WO2006024023A3 - Nanotube sensor devices for dna detection - Google Patents

Nanotube sensor devices for dna detection Download PDF

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Publication number
WO2006024023A3
WO2006024023A3 PCT/US2005/030487 US2005030487W WO2006024023A3 WO 2006024023 A3 WO2006024023 A3 WO 2006024023A3 US 2005030487 W US2005030487 W US 2005030487W WO 2006024023 A3 WO2006024023 A3 WO 2006024023A3
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WO
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Application
Patent type
Prior art keywords
electrodes
dna sequence
target dna
nanotube
sensor
Prior art date
Application number
PCT/US2005/030487
Other languages
French (fr)
Other versions
WO2006024023A2 (en )
Inventor
Jean-Christophe P Gabriel
George Gruner
Charles Steven Joiner Jr
Alexander Star
Original Assignee
Jean-Christophe P Gabriel
George Gruner
Charles Steven Joiner Jr
Nanomix Inc
Alexander Star
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403Cells and electrode assemblies
    • G01N27/414Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4146Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS involving nanosized elements, e.g. nanotubes, nanowires
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403Cells and electrode assemblies
    • G01N27/414Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4145Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors

Abstract

A nanotube device is configured as an electronic sensor for a target DNA sequence. A film of nanotubes is deposited over electrodes on a substrate. A solution of single-strand DNA is prepared so as to be complementary to a target DNA sequence. The DNA solution is deposited over the electrodes, dried, and removed from the substrate except in a region between the electrodes. The resulting structure includes strands of the desired DNA sequence in direct contact with nanotubes between opposing electrodes, to form a sensor that is electrically responsive to the presence of target DNA strands. Alternative assay embodiments are described which employ linker groups to attach ssDNA probes to the nanotube sensor device.
PCT/US2005/030487 2004-08-24 2005-08-24 Nanotube sensor devices for dna detection WO2006024023A3 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US60429304 true 2004-08-24 2004-08-24
US60/604,293 2004-08-24
US62960404 true 2004-11-19 2004-11-19
US60/629,604 2004-11-19

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20050810377 EP1781771A2 (en) 2004-08-24 2005-08-24 Nanotube sensor devices for dna detection
JP2007530178A JP2008511008A (en) 2004-08-24 2005-08-24 Dna detection nanotube sensor device

Publications (2)

Publication Number Publication Date
WO2006024023A2 true WO2006024023A2 (en) 2006-03-02
WO2006024023A3 true true WO2006024023A3 (en) 2009-06-04

Family

ID=35968333

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/030487 WO2006024023A3 (en) 2004-08-24 2005-08-24 Nanotube sensor devices for dna detection

Country Status (3)

Country Link
EP (1) EP1781771A2 (en)
JP (2) JP2008511008A (en)
WO (1) WO2006024023A3 (en)

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US9919922B2 (en) 2008-10-02 2018-03-20 Saion Kumar Sinha Bionanosensor detection device
US8106428B2 (en) 2009-03-03 2012-01-31 Board Of Regents, The University Of Texas System Nano-scale bridge biosensors
US8993346B2 (en) 2009-08-07 2015-03-31 Nanomix, Inc. Magnetic carbon nanotube based biodetection
US8519489B2 (en) * 2009-08-26 2013-08-27 Indian Institute Of Technology Madras Method and apparatus for tunable electrical conductivity
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US9880126B2 (en) 2010-09-24 2018-01-30 Ajou University Industry-Academic Cooperation Foundation Biosensor based on carbon nanotube-electric field effect transistor and method for producing the same
WO2012051199A3 (en) 2010-10-12 2012-06-07 Monsanto Technology Llc Soybean plant and seed corresponding to transgenic event mon87712 and methods for detection thereof
CN103620403B (en) 2011-01-11 2016-08-10 纽约市哥伦比亚大学理事会 Nanotubes using the systems and methods of monitoring the monomolecular
CN103380369B (en) 2011-02-23 2016-12-28 纽约市哥伦比亚大学理事会 Nanopores systems and methods for single molecule detection
EP2726618A1 (en) 2011-06-30 2014-05-07 Monsanto Technology LLC Alfalfa plant and seed corresponding to transgenic event kk 179-2 and methods for detection thereof
JP5825095B2 (en) * 2011-12-26 2015-12-02 日本精工株式会社 Target substance detection biosensor
WO2013158280A1 (en) 2012-04-20 2013-10-24 The Trustees Of Columbia University In The City Of New York Systems and methods for single-molecule nucleic-acid assay platforms
GB201306097D0 (en) * 2013-04-04 2013-05-22 Isis Innovation Sensor
DE112014002575T5 (en) * 2013-05-29 2016-03-10 Csir Feldeffektortransistor and several field effect transistors comprehensive gas detector
CN105408245A (en) * 2013-07-25 2016-03-16 东丽株式会社 Carbon nanotube composite, semiconductor device, and sensor using same
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CN104509517A (en) * 2015-01-01 2015-04-15 罗明辉 Agricultural electric unmanned plant protection machine
CN104597082B (en) * 2015-01-23 2017-02-22 清华大学 The two-dimensional hierarchical structure of the hybrid material sensitive sensor device based on thin film manufacturing method
CN104923777A (en) * 2015-03-18 2015-09-23 华南理工大学 High-salt-tolerance metal nanoparticle assembly and preparing method thereof
CN107787181A (en) 2015-06-05 2018-03-09 国际水稻研究所 Increasing hybrid seed production through higher outcrossing rate in cytoplasmic male sterile rice and related materials and methods
WO2017033922A1 (en) * 2015-08-24 2017-03-02 国立大学法人 東京大学 Method of detecting target substance using field-effect transistor
KR101663910B1 (en) * 2015-09-01 2016-10-07 고려대학교 산학협력단 Sensor for detection of zinc oxide nanowire in water and method for detection of zinc oxide nanowire using the sensor
CN106841351A (en) * 2017-02-15 2017-06-13 暨南大学 Molybdenum disulfide nanosheet electrochemical sensor, preparation method and application thereof

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Publication number Priority date Publication date Assignee Title
US4777019A (en) * 1985-04-12 1988-10-11 Thomas Dandekar Biosensor
US5164319A (en) * 1985-08-22 1992-11-17 Molecular Devices Corporation Multiple chemically modulated capacitance determination
US4963478A (en) * 1988-07-05 1990-10-16 Immucor, Inc. Article for preforming immunological assays utilizing organic dyes and method for producing and utilizing same
US5466348A (en) * 1991-10-21 1995-11-14 Holm-Kennedy; James W. Methods and devices for enhanced biochemical sensing
US5425869A (en) * 1992-04-22 1995-06-20 The Dow Chemical Company Polymeric film-based electrochemical sensor apparatus
US5849486A (en) * 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
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US20030124623A1 (en) * 2001-12-05 2003-07-03 Paul Yager Microfluidic device and surface decoration process for solid phase affinity binding assays
US20040191260A1 (en) * 2003-03-26 2004-09-30 Technion Research & Development Foundation Ltd. Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof

Also Published As

Publication number Publication date Type
WO2006024023A2 (en) 2006-03-02 application
EP1781771A2 (en) 2007-05-09 application
JP2012247432A (en) 2012-12-13 application
JP5743974B2 (en) 2015-07-01 grant
JP2008511008A (en) 2008-04-10 application

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