WO2006022671A1 - Procede de reparation in situ de cartilage articulaire lese, endommage, malade ou age a l'aide de constructions de neo-cartilage et procede de preparation associe - Google Patents

Procede de reparation in situ de cartilage articulaire lese, endommage, malade ou age a l'aide de constructions de neo-cartilage et procede de preparation associe Download PDF

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Publication number
WO2006022671A1
WO2006022671A1 PCT/US2004/024902 US2004024902W WO2006022671A1 WO 2006022671 A1 WO2006022671 A1 WO 2006022671A1 US 2004024902 W US2004024902 W US 2004024902W WO 2006022671 A1 WO2006022671 A1 WO 2006022671A1
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WO
WIPO (PCT)
Prior art keywords
cartilage
neo
chondrocytes
construct
collagen
Prior art date
Application number
PCT/US2004/024902
Other languages
English (en)
Inventor
Shuichi Mizuno
Akihiko Kusanagi
Laurence J. B. Tarrant
Toshimasa Tokuno
Robert Lane Smith
Original Assignee
Histogenics Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Histogenics Corporation filed Critical Histogenics Corporation
Priority to EP04779836A priority Critical patent/EP1796592A4/fr
Priority to JP2007523523A priority patent/JP2008507971A/ja
Priority to AU2004321311A priority patent/AU2004321311B8/en
Priority to CA2541827A priority patent/CA2541827C/fr
Priority to PCT/US2004/024902 priority patent/WO2006022671A1/fr
Publication of WO2006022671A1 publication Critical patent/WO2006022671A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3852—Cartilage, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A61F2002/30762—Means for culturing cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A61F2002/30764—Cartilage harvest sites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
    • A61F2310/00377—Fibrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
    • A61F2310/00383—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C12N2533/40—Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

Abstract

L'invention concerne un procédé de traitement de cartilage articulaire lésé, endommagé, malade ou âgé à l'aide de constructions de néo-cartilage implantées dans une lésion de cartilage articulaire in situ. L'implantation de la construction permet d'initier et d'obtenir l'incorporation de néo-cartilage dans un cartilage environnant natif. Le procédé fait appel à la formation d'une nouvelle couche de cartilage superficielle qui recouvre et scelle la lésion au niveau du cartilage articulaire. L'invention concerne également des constructions de néo-cartilage ainsi qu'un procédé de préparation associé.
PCT/US2004/024902 2004-07-30 2004-07-30 Procede de reparation in situ de cartilage articulaire lese, endommage, malade ou age a l'aide de constructions de neo-cartilage et procede de preparation associe WO2006022671A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP04779836A EP1796592A4 (fr) 2004-07-30 2004-07-30 Procede de reparation in situ de cartilage articulaire lese, endommage, malade ou age a l'aide de constructions de neo-cartilage et procede de preparation associe
JP2007523523A JP2008507971A (ja) 2004-07-30 2004-07-30 新軟骨構造体を用いて損傷若しくは傷害を受け又は病変若しくは老化した関節軟骨を生体位で修復する方法、及び新軟骨構造体の調整方法
AU2004321311A AU2004321311B8 (en) 2004-07-30 2004-07-30 Neo-cartilage constructs and methods of preparation thereof
CA2541827A CA2541827C (fr) 2004-07-30 2004-07-30 Procede de reparation in situ de cartilage articulaire lese, endommage, malade ou age a l'aide de constructions de neo-cartilage et procede de preparation associe
PCT/US2004/024902 WO2006022671A1 (fr) 2004-07-30 2004-07-30 Procede de reparation in situ de cartilage articulaire lese, endommage, malade ou age a l'aide de constructions de neo-cartilage et procede de preparation associe

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2004/024902 WO2006022671A1 (fr) 2004-07-30 2004-07-30 Procede de reparation in situ de cartilage articulaire lese, endommage, malade ou age a l'aide de constructions de neo-cartilage et procede de preparation associe

Publications (1)

Publication Number Publication Date
WO2006022671A1 true WO2006022671A1 (fr) 2006-03-02

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/024902 WO2006022671A1 (fr) 2004-07-30 2004-07-30 Procede de reparation in situ de cartilage articulaire lese, endommage, malade ou age a l'aide de constructions de neo-cartilage et procede de preparation associe

Country Status (5)

Country Link
EP (1) EP1796592A4 (fr)
JP (1) JP2008507971A (fr)
AU (1) AU2004321311B8 (fr)
CA (1) CA2541827C (fr)
WO (1) WO2006022671A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010512223A (ja) * 2006-12-12 2010-04-22 シンササム，インコーポレイテッド 組織修復のための複合材料
WO2010043979A2 (fr) * 2008-10-17 2010-04-22 Sofradim Production Matrice auto-adhesive de reparation tissulaire
WO2014200997A3 (fr) * 2013-06-10 2015-02-26 Millennium Pharmaceuticals, Inc. Procédé de préparation de cultures de cellules organotypiques tridimensionnelles et utilisations de celles-ci
US9198568B2 (en) 2010-03-04 2015-12-01 The General Hospital Corporation Methods and systems of matching voice deficits with a tunable mucosal implant to restore and enhance individualized human sound and voice production
US9216188B2 (en) 2008-09-04 2015-12-22 The General Hospital Corporation Hydrogels for vocal cord and soft tissue augmentation and repair
CN107405422A (zh) * 2015-03-18 2017-11-28 富士胶片株式会社 软骨再生材料及其制造方法
US10632207B2 (en) 2009-02-21 2020-04-28 Sofradim Production Compounds and medical devices activated with solvophobic linkers
CN111892719A (zh) * 2020-06-12 2020-11-06 华南理工大学 一种用于软骨细胞三维培养的透明质酸超分子水凝胶及其制备与应用
US11241518B2 (en) 2015-03-18 2022-02-08 Fujifilm Corporation Cartilage regenerative material

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6606680B2 (ja) * 2014-05-20 2019-11-20 国立大学法人佐賀大学 組織体形成装置及び組織体形成キット
EP3174498A4 (fr) * 2014-08-01 2018-04-18 Isto Technologies Inc. Compositions de cartilage et procédés permettant de modifier la teneur en protéoglycane

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US4851354A (en) * 1987-12-07 1989-07-25 Trustees Of The University Of Pennsylvania Apparatus for mechanically stimulating cells
US5786217A (en) * 1994-05-05 1998-07-28 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
US5989269A (en) * 1996-08-30 1999-11-23 Vts Holdings L.L.C. Method, instruments and kit for autologous transplantation
US6080194A (en) * 1995-02-10 2000-06-27 The Hospital For Joint Disease Orthopaedic Institute Multi-stage collagen-based template or implant for use in the repair of cartilage lesions
US6171610B1 (en) * 1998-04-24 2001-01-09 University Of Massachusetts Guided development and support of hydrogel-cell compositions
US20020082623A1 (en) * 1999-07-28 2002-06-27 Kurt Osther Vitro repair of bone and/or cartilage defects
US20020106625A1 (en) * 2002-02-07 2002-08-08 Hung Clark T. Bioreactor for generating functional cartilaginous tissue
US6432713B2 (en) * 2000-03-02 2002-08-13 Takagi Industrial Co., Ltd. Method and apparatus for cultivating a cell or tissue
US20030040113A1 (en) * 2001-03-23 2003-02-27 Histogenics Corporation Composition and methods for the production of biological tissues and tissue constructs
US6652872B2 (en) * 1999-07-06 2003-11-25 Ramat At Tel Aviv University Ltd. Scaffold formed of tissue treated to eliminate cellular and cytosolic elements
US20040134502A1 (en) * 2002-03-22 2004-07-15 Shuichi Mizuno Method for in situ repair of injured, damaged, diseased or aged articular cartilage

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US6528052B1 (en) * 2000-09-29 2003-03-04 The Board Of Trustees Of The Leland Stanford Junior University Method for in vivo ex vivo and in vitro repair and regeneration of cartilage and collagen and bone remodeling

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US4851354A (en) * 1987-12-07 1989-07-25 Trustees Of The University Of Pennsylvania Apparatus for mechanically stimulating cells
US5786217A (en) * 1994-05-05 1998-07-28 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
US6080194A (en) * 1995-02-10 2000-06-27 The Hospital For Joint Disease Orthopaedic Institute Multi-stage collagen-based template or implant for use in the repair of cartilage lesions
US5989269A (en) * 1996-08-30 1999-11-23 Vts Holdings L.L.C. Method, instruments and kit for autologous transplantation
US6171610B1 (en) * 1998-04-24 2001-01-09 University Of Massachusetts Guided development and support of hydrogel-cell compositions
US6652872B2 (en) * 1999-07-06 2003-11-25 Ramat At Tel Aviv University Ltd. Scaffold formed of tissue treated to eliminate cellular and cytosolic elements
US20020082623A1 (en) * 1999-07-28 2002-06-27 Kurt Osther Vitro repair of bone and/or cartilage defects
US6432713B2 (en) * 2000-03-02 2002-08-13 Takagi Industrial Co., Ltd. Method and apparatus for cultivating a cell or tissue
US20030040113A1 (en) * 2001-03-23 2003-02-27 Histogenics Corporation Composition and methods for the production of biological tissues and tissue constructs
US20020106625A1 (en) * 2002-02-07 2002-08-08 Hung Clark T. Bioreactor for generating functional cartilaginous tissue
US20040134502A1 (en) * 2002-03-22 2004-07-15 Shuichi Mizuno Method for in situ repair of injured, damaged, diseased or aged articular cartilage

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* Cited by examiner, † Cited by third party
Title
See also references of EP1796592A4 *

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010512223A (ja) * 2006-12-12 2010-04-22 シンササム，インコーポレイテッド 組織修復のための複合材料
US9216194B2 (en) 2006-12-12 2015-12-22 Synthasome, Inc. Composite material for tissue repair
US9216188B2 (en) 2008-09-04 2015-12-22 The General Hospital Corporation Hydrogels for vocal cord and soft tissue augmentation and repair
US9682169B2 (en) 2008-09-04 2017-06-20 Massachusetts Institute Of Technology Hydrogels for vocal cord and soft tissue augmentation and repair
US9855372B2 (en) 2008-10-17 2018-01-02 Sofradim Production Auto-sealant matrix for tissue repair
WO2010043979A3 (fr) * 2008-10-17 2010-06-10 Sofradim Production Matrice auto-adhesive de reparation tissulaire
WO2010043979A2 (fr) * 2008-10-17 2010-04-22 Sofradim Production Matrice auto-adhesive de reparation tissulaire
US10632207B2 (en) 2009-02-21 2020-04-28 Sofradim Production Compounds and medical devices activated with solvophobic linkers
US9198568B2 (en) 2010-03-04 2015-12-01 The General Hospital Corporation Methods and systems of matching voice deficits with a tunable mucosal implant to restore and enhance individualized human sound and voice production
WO2014200997A3 (fr) * 2013-06-10 2015-02-26 Millennium Pharmaceuticals, Inc. Procédé de préparation de cultures de cellules organotypiques tridimensionnelles et utilisations de celles-ci
CN107405422A (zh) * 2015-03-18 2017-11-28 富士胶片株式会社 软骨再生材料及其制造方法
EP3260142A4 (fr) * 2015-03-18 2018-03-21 FUJI-FILM Corporation Matériau pour la régénération du cartilage et procédé pour le produire
US11160902B2 (en) 2015-03-18 2021-11-02 Fujifilm Corporation Cartilage regenerative material and method for producing same
US11241518B2 (en) 2015-03-18 2022-02-08 Fujifilm Corporation Cartilage regenerative material
CN111892719A (zh) * 2020-06-12 2020-11-06 华南理工大学 一种用于软骨细胞三维培养的透明质酸超分子水凝胶及其制备与应用

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Publication number Publication date
AU2004321311B2 (en) 2008-10-09
CA2541827A1 (fr) 2006-03-02
EP1796592A1 (fr) 2007-06-20
CA2541827C (fr) 2013-05-14
AU2004321311B8 (en) 2009-11-19
EP1796592A4 (fr) 2008-01-02
AU2004321311A1 (en) 2006-05-04
AU2004321311A8 (en) 2008-09-18
JP2008507971A (ja) 2008-03-21

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