WO2006050033A3 - System and method for analyte sampling and analysis - Google Patents

System and method for analyte sampling and analysis Download PDF

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Publication number
WO2006050033A3
WO2006050033A3 PCT/US2005/038786 US2005038786W WO2006050033A3 WO 2006050033 A3 WO2006050033 A3 WO 2006050033A3 US 2005038786 W US2005038786 W US 2005038786W WO 2006050033 A3 WO2006050033 A3 WO 2006050033A3
Authority
WO
WIPO (PCT)
Prior art keywords
analyte
biological membrane
electrode assembly
medium
based hydrogel
Prior art date
Application number
PCT/US2005/038786
Other languages
French (fr)
Other versions
WO2006050033B1 (en
WO2006050033A2 (en
WO2006050033A9 (en
Inventor
Scott C Kellogg
Han Chuang
Original Assignee
Sontra Medical Corp
Scott C Kellogg
Han Chuang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/223,971 external-priority patent/US8224414B2/en
Application filed by Sontra Medical Corp, Scott C Kellogg, Han Chuang filed Critical Sontra Medical Corp
Publication of WO2006050033A2 publication Critical patent/WO2006050033A2/en
Publication of WO2006050033A3 publication Critical patent/WO2006050033A3/en
Publication of WO2006050033B1 publication Critical patent/WO2006050033B1/en
Publication of WO2006050033A9 publication Critical patent/WO2006050033A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6802—Sensor mounted on worn items
    • A61B5/681—Wristwatch-type devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061—Means for enhancing collection
    • A61B5/150083—Means for enhancing collection by vibration, e.g. ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150358—Strips for collecting blood, e.g. absorbent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150969—Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15134—Bladeless capillary blood sampling devices, i.e. devices for perforating the skin in order to obtain a blood sample but not using a blade, needle, canula, or lancet, e.g. by laser perforation, suction or pressurized fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B2010/0003—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements including means for analysis by an unskilled person

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Optics & Photonics (AREA)
  • Pain & Pain Management (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention relates to a transdermal analyte monitoring system comprising a medium adapted to interface with a biological membrane and to receive an analyte from the biological membrane and an electrode assembly comprising a plurality of electrodes, wherein the medium is adapted to react continuously with the analyte, an electrical signal is detected by the electrode assembly, and the electrical signal correlates to an analyte value. The analyte value may be the flux of the analyte through the biological membrane or the concentration of the analyte in a body fluid of a subject. The medium may comprise a vinyl acetate based hydrogel, an agarose based hydrogel, or a polyethylene glycol diacrylate (PEG-DA) based hydrogel, for example. The surface region of the electrode may comprise pure platinum. The system may include an interference filter located between the biological membrane and the electrode assembly for reducing interference in the system. The system may comprise a processor programmed to implement an error correction method that corrects for sensor drift.
PCT/US2005/038786 2004-10-28 2005-10-27 System and method for analyte sampling and analysis WO2006050033A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US97496304A 2004-10-28 2004-10-28
US10/974,963 2004-10-28
US20133405A 2005-08-11 2005-08-11
US11/201,334 2005-08-11
US11/223,971 US8224414B2 (en) 2004-10-28 2005-09-13 System and method for analyte sampling and analysis with hydrogel
US11/223,957 US20060094944A1 (en) 2004-10-28 2005-09-13 System and method for analyte sampling and analysis with error correction
US11/223,960 US20060094945A1 (en) 2004-10-28 2005-09-13 System and method for analyte sampling and analysis
US11/223,960 2005-09-13

Publications (4)

Publication Number Publication Date
WO2006050033A2 WO2006050033A2 (en) 2006-05-11
WO2006050033A3 true WO2006050033A3 (en) 2006-11-02
WO2006050033B1 WO2006050033B1 (en) 2006-12-14
WO2006050033A9 WO2006050033A9 (en) 2007-02-01

Family

ID=38441686

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2005/038785 WO2006050032A2 (en) 2004-10-28 2005-10-27 System and method for analyte sampling and analysis with hydrogel
PCT/US2005/038784 WO2006050031A2 (en) 2004-10-28 2005-10-27 System and method for analyte sampling and analysis with error correction
PCT/US2005/038786 WO2006050033A2 (en) 2004-10-28 2005-10-27 System and method for analyte sampling and analysis

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/US2005/038785 WO2006050032A2 (en) 2004-10-28 2005-10-27 System and method for analyte sampling and analysis with hydrogel
PCT/US2005/038784 WO2006050031A2 (en) 2004-10-28 2005-10-27 System and method for analyte sampling and analysis with error correction

Country Status (4)

Country Link
EP (1) EP1819283A4 (en)
AU (1) AU2005302584B2 (en)
CA (1) CA2584699C (en)
WO (3) WO2006050032A2 (en)

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US20090137888A9 (en) * 2001-04-27 2009-05-28 Berman Herbert L System for monitoring of patients
CN101454667B (en) 2005-12-27 2013-04-24 拜尔保健有限公司 Electrochemical sensor system using a substrate with at least one aperature and method of making the same
CN101360450A (en) * 2006-02-27 2009-02-04 爱德华兹生命科学公司 Flux limiting membrane for intravenous amperometric biosensor
RU2444980C2 (en) * 2007-03-07 2012-03-20 Эко Терапьютикс, Инк. Transdermal system of analite monitoring and methods of analite detection
CN102105103B (en) * 2008-07-31 2015-09-09 希森美康株式会社 The in vivo assay method of composition, for the data processing method of in vivo composition measurement, in vivo component measuring device and collecting part
EP2341953B1 (en) 2008-09-04 2018-11-21 The General Hospital Corporation Hydrogels for vocal cord and soft tissue augmentation and repair
EP2376059A2 (en) * 2008-11-25 2011-10-19 B.G. Negev Technologies and Applications Ltd. Pharmaceutical composition and system for permeabilizing fetal membranes
EP2208458A1 (en) * 2009-01-14 2010-07-21 Roche Diagnostics GmbH Medical monitoring network
CN102405015B (en) 2009-03-02 2017-01-18 第七感生物系统有限公司 Devices and methods for the analysis of an extractable medium
WO2012018486A2 (en) 2010-07-26 2012-02-09 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
WO2011109730A2 (en) 2010-03-04 2011-09-09 The General Hospital Corporation Methods and systems of matching voice deficits with a tunable mucosal implant to restore and enhance individualized human sound and voice production
US20120006100A1 (en) 2010-07-06 2012-01-12 Medtronic Minimed, Inc. Method and/or system for determining blood glucose reference sample times
WO2012021801A2 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
WO2012149126A1 (en) 2011-04-29 2012-11-01 Seventh Sense Biosystems, Inc. Plasma or serum production and removal of fluids under reduced pressure
EP3106092A3 (en) 2011-04-29 2017-03-08 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
ES2597081T3 (en) 2011-04-29 2017-01-13 Seventh Sense Biosystems, Inc. Delivery and / or reception of fluids
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
US9968284B2 (en) * 2011-12-02 2018-05-15 Clinitech, Llc Anti-interferent barrier layers for non-invasive transdermal sampling and analysis device
KR20170099737A (en) 2016-02-23 2017-09-01 노을 주식회사 Contact-type staining patch and staining method using the same
US10371610B2 (en) 2016-02-23 2019-08-06 Noul Co., Ltd. Contact-type patch, staining method using the same, and manufacturing method thereof
US11375931B2 (en) 2019-08-08 2022-07-05 Cambridge Medical Technologies LLC Non-invasive transdermal sampling and analysis device incorporating an electrochemical bioassay

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US6287438B1 (en) * 1996-01-28 2001-09-11 Meinhard Knoll Sampling system for analytes which are fluid or in fluids and process for its production
US20030027240A1 (en) * 1996-11-06 2003-02-06 University Of Pittsburgh Intelligent polymerized crystalline colloidal array carbohydrate sensors
US20030100846A1 (en) * 1998-01-08 2003-05-29 Linda Custer System, method, and device for non-invasive body fluid sampling and analysis
US20030100040A1 (en) * 1997-12-05 2003-05-29 Therasense Inc. Blood analyte monitoring through subcutaneous measurement
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Publication number Priority date Publication date Assignee Title
US20010017269A1 (en) * 1995-10-11 2001-08-30 Therasense, Inc. Electrochemical analyte sensors using thermostable soybean peroxidase
US6212416B1 (en) * 1995-11-22 2001-04-03 Good Samaritan Hospital And Medical Center Device for monitoring changes in analyte concentration
US6287438B1 (en) * 1996-01-28 2001-09-11 Meinhard Knoll Sampling system for analytes which are fluid or in fluids and process for its production
US20030027240A1 (en) * 1996-11-06 2003-02-06 University Of Pittsburgh Intelligent polymerized crystalline colloidal array carbohydrate sensors
US6673596B1 (en) * 1997-11-25 2004-01-06 Ut-Battelle, Llc In vivo biosensor apparatus and method of use
US20030100040A1 (en) * 1997-12-05 2003-05-29 Therasense Inc. Blood analyte monitoring through subcutaneous measurement
US6190315B1 (en) * 1998-01-08 2001-02-20 Sontra Medical, Inc. Sonophoretic enhanced transdermal transport
US20030100846A1 (en) * 1998-01-08 2003-05-29 Linda Custer System, method, and device for non-invasive body fluid sampling and analysis
US20060015058A1 (en) * 1998-01-08 2006-01-19 Kellogg Scott C Agents and methods for enhancement of transdermal transport
US20040167383A1 (en) * 1998-03-13 2004-08-26 Cygnus, Inc. Biosensor and methods of use thereof
US20040171980A1 (en) * 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
US20040176672A1 (en) * 2000-05-15 2004-09-09 Silver James H. Implantable, retrievable, thrombus minimizing sensors
US20030232895A1 (en) * 2002-04-22 2003-12-18 Hossein Omidian Hydrogels having enhanced elasticity and mechanical strength properties
US20040087671A1 (en) * 2002-08-19 2004-05-06 Tamada Janet A. Compositions and methods for enhancement of transdermal analyte flux

Also Published As

Publication number Publication date
CA2584699A1 (en) 2006-05-11
CA2584699C (en) 2015-12-08
WO2006050031A3 (en) 2007-05-18
AU2005302584A1 (en) 2006-05-11
AU2005302584B2 (en) 2011-08-11
WO2006050032A9 (en) 2006-11-02
WO2006050033B1 (en) 2006-12-14
WO2006050031A2 (en) 2006-05-11
WO2006050033A2 (en) 2006-05-11
EP1819283A2 (en) 2007-08-22
WO2006050032A3 (en) 2006-09-08
EP1819283A4 (en) 2011-08-10
WO2006050032A2 (en) 2006-05-11
WO2006050031A9 (en) 2006-06-15
WO2006050033A9 (en) 2007-02-01

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