WO2006020258A3 - Novel tetravalent bispecific antibody - Google Patents

Novel tetravalent bispecific antibody Download PDF

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Publication number
WO2006020258A3
WO2006020258A3 PCT/US2005/025472 US2005025472W WO2006020258A3 WO 2006020258 A3 WO2006020258 A3 WO 2006020258A3 US 2005025472 W US2005025472 W US 2005025472W WO 2006020258 A3 WO2006020258 A3 WO 2006020258A3
Authority
WO
WIPO (PCT)
Prior art keywords
bispecific antibody
tetravalent bispecific
antibodies
novel tetravalent
novel
Prior art date
Application number
PCT/US2005/025472
Other languages
French (fr)
Other versions
WO2006020258A2 (en
Inventor
Zhenping Zhu
Original Assignee
Imclone Systems Inc
Zhenping Zhu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imclone Systems Inc, Zhenping Zhu filed Critical Imclone Systems Inc
Priority to EP05773142A priority Critical patent/EP1786918A4/en
Priority to JP2007521716A priority patent/JP2008512352A/en
Publication of WO2006020258A2 publication Critical patent/WO2006020258A2/en
Publication of WO2006020258A3 publication Critical patent/WO2006020258A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

The invention is directed to novel tetravalent antibodies, which are preferably bi-specific. The tetravalent bispecific antibodies can be efficiently expressed in prokaryotic and eukaryotic cells, and are useful in therapeutic and diagnostic methods. The invention further describes administration of the antibodies, either alone or in combination with anti­angiogenic or anti-neoplastic drugs to inhibit tumor growth and/or angiogenesis.
PCT/US2005/025472 2004-07-17 2005-07-18 Novel tetravalent bispecific antibody WO2006020258A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP05773142A EP1786918A4 (en) 2004-07-17 2005-07-18 Novel tetravalent bispecific antibody
JP2007521716A JP2008512352A (en) 2004-07-17 2005-07-18 Novel tetravalent bispecific antibody

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58868804P 2004-07-17 2004-07-17
US60/588,688 2004-07-17

Publications (2)

Publication Number Publication Date
WO2006020258A2 WO2006020258A2 (en) 2006-02-23
WO2006020258A3 true WO2006020258A3 (en) 2006-10-12

Family

ID=35907983

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/025472 WO2006020258A2 (en) 2004-07-17 2005-07-18 Novel tetravalent bispecific antibody

Country Status (3)

Country Link
EP (1) EP1786918A4 (en)
JP (1) JP2008512352A (en)
WO (1) WO2006020258A2 (en)

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US11970538B2 (en) 2021-05-20 2024-04-30 Compass Therapeutics Llc Multispecific binding constructs against checkpoint molecules and uses thereof

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