WO2007076460A3 - Substituted thiazole ureas useful as inhibitors of protein kinases - Google Patents

Substituted thiazole ureas useful as inhibitors of protein kinases Download PDF

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Publication number
WO2007076460A3
WO2007076460A3 PCT/US2006/062524 US2006062524W WO2007076460A3 WO 2007076460 A3 WO2007076460 A3 WO 2007076460A3 US 2006062524 W US2006062524 W US 2006062524W WO 2007076460 A3 WO2007076460 A3 WO 2007076460A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitors
protein kinases
substituted thiazole
ureas useful
present
Prior art date
Application number
PCT/US2006/062524
Other languages
French (fr)
Other versions
WO2007076460A2 (en
Inventor
Mark R Herbert
Hengyuan Lang
Timothy C Gahman
Stewart A Noble
Robert L Davis
Original Assignee
Kalypsys Inc
Mark R Herbert
Hengyuan Lang
Timothy C Gahman
Stewart A Noble
Robert L Davis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kalypsys Inc, Mark R Herbert, Hengyuan Lang, Timothy C Gahman, Stewart A Noble, Robert L Davis filed Critical Kalypsys Inc
Publication of WO2007076460A2 publication Critical patent/WO2007076460A2/en
Publication of WO2007076460A3 publication Critical patent/WO2007076460A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

The present invention relates to compounds and methods useful as inhibitors of protein kinases, including B-Raf and several receptor tyrosine and cytoplasmic tyrosine kinases. The present invention is directed to new substituted pyrimidinyloxy urea compounds of Formula (I) and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulating of protein kinase activity in a human or animal subject are also provided for the treatment diseases such as cancers.
PCT/US2006/062524 2005-12-23 2006-12-21 Substituted thiazole ureas useful as inhibitors of protein kinases WO2007076460A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75348805P 2005-12-23 2005-12-23
US60/753,488 2005-12-23
US85150406P 2006-10-13 2006-10-13
US60/851,504 2006-10-13

Publications (2)

Publication Number Publication Date
WO2007076460A2 WO2007076460A2 (en) 2007-07-05
WO2007076460A3 true WO2007076460A3 (en) 2007-08-16

Family

ID=38042636

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/062524 WO2007076460A2 (en) 2005-12-23 2006-12-21 Substituted thiazole ureas useful as inhibitors of protein kinases

Country Status (1)

Country Link
WO (1) WO2007076460A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9278962B2 (en) 2011-04-22 2016-03-08 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2009000447A1 (en) 2008-02-29 2010-01-04 Array Biopharma Inc Y Genentech Inc Compounds derived from (1h-pyrrolo {2,3-b} pyridin-5-yl) -sulfonamido-substituted benzamide; preparation procedure; pharmaceutical composition; and its use in the treatment of cancer, through the inhibition of raf.
MX2010009411A (en) 2008-02-29 2010-11-30 Array Biopharma Inc Pyrazole [3, 4-b] pyridine raf inhibitors.
AR081331A1 (en) 2010-04-23 2012-08-08 Cytokinetics Inc AMINO- PYRIMIDINES COMPOSITIONS OF THE SAME AND METHODS FOR THE USE OF THE SAME
AR081626A1 (en) 2010-04-23 2012-10-10 Cytokinetics Inc AMINO-PYRIDAZINIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME TO TREAT CARDIAC AND SKELETIC MUSCULAR DISORDERS
EP2560488B1 (en) 2010-04-23 2015-10-28 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
CN103965182A (en) * 2014-05-22 2014-08-06 遵义医学院 Medicament of 1,3,4-oxadiazole containing pyrazole compound prepared for treating tumor
CN109060764B (en) * 2018-08-23 2020-12-29 安徽中科赛飞尔科技有限公司 Preparation method of functionalized SERS platform and application of functionalized SERS platform in ATP detection
CN109134451A (en) * 2018-09-10 2019-01-04 遵义医学院 1,3- 2-substituted carbamide class and thiourea derivatives and its application

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4135312A1 (en) * 1990-10-25 1992-04-30 Fuji Photo Film Co Ltd COLOR PHOTOGRAPHIC SILVER HALOGENIDE MATERIAL
WO1999032111A1 (en) * 1997-12-22 1999-07-01 Bayer Corporation INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS
WO1999032106A1 (en) * 1997-12-22 1999-07-01 Bayer Corporation Inhibition of raf kinase using substituted heterocyclic ureas
WO2004014903A1 (en) * 2002-08-02 2004-02-19 Ab Science 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors
WO2005000298A2 (en) * 2003-06-03 2005-01-06 Novartis Ag 5-membered heterocycle-based p-38 inhibitors
WO2005040139A2 (en) * 2003-10-23 2005-05-06 Ab Science 2-aminoaryloxazole compounds as tyrosine kinase inhibitors
WO2006064375A2 (en) * 2004-12-16 2006-06-22 Ab Science Aminoaryl substituted five-membered ring heterocyclic compounds for the treatment of diseases

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4135312A1 (en) * 1990-10-25 1992-04-30 Fuji Photo Film Co Ltd COLOR PHOTOGRAPHIC SILVER HALOGENIDE MATERIAL
WO1999032111A1 (en) * 1997-12-22 1999-07-01 Bayer Corporation INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS
WO1999032106A1 (en) * 1997-12-22 1999-07-01 Bayer Corporation Inhibition of raf kinase using substituted heterocyclic ureas
WO2004014903A1 (en) * 2002-08-02 2004-02-19 Ab Science 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors
WO2005000298A2 (en) * 2003-06-03 2005-01-06 Novartis Ag 5-membered heterocycle-based p-38 inhibitors
WO2005040139A2 (en) * 2003-10-23 2005-05-06 Ab Science 2-aminoaryloxazole compounds as tyrosine kinase inhibitors
WO2006064375A2 (en) * 2004-12-16 2006-06-22 Ab Science Aminoaryl substituted five-membered ring heterocyclic compounds for the treatment of diseases

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
"Interchim Intermediates", 18 January 2005, INTERCHIM, 211 BIS J.F. KENNEDY, BP 1140, MONTLUCON, 03103, FRANCE *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1940, FISCHER, HANS ET AL: "Bile pigments. XXVII. Synthesis of 4,4'-dimethyl-3,3'-diethyl-5,5'- diaminopyrromethenes", XP002434967, retrieved from STN Database accession no. 1940:10545 *
DATABASE CHEMCATS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 18 January 2005 (2005-01-18), XP002434966, retrieved from STN Database accession no. 2005:1023349 *
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 21 December 1991 (1991-12-21), XP002434965, retrieved from STN Database accession no. 138050-39-2 *
Z. PHYSIOL. CHEM. , 262, 37-46, 1939 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9278962B2 (en) 2011-04-22 2016-03-08 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use

Also Published As

Publication number Publication date
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