WO2006075094A3 - Purine derivatives compositions containing the same and use thereof against cancer - Google Patents

Purine derivatives compositions containing the same and use thereof against cancer Download PDF

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Publication number
WO2006075094A3
WO2006075094A3 PCT/FR2006/000065 FR2006000065W WO2006075094A3 WO 2006075094 A3 WO2006075094 A3 WO 2006075094A3 FR 2006000065 W FR2006000065 W FR 2006000065W WO 2006075094 A3 WO2006075094 A3 WO 2006075094A3
Authority
WO
WIPO (PCT)
Prior art keywords
same
compositions containing
purine derivatives
against cancer
derivatives compositions
Prior art date
Application number
PCT/FR2006/000065
Other languages
French (fr)
Other versions
WO2006075094A2 (en
Inventor
Chantal Carrez
Florence Fassy
Patrick Mailliet
Fabienne Thompson
Original Assignee
Aventis Pharma Sa
Chantal Carrez
Florence Fassy
Patrick Mailliet
Fabienne Thompson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa, Chantal Carrez, Florence Fassy, Patrick Mailliet, Fabienne Thompson filed Critical Aventis Pharma Sa
Priority to EP06709072A priority Critical patent/EP1841769A2/en
Priority to JP2007550815A priority patent/JP2008526930A/en
Publication of WO2006075094A2 publication Critical patent/WO2006075094A2/en
Publication of WO2006075094A3 publication Critical patent/WO2006075094A3/en
Priority to US11/773,572 priority patent/US20080119467A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Purine derivatives of formula (IA1) or (IB1), compositions containing the same and use thereof as medicaments, in particular in oncology, where Y and Z = N or CH, X = halogen, in (IA), A = N or CH and in (IB), A = O, S, NH, CH2 or CHR, B = O, S, NR', CH2 or CHR', R = H or alkyl, R' = H, alkyl, alkenyl, alkynyl, (CH2)n-aryl or heteroaryl, CH(aryl)2, C(Z)-aryl or heteroaryl, optionally substituted, n= 0, 1, 2 and Z = O, S or NR'.
PCT/FR2006/000065 2005-01-13 2006-01-11 Purine derivatives compositions containing the same and use thereof against cancer WO2006075094A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP06709072A EP1841769A2 (en) 2005-01-13 2006-01-11 Purine derivatives compositions containing the same and use thereof against cancer
JP2007550815A JP2008526930A (en) 2005-01-13 2006-01-11 Purine derivatives, compositions containing purine derivatives and uses thereof
US11/773,572 US20080119467A1 (en) 2005-01-13 2007-07-05 Purine Derivatives, Compositions Containing Them and Use Thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0500349A FR2880626B1 (en) 2005-01-13 2005-01-13 DERIVATIVES OF PURINE, COMPOSITIONS CONTAINING SAME AND USE THEREOF
FR0500349 2005-01-13

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/773,572 Continuation US20080119467A1 (en) 2005-01-13 2007-07-05 Purine Derivatives, Compositions Containing Them and Use Thereof

Publications (2)

Publication Number Publication Date
WO2006075094A2 WO2006075094A2 (en) 2006-07-20
WO2006075094A3 true WO2006075094A3 (en) 2006-12-07

Family

ID=34954725

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2006/000065 WO2006075094A2 (en) 2005-01-13 2006-01-11 Purine derivatives compositions containing the same and use thereof against cancer

Country Status (6)

Country Link
US (1) US20080119467A1 (en)
EP (1) EP1841769A2 (en)
JP (1) JP2008526930A (en)
AR (1) AR052454A1 (en)
FR (1) FR2880626B1 (en)
WO (1) WO2006075094A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
EP3421471B1 (en) * 2006-04-25 2021-05-26 Astex Therapeutics Limited Purine and deazapurine derivatives as pharmaceutical compounds
WO2008017161A1 (en) * 2006-08-09 2008-02-14 Merck Frosst Canada Ltd. Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
WO2008075007A1 (en) * 2006-12-21 2008-06-26 Cancer Research Technology Limited Morpholino-substituted bicycloheteroaryl compounds and their use as anti cancer agents
US20080233127A1 (en) * 2007-03-21 2008-09-25 Wyeth Imidazolopyrimidine analogs and their use as pi3 kinase and mtor inhibitors
WO2009047563A1 (en) 2007-10-11 2009-04-16 Astrazeneca Ab Pyrrolo [2, 3 -d] pyrimidin derivatives as protein kinase b inhibitors
JP5647998B2 (en) * 2009-03-13 2015-01-07 カトリーケ ユニバーシテイト ルーヴェン、ケー．ユー． ルーヴェン アール アンド ディー Thiazolopyrimidine modulators as immunosuppressants
SI2694056T1 (en) 2011-04-01 2019-12-31 Astrazeneca Ab Therapeutic treatment
DK2785349T4 (en) 2011-11-30 2023-01-09 Astrazeneca Ab COMBINATION TREATMENT OF CANCER
AU2013204533B2 (en) 2012-04-17 2017-02-02 Astrazeneca Ab Crystalline forms
WO2013182612A1 (en) * 2012-06-07 2013-12-12 Bayer Pharma Aktiengesellschaft Glucose transport inhibitors
WO2016169417A1 (en) * 2015-04-21 2016-10-27 成都金瑞长青生物科技有限公司 Purinyl-n-hydroxyl pyrimidine formamide derivatives, preparation method therefor and use thereof
CZ2016608A3 (en) * 2015-10-26 2017-01-18 Ústav experimentální botaniky AV ČR, v. v. i. 2,6-disubstituted purines for use as pharmaceuticals, and pharmaceutical preparations
CZ306987B6 (en) * 2015-10-26 2017-11-01 Ústav experimentální botaniky AV ČR, v. v. i. 2,6-disubstituted purines for use as pharmaceuticals and pharmaceutical preparations containing them

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993020078A1 (en) * 1992-04-03 1993-10-14 The Upjohn Company Pharmaceutically active bicyclic-heterocyclic amines
WO1998005235A1 (en) * 1996-08-01 1998-02-12 A.W. Faber-Castell Unternehmensverwaltung Gmbh & Co. Refillable soft lead pencil
WO1999002162A1 (en) * 1997-07-12 1999-01-21 Cancer Research Campaign Technology Limited Cyclin dependent kinase inhibiting purine derivatives
WO1999065909A1 (en) * 1998-06-19 1999-12-23 Pfizer Products Inc. PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS
WO2000044750A1 (en) * 1999-02-01 2000-08-03 Cv Therapeutics, Inc. PURINE INHIBITORS OF CYCLIN DEPENDENT KINASE 2 AND Iλ-A$g(a)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5929046A (en) * 1994-06-08 1999-07-27 Cancer Research Campaign Technology Limited Pyrimidine and purine derivatives and their use in treating tumour cells
FR2818642B1 (en) * 2000-12-26 2005-07-15 Hoechst Marion Roussel Inc NOVEL DERIVATIVES OF PURINE, PROCESS FOR PREPARING THEM, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND THEIR NEW USE
US7842693B2 (en) * 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
US7951592B2 (en) * 2003-11-10 2011-05-31 The Scripps Research Institute Compositions and methods for inducing cell dedifferentiation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993020078A1 (en) * 1992-04-03 1993-10-14 The Upjohn Company Pharmaceutically active bicyclic-heterocyclic amines
WO1998005235A1 (en) * 1996-08-01 1998-02-12 A.W. Faber-Castell Unternehmensverwaltung Gmbh & Co. Refillable soft lead pencil
WO1999002162A1 (en) * 1997-07-12 1999-01-21 Cancer Research Campaign Technology Limited Cyclin dependent kinase inhibiting purine derivatives
WO1999065909A1 (en) * 1998-06-19 1999-12-23 Pfizer Products Inc. PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS
WO2000044750A1 (en) * 1999-02-01 2000-08-03 Cv Therapeutics, Inc. PURINE INHIBITORS OF CYCLIN DEPENDENT KINASE 2 AND Iλ-A$g(a)

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JOHNSTON, THOMAS P. ET AL: "Synthesis of potential anticancer agents. XVI. S-Substituted derivatives of 6-mercaptopurine", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 80, 6265-71 CODEN: JACSAT; ISSN: 0002-7863, 1958, XP009052623 *
PANAGOPOULOS, KIM ET AL: "Synthesis of potent anticancer agents. I. 6-(1-Pyrrolidyl)purines, 6-(1-piperidyl)purines, and their nucleosides", ARZNEIMITTEL-FORSCHUNG , 15(3), 204-7 CODEN: ARZNAD; ISSN: 0004-4172, 1965, XP009052694 *
THOMPSON, ROBERT D. ET AL: "N6,9-Disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor", JOURNAL OF MEDICINAL CHEMISTRY , 34(9), 2877-82 CODEN: JMCMAR; ISSN: 0022-2623, 1991, XP002048672 *

Also Published As

Publication number Publication date
FR2880626B1 (en) 2008-04-18
AR052454A1 (en) 2007-03-21
EP1841769A2 (en) 2007-10-10
JP2008526930A (en) 2008-07-24
FR2880626A1 (en) 2006-07-14
US20080119467A1 (en) 2008-05-22
WO2006075094A2 (en) 2006-07-20

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