WO2006071496A3 - Appareil et procede pour la separation d'un volume de sang total en au moins trois constituants - Google Patents

Appareil et procede pour la separation d'un volume de sang total en au moins trois constituants Download PDF

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Publication number
WO2006071496A3
WO2006071496A3 PCT/US2005/044821 US2005044821W WO2006071496A3 WO 2006071496 A3 WO2006071496 A3 WO 2006071496A3 US 2005044821 W US2005044821 W US 2005044821W WO 2006071496 A3 WO2006071496 A3 WO 2006071496A3
Authority
WO
WIPO (PCT)
Prior art keywords
component
bag
separating
volume
components
Prior art date
Application number
PCT/US2005/044821
Other languages
English (en)
Other versions
WO2006071496A2 (fr
Inventor
Thomas Felt
Bruce Gibbs
Brian Holmes
Original Assignee
Gambro Inc
Thomas Felt
Bruce Gibbs
Brian Holmes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gambro Inc, Thomas Felt, Bruce Gibbs, Brian Holmes filed Critical Gambro Inc
Priority to CA002583461A priority Critical patent/CA2583461A1/fr
Priority to JP2007548272A priority patent/JP5038150B2/ja
Publication of WO2006071496A2 publication Critical patent/WO2006071496A2/fr
Publication of WO2006071496A3 publication Critical patent/WO2006071496A3/fr
Priority to US11/741,081 priority patent/US7833185B2/en
Priority to US12/633,461 priority patent/US8277406B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A61M1/0218—Multiple bag systems for separating or storing blood components with filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A61M1/0231—Multiple bag systems for separating or storing blood components with gas separating means, e.g. air outlet through microporous membrane or gas bag
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3698—Expressing processed fluid out from the turning rotor using another fluid compressing the treatment chamber; Variable volume rotors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B13/00—Control arrangements specially designed for centrifuges; Programme control of centrifuges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B04B5/0428—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles with flexible receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
    • A61M1/3633—Blood component filters, e.g. leukocyte filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A61M2205/331—Optical measuring means used as turbidity change detectors, e.g. for priming-blood or plasma-hemoglubine-interface detection
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B13/00—Control arrangements specially designed for centrifuges; Programme control of centrifuges
    • B04B2013/006—Interface detection or monitoring of separated components

Abstract

La présente invention a trait à un procédé pour la séparation d'un volume de sang total contenu dans une poche de séparation (1) en au moins trois constituants comprenant: la centrifugation de la poche de séparation (1) afin d'y séparer une première couche interne comportant du plasma, une deuxième couche intermédiaire comportant des plaquettes, une troisième couche intermédiaire comportant des lymphocytes, monocytes et granulocytes et une quatrième couche externe comportant des érythrocytes, au moins les troisième et quatrième couches se chevauchant en partie; le transfert, dans une poche de constituant plasma (2) relié à la poche de séparation (1), un constituant plasma comportant sensiblement une première fraction de la première couche; et le transfert, dans une poche de constituant de cellules mononucléaires (3a) relié à la poche de séparation (1) un constituant de cellules mononucléaires comportant au moins une fraction de la troisième couche comprenant des lymphocytes et des monocytes.
PCT/US2005/044821 2004-12-28 2005-12-12 Appareil et procede pour la separation d'un volume de sang total en au moins trois constituants WO2006071496A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002583461A CA2583461A1 (fr) 2004-12-28 2005-12-12 Appareil et procede pour la separation d'un volume de sang total en au moins trois constituants
JP2007548272A JP5038150B2 (ja) 2004-12-28 2005-12-12 一定量の全血を少なくとも３つの成分に分離する装置および方法
US11/741,081 US7833185B2 (en) 2004-12-28 2007-04-27 Apparatus for separating a volume of whole blood into at least three components
US12/633,461 US8277406B2 (en) 2004-12-28 2009-12-08 Method for separating a volume of whole blood into at least three components

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63949704P 2004-12-28 2004-12-28
US60/639,497 2004-12-28

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/741,081 Continuation US7833185B2 (en) 2004-12-28 2007-04-27 Apparatus for separating a volume of whole blood into at least three components

Publications (2)

Publication Number Publication Date
WO2006071496A2 WO2006071496A2 (fr) 2006-07-06
WO2006071496A3 true WO2006071496A3 (fr) 2007-03-08

Family

ID=36440941

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/044821 WO2006071496A2 (fr) 2004-12-28 2005-12-12 Appareil et procede pour la separation d'un volume de sang total en au moins trois constituants

Country Status (7)

Country Link
US (2) US7833185B2 (fr)
EP (2) EP2080531B1 (fr)
JP (2) JP5038150B2 (fr)
AT (1) ATE452668T1 (fr)
CA (1) CA2583461A1 (fr)
DE (1) DE602005018443D1 (fr)
WO (1) WO2006071496A2 (fr)

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Also Published As

Publication number Publication date
EP1709983A3 (fr) 2006-10-18
US8277406B2 (en) 2012-10-02
US20070203444A1 (en) 2007-08-30
EP1709983B1 (fr) 2009-12-23
JP2011206545A (ja) 2011-10-20
DE602005018443D1 (de) 2010-02-04
EP2080531A1 (fr) 2009-07-22
EP2080531B1 (fr) 2015-09-02
ATE452668T1 (de) 2010-01-15
WO2006071496A2 (fr) 2006-07-06
JP5410470B2 (ja) 2014-02-05
EP1709983A2 (fr) 2006-10-11
US20100081196A1 (en) 2010-04-01
US7833185B2 (en) 2010-11-16
JP2008525107A (ja) 2008-07-17
CA2583461A1 (fr) 2006-07-06
JP5038150B2 (ja) 2012-10-03

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