WO2006065163A1 - Dispositif de test de medicaments destine a un patient - Google Patents

Dispositif de test de medicaments destine a un patient Download PDF

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Publication number
WO2006065163A1
WO2006065163A1 PCT/RU2004/000499 RU2004000499W WO2006065163A1 WO 2006065163 A1 WO2006065163 A1 WO 2006065163A1 RU 2004000499 W RU2004000499 W RU 2004000499W WO 2006065163 A1 WO2006065163 A1 WO 2006065163A1
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WO
WIPO (PCT)
Prior art keywords
patient
testing
selector
drug
signals
Prior art date
Application number
PCT/RU2004/000499
Other languages
English (en)
Russian (ru)
Inventor
Nikolay Alekseevich Tsvetkov
Original Assignee
Nikolay Alekseevich Tsvetkov
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nikolay Alekseevich Tsvetkov filed Critical Nikolay Alekseevich Tsvetkov
Priority to PCT/RU2004/000499 priority Critical patent/WO2006065163A1/fr
Publication of WO2006065163A1 publication Critical patent/WO2006065163A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence

Definitions

  • the invention relates to medicine, namely to medical equipment and can be used for individual selection of a drug without ingestion during reflexology, electropuncture, heat and drug therapy.
  • the device allows to assess the response of the body to the effects of various substances by changing the skin conductivity.
  • a disadvantage of the known devices is the significant duration of the diagnostic process, which is associated with the need to determine the optimal acupuncture points on the patient and low diagnostic accuracy due to effects of external electromagnetic fields on acupuncture points.
  • a device for conducting medical testing [3], containing a block of influence on the object of study (AT) in the form of a constant current source and electrodes installed in contact with the patient’s body, a testing block, including several microresonant circuits and their switching elements, a program registration unit and information processing, consisting of an AT conductivity meter with an amplifier, an analog-to-digital converter (ADC) and a computing device with a display device.
  • AT object of study
  • ADC analog-to-digital converter
  • the known device does not actually use information related to the dynamics of measuring the characteristics of the study for one or another selected test effect, which reduces the effectiveness of testing and the accuracy of the selection of the drug.
  • the present invention aims to eliminate the above disadvantages.
  • the technical result achieved by its implementation is to increase the effectiveness of drug testing by selecting a drug using a device that is not affected by external electromagnetic fields.
  • monitoring the dynamics of the study and the software processing of the data obtained allows us to additionally obtain conclusions about the effectiveness of a particular drug that is adequate to the current condition of the patient.
  • the device allows to increase the accuracy of measurements, because It works without measuring the electrical conductivity and the skin is not affected by the indications and the presence of a pacemaker in the patient. Fatigue errors of the operator conducting the study are also excluded, and research is automated.
  • the apparatus for drug testing of a patient includes a device for measuring light absorption by patient tissues using light sources with a length of waves not lower than the red range and optoelectronic sensors in at least two parts of the patient’s body, the patient’s load source in the form of a drug selector containing at least one drug, and a computing device associated with a selector and a measurement device, while the computing device It is connected to the device through a digital-to-analog converter and amplifiers of signals of optoelectronic sensors and is made with the possibility of evaluating, based on the received signals, the patient’s response to the drug load Control selector for selecting the load for the next stage of testing.
  • the computing device is capable of comparing with each other the signals of each optoelectronic sensor recorded during patient testing, determining the amplitude and / or phase variability and / or variability of the shape and / or frequency of these signals and calculating numerical characteristics corresponding to various aspects of the patient's reactions.
  • the activity of metabolic processes of various organs can dynamically change.
  • the volume of blood entering these organs dynamically changes.
  • the redistribution of the amount of blood in different parts of the body is provided by a change in the conductivity of the autonomic nerve and, thus, a change in the value of the cardio pulse, which provides maximum pressure in the innervated blood vessels.
  • a change in the value of the cardiac pulse leads to a change in both the maximum pressure and the speed of blood flow in the vessel. These changes characterize the intensity of the patient’s functioning and can be recorded by measuring the amount of light absorbed by the patient’s tissues.
  • the method is based on the measurement data of blood flow parameters in the peripheral parts of the cardiovascular system. Accordingly, it is these data that contain all the possible signs of optimal functioning and the intensity of the functioning of the patient's body.
  • Monitoring the functioning of the cardiovascular system makes it possible to observe various parameters of the blood flow: the relative change in the amount of hemoglobin and oxyhemoglobin in the blood, the pulse intervals in different leads, the change in the amplitude or phase of light absorption by hemoglobin, the gravitational parameters of the vertical blood flow, and many others.
  • the most effective use of these methods is to evaluate various kinds of drug loads with the goal, for example, of predicting the patient’s response to the prescription of a particular drug.
  • the apparatus for drug testing of a patient includes, in addition to the selector, a device for measuring light absorption by the patient’s tissues.
  • the device consists of light sources with a wavelength of at least the wavelength of the red range and optoelectronic sensors installed in at least two parts of the patient’s body.
  • the dynamics of light absorption by hemoglobin or oxyhemoglobin of the blood is determined.
  • pulse variability As already noted, a change in the value of the cardio pulse leads to a change in both the maximum pressure and the speed of blood flow in the vessel.
  • phase variability A description of how much in phase the light absorption curves of hemoglobin or oxyhemoglobin of the blood taken in different parts of the patient’s body coincide are called phase variability.
  • the smaller the differences in phase the correspondingly smaller the value of phase variability, and therefore the smaller the differences in blood flow characteristics in different parts of the patient’s body, and the closer the functioning of the test blood vessels to normal.
  • Vegetative variability is understood as the mutual difference between pulse intervals or phase deviations of the light absorption curves when measuring blood flow parameters in the peripheral parts of the cardiovascular system.
  • the variable value of the optimal functioning of the patient’s body usually uses the value of its average and amplitude deviation of blood flow from the optimum.
  • the amount of blood supplied to the cells should be consistent with the need for the cells provided with blood.
  • the functioning of the blood vessel supplying the cells is also optimal: the capacity of the vessel, its elasticity and resilience, the adequacy of its reactions to the cardiac impulse (if the vessel is innervated) and other parameters allow the amount of blood required for the cells to pass through with minimal resources.
  • the similarity to the optimal functioning of the vessel in different leads of the patient's cardiovascular system using the light absorption curve of hemoglobin or oxyhemoglobin is set by indicators of the average and amplitude deviation of blood flow from the optimum (shape variability). The smaller the value of these indicators, the less discrepancies between the recorded curves and the theoretical optimum. Consequently, less deviations from the optimum in the functioning of the test blood vessels are observed.
  • the work of the proposed device is as follows.
  • the sensors are fixed on the studied surface, for example, earlobes, fingers or toes, while the nail phalanx of the finger is fixed in the sensor between its elements so that the nail is facing the emitter.
  • the patient is tested in the absence of any drug exposure.
  • the light from each radiation source propagates through the corresponding test medium, partially absorbed in it, and is received by a photodetector generating an electric current, indicating the intensity of the incident light radiation.
  • This signal is fed to the corresponding amplifier and through a multi-channel ADC in digital form is analyzed in a computing device to determine information related to the medium through which the light energy was transmitted, and determine it characteristics.
  • Repeated testing of the patient is carried out during a drug exposure, which can include not only the use of a drug applied to the skin surface, but also allows you to analyze the patient's reactions to drugs of viruses, microbes and toxins, various organ preparations, electromagnetic, thermal and other effects.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention appartient au domaine de la médecine et concerne un dispositif de test de médicaments destiné à un patient; le dispositif comprend un instrument pour mesurer l'absorption de lumière par les tissus du patient au moyen de sources lumineuses présentant une longueur d'ondes égale ou supérieure à la gamme rouge, et au moyen de capteurs optoélectroniques dans au moins deux parties du corps du patient. Une source de charge du patient se présente comme un sélecteur de médicaments qui comprend au moins un composé, et un dispositif de calcul relié au sélecteur et à l'instrument de mesure. Le dispositif de calcul est relié avec l'instrument via un convertisseur numérique analogique et des amplificateurs de signaux des capteurs optoélectroniques; il permet de comparer entre eux les signaux enregistrés pendant le test du patient et correspondant à la réaction du patient à la charge en termes de médicaments, ainsi que de commander le sélecteur à des fins de sélection pour la prochaine étape de tests. Le dispositif de calcul donne la possibilité de comparer entre eux les signaux de patient enregistrés pendant le test correspondant à chaque capteur optoélectronique, de déterminer l'amplitude et/ou la variabilité des phases et/ou la variabilité des formes et/ou de la périodicité de ces signaux, et de calculer des caractéristiques en termes de chiffres qui correspondent à des réactions différentes du patient.
PCT/RU2004/000499 2004-12-14 2004-12-14 Dispositif de test de medicaments destine a un patient WO2006065163A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/RU2004/000499 WO2006065163A1 (fr) 2004-12-14 2004-12-14 Dispositif de test de medicaments destine a un patient

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/RU2004/000499 WO2006065163A1 (fr) 2004-12-14 2004-12-14 Dispositif de test de medicaments destine a un patient

Publications (1)

Publication Number Publication Date
WO2006065163A1 true WO2006065163A1 (fr) 2006-06-22

Family

ID=36588135

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2004/000499 WO2006065163A1 (fr) 2004-12-14 2004-12-14 Dispositif de test de medicaments destine a un patient

Country Status (1)

Country Link
WO (1) WO2006065163A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3521779A1 (de) * 1985-06-19 1987-01-02 Franz Josef Seitner Schnelldiagnose-geraet fuer den medikamenten-test in der elektro-akupunktur
SU1653776A1 (ru) * 1989-06-26 1991-06-07 В.Н.Сарчук. ВАБыстоов и А.В.Яценко Устройство дл проведени этиологической диагностики и медикаментозного теста
RU2086229C1 (ru) * 1996-09-19 1997-08-10 Фоменко Валерий Иванович Аппаратно-программный комплекс "елена"
RU2200459C2 (ru) * 1999-11-30 2003-03-20 Девликанов Энвер Османович Способ выбора медикаментозных средств при лечении больных с вестибулярными нарушениями

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3521779A1 (de) * 1985-06-19 1987-01-02 Franz Josef Seitner Schnelldiagnose-geraet fuer den medikamenten-test in der elektro-akupunktur
SU1653776A1 (ru) * 1989-06-26 1991-06-07 В.Н.Сарчук. ВАБыстоов и А.В.Яценко Устройство дл проведени этиологической диагностики и медикаментозного теста
RU2086229C1 (ru) * 1996-09-19 1997-08-10 Фоменко Валерий Иванович Аппаратно-программный комплекс "елена"
RU2200459C2 (ru) * 1999-11-30 2003-03-20 Девликанов Энвер Османович Способ выбора медикаментозных средств при лечении больных с вестибулярными нарушениями

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