WO2006024023A3 - Nanotube sensor devices for dna detection - Google Patents

Nanotube sensor devices for dna detection Download PDF

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Publication number
WO2006024023A3
WO2006024023A3 PCT/US2005/030487 US2005030487W WO2006024023A3 WO 2006024023 A3 WO2006024023 A3 WO 2006024023A3 US 2005030487 W US2005030487 W US 2005030487W WO 2006024023 A3 WO2006024023 A3 WO 2006024023A3
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WO
WIPO (PCT)
Prior art keywords
electrodes
dna sequence
target dna
nanotube
sensor devices
Prior art date
Application number
PCT/US2005/030487
Other languages
French (fr)
Other versions
WO2006024023A2 (en
Inventor
Charles Steven Joiner Jr
Jean-Christophe P Gabriel
George Gruner
Alexander Star
Original Assignee
Nanomix Inc
Charles Steven Joiner Jr
Jean-Christophe P Gabriel
George Gruner
Alexander Star
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanomix Inc, Charles Steven Joiner Jr, Jean-Christophe P Gabriel, George Gruner, Alexander Star filed Critical Nanomix Inc
Priority to JP2007530178A priority Critical patent/JP2008511008A/en
Priority to EP05810377A priority patent/EP1781771A2/en
Publication of WO2006024023A2 publication Critical patent/WO2006024023A2/en
Publication of WO2006024023A3 publication Critical patent/WO2006024023A3/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4146—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS involving nanosized elements, e.g. nanotubes, nanowires
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Materials Engineering (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Composite Materials (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Carbon And Carbon Compounds (AREA)

Abstract

A nanotube device is configured as an electronic sensor for a target DNA sequence. A film of nanotubes is deposited over electrodes on a substrate. A solution of single-strand DNA is prepared so as to be complementary to a target DNA sequence. The DNA solution is deposited over the electrodes, dried, and removed from the substrate except in a region between the electrodes. The resulting structure includes strands of the desired DNA sequence in direct contact with nanotubes between opposing electrodes, to form a sensor that is electrically responsive to the presence of target DNA strands. Alternative assay embodiments are described which employ linker groups to attach ssDNA probes to the nanotube sensor device.
PCT/US2005/030487 2004-08-24 2005-08-24 Nanotube sensor devices for dna detection WO2006024023A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2007530178A JP2008511008A (en) 2004-08-24 2005-08-24 Nanotube sensor device for DNA detection
EP05810377A EP1781771A2 (en) 2004-08-24 2005-08-24 Nanotube sensor devices for dna detection

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US60429304P 2004-08-24 2004-08-24
US60/604,293 2004-08-24
US62960404P 2004-11-19 2004-11-19
US60/629,604 2004-11-19

Publications (2)

Publication Number Publication Date
WO2006024023A2 WO2006024023A2 (en) 2006-03-02
WO2006024023A3 true WO2006024023A3 (en) 2009-06-04

Family

ID=35968333

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/030487 WO2006024023A2 (en) 2004-08-24 2005-08-24 Nanotube sensor devices for dna detection

Country Status (3)

Country Link
EP (1) EP1781771A2 (en)
JP (2) JP2008511008A (en)
WO (1) WO2006024023A2 (en)

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EP2575431B1 (en) 2010-06-04 2018-03-14 Monsanto Technology LLC Transgenic brassica event mon 88302 and methods of use thereof
US9880126B2 (en) 2010-09-24 2018-01-30 Ajou University Industry-Academic Cooperation Foundation Biosensor based on carbon nanotube-electric field effect transistor and method for producing the same
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EP3444600B1 (en) 2011-01-11 2020-05-13 The Trustees of Columbia University in the City of New York System and methods for single-molecule detection using nanotubes
EP2678669A1 (en) 2011-02-23 2014-01-01 The Trustees of Columbia University in the City of New York Systems and methods for single-molecule detection using nanopores
CN103857798B (en) 2011-06-30 2018-06-15 孟山都技术公司 Alfalfa plant and seed and its detection method corresponding to transgenic event KK179-2
JP5825095B2 (en) * 2011-12-26 2015-12-02 日本精工株式会社 Target substance detection biosensor
WO2013158280A1 (en) 2012-04-20 2013-10-24 The Trustees Of Columbia University In The City Of New York Systems and methods for single-molecule nucleic-acid assay platforms
GB201306097D0 (en) * 2013-04-04 2013-05-22 Isis Innovation Sensor
JP6473444B2 (en) * 2013-05-29 2019-02-20 シーエスアイアールＣｓｉｒ Field effect transistor and gas detector including a plurality of field effect transistors
JPWO2015012186A1 (en) * 2013-07-25 2017-03-02 東レ株式会社 Carbon nanotube composite, semiconductor device, and sensor using the same
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WO2017033922A1 (en) * 2015-08-24 2017-03-02 国立大学法人 東京大学 Method of detecting target substance using field-effect transistor
KR101663910B1 (en) * 2015-09-01 2016-10-07 고려대학교 산학협력단 Sensor for detection of zinc oxide nanowire in water and method for detection of zinc oxide nanowire using the sensor
AU2017244132A1 (en) * 2016-03-30 2018-10-18 Waqas KHALID Nanostructure array based sensors for electrochemical sensing, capacitive sensing and field-emission sensing
JP2018036154A (en) * 2016-08-31 2018-03-08 国立大学法人大阪大学 Method for electrically detecting target material, method for determining amount of the material, detection system, amount determination system, and reagent
JP6949397B2 (en) * 2016-08-31 2021-10-13 国立大学法人大阪大学 Electrical quantification methods, quantification systems and reagents for target substances
CN106841351B (en) * 2017-02-15 2019-07-19 暨南大学 A kind of molybdenum disulfide nano sheet electrochemical sensor and the preparation method and application thereof
WO2018224861A1 (en) 2017-06-07 2018-12-13 International Rice Research Institute Increasing hybrid seed production through higher outcrossing rate in cytoplasmic male sterile gramineae plants and related materials and methods
US20190128829A1 (en) * 2017-10-10 2019-05-02 Thermo Electron Scientific Instruments Llc Carbon Nanotube-Based Device for Sensing Molecular Interaction
US10957626B2 (en) * 2017-12-19 2021-03-23 Thermo Electron Scientific Instruments Llc Sensor device with carbon nanotube sensor positioned on first and second substrates
US11846622B2 (en) * 2018-03-12 2023-12-19 The Trustees Of The University Of Pennsylvania Multiplexed detection of toxins using graphene-based aptasensors
JP6876661B2 (en) * 2018-09-13 2021-05-26 株式会社東芝 Organic probe and molecule detector
EP4199703A1 (en) 2020-08-18 2023-06-28 International Rice Research Institute Methods of increasing outcrossing rates in gramineae
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Also Published As

Publication number Publication date
WO2006024023A2 (en) 2006-03-02
JP5743974B2 (en) 2015-07-01
JP2008511008A (en) 2008-04-10
EP1781771A2 (en) 2007-05-09
JP2012247432A (en) 2012-12-13

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