponent threads are left without the metallized external coating characterized by antimicrobial activity. The bactericide effect in this case is maintained thanks to antiseptic coating of the internal layer of threads (Viride nitens). Threads with a humin coating (of the second type) stimulate the biogenic activation in order to restore normal function of epidermis. A prolonged mechanism of action of antiseptic and bio-stimulating agents of multicomponent threads, which cause a medical effect.

[0128] Bactericide properties of multicomponent threads (of the first type) comprised in the structure of a compressive article have been studied on Agar plates according to method (26). To conduct a comparative analysis, the material without an antiseptic coating threads was studied - refer to table HI. Table III. The efficacy of silver coating

[0129] As proved by the research, according to table III, the external layer on multicomponent threads, which comprise a silver coating, within 24 hours has fully blocked the development of a colony of Staphylococcus Aureus bacteria, where as on the surface of the control material, the number of colonies of bacteria has increased by 21 times.

[0130] The period of preservation of bactericidal action of multicomponent threads (with an antiseptic coating) being a component of the compressive article was verified repeatedly (within one year, two years, three years) and was conducted according to [0128]. The conducted research proved the presumption that bactericidal properties of a compressive article are preserved for 3 years and longer.

[0131] As claimed in the invention, a compressive article of closed geometrical shape with knitted sections was manufactured for therapeutic purposes. The said article has at least a section of the upper part of the article and a section of the cervix of the upper part, between the sections of foot and the upper part of the article. At the same time, the said sections of the compressive article are characterized by a differential pressure from section to section and are worked out by elastic knitted structure, preferred being combined structure comprising a reinforced elastomeric threads and basic threads. The basic interlacing of threads, preferred being the composite of multicomponent threads row after row, at least two types of threads: the first type - threads with double even coating. The internal layer of threads is covered with a natural antiseptic, preferred being 0.1% of a solution of Viride nitens, the external layer - metallized with Ag, Au, Pt, Zn, Cu and others or AgTi, AgNi and other alloys. The thickness of metallized layer is 50 ~ 2000 A. The second type - threads are treated with humin substances, preferred being a 0.005 ~ 0.1 % solution of potassium humate. The manufactured compressive article is essentially different from the known medical products, as ions of metal and humin substances are preserved on multicomponent threads in the active form; the estimate of distributed pressure, at the stage of design of compressive product take into account complex mechanical characteristics of the article's membrane, biomechanical and geometrical characteristics of the human leg model. The said advantages allow manufacturing a compressive article causing a specific pressure on the enveloped surface of the human body and possessing a prolonged mechanism of action of antiseptic and bio- stimulating agents. [0132] As claimed in the invention, the manufactured articles may be used for the prevention of development of fungal infections and treatment of complications in the case of diseases caused by bacterial and fungal infections, to facilitate the treatment and prevention of venous insufficiency and its pathologies as well as to improve the condition of patient feet in the case of diabetes mellitus.

References

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Claims

Claims

1. Textile article comprising metallic threads in basic interlacing, is characterized in that metallic threads have a double even coating, in which the internal layer of threads contains a natural antiseptic, the external layer is with metallization, and the textile article comprise threads that contain humin composites, and where threads with a double even coating and threads containing humin composites are multicomponent.

2. Textile article as claimed in claim 1, is characterized in that the textile article has a closed geometric shape, having knitted structure or weavings, elastic or non-elastic plaiting, with a differentiated pressure or without pressure, and is one-piece article or takes a shape as a result of subsequent cutting out of components according to a desired shape and sewed together, such as tights, stockings, knee-length socks, shin guards, wristlets, cuffs, elbow pads, gloves, T-shirts, shirts, drawers, tube-like article for partly amputated extremities etc.

3. Textile article as claimed in claim 1, is characterized in that the bandaging-like article, having knitted structure or weavings or non-woven material, elastic or non- elastic plaiting, with a differentiated pressure or without pressure, acquiring functional properties when taking shape of a ring or a spiral or that are cut out according to a desired shape, such as: non-elastic bandage, elastic bandage, interfacing, bandages etc.

4. Threads having a double even coating, for the manufacturing of textile article as claimed in claims 1, 2 or 3, are characterized in that the internal layer of threads has a coating of natural antiseptic called Viride nitens.

5. Threads impregnated with natural antiseptic as claimed in claim 4, are characterized in that the Viride nitens are taken as a solution at the concentration of 0.1%.

6. Threads having a double even coating, for the manufacturing of textile articles, as claimed in claims 1, 2 or 3, are characterized in that the external layer of threads has a metallized coating with Ag, Au, Pt, Zn, Cu and other or alloys of AgTi, AgNi and others.

7. Threads having metallized coating as claimed in claim 6, are characterized in that the thickness of the metallized layer being 50 ~ 2000 A.

8. Threads with the coating of humin composites, for the manufacturing of textile article, as claimed in claims 1, 2 or 3, are characterized in that the humin composites are potassium humates.

9. Threads having the coating of humin composites as claimed in claim 8, are characterized in that the potassium humate is taken as a solution at the concentration of0.005 ~ 0,l%.

10. Textile article in the basic interlacing containing threads where at least one kind of threads has a double even coating and the threads with the coating of humin composites as claimed in claims 1, 2 or 3, is characterized in that basic interlacing of threads includes up to 80 % of natural threads as basic threads.

11. Textile article in the basic interlacing containing threads with at least one kind of threads has a double even coating and threads with the coating of humin composites as claimed in claim 1, 2 or 3, is characterized in that the basic interlacing of threads includes up to 80 % of synthetic threads as basic threads.

12. The method for obtaining a textile article as plaimed in claims 1_? 2 or 3, is characterized in that the basic interlacing of threads is worked out of at least threads with a double even coating, where the internal coating of threads contains a natural antiseptic, preferably as 0.1 % solution of Viride nitens, the external layer metallized with Ag, Au₅ Pt, Zn, Cu and other, AgTi, AgNi and other alloys, the thickness of metallized coating being 50 ~ 2000 A.

13. The method for obtaining a textile article as claimed in claims 1, 2 or 3, is characterized in that basic interlacing of threads is worked out of at least threads containing humin composites, preferably as 0.005 ~ 0.1 % solution of potassium humate.

14. The method for obtaining a textile article as claimed in claim 12, is characterized in that the basic interlacing is worked out of at least threads with even coating of one layer of Ag, Au, Pt, Zn, Cu and others or AgTi, AgNi and other alloys, the thickness of metallized coating being 50 ~ 2000 A.

15. The method for obtaining a textile article as claimed in claims 1, 2 or 3, is characterized in that a local section of basic interlacing is worked out of at least threads with a double even coating and threads containing humin composites coating.

16. The method for obtaining a textile article as claimed in claim 15, is characterized in that the local section of basic interlacing, is worked out of at least threads with a double even coating, the internal layer of threads containing a natural antiseptic, preferably being 0.1 % solution of Viride nitens, the external layer being metallized with Ag, Au, Pt, Zn, Cu and others or alloys of AgTi, AgNi and others, the thickness of metallized coating being 50 ~ 2000 A.

17. The method for obtaining a textile article as claimed in claim 15, is characterized in that the local section of basic interlacing, is worked out of at least threads containing humin composites, preferably as a 0.005 ~ 0,1 % solution of potassium humates.

18. The method for obtaining a textile article as claimed in claim 16, is characterized in that the local section of basic interlacing, is worked out of at least threads with the even coating of one layer of Ag, Au, Pt, Zn, Cu and others or AgTi, AgNi and other alloys, the thickness of the metallized layer being 50 ~ 2000 A.

19. The method for obtaining a textile article that contaned knitted structure or weavings as claimed in claim 2, is characterized in that basic interlacing is worked out of: elastic threads, basic threads and muiticomponent threads, so that in the basic interlacing, it is preferred to combine muiticomponent threads row after row.

20. The method for obtaining a textile article that contained knitted structure or weavings as claimed in claim 2, is characterized in that the basic interlacing is worked out of: basic threads and multicomponent threads, so that in basic interlacing, it is preferred to combine multicomponent threads row after row.

21. The method for obtaining a textile article that contained knitted structure or weavings as claimed in claim 3, characterized in that the basic interlacing is worked out of: elastic threads, basic threads and multicomponent threads, so that in the basic interlacing, it is preferred to combine multicomponent threads row after row.

22. The method for obtaining a textile article that contained knitted structure or weavings as claimed in claim 3, characterized in that the basic interlacing, is worked out of: basic threads and multicomponent threads, so that in the basic interlacing, it is preferred to combine multicomponent threads row after row.