WO2006050033B1 - System and method for analyte sampling and analysis - Google Patents

System and method for analyte sampling and analysis

Info

Publication number
WO2006050033B1
WO2006050033B1 PCT/US2005/038786 US2005038786W WO2006050033B1 WO 2006050033 B1 WO2006050033 B1 WO 2006050033B1 US 2005038786 W US2005038786 W US 2005038786W WO 2006050033 B1 WO2006050033 B1 WO 2006050033B1
Authority
WO
WIPO (PCT)
Prior art keywords
monitoring system
analyte
biological membrane
transdermal
analyte monitoring
Prior art date
Application number
PCT/US2005/038786
Other languages
French (fr)
Other versions
WO2006050033A3 (en
WO2006050033A9 (en
WO2006050033A2 (en
Inventor
Scott C Kellogg
Han Chuang
Original Assignee
Sontra Medical Corp
Scott C Kellogg
Han Chuang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/223,960 external-priority patent/US20060094945A1/en
Application filed by Sontra Medical Corp, Scott C Kellogg, Han Chuang filed Critical Sontra Medical Corp
Publication of WO2006050033A2 publication Critical patent/WO2006050033A2/en
Publication of WO2006050033A3 publication Critical patent/WO2006050033A3/en
Publication of WO2006050033B1 publication Critical patent/WO2006050033B1/en
Publication of WO2006050033A9 publication Critical patent/WO2006050033A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6802—Sensor mounted on worn items
    • A61B5/681—Wristwatch-type devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061—Means for enhancing collection
    • A61B5/150083—Means for enhancing collection by vibration, e.g. ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150358—Strips for collecting blood, e.g. absorbent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150969—Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15134—Bladeless capillary blood sampling devices, i.e. devices for perforating the skin in order to obtain a blood sample but not using a blade, needle, canula, or lancet, e.g. by laser perforation, suction or pressurized fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B2010/0003—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements including means for analysis by an unskilled person

Abstract

The invention relates to a transdermal analyte monitoring system comprising a medium adapted to interface with a biological membrane and to receive an analyte from the biological membrane and an electrode assembly comprising a plurality of electrodes, wherein the medium is adapted to react continuously with the analyte, an electrical signal is detected by the electrode assembly, and the electrical signal correlates to an analyte value. The analyte value may be the flux of the analyte through the biological membrane or the concentration of the analyte in a body fluid of a subject. The medium may comprise a vinyl acetate based hydrogel, an agarose based hydrogel, or a polyethylene glycol diacrylate (PEG-DA) based hydrogel, for example. The surface region of the electrode may comprise pure platinum. The system may include an interference filter located between the biological membrane and the electrode assembly for reducing interference in the system. The system may comprise a processor programmed to implement an error correction method that corrects for sensor drift.

Claims

AMENDED CLAIMS Received by the International Bureau on 19 September 2006 (19.09.2006)
1. A transdermal analyte monitoring system comprising: a medium adapted to interface with a biological membrane and to receive an analyte from the biological membrane; and an substantially planar electrode assembly comprising a plurality of electrodes, wherein a surface region of at least one of the electrode consists essentially of pure platinum; wherein the medium is adapted to react continuously with the analyte; and wherein an electrical signal is detected by the electrode assembly, and the electrical signal correlates to an analyte value.
2. The transdermal analyte monitoring system of claim 1, wherein the analyte value is the flux of the analyte through the biological membrane.
3. The transdermal analyte monitoring system of claim 1, wherein the analyte value is the concentration of the analyte in a body fluid of a subject.
4. The transdermal analyte monitoring system of claim 1, further comprising a sensor body that supports the electrode assembly and the medium.
5. The transdermal analyte monitoring system of claim 1, wherein the analyte comprises glucose.
6. The transdermal analyte monitoring system of claim 5, wherein the medium comprises a hydrogel.
7. The transdermal analyte monitoring system of claim 6, wherein the medium further comprises glucose oxidase.
8. The transdermal analyte monitoring system of claim 5, wherein the surface region consisting essentially of pure platinum provides an increased signal representative of glucose concentration as compared with a signal from a surface region comprising platinized carbon.
9. The transdermal analyte monitoring system of claim 5, wherein the surface region consisting essentially of pure platinum provides an increased signal representative of a rate of production of hydrogen peroxide as compared with a signal from a surface region comprising platinized carbon.
10. The transdermal analyte monitoring system of claim 1, further comprising an interference filter located between the biological membrane and the electrode for reducing interference in the transdermal analyte monitoring system.
11. The transdermal analyte monitoring system of claim 10, wherein the interference filter comprises a biocompatible anionic fiuoropolymer.
46
12. The transdermal analyte monitoring system of claim 1, wherein the biological membrane comprises skin.
13. The transdermal analyte monitoring system of claim 1, wherein the electrode assembly comprises a working electrode, a counter electrode, and a reference electrode.
14. A transdermal analyte monitoring system comprising: a medium adapted to interface with a biological membrane and to receive an analyte from the biological membrane; an electrode assembly; and an interference filter located between the biological membrane and the electrode assembly for reducing interference from non-target biological moieties in the transdermal analyte monitoring system.
15. The transdermal analyte monitoring system of claim 14, wherein the medium is adapted to react continuously with the analyte, an electrical signal is detected by the electrode assembly, and the electrical signal correlates to an analyte value.
16. The transdermal analyte monitoring system of claim 14, wherein the interference filter comprises a biocompatible anionic fluoropolymer.
17. The transdermal analyte monitoring system of claim 14, wherein the interference filter comprises Nafion.
18. The transdermal analyte monitoring system of claim 14, wherein the interference filter is selected from the group consisting of: (3-mercaptopropyi)trimethylsilane, cellulose acetate, 1,8- diaminonapthaline, phenylenediamine, and a PTFE membrane., a hydrophobic membrane. Nylon and a hydrophylic mombrano.
19. The transdermal analyte monitoring system of claim 14, wherein the interference filter located between the electrode assembly and the medium.
20. The transdermal analyte monitoring system of claim 14, where the interference filter is disposed on a surface of an electrode in the electrode assembly.
21. The transdermal analyte monitoring system of claim 14, where the interference filter is disposed on an outer surface of the electrode assembly that contacts the biological membrane in operation.
22. The transdermal analyte monitoring system of claim 15, wherein the analyte value is the flux of the analyte through the biological membrane.
23. The transdermal analyte monitoring system of claim 15, wherein the analyte value is the concentration of the analyte in a body fluid of a subject.
47
24. The transdermal analyte monitoring system of claim 14, wherein the analyte comprises glucose.
25. The transdermal analyte monitoring system of claim 24, wherein the medium comprises a hydrogel and glucose oxidase.
26. The transdermal analyte monitoring system of claim 14, wherein the interference filter reduces interference effects from unwanted electrochemical oxidation.
27. The transdermal analyte monitoring system of claim 14, wherein the interference filter reduces an anodic signal produced by electrochemical oxidation of ascorbic acid, uric acide, or acetaminophen.
28. The transdermal analyte monitoring system of claim 14, wherein the interference filter reduces biofouling.
29. A method for monitoring an analyte comprising: positioning a medium with respect to a biological membrane such that the medium can receive an analyte from the biological membrane, wherein as substantially planar electrode assembly is coupled to the medium, the electrode assembly comprises a plurality of electrodes, and at least one of the electrodes comprises a surface region consisting essentially of pure platinum; continuously reacting the analyte with the medium; and detecting an electrical signal with the electrode assembly, wherein the electrical signal correlates to an analyte value.
30. The method of claim 29, further comprising pretreating the biological membrane to increase a permeability of the biological membrane.
31. The method of claim 30, wherein the pretreating step comprises applying low frequency ultrasound to the biological membrane.
32. The method of claim 29, wherein the surface region consisting essentially of pure platinum provides an increased signal representative of glucose concentration as compared with a signal from a surface region comprising platinized carbon.
33. The method of claim 29, wherein the surface region consisting essentially of pure platinum provides an increased signal representative of a rate of production of hydrogen peroxide as compared with a signal from a surface region comprising platinized carbon.
34. A method for monitoring an analyte comprising: positioning a medium with respect to a biological membrane such that the medium can receive an analyte from the biological membrane, wherein aa substantially planar electrode
48 assembly is coupled to the medium and an interference filter is positioned between an electrode in the electrode assembly and the biological membrane; continuously reacting the analyte with the medium; and detecting an electrical signal with the electrode assembly, wherein the electrical signal correlates to an analyte value.
35. The method of claim 34, further comprising pretreating the biological membrane to increase a permeability of the biological membrane.
36. The method of claim 35, wherein the pretreating step comprises applying low frequency ultrasound to the biological membrane.
37. The method of claim 34, wherein the interference filter comprises Nafion.
38. The method of claim 34, wherein the interference filter is selected from the group consisting of: (3-mercaptopropyl)trimethylsilane, cellulose acetate, 1,8-diaminonapthaline, phenyl enediamine, and a PTFE membrane., a hydrophobic membrane. Nylon and a hydrophylic membrane..
39. The method of claim 34, wherein the interference filter reduces interference effects from unwanted electrochemical oxidation.
40. The method of claim 34, wherein the interference filter reduces an anodic signal produced by electrochemical oxidation of ascorbic acid, uric acide, or acetaminophen.
41. The method of claim 34, wherein the interference filter reduces biofouling.
PCT/US2005/038786 2004-10-28 2005-10-27 System and method for analyte sampling and analysis WO2006050033A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US97496304A 2004-10-28 2004-10-28
US10/974,963 2004-10-28
US20133405A 2005-08-11 2005-08-11
US11/201,334 2005-08-11
US11/223,960 US20060094945A1 (en) 2004-10-28 2005-09-13 System and method for analyte sampling and analysis
US11/223,960 2005-09-13
US11/223,971 US8224414B2 (en) 2004-10-28 2005-09-13 System and method for analyte sampling and analysis with hydrogel
US11/223,957 US20060094944A1 (en) 2004-10-28 2005-09-13 System and method for analyte sampling and analysis with error correction

Publications (4)

Publication Number Publication Date
WO2006050033A2 WO2006050033A2 (en) 2006-05-11
WO2006050033A3 WO2006050033A3 (en) 2006-11-02
WO2006050033B1 true WO2006050033B1 (en) 2006-12-14
WO2006050033A9 WO2006050033A9 (en) 2007-02-01

Family

ID=38441686

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2005/038786 WO2006050033A2 (en) 2004-10-28 2005-10-27 System and method for analyte sampling and analysis
PCT/US2005/038785 WO2006050032A2 (en) 2004-10-28 2005-10-27 System and method for analyte sampling and analysis with hydrogel
PCT/US2005/038784 WO2006050031A2 (en) 2004-10-28 2005-10-27 System and method for analyte sampling and analysis with error correction

Family Applications After (2)

Application Number Title Priority Date Filing Date
PCT/US2005/038785 WO2006050032A2 (en) 2004-10-28 2005-10-27 System and method for analyte sampling and analysis with hydrogel
PCT/US2005/038784 WO2006050031A2 (en) 2004-10-28 2005-10-27 System and method for analyte sampling and analysis with error correction

Country Status (4)

Country Link
EP (1) EP1819283A4 (en)
AU (1) AU2005302584B2 (en)
CA (1) CA2584699C (en)
WO (3) WO2006050033A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9198568B2 (en) 2010-03-04 2015-12-01 The General Hospital Corporation Methods and systems of matching voice deficits with a tunable mucosal implant to restore and enhance individualized human sound and voice production
US9216188B2 (en) 2008-09-04 2015-12-22 The General Hospital Corporation Hydrogels for vocal cord and soft tissue augmentation and repair

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090137888A9 (en) * 2001-04-27 2009-05-28 Berman Herbert L System for monitoring of patients
JP5021678B2 (en) * 2005-12-27 2012-09-12 バイエル・ヘルスケア・エルエルシー Electrochemical sensor system using substrate having at least one electrode and method of forming the same
US20070202562A1 (en) * 2006-02-27 2007-08-30 Curry Kenneth M Flux limiting membrane for intravenous amperometric biosensor
CA2680213C (en) * 2007-03-07 2014-10-14 Echo Therapeutics, Inc. Transdermal analyte monitoring systems and methods for analyte detection
EP2322093B1 (en) * 2008-07-31 2018-01-10 Sysmex Corporation Method for assaying in vivo component and apparatus and collection member for assaying in vivo component
EP2376059A2 (en) * 2008-11-25 2011-10-19 B.G. Negev Technologies and Applications Ltd. Pharmaceutical composition and system for permeabilizing fetal membranes
EP2208458A1 (en) * 2009-01-14 2010-07-21 Roche Diagnostics GmbH Medical monitoring network
CN102405018B (en) 2009-03-02 2014-11-19 第七感生物系统有限公司 Techniques and devices associated with blood sampling
US20120006100A1 (en) 2010-07-06 2012-01-12 Medtronic Minimed, Inc. Method and/or system for determining blood glucose reference sample times
US20130158482A1 (en) 2010-07-26 2013-06-20 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
US20120039809A1 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
EP3235429B1 (en) 2011-04-29 2023-06-07 YourBio Health, Inc. Devices and methods for collection of blood from a subject
EP2701598A1 (en) 2011-04-29 2014-03-05 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
BR112013027351B1 (en) 2011-04-29 2022-03-03 Seventh Sense Biosystems, Inc Device for receiving fluid from an individual
US9968284B2 (en) 2011-12-02 2018-05-15 Clinitech, Llc Anti-interferent barrier layers for non-invasive transdermal sampling and analysis device
US10371610B2 (en) 2016-02-23 2019-08-06 Noul Co., Ltd. Contact-type patch, staining method using the same, and manufacturing method thereof
KR20170099739A (en) 2016-02-23 2017-09-01 노을 주식회사 Contact-type staining-assist patch, manufacturing method thereof and staining method using the patch
US11375931B2 (en) 2019-08-08 2022-07-05 Cambridge Medical Technologies LLC Non-invasive transdermal sampling and analysis device incorporating an electrochemical bioassay

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2907342B2 (en) 1988-01-29 1999-06-21 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア Ion infiltration non-invasive sampling or delivery device
US5458140A (en) 1993-11-15 1995-10-17 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
US5771890A (en) * 1994-06-24 1998-06-30 Cygnus, Inc. Device and method for sampling of substances using alternating polarity
US5947921A (en) 1995-12-18 1999-09-07 Massachusetts Institute Of Technology Chemical and physical enhancers and ultrasound for transdermal drug delivery
US6002961A (en) 1995-07-25 1999-12-14 Massachusetts Institute Of Technology Transdermal protein delivery using low-frequency sonophoresis
US6689265B2 (en) * 1995-10-11 2004-02-10 Therasense, Inc. Electrochemical analyte sensors using thermostable soybean peroxidase
US5711861A (en) * 1995-11-22 1998-01-27 Ward; W. Kenneth Device for monitoring changes in analyte concentration
DE19602861C2 (en) * 1996-01-28 1997-12-11 Meinhard Prof Dr Knoll Sampling system for analytes contained in carrier liquids and method for its production
US6009343A (en) 1996-02-23 1999-12-28 Abbott Laboratories Enhanced transdermal transport of fluid using vacuum
US7105352B2 (en) * 1996-11-06 2006-09-12 University Of Pittsburgh Intelligent polymerized crystalline colloidal array carbohydrate sensors
US6117643A (en) * 1997-11-25 2000-09-12 Ut Battelle, Llc Bioluminescent bioreporter integrated circuit
US6579690B1 (en) * 1997-12-05 2003-06-17 Therasense, Inc. Blood analyte monitoring through subcutaneous measurement
US6190315B1 (en) * 1998-01-08 2001-02-20 Sontra Medical, Inc. Sonophoretic enhanced transdermal transport
US7066884B2 (en) * 1998-01-08 2006-06-27 Sontra Medical, Inc. System, method, and device for non-invasive body fluid sampling and analysis
US20060015058A1 (en) * 1998-01-08 2006-01-19 Kellogg Scott C Agents and methods for enhancement of transdermal transport
CA2265119C (en) * 1998-03-13 2002-12-03 Cygnus, Inc. Biosensor, iontophoretic sampling system, and methods of use thereof
PT1077636E (en) * 1998-05-13 2004-06-30 Cygnus Therapeutic Systems SIGNAL PROCESSING FOR PHYSIOLOGICAL ANALYZES MEDICATION
US20040171980A1 (en) * 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
EP1064046A1 (en) * 1999-04-22 2001-01-03 Cygnus, Inc. Methods and devices for removing interfering species
US7181261B2 (en) * 2000-05-15 2007-02-20 Silver James H Implantable, retrievable, thrombus minimizing sensors
US6837988B2 (en) * 2001-06-12 2005-01-04 Lifescan, Inc. Biological fluid sampling and analyte measurement devices and methods
WO2003089506A1 (en) * 2002-04-22 2003-10-30 Purdue Research Foundation Hydrogels having enhanced elasticity and mechanical strength properties
US7150975B2 (en) * 2002-08-19 2006-12-19 Animas Technologies, Llc Hydrogel composition for measuring glucose flux
US6931327B2 (en) * 2003-08-01 2005-08-16 Dexcom, Inc. System and methods for processing analyte sensor data

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9216188B2 (en) 2008-09-04 2015-12-22 The General Hospital Corporation Hydrogels for vocal cord and soft tissue augmentation and repair
US9198568B2 (en) 2010-03-04 2015-12-01 The General Hospital Corporation Methods and systems of matching voice deficits with a tunable mucosal implant to restore and enhance individualized human sound and voice production

Also Published As

Publication number Publication date
WO2006050033A3 (en) 2006-11-02
WO2006050031A9 (en) 2006-06-15
CA2584699A1 (en) 2006-05-11
WO2006050031A2 (en) 2006-05-11
CA2584699C (en) 2015-12-08
EP1819283A4 (en) 2011-08-10
EP1819283A2 (en) 2007-08-22
AU2005302584A1 (en) 2006-05-11
AU2005302584B2 (en) 2011-08-11
WO2006050032A9 (en) 2006-11-02
WO2006050032A2 (en) 2006-05-11
WO2006050033A9 (en) 2007-02-01
WO2006050031A3 (en) 2007-05-18
WO2006050032A3 (en) 2006-09-08
WO2006050033A2 (en) 2006-05-11

Similar Documents

Publication Publication Date Title
WO2006050033B1 (en) System and method for analyte sampling and analysis
US4795707A (en) Electrochemical sensor having three layer membrane containing immobilized enzymes
CN107632050B (en) Oxygen-enriched anti-interference glucose electrochemical detection method
Pereira-Rodrigues et al. Electrocatalytic activity of cobalt phthalocyanine CoPc adsorbed on a graphite electrode for the oxidation of reduced l-glutathione (GSH) and the reduction of its disulfide (GSSG) at physiological pH
CN101711356B (en) Amperometric biosensor for histamine determination
BRPI0517255A (en) hydrogel analyte sampling and analysis system and method
Mascini et al. Glucose electrochemical probe with extended linearity for whole blood
Özcan et al. Selective and sensitive voltammetric determination of dopamine in blood by electrochemically treated pencil graphite electrodes
Wang et al. Chitosan/Prussian blue-based biosensors
Lukachova et al. Electrosynthesis of poly-o-diaminobenzene on the Prussian Blue modified electrodes for improvement of hydrogen peroxide transducer characteristics
Rodriguez et al. Glucose biosensor prepared by the deposition of iridium and glucose oxidase on glassy carbon transducer
EP0326421A2 (en) An electroanalytical method
Ferri et al. A Glucose Biosensor Based on Electro‐Enzyme Catalyzed Oxidation of Glucose Using a HRP‐GOD Layered Assembly
Šestáková et al. Constant Current Chronopotentiometric Stripping Analysis of Cd‐Metallothionein on Carbon and Mercury Electrodes. Comparison with Voltammetry
Yang et al. An Integrated Needle‐Type Biosensor for Intravascular Glucose and Lactate Monitoring
Mizuguchi et al. Flow-based biosensing system for glucose fabricated by using track-etched microporous membrane electrodes
WO2006081377A8 (en) Amperometric sensor comprising counter electrode isolated from liquid electrolyte
Rodriguez et al. Amperometric glucose biosensor based on the deposition of copper and glucose oxidase onto glassy carbon transducer
Riyanto et al. Determination of glucose in human urine by cyclic voltammetry method using gold electrode
Arslan et al. A new laccase-based biosensor for epinephrine determination
Xie et al. An interference-free implantable glucose microbiosensor based on use of a polymeric analyte-regulating membrane
RU2713111C1 (en) Test strip for determining content of ethyl alcohol in blood by electrochemical method using a portable amperometric cell
Abdel‐Humid et al. Needle‐type glucose biosensor with an electrochemically codeposited enzyme in a platinum black matrix
Mizuguchi Track-Etched Microporous Membrane Electrodes and Its Applications in Flow Analysis Mini-Review
JP3035572B2 (en) Cholesterol sensor

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LC LK LR LS LT LU LV LY MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase in:

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 05824841

Country of ref document: EP

Kind code of ref document: A2