WO2006027474A3 - Nouveaux derives d ' imidazopyridine presentant une affinite vis a vis des recepteurs de la melatonine , leur procede de preparation et les compositions pharmaceutiques qui les contiennet - Google Patents

Nouveaux derives d ' imidazopyridine presentant une affinite vis a vis des recepteurs de la melatonine , leur procede de preparation et les compositions pharmaceutiques qui les contiennet Download PDF

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Publication number
WO2006027474A3
WO2006027474A3 PCT/FR2005/002162 FR2005002162W WO2006027474A3 WO 2006027474 A3 WO2006027474 A3 WO 2006027474A3 FR 2005002162 W FR2005002162 W FR 2005002162W WO 2006027474 A3 WO2006027474 A3 WO 2006027474A3
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WO
WIPO (PCT)
Prior art keywords
derivatives
affinity
preparation
respect
pharmaceutical compositions
Prior art date
Application number
PCT/FR2005/002162
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English (en)
Other versions
WO2006027474A2 (fr
Inventor
Gerald Guillaumet
Sabine Berteina-Raboin
Kazzouli Said El
Philippe Delagrange
Daniel-Henri Caignard
Original Assignee
Servier Lab
Gerald Guillaumet
Sabine Berteina-Raboin
Kazzouli Said El
Philippe Delagrange
Daniel-Henri Caignard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab, Gerald Guillaumet, Sabine Berteina-Raboin, Kazzouli Said El, Philippe Delagrange, Daniel-Henri Caignard filed Critical Servier Lab
Publication of WO2006027474A2 publication Critical patent/WO2006027474A2/fr
Publication of WO2006027474A3 publication Critical patent/WO2006027474A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Composés de formule (I) : dans laquelle : - A représente un groupement -NHCOR1 ou -CONHR1 dans lesquels R1 est tel que défini dans la description, - R2 représente un groupement alkoxy, - R3 représente un groupement aryle, arylalkyle ou aroyle, et leur utilisation pour le traitement des pathologies liées au système mélatoninergique.
PCT/FR2005/002162 2004-08-31 2005-08-30 Nouveaux derives d ' imidazopyridine presentant une affinite vis a vis des recepteurs de la melatonine , leur procede de preparation et les compositions pharmaceutiques qui les contiennet WO2006027474A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0409202A FR2874611B1 (fr) 2004-08-31 2004-08-31 Nouveaux derives d'imidazopyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR0409202 2004-08-31

Publications (2)

Publication Number Publication Date
WO2006027474A2 WO2006027474A2 (fr) 2006-03-16
WO2006027474A3 true WO2006027474A3 (fr) 2006-06-08

Family

ID=34947773

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2005/002162 WO2006027474A2 (fr) 2004-08-31 2005-08-30 Nouveaux derives d ' imidazopyridine presentant une affinite vis a vis des recepteurs de la melatonine , leur procede de preparation et les compositions pharmaceutiques qui les contiennet

Country Status (3)

Country Link
AR (1) AR050542A1 (fr)
FR (1) FR2874611B1 (fr)
WO (1) WO2006027474A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5160764B2 (ja) * 2006-10-13 2013-03-13 全薬工業株式会社 特定の構造の複素環化合物を含む抗鬱剤、脳保護剤、アミロイドβ沈着抑制剤または老化抑制剤
ATE548371T1 (de) 2006-12-08 2012-03-15 Takeda Pharmaceutical Tricyclische verbindung und deren medizinische verwendung
JP4827986B2 (ja) 2007-06-08 2011-11-30 マンカインド コーポレ−ション ＩＲＥ−１αインヒビター
EP2072516A1 (fr) * 2007-12-21 2009-06-24 Santhera Pharmaceuticals (Schweiz) AG Dérivés d'imidazopyridine substitués en tant qu'antagonistes du récepteur de la mélanocortine-4

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0050563A1 (fr) * 1980-10-22 1982-04-28 Synthelabo Dérivés d'imidazo(1,2-a)pyridine, leur préparation et leur application en thérapeutique
EP0092458A2 (fr) * 1982-04-21 1983-10-26 Synthelabo Dérives d'imidazo(1,2-a)pyridine, leur préparation et leur application en thérapeutique
EP0172096A1 (fr) * 1984-08-07 1986-02-19 Synthelabo Dérivés d'acylaminométhyl-3 imidazo[1,2-a]pyridines, leur préparation et leur application en thérapeutique
WO1989001472A1 (fr) * 1987-08-17 1989-02-23 Nelson Research & Development Co. Composes analogues de la melatonine
EP0527687A2 (fr) * 1991-08-13 1993-02-17 Adir Et Compagnie Nouveaux dérivés d'aryléthylamines, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent
WO2002066478A1 (fr) * 2001-02-20 2002-08-29 Astrazeneca Ab Antagonistes de l'hormone de liberation de la gonadotropine

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0050563A1 (fr) * 1980-10-22 1982-04-28 Synthelabo Dérivés d'imidazo(1,2-a)pyridine, leur préparation et leur application en thérapeutique
EP0092458A2 (fr) * 1982-04-21 1983-10-26 Synthelabo Dérives d'imidazo(1,2-a)pyridine, leur préparation et leur application en thérapeutique
EP0172096A1 (fr) * 1984-08-07 1986-02-19 Synthelabo Dérivés d'acylaminométhyl-3 imidazo[1,2-a]pyridines, leur préparation et leur application en thérapeutique
WO1989001472A1 (fr) * 1987-08-17 1989-02-23 Nelson Research & Development Co. Composes analogues de la melatonine
EP0527687A2 (fr) * 1991-08-13 1993-02-17 Adir Et Compagnie Nouveaux dérivés d'aryléthylamines, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent
WO2002066478A1 (fr) * 2001-02-20 2002-08-29 Astrazeneca Ab Antagonistes de l'hormone de liberation de la gonadotropine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TRAPANI G ET AL: "Synthesis and Binding Affinity of 2-Phenylimidazo[1,2-alpha]pyridine Derivatives for both Central and Peripheral Benzodiazepine Receptors. A New Series of High-Affinity and Selective Ligands for the Peripheral Type", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 40, 1997, pages 3109 - 3118, XP002900938, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
FR2874611B1 (fr) 2006-11-17
WO2006027474A2 (fr) 2006-03-16
AR050542A1 (es) 2006-11-01
FR2874611A1 (fr) 2006-03-03

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