WO2006084882A3 - Substituierte 4-(indol-3-yl)chinazoline und ihre verwendung - Google Patents

Substituierte 4-(indol-3-yl)chinazoline und ihre verwendung Download PDF

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Publication number
WO2006084882A3
WO2006084882A3 PCT/EP2006/050813 EP2006050813W WO2006084882A3 WO 2006084882 A3 WO2006084882 A3 WO 2006084882A3 EP 2006050813 W EP2006050813 W EP 2006050813W WO 2006084882 A3 WO2006084882 A3 WO 2006084882A3
Authority
WO
WIPO (PCT)
Prior art keywords
indol
substituted
quinazolines
salts
protein kinase
Prior art date
Application number
PCT/EP2006/050813
Other languages
English (en)
French (fr)
Other versions
WO2006084882A8 (de
WO2006084882A2 (de
Inventor
Werner Loewe
Anja Lueth
Original Assignee
Freie Universtiaet Berlin
Werner Loewe
Anja Lueth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Freie Universtiaet Berlin, Werner Loewe, Anja Lueth filed Critical Freie Universtiaet Berlin
Priority to EP06708157A priority Critical patent/EP1846396A2/de
Publication of WO2006084882A2 publication Critical patent/WO2006084882A2/de
Publication of WO2006084882A3 publication Critical patent/WO2006084882A3/de
Publication of WO2006084882A8 publication Critical patent/WO2006084882A8/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Die vorliegende Erfindung betrifft die Verwendung substituierter 4-(Indol-3-yl)chinazoline oder eines ihrer Salze zur Hemmung der Proteinkinaseaktivität, insbesondere der EGF- rezeptorspezifischen Tyrosinproteinkinase, zur Behandlung von Tumorerkrankungen, Osteoporose oder proliferativen Epidermiserkrankungen, sowie neuartige substituierte 4-(Indol-3-yl)chinazoline oder eines ihrer Salze und Verfahren zu deren Herstellung. Die Erfindung bezieht sich ferner auf die Verwendung substituierter 4-(Indol-3- yl)chinazolin-Derivate oder eines ihrer Salze zur Hemmung der Proteinkinaseaktivität, insbesondere im Pflanzenschutz im Rahmen der Entwicklung fungizider, herbizider oder insektizider Wirkstoffe.
PCT/EP2006/050813 2005-02-11 2006-02-09 Substituierte 4-(indol-3-yl)chinazoline und ihre verwendung WO2006084882A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06708157A EP1846396A2 (de) 2005-02-11 2006-02-09 Substituierte 4-(indol-3-yl)chinazoline und ihre verwendung

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005007151.1 2005-02-11
DE102005007151 2005-02-11

Publications (3)

Publication Number Publication Date
WO2006084882A2 WO2006084882A2 (de) 2006-08-17
WO2006084882A3 true WO2006084882A3 (de) 2006-12-07
WO2006084882A8 WO2006084882A8 (de) 2007-06-07

Family

ID=36673507

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/050813 WO2006084882A2 (de) 2005-02-11 2006-02-09 Substituierte 4-(indol-3-yl)chinazoline und ihre verwendung

Country Status (2)

Country Link
EP (1) EP1846396A2 (de)
WO (1) WO2006084882A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008009609A1 (de) * 2008-02-18 2009-08-20 Freie Universität Berlin Substituierte 4-(Indol-3-yl)chinazoline und deren Verwendung und Herstellung
AU2013312477B2 (en) 2012-09-06 2018-05-31 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
CN111087391A (zh) * 2020-01-06 2020-05-01 郑州大学 4-吲哚喹唑啉类化合物及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039145A1 (en) * 1995-06-06 1996-12-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of her-2 autophosphorylation properties
WO2003055877A1 (en) * 2001-12-21 2003-07-10 Astrazeneca Ab Use of oxindole derivatives in the treatment of dementia related diseases, alzheimer's disease and conditions associated with glycogen synthase kinase-3

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039145A1 (en) * 1995-06-06 1996-12-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of her-2 autophosphorylation properties
WO2003055877A1 (en) * 2001-12-21 2003-07-10 Astrazeneca Ab Use of oxindole derivatives in the treatment of dementia related diseases, alzheimer's disease and conditions associated with glycogen synthase kinase-3

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ALEXANDER J. BRIDGES: "Chemical Inhibitors of Protein Kinases", CHEM. REV., vol. 101, 2001, pages 2541 - 2571, XP002391601 *

Also Published As

Publication number Publication date
WO2006084882A8 (de) 2007-06-07
WO2006084882A2 (de) 2006-08-17
EP1846396A2 (de) 2007-10-24

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