WO2005113748B1 - Generation de cellules mapc de tissu pulmonaire - Google Patents
Generation de cellules mapc de tissu pulmonaireInfo
- Publication number
- WO2005113748B1 WO2005113748B1 PCT/US2005/013651 US2005013651W WO2005113748B1 WO 2005113748 B1 WO2005113748 B1 WO 2005113748B1 US 2005013651 W US2005013651 W US 2005013651W WO 2005113748 B1 WO2005113748 B1 WO 2005113748B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- epithelial cells
- alveolar type
- lung tissue
- alveolar
- subject
- Prior art date
Links
- 210000004072 Lung Anatomy 0.000 title claims abstract 9
- 210000001519 tissues Anatomy 0.000 title claims abstract 9
- 210000002919 epithelial cells Anatomy 0.000 claims 15
- 230000002685 pulmonary Effects 0.000 claims 4
- 206010069351 Acute lung injury Diseases 0.000 claims 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 2
- 208000006673 Asthma Diseases 0.000 claims 2
- 206010063725 Idiopathic pneumonia syndrome Diseases 0.000 claims 2
- 206010022114 Injury Diseases 0.000 claims 2
- 208000009856 Lung Disease Diseases 0.000 claims 2
- 206010067472 Organising pneumonia Diseases 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 230000001154 acute Effects 0.000 claims 2
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- 201000003883 cystic fibrosis Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 230000004064 dysfunction Effects 0.000 claims 2
- 239000000779 smoke Substances 0.000 claims 2
- 210000002469 Basement Membrane Anatomy 0.000 claims 1
- 210000000981 Epithelium Anatomy 0.000 claims 1
- 230000024245 cell differentiation Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000001963 growth media Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 230000001225 therapeutic Effects 0.000 claims 1
- 230000001058 adult Effects 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
Abstract
La présente invention concerne des méthode destinées à améliorer la fonction du tissu pulmonaire par administration d'une population de cellules progénitrices adultes multipotentes ('MAPCs') ou de leur descendance différenciée.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05778684A EP1737947B9 (fr) | 2004-04-21 | 2005-04-21 | Generation de tissu pulmonaire des cellules mapc |
| AT05778684T ATE512212T1 (de) | 2004-04-21 | 2005-04-21 | Erzeugung von lungengewebe aus multipotenten adulten progenitorzellen (mapc) |
| CA2564652A CA2564652C (fr) | 2004-04-21 | 2005-04-21 | Generation de cellules mapc de tissu pulmonaire |
| US11/587,511 US8609412B2 (en) | 1999-08-05 | 2005-04-21 | Mapc generation of lung tissue |
| HK07105856.5A HK1098507A1 (en) | 2004-04-21 | 2007-06-01 | Mapc generation of lung tissue |
| US14/107,242 US20140234267A1 (en) | 2004-04-21 | 2013-12-16 | MAPC Generation of Lung Tissue |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56462804P | 2004-04-21 | 2004-04-21 | |
| US60/564,628 | 2004-04-21 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US11/587,511 A-371-Of-International US8609412B2 (en) | 1999-08-05 | 2005-04-21 | Mapc generation of lung tissue |
| US14/107,242 Continuation US20140234267A1 (en) | 2004-04-21 | 2013-12-16 | MAPC Generation of Lung Tissue |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO2005113748A2 WO2005113748A2 (fr) | 2005-12-01 |
| WO2005113748A3 WO2005113748A3 (fr) | 2006-02-02 |
| WO2005113748B1 true WO2005113748B1 (fr) | 2006-04-06 |
Family
ID=35427666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2005/013651 WO2005113748A2 (fr) | 1999-08-05 | 2005-04-21 | Generation de cellules mapc de tissu pulmonaire |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20140234267A1 (fr) |
| EP (1) | EP1737947B9 (fr) |
| AT (1) | ATE512212T1 (fr) |
| CA (1) | CA2564652C (fr) |
| HK (1) | HK1098507A1 (fr) |
| WO (1) | WO2005113748A2 (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8147824B2 (en) | 1999-08-05 | 2012-04-03 | Athersys, Inc. | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
| US8609412B2 (en) | 1999-08-05 | 2013-12-17 | Regents Of The University Of Minnesota | Mapc generation of lung tissue |
| AU2005331559B2 (en) * | 2005-05-05 | 2012-04-19 | Regents Of The University Of Minnesota | Use of NK cell inhibition to facilitate persistence of engrafted MHC-I negative cells |
| US11000546B2 (en) | 2005-11-09 | 2021-05-11 | Athersys, Inc. | Immunomodulatory properties of MAPCs and uses thereof |
| US10117900B2 (en) | 2005-11-09 | 2018-11-06 | Athersys, Inc. | MAPC treatment of brain injuries and diseases |
| ES2308877B1 (es) | 2005-11-28 | 2009-10-26 | Consejo Superior Investig. Cientificas | Empleo de nuemocitos tipo ii en el tratamiento de enfermedades pulmonares que cursan con fibrosis pulmonar. |
| CN104027359A (zh) | 2006-01-23 | 2014-09-10 | 阿特西斯公司 | 无附加的免疫抑制治疗的mapc治疗法 |
| WO2007121443A2 (fr) * | 2006-04-17 | 2007-10-25 | Bioe, Inc. | Différenciation des cellules progénitrices à lignées multiples et cellules épithéliales respiratoires |
| CA2670497A1 (fr) | 2006-11-24 | 2008-05-29 | Regents Of The University Of Minnesota | Cellules progenitrices endothermiques |
| WO2008103810A1 (fr) * | 2007-02-21 | 2008-08-28 | Board Of Regents Of The University Of Texas System | Procédé de préparation de cellules épithéliales alvéolaires du poumon de type ii dérivées de cellules souches embryoniques |
| CN102388127B (zh) * | 2009-02-04 | 2016-10-26 | 耶鲁大学 | 肺的组织改造 |
| WO2011143415A1 (fr) | 2010-05-12 | 2011-11-17 | Abt Holding Company | Modulation des splénocytes en thérapie cellulaire |
| CA2909267C (fr) | 2013-04-12 | 2022-10-25 | Saverio LA FRANCESCA | Amelioration d'organes pour une transplantation |
| CA2921190C (fr) | 2013-08-16 | 2024-02-27 | Yale University | Differenciation des cellules epitheliales de cellules stromales mesenchymateuses humaines |
| EP3405566B1 (fr) | 2016-01-21 | 2023-10-18 | ABT Holding Company | Cellules souches pour la cicatrisation des ulcères de la peau |
| WO2022020985A1 (fr) * | 2020-07-27 | 2022-02-03 | 上海市公共卫生临床中心 | Méthode et application pour prévenir et traiter des maladies infectieuses des voies respiratoires en utilisant une membrane de cellule épithéliale des voies respiratoires |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8609412B2 (en) * | 1999-08-05 | 2013-12-17 | Regents Of The University Of Minnesota | Mapc generation of lung tissue |
| EP1367899A4 (fr) * | 2001-02-14 | 2004-07-28 | Leo T Furcht | Cellules souches adultes totipotentes, sources de ces cellules, procedes d'obtention et de maintien de ces dernieres, procedes de differentiation de ces cellules, procedes d'utilisation correspondants et cellules derivees des cellules susmentionnees |
| WO2003080649A2 (fr) * | 2002-03-20 | 2003-10-02 | Regents Of The University Of Minnesota | Induction de la proliferation d'hepatocytes in vitro par inhibition d'inhibiteurs du cycle cellulaire |
| GB0218332D0 (en) * | 2002-08-07 | 2002-09-18 | Imp College Innovations Ltd | Preparation of type pneumocytes |
-
2005
- 2005-04-21 AT AT05778684T patent/ATE512212T1/de not_active IP Right Cessation
- 2005-04-21 EP EP05778684A patent/EP1737947B9/fr not_active Not-in-force
- 2005-04-21 WO PCT/US2005/013651 patent/WO2005113748A2/fr active Application Filing
- 2005-04-21 CA CA2564652A patent/CA2564652C/fr active Active
-
2007
- 2007-06-01 HK HK07105856.5A patent/HK1098507A1/xx not_active IP Right Cessation
-
2013
- 2013-12-16 US US14/107,242 patent/US20140234267A1/en not_active Abandoned
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