WO2006018340A9 - Wirkstoffhaltiges tape zur behandlung von gelenkerkrankungen - Google Patents
Wirkstoffhaltiges tape zur behandlung von gelenkerkrankungenInfo
- Publication number
- WO2006018340A9 WO2006018340A9 PCT/EP2005/052858 EP2005052858W WO2006018340A9 WO 2006018340 A9 WO2006018340 A9 WO 2006018340A9 EP 2005052858 W EP2005052858 W EP 2005052858W WO 2006018340 A9 WO2006018340 A9 WO 2006018340A9
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- skin
- carrier material
- use according
- adhesive
- pads
- Prior art date
Links
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- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 229960005253 procyclidine Drugs 0.000 description 1
- 229960002262 profenamine Drugs 0.000 description 1
- CDOZDBSBBXSXLB-UHFFFAOYSA-N profenamine Chemical compound C1=CC=C2N(CC(C)N(CC)CC)C3=CC=CC=C3SC2=C1 CDOZDBSBBXSXLB-UHFFFAOYSA-N 0.000 description 1
- OJCPSBCUMRIPFL-UHFFFAOYSA-N prolintane Chemical compound C1CCCN1C(CCC)CC1=CC=CC=C1 OJCPSBCUMRIPFL-UHFFFAOYSA-N 0.000 description 1
- 229960004654 prolintane Drugs 0.000 description 1
- 229960003910 promethazine Drugs 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 1
- 229960000948 quinine Drugs 0.000 description 1
- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 238000010079 rubber tapping Methods 0.000 description 1
- BZGIPVGCJGXQTA-UHFFFAOYSA-N s-[2-(diethylamino)ethyl] n,n-diphenylcarbamothioate Chemical compound C=1C=CC=CC=1N(C(=O)SCCN(CC)CC)C1=CC=CC=C1 BZGIPVGCJGXQTA-UHFFFAOYSA-N 0.000 description 1
- 150000003902 salicylic acid esters Chemical class 0.000 description 1
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 1
- 229960002646 scopolamine Drugs 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- SLRCCWJSBJZJBV-AJNGGQMLSA-N sparteine Chemical compound C1N2CCCC[C@H]2[C@@H]2CN3CCCC[C@H]3[C@H]1C2 SLRCCWJSBJZJBV-AJNGGQMLSA-N 0.000 description 1
- 229960001945 sparteine Drugs 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229920003051 synthetic elastomer Polymers 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 239000005061 synthetic rubber Substances 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 229960002372 tetracaine Drugs 0.000 description 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 229960002784 thioridazine Drugs 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 229960004605 timolol Drugs 0.000 description 1
- 229960003741 tranylcypromine Drugs 0.000 description 1
- ZEWQUBUPAILYHI-UHFFFAOYSA-N trifluoperazine Chemical compound C1CN(C)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C21 ZEWQUBUPAILYHI-UHFFFAOYSA-N 0.000 description 1
- 229960002324 trifluoperazine Drugs 0.000 description 1
- IRYJRGCIQBGHIV-UHFFFAOYSA-N trimethadione Chemical compound CN1C(=O)OC(C)(C)C1=O IRYJRGCIQBGHIV-UHFFFAOYSA-N 0.000 description 1
- 229960004453 trimethadione Drugs 0.000 description 1
- ZSCDBOWYZJWBIY-UHFFFAOYSA-N trimipramine Chemical compound C1CC2=CC=CC=C2N(CC(CN(C)C)C)C2=CC=CC=C21 ZSCDBOWYZJWBIY-UHFFFAOYSA-N 0.000 description 1
- 229960002431 trimipramine Drugs 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
- 229940048102 triphosphoric acid Drugs 0.000 description 1
- PRBORDFJHHAISJ-UHFFFAOYSA-N tybamate Chemical compound CCCCNC(=O)OCC(C)(CCC)COC(N)=O PRBORDFJHHAISJ-UHFFFAOYSA-N 0.000 description 1
- 229960002560 tybamate Drugs 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 description 1
- 229960000604 valproic acid Drugs 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0203—Adhesive bandages or dressings with fluid retention members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/58—Adhesives
- A61L15/585—Mixtures of macromolecular compounds
Definitions
- the invention relates to the combination of a preferably self-adhesive tape and an active ingredient-containing skin layer for the production of a tape dressing for the treatment of joint diseases or for the care of the skin in the joint area.
- Transdermal Therapeutic Systems are dosage forms of drugs that deliver one or more drugs to the skin at their site of use for a defined period of time. A distinction is made between systemically and locally effective administration forms.
- the active ingredient passes through the diffusion through the
- Active substance remains in the skin or in the underlying layers.
- the adhesive of the patch can be used as the drug-containing matrix.
- solution applied self-adhesive also become for example, EP 0 663 431 A, EP 0 452 034 A, EP 0 305 757 A, DE-OS 43 10 012, DE-OS 42 22 334 and DE-C 42 24 325.
- active ingredients These are listed as systemically active when they are named.
- Capsaicin and nonivamide are known active ingredients of such local, blood circulation-promoting patch. Due to their application to the musculoskeletal system they usually have to stick strongly. Usually, the patches are coated over the entire surface with a resin-rubber adhesive containing the active ingredient.
- WO 94/02123 describes an active ingredient patch based on pressure-sensitive hotmelt adhesives which contains low-melting and / or highly volatile active ingredients in a concentration of 2.5% by weight to 25% by weight.
- Active substance-containing tapes or wound dressings can only be adequately fixed on joints due to the mechanical stress. A frequent dressing change is also common to administer suitable active ingredients of the site to be treated at or around the joint.
- the object of the invention was therefore to provide a treatment option for the treatment of joint diseases or for the care of the skin at joints, which does not have the disadvantages known from the prior art. Also, the treatment should be easy and uncomplicated by layman.
- the invention relates to the use of a combination of tape dressing and active ingredient-containing skin layer for the production of a self-adhesive tape dressing for the treatment of joint diseases or for the care of the skin on or around joints.
- the loaded with drug, doped skin layer is applied to a carrier material, which in turn is coated with an adhesive. It is advantageous that not as known from the prior art, the active ingredient in the adhesive of the carrier material must be incorporated and this can then penetrate the entire surface adhered to the substrate skin. Rather, one or more skin pads is applied to the carrier material coated with an undoped adhesive.
- the active ingredient-containing skin layer also referred to as a patch, according to the invention may have different sizes and shapes and thereby targeted only the area of a joint to be treated or Cover skin areas, so that the further then wrapped only with support material skin remains intact and is not unnecessarily burdened with active ingredients.
- the carrier material can be bound or glued overlapping around the joint and thus leads to a better fixation of the skin or layers and to an additional supporting effect on the treated joint. This is in particular a significant advantage of the inventive combination of drug patch and tapping method.
- the skin layer is doped with a total of up to 10 - 70 wt.%, Based on the total mass of the pad, with one or more active ingredients.
- the dimensions of the carrier material may preferably be between 30 cm and 70 cm in length and between 5 cm and 10 cm in width.
- the carrier material may in turn consist of a film, a polymer, a fabric or a nonwoven.
- the material may advantageously be elastic, being extensible in the range of 0-200%, in particular up to 100%, in the longitudinal and transverse directions.
- One or more active agent patches having a total area between 10 and 70% of the area of the carrier material may be applied.
- the carrier material can also be partially equipped with adhesive in addition to a full-surface coating with adhesive.
- an embodiment is preferred according to the invention, in which the tape bandage is not adhesive, and for fixing the bandage at the ends has only one closure, in particular a hook-and-loop fastener. This Velcro fastener allows the attachment of the carrier material to itself.
- Suitable support materials are stretchable fabrics of synthetic and natural raw materials. Preference is given to support materials which, after application of the self-adhesive composition, can be used in such a way that they fulfill the properties of a functionally appropriate dressing.
- textiles such as wovens, knits, fabrics, nonwovens, laminates, nets, films, foams and papers are listed which have a ductility of at least 10% under a load of 10 N / cm.
- the combinations of the materials mentioned are also suitable.
- Common pretreatments are corona and hydrophobing;
- Common aftertreatments are calendering, tempering, laminating, stamping and covering, UV / IR irradiation or electron irradiation.
- non-steroidal anti-inflammatory drugs such as Ibuptofen (and salts such as lysine salt), ketoprofen, diclofenac (and salts thereof) and etofenamate
- warming agents such as capsaicinoids, nicotinic acid, benzyl nicotinate, nonivamide and methyl or ethyl salicylate
- essential oils such as mint oil, eucalyptus and menthol or mixtures thereof are suitable for cooling and treatment without heat effects.
- active ingredients in the context of the present invention are meant chemical elements, organic and inorganic compounds which can migrate out of the constituent parts of a generic device and thereby produce a desired effect - And veterinary medicine of particular importance, in which case an embodiment of the invention in patch form is particularly preferred.
- the care of the skin in the joints can be in the focus. Accordingly, the skin layer with suitable skin care agents such. As jojoba oil, dexpanthenol, urea, aloe vera, coenzyme Q10 or other substances known from cosmetics may be doped.
- the skin patch is advantageously also constructed from a pressure-sensitive adhesive.
- the patch can also be executed in a non-adhesive form.
- the matrix may be a polymer matrix of hydrophilic polymers (eg acrylates, polyvinylpyrrolidone / polyacrylic acid, polyacrylic acid / polyvinyl alcohol) or hydrophobic polymers (eg polyisobutylenes, styrene-isoprene-styrene polymers, styrene-butadiene-styrene polymers, polyisoprenes, silicones or polyurethanes).
- hydrophilic polymers eg acrylates, polyvinylpyrrolidone / polyacrylic acid, polyacrylic acid / polyvinyl alcohol
- hydrophobic polymers eg polyisobutylenes, styrene-isoprene-styrene polymers, styrene-butadiene-s
- the patch is equipped with a barrier layer on the side of the support carrier, the carrier material, in order to prevent the material from migrating to the carrier material.
- a barrier layer on the side of the support carrier, the carrier material, in order to prevent the material from migrating to the carrier material.
- polyester, polyethylene or polypropylene is conceivable.
- the side facing the substrate may be equipped with an adhesive layer or a hook and loop fastener.
- the accessible ground side of the patch is covered with a siliconized paper or a siliconized film (see Figure 1).
- Thermoplastic hot melt self-adhesive compositions based on natural and synthetic rubbers and other synthetic polymers, such as acrylates, methacrylates, polyurethanes, polyolefins, polyvinyl derivatives, polyesters or silicones with appropriate additives, such as tackifier resins, plasticizers, stabilizers and other auxiliaries, can be used as required as adhesives for the support material.
- natural and synthetic rubbers and other synthetic polymers such as acrylates, methacrylates, polyurethanes, polyolefins, polyvinyl derivatives, polyesters or silicones with appropriate additives, such as tackifier resins, plasticizers, stabilizers and other auxiliaries, can be used as required as adhesives for the support material.
- hot melt self-adhesive compositions based on block copolymers are characterized by their wide range of possible variations, because by deliberately lowering the glass transition temperature of the self-adhesive composition as a result of the selection of tackifiers, plasticizers, polymer molecule size and molecular distribution of the starting components, the necessary functional bonding with the skin becomes critical Guaranteed placement of the human musculoskeletal system.
- the high shear strength of the hot melt self-adhesive composition is achieved by the high cohesiveness of the polymer.
- the good tack is the result of the range of tackifiers and plasticizers used.
- the hot-melt self-adhesive composition is preferably based on block copolymers, in particular AB, ABA block copolymers or mixtures thereof.
- the hard phase A is predominantly polystyrene or its derivatives
- the soft phase B contains ethylene, propylene, butylene, butadiene, isoprene or mixtures thereof, particularly preferably ethylene and butylene or mixtures thereof.
- polystyrene blocks can also be present in the soft phase B, up to 20% by weight.
- the total styrene content should always be lower than 35 wt .-%. Preference is given to styrene shares between 5 wt .-% and 30 wt .-%, since a lower styrene content makes the adhesive smoother.
- Spinning technology can be used for the application of thermoplastics and adhesives as a preferred method for the inventive open-pored coating of air and water vapor-permeable doped adhesive layers.
- Skin pad blended Enhancem modulated or reinforced by the occlusive effect of mass and coverage.
- skin coverings in conjunction with elastic, also breathable carrier materials in particular, for example during sports
- the adhesive of the carrier material is foamed. This must ensure the functional use of the material for special applications.
- foaming generally reduces the viscosity of the adhesives. As a result, the melting energy is lowered, and it can also thermally stable carrier materials are coated directly.
- Suitable carrier materials are all rigid and elastic fabrics made of synthetic and natural raw materials. Preference is given to support materials which, after application of the adhesive, can be used in such a way that they fulfill the properties of a functionally appropriate dressing.
- Examples include textiles such as fabrics, knits, fabrics, nonwovens, laminates, nets, and films, foams and papers listed. Furthermore, these materials can be pre- or post-treated. Common pretreatments are corona and hydrophobing; Common aftertreatments include calendering, tempering, laminating, stamping and coverslipping and crosslinking.
- the carrier material may take on known shapes and lengths of a dressing or tape.
- the foamed hot melt self-adhesive composition can be applied directly or first applied to a subcarrier and then transferred to the final carrier.
- the combination according to the invention With the combination according to the invention, the treatment of joint disease or the care of the skin with appropriate active ingredients and at the same time a relief of the joint by the supporting effect of the tape association on the carrier material is possible.
- the combination according to the invention is simple and uncomplicated to use and represents an "all in one" product for treatment and care.
- the finished mass is then pressed between release paper with a hydraulic press and then laminated on a 12 ⁇ m polyester film and release film. You punch out individual patches, skin pads.
- the mass is produced in a 50 mm Leistritz double-screw extruder with a mass output of 40 kg / h.
- the temperature profile for the process is 130 - 100 0 C from the task zone to the discharge zone.
- the ingredients of the adhesive matrix are added sequentially along the total length of the process part in the following order:
- the mass is continuously produced and discharged from a slot die.
- Discharge zone and slot die is installed a gear pump, which ensures a uniform Massausustrag.
- the adhesive is then passed through a calender between substrate and a
- the patches are individually packaged and placed on the carrier material before application.
- the PSA present on the carrier material then possibly ensures the adhesion of the patch to the carrier.
- the user can thus position the skin support as needed.
- FIG. 1 shows the schematic structure of the combination according to the invention.
- Figure 2 shows a plan view of the carrier material without adhesive and with Velcro.
- FIG. 3 shows various variations in the side view.
- FIG. 4 shows various variations in plan view.
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE200410039728 DE102004039728A1 (de) | 2004-08-16 | 2004-08-16 | Wirkstoffhaltiges Tape zur Behandlung von Gelenkerkrankungen |
DE102004039728.7 | 2004-08-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006018340A1 WO2006018340A1 (de) | 2006-02-23 |
WO2006018340A9 true WO2006018340A9 (de) | 2006-07-06 |
Family
ID=34979699
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2005/052858 WO2006018340A1 (de) | 2004-08-16 | 2005-06-21 | Wirkstoffhaltiges tape zur behandlung von gelenkerkrankungen |
Country Status (2)
Country | Link |
---|---|
DE (1) | DE102004039728A1 (de) |
WO (1) | WO2006018340A1 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102006040533A1 (de) * | 2006-08-30 | 2008-03-13 | Beiersdorf Ag | Stabilisiert geschäumte Klebemassen |
DE102011081818A1 (de) | 2011-08-30 | 2013-02-28 | Beiersdorf Ag | Wirkstoffhaltige Hautauflagen |
EP2898878A1 (de) * | 2014-01-23 | 2015-07-29 | LTS LOHMANN Therapie-Systeme AG | Klebeband enthaltend Beinwell |
DE102014113770A1 (de) | 2014-09-23 | 2016-03-24 | Msf Medizinische Sportwerke Frankfurt Gmbh | Pflaster mit öligen Pflanzenextrakten |
DE102015118780A1 (de) * | 2015-09-15 | 2017-03-16 | Andre Piontek | Medizinisches Pflaster |
DE102017110405A1 (de) | 2017-05-12 | 2018-11-15 | Msf Medizinische Sportwerke Frankfurt Gmbh | Ölige Pflanzenextrakte enthaltende Elemente und Pflaster, die derartige wirkstoffhaltige Elemente enthalten |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4619654A (en) * | 1984-01-10 | 1986-10-28 | George Abplanalp | Ointment applicator |
DE3743947A1 (de) * | 1987-09-01 | 1989-03-09 | Lohmann Gmbh & Co Kg | Vorrichtung zur gesteuerten abgabe von nicotin, verfahren zu ihrer herstellung sowie ihre verwendung |
CA2038902A1 (en) * | 1990-04-13 | 1991-10-14 | Randall Paul Sweet | Hot-melt silicone pressure sensitive adhesives with phenyl-containing siloxane fluid additive and related methods and articles |
DE4222334A1 (de) * | 1992-07-08 | 1994-01-13 | Beiersdorf Ag | Schmelzhaftkleber für Medical-Produkte |
DE4224325C1 (de) * | 1992-07-23 | 1994-02-10 | Sanol Arznei Schwarz Gmbh | Wirkstoffpflaster für niedrigschmelzende und/oder flüchtige Wirkstoffe und Verfahren zu seiner Herstellung |
DE4310012A1 (de) * | 1993-03-27 | 1994-09-29 | Roehm Gmbh | Dermales therapeutisches System aus einer schmelzfähigen Poly(meth)acrylat-Mischung |
US5482988A (en) * | 1994-01-14 | 1996-01-09 | Dow Corning Corporation | Hot-melt silicone pressure sensitive adhesive with siloxylated polyether waxes as additives |
DE19546024C2 (de) * | 1995-12-09 | 1998-09-10 | Lohmann Therapie Syst Lts | Transdermale pharmazeutische Zubereitung und deren Herstellung |
US5843018A (en) * | 1996-06-07 | 1998-12-01 | Tapeless Technologies, Inc. | Disposable sterile emollient carrier device |
DE19728279A1 (de) * | 1996-07-03 | 1998-01-08 | Stc Corp | Ketoprofen-Pflaster mit Langzeit/Sofort-Wirkung und Verfahren zu seiner Herstellung |
DE19650471A1 (de) * | 1996-12-05 | 1998-06-10 | Beiersdorf Ag | Wirkstoffhaltige Pflaster |
DE19749467C2 (de) * | 1997-11-08 | 1999-09-23 | Beiersdorf Ag | Wirkstoffhaltige Pflaster |
JP4275768B2 (ja) * | 1998-06-18 | 2009-06-10 | 久光製薬株式会社 | 水性粘着膏体 |
DE19830649C2 (de) * | 1998-07-09 | 2003-04-10 | Lohmann Therapie Syst Lts | Topisches Pflaster mit nichtsteroidalen Antirheumatika mit Säuregruppe |
DE10003767A1 (de) * | 2000-01-28 | 2001-10-04 | Beiersdorf Ag | Hautfreundliches Wirkstoffpflaster zur transdermalen Verabreichung nichtsteroidaler Antirheumatika |
DE10032132A1 (de) * | 2000-07-01 | 2002-01-17 | Lohmann Therapie Syst Lts | Dermales Therapeutisches System enthaltend nichtsteroidale Antiphlogistika mit selektiver COX-2-Hemmung |
DE10032537A1 (de) * | 2000-07-05 | 2002-01-31 | Labtec Gmbh | Dermales System, enthaltend 2-(3-Benzophenyl)Propionsäure |
DE10056012A1 (de) * | 2000-11-11 | 2002-05-16 | Beiersdorf Ag | Flexible Barrierefolie für ein Trägermaterial für medizinische Zwecke |
US6682757B1 (en) * | 2000-11-16 | 2004-01-27 | Euro-Celtique, S.A. | Titratable dosage transdermal delivery system |
DE10103860B4 (de) * | 2001-01-30 | 2004-12-23 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System für die Verabreichung carboxylgruppenhaltiger, nichtsteroidaler Antiphlogistika, sowie Verfahren zu seiner Herstellung |
US6399852B1 (en) * | 2001-02-09 | 2002-06-04 | Gary Barron | Bandage assembly |
DE10212864B4 (de) * | 2002-03-22 | 2005-12-22 | Beiersdorf Ag | Polymermatrizes umfassend ein Mischsystem zur Löslichkeitsvermittlung von pharmazeutischen Wirkstoffen, Verfahren zu deren Herstellung und deren Verwendung |
-
2004
- 2004-08-16 DE DE200410039728 patent/DE102004039728A1/de not_active Withdrawn
-
2005
- 2005-06-21 WO PCT/EP2005/052858 patent/WO2006018340A1/de active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2006018340A1 (de) | 2006-02-23 |
DE102004039728A1 (de) | 2006-02-23 |
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