WO2005115304A3 - Utilisation d'inhibiteurs de c-kit pour le traitement de la fibrodysplasie - Google Patents

Utilisation d'inhibiteurs de c-kit pour le traitement de la fibrodysplasie Download PDF

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Publication number
WO2005115304A3
WO2005115304A3 PCT/IB2005/001371 IB2005001371W WO2005115304A3 WO 2005115304 A3 WO2005115304 A3 WO 2005115304A3 IB 2005001371 W IB2005001371 W IB 2005001371W WO 2005115304 A3 WO2005115304 A3 WO 2005115304A3
Authority
WO
WIPO (PCT)
Prior art keywords
kit inhibitors
fibrodysplasia
treating
treating fibrodysplasia
inhibitors
Prior art date
Application number
PCT/IB2005/001371
Other languages
English (en)
Other versions
WO2005115304A2 (fr
Inventor
Alain Moussy
Jean-Pierre Kinet
Original Assignee
Ab Science
Alain Moussy
Jean-Pierre Kinet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ab Science, Alain Moussy, Jean-Pierre Kinet filed Critical Ab Science
Publication of WO2005115304A2 publication Critical patent/WO2005115304A2/fr
Publication of WO2005115304A3 publication Critical patent/WO2005115304A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne un procédé qui permet de traiter la fibrodysplasie telle que la fibrodysplasie ossifiante progressive, selon lequel on administre un composé capable de dépléter les mastocytes ou un composé inhibant la dégranulation des mastocytes à un humain qui en a besoin. Les composés tels que le composé précité peuvent être choisis parmi des inhibiteurs de c-kit et, en particulier, parmi des inhibiteurs de c-kit puissants, sélectifs et non toxiques. De préférence, l'inhibiteur n'est pas capable de promouvoir la mort des cellules dépendantes de l'IL-3 cultivées en présence d'IL-3.
PCT/IB2005/001371 2004-05-24 2005-04-19 Utilisation d'inhibiteurs de c-kit pour le traitement de la fibrodysplasie WO2005115304A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57334504P 2004-05-24 2004-05-24
US60/573,345 2004-05-24

Publications (2)

Publication Number Publication Date
WO2005115304A2 WO2005115304A2 (fr) 2005-12-08
WO2005115304A3 true WO2005115304A3 (fr) 2006-04-06

Family

ID=35276073

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/001371 WO2005115304A2 (fr) 2004-05-24 2005-04-19 Utilisation d'inhibiteurs de c-kit pour le traitement de la fibrodysplasie

Country Status (1)

Country Link
WO (1) WO2005115304A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006244203B2 (en) 2005-05-09 2012-05-03 Achillion Pharmaceuticals, Inc. Thiazole compounds and methods of use
EP3255061B1 (fr) 2006-11-03 2021-06-16 The Board of Trustees of the Leland Stanford Junior University Immunodéplétion sélective de niche de cellules souches endogènes pour greffe
EP2164846A2 (fr) 2007-05-22 2010-03-24 Achillion Pharmaceuticals, Inc. Thiazoles à substitution hétéroaryle et leur utilisation comme agents antivirales
WO2009114552A1 (fr) * 2008-03-10 2009-09-17 The Board Of Trustees Of The Leland Stanford Junior University Composés hétéroaryle, compositions et procédés d’utilisation dans le traitement du cancer
US8106209B2 (en) 2008-06-06 2012-01-31 Achillion Pharmaceuticals, Inc. Substituted aminothiazole prodrugs of compounds with anti-HCV activity
CA2728228A1 (fr) 2008-07-14 2010-01-21 Gilead Sciences, Inc. Composes inhibiteurs de l'oxindolyle
US8124764B2 (en) 2008-07-14 2012-02-28 Gilead Sciences, Inc. Fused heterocyclyc inhibitor compounds
CA2729909A1 (fr) 2008-07-14 2010-01-21 Gilead Sciences, Inc. Composes inhibiteurs de pyrimidine imidazolyle
CA2731323A1 (fr) 2008-07-28 2010-02-04 Gilead Sciences, Inc. Composes inhibiteurs de cycloalkylidene et d'heterocycloalkylidene d'histone desacetylase
ES2463826T3 (es) 2009-06-08 2014-05-29 Gilead Sciences, Inc. Compuestos inhibidores de HDAC de cicloalquilcarbamato benzamida anilina
CA2763786C (fr) 2009-06-08 2014-09-30 Gilead Sciences, Inc. Composes inhibiteurs d'hdac a base d'alkanoylamino benzamide aniline
CN103200937B (zh) 2010-09-01 2020-07-03 托马斯杰弗逊大学 用于肌肉修复和再生的组合物和方法
CN105073728A (zh) 2013-03-15 2015-11-18 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
EA202092627A1 (ru) 2013-11-18 2021-09-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
MX2018015108A (es) 2016-06-08 2019-08-29 Clementia Pharmaceuticals Inc Metodos para tratar la osificacion heterotopica.
AU2017359673B2 (en) 2016-11-16 2021-10-21 Clementia Pharmaceuticals Inc. Methods for treating multiple osteochondroma (MO)
EP3675878A4 (fr) 2017-10-02 2021-06-16 Fred Hutchinson Cancer Research Center Agents de liaison aux récepteurs de l'hormone lutéinisante et agonistes de l'hormone lutéinisante utilisés pour identifier, multiplier, retirer et modifier des populations de cellules souches primitives
WO2021214019A1 (fr) 2020-04-24 2021-10-28 Bayer Aktiengesellschaft Aminothiazoles substitués utilisés comme inhibiteurs de la dgk zêta pour l'activation immunitaire

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000010391A1 (fr) * 1998-08-25 2000-03-02 Medco Research, Inc. Utilisation d'antagonistes de recepteurs d'adenosine a3 pour inhiber la croissance tumorale
WO2002045652A2 (fr) * 2000-12-04 2002-06-13 Merck & Co., Inc. Inhibiteurs de tyrosine-kinase
WO2002053101A2 (fr) * 2000-12-29 2002-07-11 Alteon, Inc. Procede de traitement de troubles fibrogenes et autres symptomes de type ivc
WO2002094842A2 (fr) * 2001-05-24 2002-11-28 University Of Western Ontario Regulation de la myogenese par modulation de l'activite de la proteine-kinase p38 associee aux membranes
WO2003002109A2 (fr) * 2001-06-29 2003-01-09 Ab Science Utilisation d'inhibiteurs de tyrosine kinase destines a traiter des maladies auto-immunes
WO2004014903A1 (fr) * 2002-08-02 2004-02-19 Ab Science 2-(3-aminoaryl)amino-4-aryl-thiazoles et leur utilisation en tant que inhibiteurs de c-kit

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000010391A1 (fr) * 1998-08-25 2000-03-02 Medco Research, Inc. Utilisation d'antagonistes de recepteurs d'adenosine a3 pour inhiber la croissance tumorale
WO2002045652A2 (fr) * 2000-12-04 2002-06-13 Merck & Co., Inc. Inhibiteurs de tyrosine-kinase
WO2002053101A2 (fr) * 2000-12-29 2002-07-11 Alteon, Inc. Procede de traitement de troubles fibrogenes et autres symptomes de type ivc
WO2002094842A2 (fr) * 2001-05-24 2002-11-28 University Of Western Ontario Regulation de la myogenese par modulation de l'activite de la proteine-kinase p38 associee aux membranes
WO2003002109A2 (fr) * 2001-06-29 2003-01-09 Ab Science Utilisation d'inhibiteurs de tyrosine kinase destines a traiter des maladies auto-immunes
WO2004014903A1 (fr) * 2002-08-02 2004-02-19 Ab Science 2-(3-aminoaryl)amino-4-aryl-thiazoles et leur utilisation en tant que inhibiteurs de c-kit

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GANNON FRANCIS H ET AL: "Mast cell involvement in fibrodysplasia ossificans progressiva", HUMAN PATHOLOGY, vol. 32, no. 8, August 2001 (2001-08-01), pages 842 - 848, XP002354246, ISSN: 0046-8177 *
JOB-DESLANDRE CHANTAL: "Inherited ossifying diseases.", JOINT, BONE, SPINE : REVUE DU RHUMATISME. MAR 2004, vol. 71, no. 2, March 2004 (2004-03-01), pages 98 - 101, XP002354247, ISSN: 1297-319X *

Also Published As

Publication number Publication date
WO2005115304A2 (fr) 2005-12-08

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