WO2006082941A1 - Inhalateur - Google Patents

Inhalateur Download PDF

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Publication number
WO2006082941A1
WO2006082941A1 PCT/JP2006/301906 JP2006301906W WO2006082941A1 WO 2006082941 A1 WO2006082941 A1 WO 2006082941A1 JP 2006301906 W JP2006301906 W JP 2006301906W WO 2006082941 A1 WO2006082941 A1 WO 2006082941A1
Authority
WO
WIPO (PCT)
Prior art keywords
inhaler
detection means
inclination
ection
liquid formulation
Prior art date
Application number
PCT/JP2006/301906
Other languages
English (en)
Inventor
Toshiyuki Nobutani
Original Assignee
Canon Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Canon Kabushiki Kaisha filed Critical Canon Kabushiki Kaisha
Publication of WO2006082941A1 publication Critical patent/WO2006082941A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
    • A61M15/025—Bubble jet droplet ejection devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0085—Inhalators using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
    • A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
    • A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0027—Accessories therefor, e.g. sensors, vibrators, negative pressure pressure meter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
    • A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
    • A61M2016/0039—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the inspiratory circuit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/21—General characteristics of the apparatus insensitive to tilting or inclination, e.g. spill-over prevention
    • A61M2205/215—Tilt detection, e.g. for warning or shut-off
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback

Definitions

  • the present invention relates to an inhaler, particularly to an inhaler . for ej ecting a liquid formulation of a drug, an aroma, a favorite food such as nicotine or the like as fine droplets to make a user inhale it .
  • diabetes mellitus patients need to be administered with insulin, and the administration has generally been performed by inj ection before meals .
  • administration using an injection syringe will cause considerable pain to a patient .
  • administration of a drug through respiratory system has been considered .
  • This generally includes three methods , specifically one using a metered dose inhaler, one using a dry powder inhaler, and one using an atomizer .
  • the metered dose inhaler (MDI ) is widely used for treatment of asthma .
  • the MDI has a valve for discharging a metered dose of aerosol upon operation and is convenient for its portability because of size reducibility of its body.
  • the discharge amount will vary over a considerably wide range .
  • some degree of synchronization between manual valve operation and inhalation is required, so that many users feel this synchronization difficult .
  • the atomizer atomizes a liquid of a carrier gas flow to generate aerosol and requires a continuously- operating gas compressor or a large amount of compressed gas .
  • the size of a fine droplet of aerosol is a function of carrier gas pressure and velocity, so that it is not easy to independently change the concentration of a drug in a gas flow .
  • the atomized amount and particle size are influenced by the period and strength of breathing .
  • the above-mentioned inhaling devices generally have a problem in the accuracy of administering a drug having a proper particle size to an applied portion in. a proper amount, so that their use is limited only to a drug having a wide allowance for dose . In any device, it is a current situation that administration to an intended proper portion depends on the technique of a user .
  • diabetes mellitus patients who are increasing at present, the so-called •insulin-dependent type (type I ) diabetes mellitus patients have no secretion of insulin from their pancreas and need to be regularly admin-istered with insulin . Because insulin is administered by subcutaneous injection at present, the physical and mental labor of patients is large . In order to reduce the labor of such patients, a pen-shaped inj ection syringe has been developed which has a thin needle and gives less pain to a patient .
  • type I •insulin-dependent type
  • the above-mentioned conventional examples include methods of a system in which the particle diameter or ej ection amount of the ej ected liquid droplets, is changed depending on the orientation of an inhaler .
  • the change in the particle diameter of a liquid droplet influences the probability of reaching lungs and the change in the ej ection amount influences administration of a proper amount, each of which may become a factor of failure to inhale a drug in a proper dose prescribed by a doctor .
  • the present invention provides an inhaler for a user to inhale a liquid formulation from an inbreathing port, which comprises a detection means for detecting or measuring inclination of a housing with respect to an inclination reference .
  • the inhaler further comprises a noticing means (e . g . , ⁇ vibration motor described later) connected to the detection means, for serving notice to the user in accordance with an information from the detection means .
  • a noticing means e . g . , ⁇ vibration motor described later
  • the inhaler further comprises a control means (e . g . , control circuit described later) for controlling ejection of the liquid formulation in accordance with an information from the detection means .
  • a control means e . g . , control circuit described later
  • the inhaler further comprises the both means .
  • the inhaler further comprises a storage means (e . g . , memory described later) for storing an information from the detection means .
  • a storage means e . g . , memory described later
  • the detection means it is possible to use an acceleration sensor .
  • the acceleration sensor As the means for detecting inclination is effective because the direction of gravity G in an environment in which the inhaler is used is a vertical direction .
  • the inhaler according to the present invention includes a detection means for detecting or measuring inclination of a housing with respect to an inclination reference .
  • FIG . 1 is a schematic perspective view showing an example of the inhaler according to the present invention. •
  • FIG . 2 is a schematic perspective view showing the inhaler of FIG . 1 when an access cover is opened;
  • FIG . 3 is a schematic perspective view showing an example of a cartridge (CRG) unit
  • FIG. 4 is a vertical sectional view of an example of a mouthpiece
  • FIG. 5 is a horizontal sectional view of the mouthpiece shown in FIG . 4 ;
  • FIG . 6 is a vertical sectional view showing the dispositional relationship between the mouthpiece shown in FIG.. 4 , a negative pressure sensor, and an ej ection head of a cartridge unit;
  • FIG . 7 is an entire sectional view of the inhaler shown in FIG. 1;
  • FIG. 8 is a graphical representation for explaining an example of the inhalation operation of the inhaler shown in FIG . 1 ;
  • FIG . 9 is a sectional view of a mouthpiece of a parallel-flow-path type and the vicinity thereof;
  • FIG . 10 is a block diagram of an example of the inhaler according to the present invention
  • FIG. 11 is a schematic view illustrating the vibration patterns of a vibration motor of an example of the inhaler according to the present invention
  • FIG. 12 is a block diagram of a head driver of an example of the inhaler according to the present invention .
  • FIG . 1 is a schematic perspective view showing the appearance of an example of the inhaler (hereinafter sometimes referred to as "the device") according to the present invention .
  • reference numeral 1 denotes an inhaler body
  • reference numeral 2 denotes an access cover
  • reference numeral 3 denotes a front cover
  • a housing is formed by these components-.
  • Reference numeral 5 denotes a lock lever which is formed such that a claw-shaped portion formed at the front edge of the lock lever 5 urged by a spring engages with a protrusion 2a formed at the front edge of the access cover 2 in order that the access cover 2 does not open when used.
  • FIG. 2 illustrates a state when the access cover 2 opens .
  • a hinge axis (not shown) being used as a rotation center by the force of an access-cover-returning spring urging the access cover 2.
  • reference numeral 120 denotes a power supply switch
  • reference numeral 1 104 denotes a display LED which displays that an ej ection head cartridge (CRG) unit or mouthpiece described later is not mounted or that no liquid formulation remains in the tank of the cartridge unit .
  • the display LED 104 will be further described later
  • FIG. 2 illustrates a state when the access cover 2 opens .
  • a cartridge unit 6 and a mouthpiece 4 mounted in the housing along a cartridge guide 20 can be seen .
  • FIG . 3 shows the entirety of the cartridge unit 6.
  • the cartridge unit 6 has a tank 7 for containing a liquid formulation and a head portion (ejection portion) 8 for ej ecting the liquid formulation .
  • the cartridge unit further has a portion (electric connection portion) 9 having an electric connection face for supplying a power for providing a heat energy to generate bubbles by a heater provided in the head portion 8 from a battery 10 ( see FIG . 7 ) .
  • the configuration of the head portion is not limited to the above, and there may be adopted a configuration in which a piezoelectric device is provided instead of the heater or a configuration for forming liquid droplets by applying a vibration energy to a mesh structure film having a number of holes provided therethrough .
  • the battery 10 can be recharged as a secondary battery holding the power for applying the energy to the heater in the inhaler .
  • the front face portion of the cartridge unit 6 is formed so as to be opened around a hinge portion 24 thereby making it possible to access the tank 7.
  • a protrusion or the like is formed, so that when closing the front face portion, the protrusion simultaneously enters the tank 7 to slightly pressurize the liquid formulation in the tank 7 to refresh the ej ection port of the head portion 8.
  • FIGS . 4 and 5 show sectional views of the mouthpiece 4.
  • the mouthpiece 4 forms an air flow path by only the mouthpiece 4 itself and a window (liquid formulation intake port) 12 for intaking a liquid formulation into the mouthpiece 4 from an ej ection port provided in the head portion 8 of the cartridge unit 6 is opened at a portion close to the air intake port 11.
  • a drawn portion 4a is formed which has a shape gradually changing in the direction in which the sectional area decreases .
  • a hole 13 is provided which communicates with a measuring hole of a negative pressure sensor 19 for sensing a negative pressure to detect an inhalation speed or a flow rate as an integrated value of the speed.
  • the negative pressure sensor 19 is disposed on a control board 21 (see FIGS . 6 and 7 ) .
  • an expanded space 22 is provided in the middle of a flow path communicating with the negative pressure sensor 19 from ' the air hole 13, in the middle of a flow path communicating with the negative pressure sensor 19 from ' the air hole 13, an expanded space 22 is provided. This is formed as a collection place for dust, dirt, water drops, liquid formulation, and . the like and prevents these from intruding from the air hole 13 and attaching to the surface of the negative pressure sensor 19 to cause a malfunction .
  • a mouthpiece 4 exit (inbreathing port) 15 having such a shape that a person can put it in his mouth .
  • the cross section of the mouthpiece exit 15 is formed in an elliptical shape according to the shape of the mouth of a person and a flow path exit 14 serving as a route of the liquid formulation is provided at an inner side of a duplex structure .
  • the flow path exit 14 has a shape in which the sectional area gradually increases in order to prevent that a mixed fluid of air and the liquid formulation abruptly expands at the exit and attaches to teeth of the mouth of a person having the mouthpiece exit 15 in this mouth .
  • FIG. 7 is an entire longitudinal sectional view of the inhaler of this example .
  • the control board 21 for controlling the inhaler is disposed under a battery 10.
  • a probe board 16 connected to the control board 21 by a cable or connector ( connector 25 being used in FIG . 7 ) is disposed under the cartridge unit 6. Furthermore, a contact probe 17 for performing energization for heat generation to the head portion- 8 of the cartridge unit 6 is provided for connection from the probe board 16 to the electric connection portion 9 of the cartridge unit 6.
  • a vibration motor 18 is disposed in a space between the battery 10 and the mouthpiece 4 so as to be in contact with the control board 21.
  • FIG . 8 shows a relation between an inhaling curve in breathing and a period for ej ection .
  • the vibration motor 18 vibrates for an additional inhaling time after the completed of ej ection so as to attain inhalation in an additional inhaling amount on the basis of the inhaling speed and inhalation duration computed from the negative pressure value measured -by the negative pressure sensor 19. Thereby, the user is urged to perform inhalation so that the ej ected liquid formulation completely reaches lungs .
  • the vibration of the vibration motor 18 is completed, the user or patient stops inhalation .
  • the liquid formulation ej ection and the inhalation are brought into association with each other, so that it becomes possible to securely deliver the liquid formulation to lungs and there is no fail such as insufficient inhalation .
  • the mouthpiece exit 15 prevents the leakage of the mixed fluid from the lateral sides of the mouth to reduce the waste of inhalation and suppresses easy collision of the mixed fluid against an obstacle such as teeth in the mouth, whereby the liquid formulation is efficiently inhaled into the body of the user .
  • FIG. 9 shows a modified example in which only the configuration of the flow path up to the pressure detection portion (hole 13 for communication with negative pressure sensor 19) is different from Example 1.
  • the communication hole 13 is provided at the outside of the flow path exit 14 of the mouthpiece exit 15 present at the front end of the mouthpiece 4 , whereby the negative pressure detection flow path leading to the negative pressure sensor 19- is completely separated from the ' air flow path of the mouthpiece 4 and disposed parallel thereto .
  • the mounting direction is a direction in which the communication hole 13 comes into contact with the negative pressure detection flow path leading to the negative pressure sensor 19, which is advantageous to prevent air leakage .
  • FIG . 10 shows an entire block diagram of the control board 21 and the- vicinity thereof of the present device .
  • reference numeral 101 denotes a CPU, which is an arithmetic processing unit and including therein a flash ROM that stores a program.
  • Reference numeral 102 denotes an SRAM which is a readable/writable memory for temporarily storing data when the program operates .
  • Reference numeral 104 denotes the aforementioned LED which is a display unit for showing the state of the device to a ⁇ ser or maintenance worker .
  • Reference numeral 105 denotes a radio unit for performing radiocommunication for transferring the state of the device or storage content to a host computer or receiving data from the host computer, and reference numeral 106 denotes an antenna for the radio unit .
  • Reference numeral 107 denotes a cover sensor for detecting the opening/closing state of the access cover 2.
  • Reference numeral 108 denotes an amplifier for level converting and amplifying an output of the negative pressure sensor 19 and reference numeral 109 denotes an AD converter for converting an analog output of the amplifier 108 to a digital signal .
  • Reference numeral 110 denotes a driver for controlling the head portion 8.
  • Reference numeral 111 denotes an RTC (real time clock) having a calendar/clock function and reference numeral 112 denotes a backup battery for the RTC 111.
  • Reference numeral 113 denotes a power supply for generating various voltages to be supplied to electric circuits, which includes a main battery, a charging circuit, a reset circuit, the aforementioned power supply switch 120 , and the like .
  • reference numeral 114 denotes a sensor for detecting the inclination of the device which is a characteristic of the. present invention
  • reference numeral 115 denotes a detection circuit for processing an output of the sensor 114
  • reference numeral 116 denotes an AD converter for converting an analog signal which is an output of the detection circuit 115 to a digital signal .
  • the sensor 114 is attached in a proper space in the inhaler body at a predetermined orientation .
  • reference numeral 117 denotes a control circuit for processing output/input signals to or from various blocks, which is connected to the CPU 101 through a bus . Further, a USB port connected to the CPU 101 is also provided as an external interface .
  • the sensor 114 for detecting inclination it is possible to use one of various types of inclination sensors and acceleration sensors and a suitable one may be chosen depending on the specification of the inhaler .
  • the acceleration sensor include an electrostatic-capacity-type acceleration sensor and a piezoelectric-type 3-axis acceleration sensor .
  • the electrostatic-capacity-type acceleration sensor has a configuration in which there are provided a plurality pairs of electrostatic capacity elements each prepared by attaching electrodes to opposing surfaces of a fixed substrate made of glass or the like and a flexible substrate made of silicon or the like and disposing them in opposition to each other and a change in acceleration of each of X-, Y-, and Z-axis directional components is detected based on an electrostatic capacity change between the plurality pairs of electrostatic capacity elements .
  • the piezoelectric-type 3-axis acceleration sensor is configured such that when an acceleration acts on a weight, a deflection is generated at a portion of a piezoelectric ceramic substrate existing around the weight .
  • the 3-axis acceleration sensor is commercially available from various companies and examples thereof include HAAM301 (trade name) manufactured by HOKURIKU ELECTRIC INDUSTRY CO . , LTD . and ML8950 (trade name) manufactured by Oki Electric Industry Co . , Ltd.
  • the reference of inclination of the device when detecting the inclination includes , for example, an inclined orientation of the device when the ej ection direction of the ej ection head is a horizontal direction, an inclined orientation of the device when the .ej ection direction of the ej ection head is downward in a vertical direction, and an inclined orientation of the device when the ej ection direction of the ejection head forms a certain angle relative to a vertical direction.
  • the reference of inclination may suitably be defined considering the characteristics and performance of the ej ection head and further the use of the result of inclination • detection .
  • the power supply 113 when the power supply switch 120 is turned on, the power supply 113 outputs a reset signal to the CPU 101 and the CPU 101 is initialized in accordance with the signal . Thereafter, an operation starts by the program stored in the internal flash ROM, and when any special setting is not made, the operation starts in a normal operation mode .
  • the output of the negative pressure sensor 19 is changed and the change is conveyed to the CPU 101 through the amplifier 108 , AD converter 109, and control circuit 117.
  • the CPU 101 applies a voltage to the vibration motor 18 to vibrate it and sends a pulse signal to the head portion 8 through the control circuit 117 and the driver 10, whereby a liquid formulation contained in the cartridge unit 6 is ej ected .
  • the vibration motor 18 continues vibration for another specified time period to urge the user to perform inhalation during the another specified time period .
  • the CPU 101 sequentially monitors the information of the sensor 114 , and for example when the information to inclination exceeds a threshold value, the CPU 101 changes the control for the head portion 8 through the control circuit 117 (for example, applied voltage or pulse width is changed) . Thereby, for example, the particle diameter of liquid droplets ejected by the head portion 8 is controlled . Moreover, for example when the inclination exceeds a second threshold val.ue, the CPU 101 changes the vibration pattern of the vibration motor 18 to instruct the user not to perform further inclination .
  • FIG. 11 shows a vibration pattern (a) at a normal inclination and a vibration pattern (b) when the inclination exceeds the second threshold value .
  • the control may be made such that when the state in which the inclination exceeds the second threshold value continues for a . certain period, the ej ection of liquid droplets is stopped.
  • any sensor can be used as described above .
  • a sensor which includes a detection circuit and an AD converter it is possible to connect the sensor 114 directly to the control circuit 117 or CPU 101 , not through the detection circuit 115 and AD converter 116.
  • FIG . 12 explains an example of control when the inclination exceeds a threshold value .
  • the driver 110 drives a head 8a for normal orientation .
  • the driver 110 drives a head 8b for inclined orientation .
  • the head 8a for normal orientation and the head 8b for inclined orientation are constituted such that their ej ection particle diameters are different from each other (in this case, it suffices to set the both heads parallel to each other at the same orientation) .
  • the detection information to the inclination of the inhaler for the following purpose instead of use for control of the ej ection head . That is, the inclination of the inhaler during its use can be stored in a memory and thereafter subj ected to examination on the record of state of use by a doctor or the like . In this case, it is possible to use the detection information as data for performing proper decision based on the record of state of use .
  • the proper decision includes instructions to a patient of how to use, estimation of physical condition of a patient, determination as to whether a patient performs inhalation in a recumbent position or in a standing position, adj ustment of the ej ection rate of an ej ection head, replacement of an ej ection head with another one, or the like .

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Special Spraying Apparatus (AREA)

Abstract

Inhalateur comprenant un moyen de détection destiné à détecter ou mesurer l'inclinaison d'un boîtier afin de permettre l'inhalation efficace d'un médicament tout en simplifiant l'utilisation de l'inhalateur par une réduction de l'effort physique et mental à fournir par le patient lors de l'inhalation. L'inhalateur est prévu pour permettre à un utilisateur d'inhaler une formulation liquide par un orifice d'inspiration. L'inhalateur est pourvu d'un moyen de détection destiné à détecter ou mesurer l'inclinaison du boîtier par rapport à une référence d'inclinaison. En outre, l'inhalateur peut éventuellement comprendre un moyen d'avertissement raccordé au moyen de détection destiné à alerter l'utilisateur en fonction des informations transmises par le moyen de détection et/ou un moyen de commande destiné à contrôler l'expulsion de la formulation liquide en fonction des informations transmises par le moyen de détection, ou encore un moyen de stockage des informations transmises par le moyen de détection.
PCT/JP2006/301906 2005-02-01 2006-01-30 Inhalateur WO2006082941A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005025425A JP2006212088A (ja) 2005-02-01 2005-02-01 吸入装置
JP2005-025425 2005-02-01

Publications (1)

Publication Number Publication Date
WO2006082941A1 true WO2006082941A1 (fr) 2006-08-10

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WO (1) WO2006082941A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008050542A1 (fr) * 2006-09-29 2008-05-02 Canon Kabushiki Kaisha Inhalateur
WO2017141033A1 (fr) * 2016-02-15 2017-08-24 University Of Wales Trinity St David Dispositif inhalateur
EP3593654A1 (fr) * 2011-12-20 2020-01-15 British American Tobacco (Investments) Limited Articles à fumer et d'autres articles de distribution d'écoulement
US10799652B2 (en) 2015-01-08 2020-10-13 Convexity Scientific Inc. Nebulizer device
CN113692293A (zh) * 2019-04-09 2021-11-23 日本烟草产业株式会社 气溶胶供给装置
US11344685B2 (en) 2016-11-18 2022-05-31 Norton (Waterford) Limited Drug delivery device with electronics

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106999681B (zh) 2014-08-28 2021-02-02 诺顿（沃特福特）有限公司 吸入器的依从性辅助模块

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62288402A (ja) * 1986-06-05 1987-12-15 松下電工株式会社 スチ−ム発生装置
JP3559864B2 (ja) * 1993-02-16 2004-09-02 エタブリスマン バロワ 携帯式の吸入作動型噴霧装置

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62288402A (ja) * 1986-06-05 1987-12-15 松下電工株式会社 スチ−ム発生装置
JP3559864B2 (ja) * 1993-02-16 2004-09-02 エタブリスマン バロワ 携帯式の吸入作動型噴霧装置

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008050542A1 (fr) * 2006-09-29 2008-05-02 Canon Kabushiki Kaisha Inhalateur
EP3593654A1 (fr) * 2011-12-20 2020-01-15 British American Tobacco (Investments) Limited Articles à fumer et d'autres articles de distribution d'écoulement
US10799652B2 (en) 2015-01-08 2020-10-13 Convexity Scientific Inc. Nebulizer device
WO2017141033A1 (fr) * 2016-02-15 2017-08-24 University Of Wales Trinity St David Dispositif inhalateur
US11344685B2 (en) 2016-11-18 2022-05-31 Norton (Waterford) Limited Drug delivery device with electronics
US11351317B2 (en) 2016-11-18 2022-06-07 Norton (Waterford) Limited Drug delivery device with electronics
US11357935B2 (en) 2016-11-18 2022-06-14 Norton (Waterford) Limited Drug delivery device with electronics
US11439777B2 (en) 2016-11-18 2022-09-13 Norton (Waterford) Limited Drug delivery device with electronics
CN113692293A (zh) * 2019-04-09 2021-11-23 日本烟草产业株式会社 气溶胶供给装置
CN113692293B (zh) * 2019-04-09 2023-11-28 日本烟草产业株式会社 气溶胶供给装置

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