WO2006022409A1

WO2006022409A1 - Hazardous substance scavenger and application apparatus and application method therefor

Info

Publication number: WO2006022409A1
Application number: PCT/JP2005/015633
Authority: WO
Inventors: Jun-Ichiro Arai; Mitsugu Yamashita
Original assignee: Daikin Industries, Ltd.
Priority date: 2004-08-27
Filing date: 2005-08-29
Publication date: 2006-03-02
Also published as: WO2006022409A8; JP2006063019A

Abstract

A hazardous substance scavenger (10) adhering to the surface of a living body which captures a hazardous substance (20) upon contact with the hazardous substance (20). This hazardous substance scavenger (10) contains a chicken egg antibody as a hazardous substance scavenger component.

Description

Specification

Hazardous substance scavenger, spraying device and spraying method thereof

Technical field

[0001] The present invention relates to a biological surface that captures a harmful substance (20) by contact with a harmful substance (20) by being attached to a mucosal surface such as the nose or vulva, airway epithelial surface, or corneal surface. The present invention relates to an adhering harmful substance trapping agent (10), and a spraying device (30) and spraying method thereof.

Background art

There are various methods for preventing the infection of the human body with viruses.

[0003] Japanese National Publication No. Hei 8-508240 discloses a method for preventing infection derived from wounds, burns or biomaterial forces in humans and animal hosts, and is based on a host defense mechanism prior to microbial attachment and biofilm formation. Disclosed is a method comprising the step of directly applying to the wound, burn or biomaterial an immunoglobulin composition in an amount sufficient to cultivate the microorganism for pre-phagocytosis in preparation for phagocytosis or sterilization. It is described that the composition of the present invention is particularly applicable to prevention of infection.

[0004] By the way, as a method for preventing infection with influenza virus, it is mainly possible to wear a mask, wash hands and gargle. However, in the case of wearing a mask, even if the spray is temporarily stopped, it is not possible to prevent the virus particles that have become the spray core from passing through. In addition, when washing hands or gargles, if the virus is not applied immediately after adhering to the mucous membrane, it will not be effective, and if the timing is missed, the virus will be infected by oral or transmucosal infection.

[0005] The present invention has been made in view of the strong point, and the object of the present invention is to capture harmful substances (20) such as viruses and the like, and to capture harmful substances that can be used easily at low cost. (1 0) and a spraying device (30) and a spraying method thereof.

Disclosure of the invention

[0006] The present invention to achieve the above object is a biological surface-attached harmful substance scavenger (10) that captures the harmful substance (20) by contact with the harmful substance (20),

It contains chicken egg antibody (11) as a harmful substance-capturing component. [0007] In the case of such a harmful substance scavenger (10), it may be harmful by applying it to the site where the harmful substance (20) adheres or by spraying it on the surface in advance. Since the substance (20) is captured by the chicken egg antibody (11), a high preventive effect against infection by the harmful substance (20) can be obtained. In addition, even if harmful substances (20) are attached, the harmful substance (20) can be removed by the egg antibody (11) by attaching the harmful substance capturing agent (10) to the surface of the harmful substance (20). Since it is trapped, it is possible to obtain an effect of preventing the infection after the harmful substances (20) are attached. In addition, chicken egg antibody (11) is used as a harmful substance-capturing component, so that it is inexpensive and can be easily used such as coating and gauze because it is a substance attached to the surface of the living body rather than being injected.

[0008] The harmful substance-trapping agent (10) of the present invention may be in the form of a liquid in which the chicken egg antibody (11) is dissolved in a solvent, or in the form of a powder.

[0009] In the case of powder, it is desirable that the particle size is 2 to 10 μm U. Inhaled viruses and other harmful substances (20) often adhere to the upper respiratory tract (40), but if the harmful substance scavenger (10) has a particle size of ^ ~ 10 m, it is the upper respiratory tract (40). Therefore, the trapping of harmful substances (20) is effectively carried out.

[0010] Here, the harmful substance (20) to be captured by the harmful substance-trapping agent (10) of the present invention is, for example, bacteria, molds, winoles, and arenoregens.

[0011] When the harmful substance-capturing agent (10) of the present invention is a liquid substance in which a chicken egg antibody (11) is dissolved in a solvent as a harmful substance-capturing component, the particle size of 2 to It contains hen egg antibody (11) as a harmful substance trapping component that can be sprayed in the form of a mist and sprayed in the case of a powder with a particle size of 2 ~: LO / zm (30) It can be sprayed in the form of a mist.

[0012] If the harmful substance scavenger (10) is sprayed in this way, the harmful substance scavenger (10) stays in the upper respiratory tract (40) as described above, so that the trapping of the harmful substance (20) is effective. Will be run. Brief Description of Drawings

[0013] Fig. 1 is a schematic diagram of a chicken egg antibody (11).

FIG. 2 is an explanatory diagram showing a method for removing harmful substances (20).

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, embodiments of the present invention will be described in detail.

[Embodiment 1]

The harmful substance-capturing agent (10) according to the first embodiment is a liquid substance in which the chicken egg antibody (11) as a harmful substance-capturing component is dissolved in a solvent such as water. This harmful substance-trapping agent (10) has a concentration of chicken egg antibody (11) of 0.01 to 23% by mass (preferably 0.5 to 8% by mass). Contains chicken egg antibody (11).

FIG. 1 shows a chicken egg antibody (11).

[0017] The chicken egg antibody (11) is a protein that specifically reacts (antigen-antibody reaction) with a specific harmful substance (20) (antigen), has a molecular size of 7-8 nm, and has a Y-shape. It has a molecular shape. The pair of branches in the Y-shaped molecular form of chicken egg antibody (11) is called Fab (lla) and the trunk is called Fc (llb). Of these, the Fab (l la) part is a toxic substance (20) To capture.

[0018] The type of chicken egg antibody (11) corresponds to the type of harmful substance (20) that can be captured. Examples of the harmful substance (20) captured by the chicken egg antibody (11) include bacteria, molds, viruses, allergens and mycoplasma. Specific examples of bacteria include Gram-positive bacteria, Staphylococcus (S. aureus and Staphylococcus epidermidis), Micrococcus, Bacillus anthracis, Bacillus cereus, Bacillus subtilis, Acne, and Gram-negative. Examples include Pseudomonas aeruginosa, Serratia, Sephacia, Streptococcus pneumoniae, Legionella, and Mycobacterium tuberculosis. Examples of molds include yeast, Aspergillus, Vesirius, and Cladosporum. Viruses include varicella virus and measles virus that infect air when splashes are less than 5 μm, influenza virus, coronavirus (SAR S virus), adenovirus, mumps virus, and rubella virus that are splashes larger than 5 μm. And herpes viruses that are contact-infected. Examples of allergens include pollen, mite allergen (mite digest), mold spores, and cat allergen (pet dander). Bacteria and fungi are not inactivated by chicken egg antibody (11), but they are bacteriostatic due to high adsorption effect, whereas viruses and allergens are sterilized.

[0019] The chicken egg antibody (11) can be produced by administering an antigen to a chick bird to produce an immunized egg, purifying the egg yolk powder power obtained by sterilizing and spray-drying the egg yolk liquid. . That is chicken Egg antibody (11) is easy and can be produced in large quantities.

[0020] In addition to toxic substance scavenger (10), glycerin, ethanol, polysorbate 80, sodium hydrogen phosphate, sodium dihydrogen phosphate, sodium hydroxide, hydrochloric acid, 1-menthol, no Occasional oil may be included.

[0021] This harmful substance-capturing agent (10) can be produced by dissolving the chicken egg antibody (11) in a solution of water or other additives dissolved in the solvent. As shown in the figure, the tank of the portable spraying device (dispersing device) (30) is filled and used. The spraying device (30) is for spraying a liquid harmful substance trapping agent (10) in the form of a mist in the form of droplets having a particle size of 2 to 10 m, and its type is particularly limited. For example, the type of spraying with pressurized air, the type of spraying with ultrasonic waves, the type of spraying with vibration, the type of spraying with rotation of a rotating disk, the type of spraying with static electricity It may be of any type.

[0022] In use, the spraying device (30) sprays the harmful substance-trapping agent (10) in the form of droplets having a particle size of 2 to 10 m in the form of a mist onto the oral cavity, nasal cavity, eyes, or vulva. To do. As a result, the harmful substance scavenger (10) has adhered to the oral cavity, nasal cavity, eyes, or mucous membrane of the vulva, and has been invaded from harmful substances such as viruses (20) attached to the mucosa. Capture toxic substances (20). In addition, harmful substances such as viruses that have entered the body (20) often adhere to the upper respiratory tract (40), but the harmful substance-trapping agent (10) injected into the oral cavity or nasal cavity has a particle size of 2-10. Because it is m, it reaches the upper airway (40) and stays there, where it traps harmful substances (20).

[0023] The harmful substance scavenger (10) described above is harmful when going to a place where there is a risk of being infected with harmful substances (20), for example, before getting on a train or before entering a crowd. By pre-attaching the surface to the site to which the substance (20) is attached, the harmful substance (20) is captured by the egg antibody (11), so that a high preventive effect against infection by the harmful substance (20) is obtained. be able to

[0024] Further, for example, even if a harmful substance (20) adheres, such as immediately after inhaling a cough of a person with a cold, this harmful substance scavenger (10) is used as a harmful substance (20 ), The harmful substance (20) is captured by the chicken egg antibody (11), so that a high preventive effect on infection after the harmful substance (20) is attached can be obtained. [0025] Furthermore, chicken egg antibody (11) is used as a harmful substance-capturing component, so that it is inexpensive and is not injected, but is attached to the surface of the living body, and is applied to the oral cavity, nasal cavity, eyes, or vulva. It can be used easily, just by spraying with the spray device (30).

[0026] In the present embodiment, the liquid harmful substance trapping agent (10) is used by being sprayed by the spray device (30), but is not particularly limited thereto, and is used as a gargle. You can also.

[Embodiment 2]

The harmful substance-capturing agent (10) according to the second embodiment is in the form of a powder having a particle diameter of 2 to 10 m and containing a chicken egg antibody (11) as a harmful substance-capturing component. This harmful substance-capturing agent (10) is obtained by embedding a chicken egg antibody (11) in an excipient, a pH regulator and a tonicity agent, and the concentration of the chicken egg antibody (11) is 0.01 to 23. For example, it is one containing about 10 mg of chicken egg antibody (11) in 1 g of freeze-dried lg.

[0028] The composition of the chicken egg antibody (11) is the same as in the first embodiment.

[0029] Examples of excipients include lactose, sucrose, D-manntol, D-sorbitol, denpun, pregelatinized starch, dextrin, crystalline cellulose, low-substituted hydroxypropyl cellulose, carboxymethylcellulose sodium Arabic gum, pullulan, light anhydrous caustic acid, synthetic aluminum silicate, magnesium aluminate metasilicate and the like.

[0030] Examples of the pH adjuster include sodium hydrogen phosphate, sodium dihydrogen phosphate, sodium hydroxide, hydrochloric acid and the like.

[0031] Examples of the tonicity agent include sodium chloride salt, glycerin, D-mannitol, D-sorbitol, glucose and the like.

[0032] The harmful substance-capturing agent (10) is prepared by weighing the egg antibody (11), excipient, pH adjusting agent, and tonicity agent, kneading them, and granulating them. It can be manufactured by sizing and mixing, and is used by being filled in a tank of a portable spraying device (30). The spraying device (30) is for spraying powder that sprays a toxic substance trapping agent (10) in the form of powder with a particle size of 2 to 10 m, and its type is particularly limited is not.

[0033] In use, as shown in FIG. 2, a powdery harmful substance scavenger (10 to 10 m in diameter) is applied to the oral cavity, nasal cavity, eyes, or vulva by means of a spraying device (30). ) In the form of a mist. this As a result, the harmful substance trapping agent (10) adheres to the oral cavity, nasal cavity, eyes, or mucous membrane of the vulva, and the harmful substances such as viruses (20) adhering to the mucous membrane are present. Captures harmful substances (20). In addition, harmful substances such as viruses that have entered the body (20) often adhere to the upper respiratory tract (40), but the harmful substance-trapping agent (10) injected into the oral cavity or nasal cavity has a particle size power of ~ ~ Since it is 10 m, it reaches the upper airway (40) and stays there, where it traps harmful substances (20). The chicken egg antibody (11) becomes active only in the presence of water, but in this case, it is activated by the water in the body.

[0034] The operational effects are the same as in the first embodiment.

Industrial applicability

[0035] The present invention provides a biological surface-attached harmful substance capturing agent (10) for capturing the harmful substance (20) by contact with the harmful substance (20), and a spraying device (30) and a spraying method thereof. Useful for.

Claims

The scope of the claims

[1] A biological surface-attached harmful substance scavenger (10) that captures the harmful substance (20) by contact with the harmful substance (20),

A harmful substance-capturing agent containing a chicken egg antibody (11) as a harmful substance-capturing component.

[2] In the hazardous substance scavenger (10) according to claim 1,

A harmful substance-capturing agent in a liquid form in which the chicken egg antibody (11) is dissolved in a solvent.

[3] In the hazardous substance scavenger (10) according to claim 1,

A harmful substance scavenger in powder form.

[4] In the hazardous substance scavenger (10) according to claim 3,

Hazardous substance scavenger with a particle size of 2-10 μm.

[5] In the hazardous substance scavenger (10) according to any one of claims 1 to 4,

A hazardous substance scavenger wherein the harmful substance (20) is at least one selected from bacteria, molds, viruses and allergens.

[6] Hazardous substance sprayed in the form of droplets with a particle size of 2 to 10 m in the form of a liquid harmful substance trapping agent (10) in which chicken egg antibody (11) is dissolved in a solvent as a harmful substance trapping component Scattering device (10).

[7] Spraying device for toxic substance scavenger (10) spraying powdery toxic substance scavenger (10) with particle size of 2 to 10 m containing chicken egg antibody (11) as a toxic substance scavenger .

[8] Toxic substance sprayed in the form of a mist of 2 to 10 m droplets of liquid harmful substance trapping agent (10) in which egg antibody (11) is dissolved in a solvent as a harmful substance-capturing component How to spread the scavenger (10).

[9] Spraying method of harmful substance scavenger (10) spraying powdery harmful substance scavenger (10) containing hen egg antibody (11) as a harmful substance scavenger component and having a particle size of 2 to 10 m .