WO2006075095A3 - Utilisation de derives de la purine comme inhibiteurs de la proteine hsp90 et pour le traitement du cancer - Google Patents

Utilisation de derives de la purine comme inhibiteurs de la proteine hsp90 et pour le traitement du cancer Download PDF

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Publication number
WO2006075095A3
WO2006075095A3 PCT/FR2006/000066 FR2006000066W WO2006075095A3 WO 2006075095 A3 WO2006075095 A3 WO 2006075095A3 FR 2006000066 W FR2006000066 W FR 2006000066W WO 2006075095 A3 WO2006075095 A3 WO 2006075095A3
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WO
WIPO (PCT)
Prior art keywords
cancer
treatment
hsp90 protein
purine derivatives
protein inhibitors
Prior art date
Application number
PCT/FR2006/000066
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English (en)
Other versions
WO2006075095A2 (fr
Inventor
Chantal Carrez
Florence Fassy
Original Assignee
Aventis Pharma Sa
Mailliet Patrick
Chantal Carrez
Florence Fassy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa, Mailliet Patrick, Chantal Carrez, Florence Fassy filed Critical Aventis Pharma Sa
Priority to EP06709073A priority Critical patent/EP1838322A2/fr
Priority to JP2007550816A priority patent/JP2008526931A/ja
Publication of WO2006075095A2 publication Critical patent/WO2006075095A2/fr
Publication of WO2006075095A3 publication Critical patent/WO2006075095A3/fr
Priority to US11/773,577 priority patent/US20080108612A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne l'utilisation de dérivés de la purine comme inhibiteurs de l'activité de la protéine chaperone Hsp90, et plus particulièrement leur utilisation comme inhibiteurs de l'activité catalytique de type ATPasique de la protéine chaperone Hsp90.
PCT/FR2006/000066 2005-01-13 2006-01-11 Utilisation de derives de la purine comme inhibiteurs de la proteine hsp90 et pour le traitement du cancer WO2006075095A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP06709073A EP1838322A2 (fr) 2005-01-13 2006-01-11 Utilisation de derives de la purine comme inhibiteurs de la proteine hsp90 et pour le traitement du cancer
JP2007550816A JP2008526931A (ja) 2005-01-13 2006-01-11 Ｈｓｐ９０蛋白質阻害剤としての及び癌治療のためのプリン誘導体の使用
US11/773,577 US20080108612A1 (en) 2005-01-13 2007-07-05 Use of Purine Derivatives as HSP90 Protein Inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0500350A FR2880540B1 (fr) 2005-01-13 2005-01-13 Utilisation de derives de la purine comme inhibiteurs de la proteine hsp90
FR0500350 2005-01-13

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/773,577 Continuation US20080108612A1 (en) 2005-01-13 2007-07-05 Use of Purine Derivatives as HSP90 Protein Inhibitors

Publications (2)

Publication Number Publication Date
WO2006075095A2 WO2006075095A2 (fr) 2006-07-20
WO2006075095A3 true WO2006075095A3 (fr) 2006-12-14

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2006/000066 WO2006075095A2 (fr) 2005-01-13 2006-01-11 Utilisation de derives de la purine comme inhibiteurs de la proteine hsp90 et pour le traitement du cancer

Country Status (5)

Country Link
US (1) US20080108612A1 (fr)
EP (1) EP1838322A2 (fr)
JP (1) JP2008526931A (fr)
FR (1) FR2880540B1 (fr)
WO (1) WO2006075095A2 (fr)

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MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
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GB0519245D0 (en) * 2005-09-20 2005-10-26 Vernalis R&D Ltd Purine compounds
EP3719018A1 (fr) 2006-04-25 2020-10-07 Astex Therapeutics Ltd Dérivés de purine et de déazapurine comme composés pharmaceutiques
WO2007134298A2 (fr) 2006-05-12 2007-11-22 Myriad Genetics, Inc. Composés thérapeutiques et leur utilisation contre le cancer
WO2008024981A1 (fr) * 2006-08-24 2008-02-28 Serenex, Inc. Benzothiophènes à substitution pipérazine pour le traitement de troubles mentaux
GB0617161D0 (en) * 2006-08-31 2006-10-11 Vernalis R&D Ltd Enzyme inhibitors
FR2907453B1 (fr) * 2006-10-24 2008-12-26 Sanofi Aventis Sa Nouveaux derives du fluorene,compositions les contenant et utilisation
KR101494734B1 (ko) 2007-10-11 2015-02-26 아스트라제네카 아베 단백질 키나제 ｂ 억제제로서 피롤로[2,3-ｄ]피리미딘 유도체
NZ586129A (en) * 2007-11-14 2012-06-29 Myrexis Inc Therapeutic compounds and their use in treating diseases and disorders
LT5623B (lt) 2008-04-30 2010-01-25 Biotechnologijos Institutas, , 5-aril-4-(5-pakeistieji 2,4-dihidroksifenil)-1,2,3-tiadiazolai kaip hsp90 šaperono slopikliai ir tarpiniai junginiai jiems gauti
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
MY169449A (en) 2011-04-01 2019-04-11 Astrazeneca Ab Therapeutic treatment
DK2785349T4 (da) 2011-11-30 2023-01-09 Astrazeneca Ab Kombinationsbehandling af cancer
AU2013204533B2 (en) 2012-04-17 2017-02-02 Astrazeneca Ab Crystalline forms

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Also Published As

Publication number Publication date
EP1838322A2 (fr) 2007-10-03
US20080108612A1 (en) 2008-05-08
FR2880540B1 (fr) 2008-07-11
WO2006075095A2 (fr) 2006-07-20
FR2880540A1 (fr) 2006-07-14
JP2008526931A (ja) 2008-07-24

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