WO2005099745A3 - Gcp-170 fusion proteins and uses thereof - Google Patents

Gcp-170 fusion proteins and uses thereof Download PDF

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Publication number
WO2005099745A3
WO2005099745A3 PCT/US2005/012839 US2005012839W WO2005099745A3 WO 2005099745 A3 WO2005099745 A3 WO 2005099745A3 US 2005012839 W US2005012839 W US 2005012839W WO 2005099745 A3 WO2005099745 A3 WO 2005099745A3
Authority
WO
WIPO (PCT)
Prior art keywords
fusion proteins
gcp
amino acid
acid sequence
protein
Prior art date
Application number
PCT/US2005/012839
Other languages
French (fr)
Other versions
WO2005099745A2 (en
Inventor
Elizabeth Sztul
Original Assignee
Uab Research Foundation
Elizabeth Sztul
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uab Research Foundation, Elizabeth Sztul filed Critical Uab Research Foundation
Publication of WO2005099745A2 publication Critical patent/WO2005099745A2/en
Publication of WO2005099745A3 publication Critical patent/WO2005099745A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to chimeric or fusion proteins comprising an amino acid sequence encoding a fluorescent protein and an amino acid sequence encoding a GCP170 protein or fragment thereof. The invention also provides the use of these fusion proteins to identify agents that modulate protein aggregation in cells.
PCT/US2005/012839 2004-04-13 2005-04-13 Gcp-170 fusion proteins and uses thereof WO2005099745A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56163404P 2004-04-13 2004-04-13
US60/561,634 2004-04-13

Publications (2)

Publication Number Publication Date
WO2005099745A2 WO2005099745A2 (en) 2005-10-27
WO2005099745A3 true WO2005099745A3 (en) 2006-03-30

Family

ID=35150500

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/012839 WO2005099745A2 (en) 2004-04-13 2005-04-13 Gcp-170 fusion proteins and uses thereof

Country Status (1)

Country Link
WO (1) WO2005099745A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202106690QA (en) 2019-02-08 2021-07-29 Dewpoint Therapeutics Inc Methods of characterizing condensate-associated characteristics of compounds and uses thereof
CA3153010A1 (en) 2019-09-18 2021-03-25 Dewpoint Therapeutics, Inc. Methods of screening for condensate-associated specificity and uses thereof

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CELLULAR AND MOLECULAR BIOLOGY LETTERS, vol. 6, no. 2, 2001, pages 186 *
DATABASE BIOSIS [online] ALVAREZ C. ET AL: "Role Of Golgi Matrix Proteins in Regulating Secretory Traffic", XP002996119, Database accession no. 200100513714 *
DATABASE BIOSIS [online] MISUMI Y. ET AL: "Molecular Characterization of GCP170, a 170-kDa Protein Associated with the Cytoplasmic Face of the Golgi Membrane", XP002996117, Database accession no. 199799781663 *
MISUMI Y. ET AL: "The Targeting Domains of the Peripheral Golgi Protein GCP170", CELL STRUCTURE AND FUNCTION, vol. 26, no. 5, October 2001 (2001-10-01), pages 4 - 18, XP008062148 *
OHTA E. ET AL: "Identification and Characterization of GCP16, a Novel Acylated Golgi Protein that Interacts with GCP170", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 51, 19 December 2003 (2003-12-19), pages 51957 - 51967, XP002996118 *
SUBRAMANIAM V. ET AL: "Photophysics of Green and Red Fluorescent Proteins: Implications for Quantitative Microscopy", METHODS IN ENZYMOLOGY, vol. 360, no. 6, 2003, pages 178 - 201, XP008062157 *
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 38, 19 September 1997 (1997-09-19), pages 23851 - 23858 *

Also Published As

Publication number Publication date
WO2005099745A2 (en) 2005-10-27

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