WO2006075094A3 - Derives de la purine, compositions les contenant et leurs utilisation contre le cancer - Google Patents
Derives de la purine, compositions les contenant et leurs utilisation contre le cancer Download PDFInfo
- Publication number
- WO2006075094A3 WO2006075094A3 PCT/FR2006/000065 FR2006000065W WO2006075094A3 WO 2006075094 A3 WO2006075094 A3 WO 2006075094A3 FR 2006000065 W FR2006000065 W FR 2006000065W WO 2006075094 A3 WO2006075094 A3 WO 2006075094A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- same
- compositions containing
- purine derivatives
- against cancer
- derivatives compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Dérivés de la purine de formule (IA1) ou (IB1):, compositions les contenant et utilisation comme médicaments, en particulier en oncologie, dans laquelle Y et Z représentent N ou CH ; X représente un atome d'halogène ; dans (IA), A représente N ou CH et dans (IB), A représente O, S, NH, CH2 ou CHR ; B représente O, S, NR’, CH2 ou CHR’ ; R représente H ou alkyle ; R’ représente H, alkyle, alkényle, alkynyle ; (CH2)n-aryle ou hétéroaryle ;-CH(aryle)2; C(Z)-aryle ou hétéroaryle ; éventuellement substitués ; n= 0, 1 , 2 ; Z représente O, S ou NR'.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06709072A EP1841769A2 (fr) | 2005-01-13 | 2006-01-11 | Derives de la purine, compositions les contenant et leurs utilisation contre le cancer |
JP2007550815A JP2008526930A (ja) | 2005-01-13 | 2006-01-11 | プリン誘導体、プリン誘導体を含有する組成物およびこの使用 |
US11/773,572 US20080119467A1 (en) | 2005-01-13 | 2007-07-05 | Purine Derivatives, Compositions Containing Them and Use Thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0500349A FR2880626B1 (fr) | 2005-01-13 | 2005-01-13 | Derives de la purine, compositions les contenant et utilisation |
FR0500349 | 2005-01-13 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/773,572 Continuation US20080119467A1 (en) | 2005-01-13 | 2007-07-05 | Purine Derivatives, Compositions Containing Them and Use Thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006075094A2 WO2006075094A2 (fr) | 2006-07-20 |
WO2006075094A3 true WO2006075094A3 (fr) | 2006-12-07 |
Family
ID=34954725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2006/000065 WO2006075094A2 (fr) | 2005-01-13 | 2006-01-11 | Derives de la purine, compositions les contenant et leurs utilisation contre le cancer |
Country Status (6)
Country | Link |
---|---|
US (1) | US20080119467A1 (fr) |
EP (1) | EP1841769A2 (fr) |
JP (1) | JP2008526930A (fr) |
AR (1) | AR052454A1 (fr) |
FR (1) | FR2880626B1 (fr) |
WO (1) | WO2006075094A2 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
DK3421471T3 (da) * | 2006-04-25 | 2021-06-14 | Astex Therapeutics Ltd | Purin- og deazapurinderivater som farmaceutiske forbindelser |
CA2660114A1 (fr) * | 2006-08-09 | 2008-02-14 | Merck Frosst Canada Ltd. | Derives d'azacycloalcane en tant qu'inhibiteurs de la stearoyl-coenzyme a delta-9 desaturase |
WO2008075007A1 (fr) * | 2006-12-21 | 2008-06-26 | Cancer Research Technology Limited | Composé bicyclohétéroarylés substitué par morpholino et leur utilisation en tant qu'agents anti-cancer |
US20080233127A1 (en) * | 2007-03-21 | 2008-09-25 | Wyeth | Imidazolopyrimidine analogs and their use as pi3 kinase and mtor inhibitors |
SI2201012T1 (sl) | 2007-10-11 | 2014-10-30 | Astrazeneca Ab | Derivati pirolo(2,3-D)pirimidina kot inhibitorji proteina kinaze B |
ES2665277T3 (es) * | 2009-03-13 | 2018-04-25 | Katholieke Universiteit Leuven K.U. Leuven R&D | Análogos de purina y su uso como agentes inmunosupresores |
DK2694056T3 (da) | 2011-04-01 | 2020-01-02 | Astrazeneca Ab | Terapeutisk behandling |
MY175800A (en) | 2011-11-30 | 2020-07-09 | Astrazeneca Ab | Combination treatment of cancer |
AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
WO2013182612A1 (fr) * | 2012-06-07 | 2013-12-12 | Bayer Pharma Aktiengesellschaft | Inhibiteurs de transport du glucose |
CA2983042C (fr) * | 2015-04-21 | 2020-01-07 | Lijuan Chen | Derives de purinyl-n-hydroxylpyrimidine-formamide, leur procede de preparation et leur utilisation |
CZ2016608A3 (cs) * | 2015-10-26 | 2017-01-18 | Ústav experimentální botaniky AV ČR, v. v. i. | 2,6-disubstituované puriny pro použití jako léčiva, a farmaceutické přípravky |
CZ306987B6 (cs) * | 2015-10-26 | 2017-11-01 | Ústav experimentální botaniky AV ČR, v. v. i. | 2,6-disubstituované puriny pro použití jako léčiva a farmaceutické přípravky je obsahující |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993020078A1 (fr) * | 1992-04-03 | 1993-10-14 | The Upjohn Company | Amines bicycliques-heterocycliques efficaces pharmaceutiquement |
WO1998005235A1 (fr) * | 1996-08-01 | 1998-02-12 | A.W. Faber-Castell Unternehmensverwaltung Gmbh & Co. | Crayon a mine tendre |
WO1999002162A1 (fr) * | 1997-07-12 | 1999-01-21 | Cancer Research Campaign Technology Limited | Derives de purine inhibant la kinase dependant de la cycline |
WO1999065909A1 (fr) * | 1998-06-19 | 1999-12-23 | Pfizer Products Inc. | COMPOSES DE PYRROLO[2,3-d]PYRIMIDINE |
WO2000044750A1 (fr) * | 1999-02-01 | 2000-08-03 | Cv Therapeutics, Inc. | INHIBITEURS PURIQUES DES KINASES 2 ET IλB-α DEPENDANTES DES CYCLINES |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5929046A (en) * | 1994-06-08 | 1999-07-27 | Cancer Research Campaign Technology Limited | Pyrimidine and purine derivatives and their use in treating tumour cells |
FR2818642B1 (fr) * | 2000-12-26 | 2005-07-15 | Hoechst Marion Roussel Inc | Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilistion |
US7842693B2 (en) * | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
EP1682150B1 (fr) * | 2003-11-10 | 2012-12-26 | The Scripps Research Institute | Compositions et procedes pour induire la dedifferenciation cellulaire |
-
2005
- 2005-01-13 FR FR0500349A patent/FR2880626B1/fr not_active Expired - Fee Related
-
2006
- 2006-01-11 AR ARP060100113A patent/AR052454A1/es not_active Application Discontinuation
- 2006-01-11 JP JP2007550815A patent/JP2008526930A/ja not_active Withdrawn
- 2006-01-11 WO PCT/FR2006/000065 patent/WO2006075094A2/fr active Application Filing
- 2006-01-11 EP EP06709072A patent/EP1841769A2/fr not_active Withdrawn
-
2007
- 2007-07-05 US US11/773,572 patent/US20080119467A1/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993020078A1 (fr) * | 1992-04-03 | 1993-10-14 | The Upjohn Company | Amines bicycliques-heterocycliques efficaces pharmaceutiquement |
WO1998005235A1 (fr) * | 1996-08-01 | 1998-02-12 | A.W. Faber-Castell Unternehmensverwaltung Gmbh & Co. | Crayon a mine tendre |
WO1999002162A1 (fr) * | 1997-07-12 | 1999-01-21 | Cancer Research Campaign Technology Limited | Derives de purine inhibant la kinase dependant de la cycline |
WO1999065909A1 (fr) * | 1998-06-19 | 1999-12-23 | Pfizer Products Inc. | COMPOSES DE PYRROLO[2,3-d]PYRIMIDINE |
WO2000044750A1 (fr) * | 1999-02-01 | 2000-08-03 | Cv Therapeutics, Inc. | INHIBITEURS PURIQUES DES KINASES 2 ET IλB-α DEPENDANTES DES CYCLINES |
Non-Patent Citations (3)
Title |
---|
JOHNSTON, THOMAS P. ET AL: "Synthesis of potential anticancer agents. XVI. S-Substituted derivatives of 6-mercaptopurine", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 80, 6265-71 CODEN: JACSAT; ISSN: 0002-7863, 1958, XP009052623 * |
PANAGOPOULOS, KIM ET AL: "Synthesis of potent anticancer agents. I. 6-(1-Pyrrolidyl)purines, 6-(1-piperidyl)purines, and their nucleosides", ARZNEIMITTEL-FORSCHUNG , 15(3), 204-7 CODEN: ARZNAD; ISSN: 0004-4172, 1965, XP009052694 * |
THOMPSON, ROBERT D. ET AL: "N6,9-Disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor", JOURNAL OF MEDICINAL CHEMISTRY , 34(9), 2877-82 CODEN: JMCMAR; ISSN: 0022-2623, 1991, XP002048672 * |
Also Published As
Publication number | Publication date |
---|---|
US20080119467A1 (en) | 2008-05-22 |
FR2880626A1 (fr) | 2006-07-14 |
JP2008526930A (ja) | 2008-07-24 |
WO2006075094A2 (fr) | 2006-07-20 |
EP1841769A2 (fr) | 2007-10-10 |
AR052454A1 (es) | 2007-03-21 |
FR2880626B1 (fr) | 2008-04-18 |
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