WO2006038185A3 - Use of the staudinger ligation in imaging and therapy end kits for imaging and therapy - Google Patents
Use of the staudinger ligation in imaging and therapy end kits for imaging and therapy Download PDFInfo
- Publication number
- WO2006038185A3 WO2006038185A3 PCT/IB2005/053258 IB2005053258W WO2006038185A3 WO 2006038185 A3 WO2006038185 A3 WO 2006038185A3 IB 2005053258 W IB2005053258 W IB 2005053258W WO 2006038185 A3 WO2006038185 A3 WO 2006038185A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- imaging
- therapy
- targeted
- staudinger ligation
- ligation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/66—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
- A61K47/665—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells the pre-targeting system, clearing therapy or rescue therapy involving biotin-(strept) avidin systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05788346A EP1799273A2 (en) | 2004-10-07 | 2005-10-04 | Use of the staudinger ligation in imaging and therapy end kits for imaging and therapy |
JP2007535308A JP2008515876A (en) | 2004-10-07 | 2005-10-04 | Use of Staudinger ligation in imaging and therapy end kits for imaging and therapy |
US11/576,536 US20080181847A1 (en) | 2004-10-07 | 2005-10-04 | Targeted Imaging and/or Therapy Using the Staudinger Ligation |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04104913 | 2004-10-07 | ||
EP04104913.1 | 2004-10-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006038185A2 WO2006038185A2 (en) | 2006-04-13 |
WO2006038185A3 true WO2006038185A3 (en) | 2006-07-13 |
Family
ID=35539273
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2005/053258 WO2006038185A2 (en) | 2004-10-07 | 2005-10-04 | Use of the staudinger ligation in imaging and therapy end kits for imaging and therapy |
PCT/IB2005/053257 WO2006038184A2 (en) | 2004-10-07 | 2005-10-04 | Compounds, kits and methods for use in medical imaging |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2005/053257 WO2006038184A2 (en) | 2004-10-07 | 2005-10-04 | Compounds, kits and methods for use in medical imaging |
Country Status (5)
Country | Link |
---|---|
US (2) | US20080075661A1 (en) |
EP (2) | EP1799273A2 (en) |
JP (2) | JP2008515875A (en) |
CN (2) | CN101035565A (en) |
WO (2) | WO2006038185A2 (en) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0428012D0 (en) | 2004-12-22 | 2005-01-26 | Hammersmith Imanet Ltd | Radiolabelling methods |
EP1894577A4 (en) * | 2005-06-14 | 2012-03-28 | Nihon Mediphysics Co Ltd | Radioactive diagnostic imaging agent |
JP2009512642A (en) * | 2005-10-04 | 2009-03-26 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Staudinger reaction in imaging and therapy and kits used for imaging and therapy |
RU2459866C2 (en) | 2005-10-12 | 2012-08-27 | Зе Скрипс Ресеч Инститьют | Selective post-translational modification of phage-displayed polypeptides |
WO2007047668A2 (en) * | 2005-10-14 | 2007-04-26 | California Institute Of Technology | Use of non-canonical amino acids as metabolic markers for rapidly-dividing cells |
US7910335B2 (en) * | 2005-10-27 | 2011-03-22 | President And Fellows Of Harvard College | Methods and compositions for labeling nucleic acids |
DK1991273T4 (en) | 2006-02-10 | 2022-02-07 | Life Technologies Corp | LABELING AND DETECTION OF POST-TRANSLATIONALLY MODIFIED PROTEINS |
US8114636B2 (en) | 2006-02-10 | 2012-02-14 | Life Technologies Corporation | Labeling and detection of nucleic acids |
RU2008142542A (en) * | 2006-03-28 | 2010-05-10 | Конинклейке Филипс Электроникс Н.В. (Nl) | APPLICATION OF STUDINGER LIGATION IN THE IN VIVO ASSEMBLY OF A BIOLOGICALLY ACTIVE COMPOUND |
MX2009009291A (en) * | 2007-03-01 | 2009-12-14 | Bayer Schering Pharma Ag | Radio fluoridation methods. |
CN101925366B (en) | 2007-11-21 | 2015-02-04 | 乔治亚大学研究基金公司 | Alkynes and methods of reacting alkynes with 1,3-dipole-functional compounds |
CN102119223A (en) | 2008-05-16 | 2011-07-06 | 生命技术公司 | Dual labeling methods for measuring cellular proliferation |
EP2300601A1 (en) * | 2008-07-14 | 2011-03-30 | Koninklijke Philips Electronics N.V. | Process for providing an assembly of cell microcarriers |
EP2361098B1 (en) | 2008-10-31 | 2019-08-28 | The General Hospital Corporation | Compositions and methods for delivering a substance to a biological target |
DE102009012640A1 (en) | 2009-03-09 | 2010-09-30 | Freie Universität Berlin | Phosphoamidate group modified compound and its use |
JP5594742B2 (en) * | 2009-05-15 | 2014-09-24 | 独立行政法人理化学研究所 | 18F labeled azide compound, 18F labeling reagent, and 18F labeling method for alkyne compound using the same |
EP2552861A1 (en) * | 2010-03-29 | 2013-02-06 | Siemens Medical Solutions USA, Inc. | Application of staudinger ligation in pet imaging |
US9649394B2 (en) | 2010-11-22 | 2017-05-16 | The General Hospital Corporation | Compositions and methods for in vivo imaging |
JP5992435B2 (en) | 2010-12-21 | 2016-09-14 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | Remover of biomolecules from circulation |
WO2012121746A2 (en) | 2011-03-09 | 2012-09-13 | The General Hospital Corporation | Imaging beta cell mass |
DE102011109187A1 (en) | 2011-08-02 | 2013-02-07 | Aptenia Srl | Conjugation agent useful e.g. for bioassay and in medical diagnosis, comprises protected Staudinger component that is convertible into unprotected Staudinger component before conjugation reaction, and is linked with carrier by spacer group |
WO2014065860A1 (en) | 2012-10-24 | 2014-05-01 | The General Hospital Corporation | Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions |
WO2014182704A2 (en) | 2013-05-06 | 2014-11-13 | The General Hospital Corporation | Bioorthogonal turn-on probes |
DE102013224412A1 (en) * | 2013-11-28 | 2015-05-28 | Leica Microsystems Cms Gmbh | Method for examining a sample by CARS microscopy |
EA033889B1 (en) | 2014-01-21 | 2019-12-05 | Янссен Фармацевтика Нв | Combination comprising sv2a ligand and positive allosteric modulator of metabotropic glutamatergic receptor subtype 2 |
ES2860298T3 (en) | 2014-01-21 | 2021-10-04 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators of metabotropic glutamatergic receptor subtype 2 and their use |
CN106890345B (en) * | 2015-12-17 | 2020-09-01 | 中国科学院苏州纳米技术与纳米仿生研究所 | Contrast agent molecule targeting mitochondria as T2Use of contrast agents |
WO2019151128A1 (en) * | 2018-02-05 | 2019-08-08 | 国立大学法人 宮崎大学 | Cell labeling agent and cell labeling kit |
US11224666B2 (en) * | 2018-02-14 | 2022-01-18 | Boston Scientific Scimed, Inc. | Gadolinium contrast agents, scavenging methods, and scavenging system |
WO2019177740A1 (en) * | 2018-03-12 | 2019-09-19 | Boston Scientific Scimed, Inc. | Scavenging methods, and scavenging system for radiocontrast agents |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1987002708A1 (en) * | 1985-10-24 | 1987-05-07 | Siska Diagnostics, Inc. | Lanthanide chelate-tagged nucleic acid probes |
WO1989004375A1 (en) * | 1987-10-23 | 1989-05-18 | Siska Diagnostics, Inc. | Lanthanide chelate-tagged nucleic acid probes |
EP0659764A2 (en) * | 1993-12-21 | 1995-06-28 | SORIN BIOMEDICA S.p.A. | Peptides modified by the phosphine group for marking with 99mTC and 186-188Re or paramagnetic agents |
US5948386A (en) * | 1997-03-14 | 1999-09-07 | The Curators Of The University Of Missouri | Conjugate and method for forming aminomethyl phosphorus conjugates |
WO2001068565A2 (en) * | 2000-03-16 | 2001-09-20 | The Regents Of The University Of California | Chemoselective ligation by use of a phosphine |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4741900A (en) * | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
US5326856A (en) * | 1992-04-09 | 1994-07-05 | Cytogen Corporation | Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding |
US5608060A (en) * | 1992-06-09 | 1997-03-04 | Neorx Corporation | Biotinidase-resistant biotin-DOTA conjugates |
IL106692A (en) * | 1993-08-13 | 1997-04-15 | Israel Atomic Energy Comm | AZIDOALKYL DERIVATIVES AND THEIR USE FOR THE PREPARATION OF 99mTc COMPLEXES FOR IMAGING |
US6770261B2 (en) * | 1995-06-02 | 2004-08-03 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
AU709345B2 (en) * | 1995-09-07 | 1999-08-26 | Emory University | Therapeutic azide compounds |
-
2005
- 2005-10-04 EP EP05788346A patent/EP1799273A2/en not_active Withdrawn
- 2005-10-04 WO PCT/IB2005/053258 patent/WO2006038185A2/en active Application Filing
- 2005-10-04 CN CNA2005800342012A patent/CN101035565A/en active Pending
- 2005-10-04 US US11/576,537 patent/US20080075661A1/en not_active Abandoned
- 2005-10-04 CN CNA2005800344713A patent/CN101068577A/en active Pending
- 2005-10-04 EP EP05788312A patent/EP1809339A2/en not_active Withdrawn
- 2005-10-04 US US11/576,536 patent/US20080181847A1/en not_active Abandoned
- 2005-10-04 JP JP2007535307A patent/JP2008515875A/en active Pending
- 2005-10-04 JP JP2007535308A patent/JP2008515876A/en not_active Withdrawn
- 2005-10-04 WO PCT/IB2005/053257 patent/WO2006038184A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1987002708A1 (en) * | 1985-10-24 | 1987-05-07 | Siska Diagnostics, Inc. | Lanthanide chelate-tagged nucleic acid probes |
WO1989004375A1 (en) * | 1987-10-23 | 1989-05-18 | Siska Diagnostics, Inc. | Lanthanide chelate-tagged nucleic acid probes |
EP0659764A2 (en) * | 1993-12-21 | 1995-06-28 | SORIN BIOMEDICA S.p.A. | Peptides modified by the phosphine group for marking with 99mTC and 186-188Re or paramagnetic agents |
US5948386A (en) * | 1997-03-14 | 1999-09-07 | The Curators Of The University Of Missouri | Conjugate and method for forming aminomethyl phosphorus conjugates |
WO2001068565A2 (en) * | 2000-03-16 | 2001-09-20 | The Regents Of The University Of California | Chemoselective ligation by use of a phosphine |
Non-Patent Citations (9)
Title |
---|
CAI JIANFENG ET AL: "Nucleic acid-triggered fluorescent probe activation by the Staudinger reaction.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 22 DEC 2004, vol. 126, no. 50, 22 December 2004 (2004-12-22), pages 16324 - 16325, XP002363183, ISSN: 0002-7863 * |
GOLOLOBOY Y G ET AL: "SIXTY YEARS OF STAUDINGER REACTION", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 37, 1981, pages 437 - 472, XP001026177, ISSN: 0040-4020 * |
GOODWIN D A: "Tumor Pretargeting: Almost the Bottom Line", JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE, RESTON, VA, US, vol. 36, no. 5, May 1995 (1995-05-01), pages 876 - 879, XP002100555, ISSN: 0161-5505 * |
KIICK K L ET AL: "Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 99, no. 1, 8 January 2002 (2002-01-08), pages 19 - 24, XP002904363, ISSN: 0027-8424 * |
LEMIEUX GEORGE A ET AL: "A fluorogenic dye activated by the staudinger ligation.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 23 APR 2003, vol. 125, no. 16, 23 April 2003 (2003-04-23), pages 4708 - 4709, XP002363184, ISSN: 0002-7863 * |
PAGANELLI G ET AL: "MONOCLONAL ANTIBODY PRETARGETING TECHNIQUES FOR TUMOUR LOCALIZATIONTHE AVIDIN-BIOTIN SYSTEM", NUCLEAR MEDICINE COMMUNICATIONS, vol. 12, no. 3, 1 March 1991 (1991-03-01), pages 211 - 234, XP000373577, ISSN: 0143-3636 * |
PRESCHER JENNIFER A ET AL: "Chemical remodelling of cell surfaces in living animals.", NATURE. 19 AUG 2004, vol. 430, no. 7002, 19 August 2004 (2004-08-19), pages 873 - 877, XP002363185, ISSN: 1476-4687 * |
RENN O ET AL: "NEW APPROACHES TO DELIVERING METAL-LABELED ANTIBODIES TO TUMORS: SYNTHESIS AND CHARACTERIZATION OF NEW BIOTINYL CHELATE CONJUGATES FOR PRE-TARGETED DIAGNOSIS AND THERAPY", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 39, no. 2/3, 1 May 1996 (1996-05-01), pages 239 - 249, XP000589686, ISSN: 0168-3659 * |
SEN GUPTA SAYAM ET AL: "Accelerated bioorthogonal conjugation: a practical method for the ligation of diverse functional molecules to a polyvalent virus scaffold.", BIOCONJUGATE CHEMISTRY. 2005 NOV-DEC, vol. 16, no. 6, November 2005 (2005-11-01), pages 1572 - 1579, XP002362784, ISSN: 1043-1802 * |
Also Published As
Publication number | Publication date |
---|---|
US20080075661A1 (en) | 2008-03-27 |
JP2008515876A (en) | 2008-05-15 |
WO2006038184A2 (en) | 2006-04-13 |
EP1809339A2 (en) | 2007-07-25 |
WO2006038185A2 (en) | 2006-04-13 |
CN101068577A (en) | 2007-11-07 |
EP1799273A2 (en) | 2007-06-27 |
JP2008515875A (en) | 2008-05-15 |
CN101035565A (en) | 2007-09-12 |
WO2006038184A3 (en) | 2006-06-22 |
US20080181847A1 (en) | 2008-07-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2006038185A3 (en) | Use of the staudinger ligation in imaging and therapy end kits for imaging and therapy | |
WO2007039858A3 (en) | Targeted imaging and/or therapy using the [3+2] azide-alkyne cycloaddition | |
WO2007112193A3 (en) | Camptothecin-binding moiety conjugates | |
WO2003020949A3 (en) | Targeted nucleic acid constructs and uses related thereto | |
WO2004064595A3 (en) | Multivalent constructs for therapeutic and diagnostic applications | |
WO2009100194A3 (en) | Camptothecin-binding moiety conjugates | |
WO2007133290A3 (en) | Anti-ox40l antibodies and methods using same | |
WO2007011813A3 (en) | Balanced ultrasonic curved blade | |
WO2007130697A8 (en) | Anti-ephb4 antibodies and methods using same | |
WO2006083936A3 (en) | Anti-ephb2 antibodies and methods using same | |
WO2007105027A8 (en) | Anticancer drugs conjugated to antibody via an enzyme cleavable linker | |
WO2008033804A3 (en) | Quantum dot barcode structures and uses thereof | |
TW200706689A (en) | Gas providing member and processing device | |
WO2008064910A3 (en) | Metastasis-specific peptides and their diagnostic and therapeutic applications | |
TW200626737A (en) | Tubular sputtering target | |
WO2004100926A3 (en) | Delivery of agents using hydrolyzable leaving groups | |
WO2007127506A8 (en) | Anti-ephrinb2 antibodies and methods using same | |
WO2007027796A3 (en) | Proximity ligation assays with peptide conjugate 'burrs' and aptamers for the sensitive detection of spores and cancer cells | |
MA31014B1 (en) | VACCINE AGAINST LEISHMANIA CANINE. | |
WO2006072607A3 (en) | Transplastomic plants free of the selectable marker gene | |
WO2008126613A1 (en) | Actuator body and throttle mechanism | |
WO2008036953A8 (en) | In vivo transformation of pancreatic acinar cells into insulin-producing cells | |
WO2006119997A3 (en) | Treatment probe | |
WO2006017857A3 (en) | Antibiotic resistance free dna vaccines | |
MX2010006509A (en) | Herbicidal formulations for triethanolamine salts of glyphosate. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV LY MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2005788346 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 11576536 Country of ref document: US |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1400/CHENP/2007 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007535308 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 200580034471.3 Country of ref document: CN |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWP | Wipo information: published in national office |
Ref document number: 2005788346 Country of ref document: EP |