WO2011017077A3 - Nanochannel-based sensor system with controlled sensitivity - Google Patents

Nanochannel-based sensor system with controlled sensitivity Download PDF

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Publication number
WO2011017077A3
WO2011017077A3 PCT/US2010/043326 US2010043326W WO2011017077A3 WO 2011017077 A3 WO2011017077 A3 WO 2011017077A3 US 2010043326 W US2010043326 W US 2010043326W WO 2011017077 A3 WO2011017077 A3 WO 2011017077A3
Authority
WO
WIPO (PCT)
Prior art keywords
nanochannel
sensor system
based sensor
sensor
controlled sensitivity
Prior art date
Application number
PCT/US2010/043326
Other languages
French (fr)
Other versions
WO2011017077A2 (en
WO2011017077A9 (en
Inventor
Pritiraj Mohanty
Shyamsunder Erramilli
Yu Chen
Mi K. Hong
Original Assignee
Trustees Of Boston University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trustees Of Boston University filed Critical Trustees Of Boston University
Publication of WO2011017077A2 publication Critical patent/WO2011017077A2/en
Publication of WO2011017077A3 publication Critical patent/WO2011017077A3/en
Publication of WO2011017077A9 publication Critical patent/WO2011017077A9/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4146—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS involving nanosized elements, e.g. nanotubes, nanowires
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Nanotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)

Abstract

Disclosed are sensors, devices, systems, arrays of sensors and methods, including a sensing device that includes a sensor including one or more nanochannels constructed from semiconductor material and connected at their opposite ends to electrodes, the one or more nanochannels having at least one electrical property that varies based, at least in part, on an interaction with at least one analyte contained in a sample introduced to the sensor. The device also includes a controller to control sensitivity of the sensor to the presence of the at least one analyte.
PCT/US2010/043326 2009-07-27 2010-07-27 Nanochannel-based sensor system with controlled sensitivity WO2011017077A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US22884409P 2009-07-27 2009-07-27
US22884609P 2009-07-27 2009-07-27
US22884009P 2009-07-27 2009-07-27
US61/228,840 2009-07-27
US61/228,844 2009-07-27
US61/228,846 2009-07-27

Publications (3)

Publication Number Publication Date
WO2011017077A2 WO2011017077A2 (en) 2011-02-10
WO2011017077A3 true WO2011017077A3 (en) 2011-04-28
WO2011017077A9 WO2011017077A9 (en) 2011-05-26

Family

ID=43544854

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/043326 WO2011017077A2 (en) 2009-07-27 2010-07-27 Nanochannel-based sensor system with controlled sensitivity

Country Status (1)

Country Link
WO (1) WO2011017077A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130214332A1 (en) * 2011-08-26 2013-08-22 Diagtronix, Inc. Nanogrid channel fin-fet transistor and biosensor
WO2013155116A1 (en) 2012-04-09 2013-10-17 Takulapalli Bharath Field effect transistor, device including the transistor, and methods of forming and using same
KR20150023721A (en) * 2012-06-15 2015-03-05 스트링 테라퓨틱스 Methods and compositions for personalized medicine by point-of-care devices for fsh, lh, hcg and bnp
US9678078B2 (en) 2012-06-15 2017-06-13 Autotelic Llc Methods and compositions for personalized medicine by point-of-care devices for brain natriuretic peptide
US10126263B2 (en) * 2012-10-16 2018-11-13 Koninklijke Philips N.V. Wide dynamic range fluid sensor based on nanowire platform
CN105431889B (en) * 2013-03-15 2020-08-04 巴拉什·塔库拉帕里 Biomarker sensor arrays and circuits and methods of use and formation thereof
US10670611B2 (en) 2014-09-26 2020-06-02 Somalogic, Inc. Cardiovascular risk event prediction and uses thereof
US10639633B2 (en) 2015-01-30 2020-05-05 Hewlett-Packard Development Company, L.P. Signal transmission bandwidth allocation on a microfluidic chip
FR3046243B1 (en) 2015-12-24 2017-12-22 Commissariat Energie Atomique NW-FET SENSOR COMPRISING AT LEAST TWO SEPARATE NANOFIL DETECTORS OF SEMICONDUCTOR
EP3960295B1 (en) 2016-01-29 2023-01-04 Hewlett-Packard Development Company, L.P. Microfluidics system
EP3446113A4 (en) 2016-04-19 2020-01-08 Takulapalli, Bharath Nanopore sensor, structure and device including the sensor, and methods of forming and using same
US20200064291A1 (en) * 2018-08-22 2020-02-27 AerNos, Inc. Pattern recognition algorithm for identifying and quantifying single and mixed contaminants in air with an array of nanomaterial-based gas sensors
LU101020B1 (en) * 2018-11-28 2020-05-28 Luxembourg Inst Science & Tech List Ion-sensitive field effect transistor
US20200326325A1 (en) * 2019-04-12 2020-10-15 Lisa Diamond Nanosensor chip with compound nanopores

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080210987A1 (en) * 2005-05-31 2008-09-04 Thales Array of Fet Transistors Having a Nanotube or Nanowire Semiconductor Element and Corresponding Electronic Device, For the Detection of Analytes
KR20090049095A (en) * 2000-12-11 2009-05-15 프레지던트 앤드 펠로우즈 오브 하버드 칼리지 Nanosensors
WO2009085356A2 (en) * 2007-10-01 2009-07-09 University Of Southern California Usc Stevens Methods of using and constructing nanosensor platforms

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090049095A (en) * 2000-12-11 2009-05-15 프레지던트 앤드 펠로우즈 오브 하버드 칼리지 Nanosensors
US20080210987A1 (en) * 2005-05-31 2008-09-04 Thales Array of Fet Transistors Having a Nanotube or Nanowire Semiconductor Element and Corresponding Electronic Device, For the Detection of Analytes
WO2009085356A2 (en) * 2007-10-01 2009-07-09 University Of Southern California Usc Stevens Methods of using and constructing nanosensor platforms

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
YU CHEN ET AL.: "Nanoscale field effect transistor for biomolecular signal amplification", APPLIED PHYSICS LETTERS, vol. 91, no. ISS.24, 14 December 2007 (2007-12-14) *
YU CHEN ET AL.: "Silicon-based nanoelectronic field-effect pH sensor with local gate control", APPLIED PHYSICS LETTERS, vol. 89, no. ISS.22, 29 October 2006 (2006-10-29) *

Also Published As

Publication number Publication date
WO2011017077A2 (en) 2011-02-10
WO2011017077A9 (en) 2011-05-26

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