WO2006069240A3 - Composition and treatment methods for coronary artery disease - Google Patents

Composition and treatment methods for coronary artery disease Download PDF

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Publication number
WO2006069240A3
WO2006069240A3 PCT/US2005/046591 US2005046591W WO2006069240A3 WO 2006069240 A3 WO2006069240 A3 WO 2006069240A3 US 2005046591 W US2005046591 W US 2005046591W WO 2006069240 A3 WO2006069240 A3 WO 2006069240A3
Authority
WO
WIPO (PCT)
Prior art keywords
icp
cholesterol
hdl
treatment
coronary artery
Prior art date
Application number
PCT/US2005/046591
Other languages
French (fr)
Other versions
WO2006069240A2 (en
WO2006069240B1 (en
Inventor
Byung-Hong Chung
Byung-Hui Cho
Original Assignee
Uab Research Foundation
Byung-Hong Chung
Byung-Hui Cho
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uab Research Foundation, Byung-Hong Chung, Byung-Hui Cho filed Critical Uab Research Foundation
Priority to US11/722,664 priority Critical patent/US20080207503A1/en
Publication of WO2006069240A2 publication Critical patent/WO2006069240A2/en
Publication of WO2006069240A3 publication Critical patent/WO2006069240A3/en
Publication of WO2006069240B1 publication Critical patent/WO2006069240B1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1275—Lipoproteins; Chylomicrons; Artificial HDL, LDL, VLDL, protein-free species thereof; Precursors thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Abstract

The present disclosure demonstrates that cholesterol-free discoidal reconstituted HDL (R-HDL), phosphatidylcholine (PC) and PC liposomes effectively released cholesterol from ICP. Native HDL and its apolipoproteins were not able to release cholesterol from ICP. The release of ICP cholesterol by R-HDL was dose-dependent and accompanied by the transfer of >8x more PC in the reverse direction (i.e., from R-HDL to ICP), resulting in a marked enrichment of ICP with PC. The enrichment of ICP with PC resulted in the dissolution of cholesterol crystals on ICP and allowed the removal of ICP cholesterol by apo HDL and plasma. The present disclosure provides a method of treatment for removal of cholesterol from ICP in vivo and compositions for use in such method of treatment. Such methods may be used in the treatment and/or prevention of atherosclerosis, coronary artery disease, and related disease states and conditions.
PCT/US2005/046591 2004-12-22 2005-12-22 Composition and treatment methods for coronary artery disease WO2006069240A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/722,664 US20080207503A1 (en) 2005-06-22 2005-12-22 Composition and Treatment Methods for Coronary Artery Disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63901104P 2004-12-22 2004-12-22
US60/639,011 2004-12-22

Publications (3)

Publication Number Publication Date
WO2006069240A2 WO2006069240A2 (en) 2006-06-29
WO2006069240A3 true WO2006069240A3 (en) 2006-08-10
WO2006069240B1 WO2006069240B1 (en) 2006-10-05

Family

ID=36602326

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/046591 WO2006069240A2 (en) 2004-12-22 2005-12-22 Composition and treatment methods for coronary artery disease

Country Status (1)

Country Link
WO (1) WO2006069240A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858399A (en) * 1992-04-09 1999-01-12 Northwestern University Acoustically reflective liposomes and methods to make and use the same
US6248728B1 (en) * 2000-03-10 2001-06-19 Kansas State University Research Foundation Phosphatidylcholine compositions and methods for lowering intestinal absorption and plasma levels of cholesterol
US6555579B2 (en) * 1998-08-13 2003-04-29 The Wistar Institute Methods for reducing atherosclerotic plaques
US20040037781A1 (en) * 2000-06-30 2004-02-26 Mccormack Jr Francis X. Peptides with antioxidant and antimicrobial properties

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858399A (en) * 1992-04-09 1999-01-12 Northwestern University Acoustically reflective liposomes and methods to make and use the same
US6555579B2 (en) * 1998-08-13 2003-04-29 The Wistar Institute Methods for reducing atherosclerotic plaques
US6248728B1 (en) * 2000-03-10 2001-06-19 Kansas State University Research Foundation Phosphatidylcholine compositions and methods for lowering intestinal absorption and plasma levels of cholesterol
US20040037781A1 (en) * 2000-06-30 2004-02-26 Mccormack Jr Francis X. Peptides with antioxidant and antimicrobial properties

Also Published As

Publication number Publication date
WO2006069240A2 (en) 2006-06-29
WO2006069240B1 (en) 2006-10-05

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